{"id":"https://openalex.org/W4308334523","doi":"https://doi.org/10.3389/fnins.2022.1042865","title":"Manipulation of the diet\u2013microbiota\u2013brain axis in Alzheimer\u2019s disease","display_name":"Manipulation of the diet\u2013microbiota\u2013brain axis in Alzheimer\u2019s disease","publication_year":2022,"publication_date":"2022-11-04","ids":{"openalex":"https://openalex.org/W4308334523","doi":"https://doi.org/10.3389/fnins.2022.1042865","pmid":"https://pubmed.ncbi.nlm.nih.gov/36408394","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9672822"},"language":"en","primary_location":{"id":"doi:10.3389/fnins.2022.1042865","doi":"https://doi.org/10.3389/fnins.2022.1042865","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnins.2022.1042865","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnins.2022.1042865/pdf","source":{"id":"https://openalex.org/S115201632","display_name":"Frontiers in Neuroscience","issn_l":"1662-453X","issn":["1662-453X","1662-4548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroscience","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fnins.2022.1042865/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100392997","display_name":"Daniel D. Lee","orcid":"https://orcid.org/0000-0003-1301-8501","observed_orcids":["https://orcid.org/0000-0003-1301-8501"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel Lee","raw_affiliation_strings":["Middleton High School, Middleton, WI, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Middleton High School, Middleton, WI, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065852445","display_name":"Virginia M.\u2010Y. Lee","orcid":"https://orcid.org/0000-0003-3536-6902","observed_orcids":["https://orcid.org/0000-0003-3536-6902"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Virginia M-Y. Lee","raw_affiliation_strings":["Center for Neurodegenerative Disease Research, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States","Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neurodegenerative Disease Research, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004278589","display_name":"Seong Kwon Hur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Seong Kwon Hur","raw_affiliation_strings":["Center for Neurodegenerative Disease Research, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States","Department of Neuroscience, Genentech, Inc., South San Francisco, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neurodegenerative Disease Research, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Neuroscience, Genentech, Inc., South San Francisco, CA, United States","institution_ids":["https://openalex.org/I183934855"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5004278589"],"corresponding_institution_ids":["https://openalex.org/I183934855","https://openalex.org/I79576946"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":0.604,"has_fulltext":true,"cited_by_count":32,"citation_normalized_percentile":{"value":0.5497399,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"16","issue":null,"first_page":"1042865","last_page":"1042865"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.8687000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.8687000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0940999984741211,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.007300000172108412,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":1.0},{"id":"https://openalex.org/keywords/gut-brain-axis","display_name":"gut-brain axis","score":0.921999990940094},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9629999995231628},{"id":"https://openalex.org/keywords/diet","display_name":"diet","score":0.7699999809265137},{"id":"https://openalex.org/keywords/mediterranean-diet","display_name":"Mediterranean diet","score":0.9589999914169312},{"id":"https://openalex.org/keywords/western-diet","display_name":"Western diet","score":0.9990000128746033},{"id":"https://openalex.org/keywords/probiotics","display_name":"probiotics","score":0.9380000233650208},{"id":"https://openalex.org/keywords/gut-dysbiosis","display_name":"gut dysbiosis","score":0.8709999918937683},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.9039999842643738},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9950000047683716},{"id":"https://openalex.org/keywords/dietary-intervention","display_name":"dietary intervention","score":0.4749999940395355}],"concepts":[{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.7159494757652283},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.7090401649475098},{"id":"https://openalex.org/C177857423","wikidata":"https://www.wikidata.org/wiki/Q17077315","display_name":"Gut\u2013brain axis","level":3,"score":0.6822572946548462},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.6684521436691284},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5333207845687866},{"id":"https://openalex.org/C2777165150","wikidata":"https://www.wikidata.org/wiki/Q269334","display_name":"Dysbiosis","level":3,"score":0.5140763521194458},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.47052088379859924},{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.4490078091621399},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4278082549571991},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.420653760433197},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.41432714462280273},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36070871353149414},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.350921094417572},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.23840487003326416},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.23283171653747559},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fnins.2022.1042865","doi":"https://doi.org/10.3389/fnins.2022.1042865","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnins.2022.1042865","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnins.2022.1042865/pdf","source":{"id":"https://openalex.org/S115201632","display_name":"Frontiers in Neuroscience","issn_l":"1662-453X","issn":["1662-453X","1662-4548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9672822","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9672822","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Neurosci","raw_type":"Text"},{"id":"pmid:36408394","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36408394","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:6d317899ec664ddea3f0a3b1c1ed3840","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6d317899ec664ddea3f0a3b1c1ed3840","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Neuroscience, Vol 16 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fnins.2022.1042865","doi":"https://doi.org/10.3389/fnins.2022.1042865","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnins.2022.1042865","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnins.2022.1042865/pdf","source":{"id":"https://openalex.org/S115201632","display_name":"Frontiers in Neuroscience","issn_l":"1662-453X","issn":["1662-453X","1662-4548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000893192","display_name":"Training in age related neurodegenerative diseases","funder_award_id":"T32AG000255","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4308334523.pdf","grobid_xml":"https://content.openalex.org/works/W4308334523.grobid-xml"},"referenced_works_count":395,"referenced_works":["https://openalex.org/W560330100","https://openalex.org/W1124117323","https://openalex.org/W1526611045","https://openalex.org/W1560531583","https://openalex.org/W1599723250","https://openalex.org/W1663623302","https://openalex.org/W1677668605","https://openalex.org/W1684361681","https://openalex.org/W1747046738","https://openalex.org/W1804731458","https://openalex.org/W1893987280","https://openalex.org/W1959339737","https://openalex.org/W1963723331","https://openalex.org/W1966418958","https://openalex.org/W1968083875","https://openalex.org/W1969619562","https://openalex.org/W1972493045","https://openalex.org/W1974952112","https://openalex.org/W1975040221","https://openalex.org/W1978197327","https://openalex.org/W1981500982","https://openalex.org/W1981801578","https://openalex.org/W1985747467","https://openalex.org/W1988226686","https://openalex.org/W1988999655","https://openalex.org/W1991763618","https://openalex.org/W1991892080","https://openalex.org/W1992680479","https://openalex.org/W1995281235","https://openalex.org/W1995903088","https://openalex.org/W1996557575","https://openalex.org/W1996807233","https://openalex.org/W1997608252","https://openalex.org/W1998821360","https://openalex.org/W2000225222","https://openalex.org/W2005503435","https://openalex.org/W2006205371","https://openalex.org/W2006395355","https://openalex.org/W2006575849","https://openalex.org/W2006858320","https://openalex.org/W2011848880","https://openalex.org/W2014141048","https://openalex.org/W2014632252","https://openalex.org/W2014739744","https://openalex.org/W2016076695","https://openalex.org/W2018681635","https://openalex.org/W2020957551","https://openalex.org/W2023234131","https://openalex.org/W2027582763","https://openalex.org/W2028901643","https://openalex.org/W2031202094","https://openalex.org/W2032643430","https://openalex.org/W2033386838","https://openalex.org/W2034147064","https://openalex.org/W2034286717","https://openalex.org/W2038003980","https://openalex.org/W2038274440","https://openalex.org/W2038977910","https://openalex.org/W2040721401","https://openalex.org/W2042322971","https://openalex.org/W2042677753","https://openalex.org/W2043036577","https://openalex.org/W2043175749","https://openalex.org/W2043666422","https://openalex.org/W2043870032","https://openalex.org/W2044960087","https://openalex.org/W2045119680","https://openalex.org/W2047111948","https://openalex.org/W2047159195","https://openalex.org/W2047777561","https://openalex.org/W2052792956","https://openalex.org/W2053771014","https://openalex.org/W2055544117","https://openalex.org/W2055995786","https://openalex.org/W2057569612","https://openalex.org/W2057574272","https://openalex.org/W2057712792","https://openalex.org/W2063084036","https://openalex.org/W2063294396","https://openalex.org/W2065925831","https://openalex.org/W2065968189","https://openalex.org/W2068826328","https://openalex.org/W2071068165","https://openalex.org/W2072623748","https://openalex.org/W2075193321","https://openalex.org/W2077553363","https://openalex.org/W2078825616","https://openalex.org/W2079446591","https://openalex.org/W2079873627","https://openalex.org/W2081736790","https://openalex.org/W2082299629","https://openalex.org/W2082442375","https://openalex.org/W2082704291","https://openalex.org/W2084566588","https://openalex.org/W2086667809","https://openalex.org/W2088125915","https://openalex.org/W2088343957","https://openalex.org/W2089529899","https://openalex.org/W2089607910","https://openalex.org/W2090248973","https://openalex.org/W2091052564","https://openalex.org/W2091319478","https://openalex.org/W2092038168","https://openalex.org/W2094869269","https://openalex.org/W2103890427","https://openalex.org/W2108281900","https://openalex.org/W2108900121","https://openalex.org/W2109113634","https://openalex.org/W2109527205","https://openalex.org/W2110169856","https://openalex.org/W2110934770","https://openalex.org/W2110936821","https://openalex.org/W2113009616","https://openalex.org/W2116492181","https://openalex.org/W2125411036","https://openalex.org/W2125747535","https://openalex.org/W2126128897","https://openalex.org/W2128730397","https://openalex.org/W2128744963","https://openalex.org/W2129284860","https://openalex.org/W2130404519","https://openalex.org/W2130940116","https://openalex.org/W2132154794","https://openalex.org/W2133719476","https://openalex.org/W2136797809","https://openalex.org/W2138276746","https://openalex.org/W2142179862","https://openalex.org/W2147372806","https://openalex.org/W2148457471","https://openalex.org/W2149074973","https://openalex.org/W2152532350","https://openalex.org/W2153654233","https://openalex.org/W2159992457","https://openalex.org/W2161996137","https://openalex.org/W2162088497","https://openalex.org/W2162794208","https://openalex.org/W2163174986","https://openalex.org/W2163245612","https://openalex.org/W2170644095","https://openalex.org/W2170724437","https://openalex.org/W2174278940","https://openalex.org/W2201843899","https://openalex.org/W2210309500","https://openalex.org/W2211097356","https://openalex.org/W2238677510","https://openalex.org/W2238821644","https://openalex.org/W2261687388","https://openalex.org/W2277652576","https://openalex.org/W2289713660","https://openalex.org/W2292502644","https://openalex.org/W2314634699","https://openalex.org/W2318314565","https://openalex.org/W2326153453","https://openalex.org/W2326200998","https://openalex.org/W2341425007","https://openalex.org/W2345604850","https://openalex.org/W2398058290","https://openalex.org/W2409656339","https://openalex.org/W2412626606","https://openalex.org/W2418137121","https://openalex.org/W2418217944","https://openalex.org/W2426632426","https://openalex.org/W2466890096","https://openalex.org/W2471197622","https://openalex.org/W2508213551","https://openalex.org/W2510053021","https://openalex.org/W2512797224","https://openalex.org/W2527820662","https://openalex.org/W2528415721","https://openalex.org/W2528438579","https://openalex.org/W2537399682","https://openalex.org/W2539380384","https://openalex.org/W2549210709","https://openalex.org/W2557717486","https://openalex.org/W2558041282","https://openalex.org/W2566271081","https://openalex.org/W2572551054","https://openalex.org/W2572710398","https://openalex.org/W2574784626","https://openalex.org/W2585111741","https://openalex.org/W2587087311","https://openalex.org/W2587539025","https://openalex.org/W2593993348","https://openalex.org/W2597385024","https://openalex.org/W2599579733","https://openalex.org/W2607259606","https://openalex.org/W2612161536","https://openalex.org/W2616526198","https://openalex.org/W2616825195","https://openalex.org/W2618537066","https://openalex.org/W2622807556","https://openalex.org/W2686471536","https://openalex.org/W2695618445","https://openalex.org/W2728135146","https://openalex.org/W2737081537","https://openalex.org/W2737314812","https://openalex.org/W2746385392","https://openalex.org/W2755335783","https://openalex.org/W2761210275","https://openalex.org/W2762408398","https://openalex.org/W2766407589","https://openalex.org/W2766754487","https://openalex.org/W2768957663","https://openalex.org/W2769145826","https://openalex.org/W2770311021","https://openalex.org/W2771750816","https://openalex.org/W2772553845","https://openalex.org/W2772974937","https://openalex.org/W2774460247","https://openalex.org/W2776096008","https://openalex.org/W2781583747","https://openalex.org/W2782421321","https://openalex.org/W2782617447","https://openalex.org/W2782715813","https://openalex.org/W2782843255","https://openalex.org/W2784298198","https://openalex.org/W2789527058","https://openalex.org/W2789690147","https://openalex.org/W2790004059","https://openalex.org/W2790416725","https://openalex.org/W2790928417","https://openalex.org/W2791135917","https://openalex.org/W2791209961","https://openalex.org/W2791853645","https://openalex.org/W2791998898","https://openalex.org/W2792709687","https://openalex.org/W2793877525","https://openalex.org/W2794075472","https://openalex.org/W2794459165","https://openalex.org/W2797690486","https://openalex.org/W2799884346","https://openalex.org/W2800822268","https://openalex.org/W2802421303","https://openalex.org/W2805127282","https://openalex.org/W2807772034","https://openalex.org/W2808457437","https://openalex.org/W2810013502","https://openalex.org/W2810261013","https://openalex.org/W2842332612","https://openalex.org/W2883253765","https://openalex.org/W2885492105","https://openalex.org/W2886484225","https://openalex.org/W2886952520","https://openalex.org/W2887230896","https://openalex.org/W2887857133","https://openalex.org/W2888024736","https://openalex.org/W2888303999","https://openalex.org/W2888331922","https://openalex.org/W2894133314","https://openalex.org/W2895297968","https://openalex.org/W2898270244","https://openalex.org/W2900969351","https://openalex.org/W2902315967","https://openalex.org/W2902636332","https://openalex.org/W2902711118","https://openalex.org/W2905037443","https://openalex.org/W2906257674","https://openalex.org/W2906772580","https://openalex.org/W2907509362","https://openalex.org/W2908339646","https://openalex.org/W2909041556","https://openalex.org/W2909668868","https://openalex.org/W2911396153","https://openalex.org/W2913433391","https://openalex.org/W2914698268","https://openalex.org/W2914725672","https://openalex.org/W2917793655","https://openalex.org/W2918069149","https://openalex.org/W2919889513","https://openalex.org/W2920551324","https://openalex.org/W2930481668","https://openalex.org/W2937882491","https://openalex.org/W2940158686","https://openalex.org/W2943016427","https://openalex.org/W2944734574","https://openalex.org/W2945016564","https://openalex.org/W2945258634","https://openalex.org/W2946372752","https://openalex.org/W2947959068","https://openalex.org/W2951769614","https://openalex.org/W2953423286","https://openalex.org/W2953534538","https://openalex.org/W2958665365","https://openalex.org/W2966476674","https://openalex.org/W2968152726","https://openalex.org/W2968836721","https://openalex.org/W2970322445","https://openalex.org/W2970686316","https://openalex.org/W2970854520","https://openalex.org/W2971056870","https://openalex.org/W2972760837","https://openalex.org/W2973319155","https://openalex.org/W2975942932","https://openalex.org/W2979144550","https://openalex.org/W2981842151","https://openalex.org/W2982436424","https://openalex.org/W2982623437","https://openalex.org/W2984712817","https://openalex.org/W2990201855","https://openalex.org/W2990286460","https://openalex.org/W2990398315","https://openalex.org/W2991099207","https://openalex.org/W2991180574","https://openalex.org/W2995167752","https://openalex.org/W2995308649","https://openalex.org/W2996080671","https://openalex.org/W2996654920","https://openalex.org/W2998768314","https://openalex.org/W2999771355","https://openalex.org/W3000211436","https://openalex.org/W3000313970","https://openalex.org/W3000726342","https://openalex.org/W3001550795","https://openalex.org/W3003912482","https://openalex.org/W3004007042","https://openalex.org/W3004054067","https://openalex.org/W3004055294","https://openalex.org/W3004151941","https://openalex.org/W3005810664","https://openalex.org/W3006261429","https://openalex.org/W3007853567","https://openalex.org/W3007924994","https://openalex.org/W3010923525","https://openalex.org/W3011519276","https://openalex.org/W3012943203","https://openalex.org/W3013362494","https://openalex.org/W3013784088","https://openalex.org/W3016877536","https://openalex.org/W3017847747","https://openalex.org/W3021572424","https://openalex.org/W3022473425","https://openalex.org/W3023197304","https://openalex.org/W3027118763","https://openalex.org/W3027193583","https://openalex.org/W3027658010","https://openalex.org/W3032022742","https://openalex.org/W3033413733","https://openalex.org/W3035275243","https://openalex.org/W3035812050","https://openalex.org/W3037102761","https://openalex.org/W3038338923","https://openalex.org/W3044057346","https://openalex.org/W3047682179","https://openalex.org/W3080973387","https://openalex.org/W3081422897","https://openalex.org/W3082782623","https://openalex.org/W3083042235","https://openalex.org/W3088139956","https://openalex.org/W3092216791","https://openalex.org/W3092672783","https://openalex.org/W3093399909","https://openalex.org/W3094482185","https://openalex.org/W3096586635","https://openalex.org/W3097527510","https://openalex.org/W3097879441","https://openalex.org/W3107395714","https://openalex.org/W3110480011","https://openalex.org/W3110491897","https://openalex.org/W3112370620","https://openalex.org/W3112585763","https://openalex.org/W3114822561","https://openalex.org/W3115259887","https://openalex.org/W3115444154","https://openalex.org/W3118702262","https://openalex.org/W3119286420","https://openalex.org/W3120487633","https://openalex.org/W3121452954","https://openalex.org/W3123195464","https://openalex.org/W3127050546","https://openalex.org/W3129925389","https://openalex.org/W3132872530","https://openalex.org/W3133846109","https://openalex.org/W3134008378","https://openalex.org/W3144939695","https://openalex.org/W3147786781","https://openalex.org/W3159579165","https://openalex.org/W3163554152","https://openalex.org/W3164845344","https://openalex.org/W3165543316","https://openalex.org/W3175256745","https://openalex.org/W3180475914","https://openalex.org/W3182564971","https://openalex.org/W3193270327","https://openalex.org/W3193421084","https://openalex.org/W3193450232","https://openalex.org/W3195378778","https://openalex.org/W3197066648","https://openalex.org/W3198551718","https://openalex.org/W3202085543","https://openalex.org/W4200258450","https://openalex.org/W4205354830","https://openalex.org/W4210260312","https://openalex.org/W4210821588","https://openalex.org/W4210987525","https://openalex.org/W7101084658"],"related_works":["https://openalex.org/W6990747317","https://openalex.org/W3157657875","https://openalex.org/W7171919282","https://openalex.org/W3093492766","https://openalex.org/W4389962137","https://openalex.org/W4416122037","https://openalex.org/W3049053732","https://openalex.org/W4414512301","https://openalex.org/W3011358143","https://openalex.org/W7164211852"],"abstract_inverted_index":{"Several":[0],"studies":[1,101,160],"investigating":[2],"the":[3,15,18,33,60,71,92,123,126,136,141,150,163,183,194,200,219,240],"pathogenesis":[4],"of":[5,17,36,65,73,87,125,135,140,158,196,202,222],"Alzheimer\u2019s":[6,78,130,177,203,237],"disease":[7,79,131,178,204,238],"have":[8,80,95,166],"identified":[9],"various":[10,42,111],"interdependent":[11],"constituents":[12],"contributing":[13],"to":[14,110,120,217],"exacerbation":[16],"disease,":[19,137,142],"including":[20],"A\u03b2":[21],"plaque":[22],"formation,":[23],"tau":[24],"protein":[25],"hyperphosphorylation,":[26],"neurofibrillary":[27],"tangle":[28],"accumulation,":[29],"glial":[30],"inflammation,":[31],"and":[32,44,70,113,118,185,189,211,224,231],"eventual":[34],"loss":[35],"proper":[37],"neural":[38],"plasticity.":[39],"Recently,":[40],"using":[41],"models":[43],"human":[45,105],"patients,":[46],"another":[47],"key":[48],"factor":[49],"has":[50],"been":[51],"established":[52],"as":[53,173],"an":[54],"influential":[55],"determinant":[56],"in":[57,104,108,129,149,235],"brain":[58],"homeostasis:":[59],"gut\u2013brain":[61,93,151,241],"axis.":[62,242],"The":[63],"implications":[64],"a":[66,74,82,133,138],"rapidly":[67],"aging":[68],"population":[69],"absence":[72],"definitive":[75],"cure":[76],"for":[77,84,176],"prompted":[81],"search":[83],"non-pharmaceutical":[85],"tools,":[86],"which":[88],"gut-modulatory":[89],"therapies":[90],"targeting":[91],"axis":[94],"shown":[96],"promise.":[97],"Yet":[98],"multiple":[99],"recent":[100],"examining":[102],"changes":[103],"gut":[106,127,191],"flora":[107],"response":[109],"probiotics":[112],"environmental":[114],"factors":[115],"are":[116],"limited":[117],"difficult":[119],"generalize;":[121],"whether":[122],"state":[124],"microbiota":[128],"is":[132],"cause":[134],"result":[139],"or":[143],"both":[144],"through":[145,205],"numerous":[146],"feedback":[147],"loops":[148],"axis,":[152],"remains":[153],"unclear.":[154],"However,":[155],"preliminary":[156],"findings":[157],"longitudinal":[159],"conducted":[161],"over":[162],"past":[164],"decades":[165],"highlighted":[167],"dietary":[168,233],"interventions,":[169],"especially":[170],"Mediterranean":[171],"diets,":[172],"preventative":[174],"measures":[175],"by":[179],"reversing":[180],"neuroinflammation,":[181],"modifying":[182],"intestinal":[184],"blood\u2013brain":[186],"barrier":[187,209],"(BBB),":[188],"addressing":[190],"dysbiosis.":[192],"Conversely,":[193],"consumption":[195],"Western":[197],"diets":[198],"intensifies":[199],"progression":[201],"genetic":[206],"alterations,":[207],"impaired":[208],"function,":[210],"chronic":[212],"inflammation.":[213],"This":[214],"review":[215],"aims":[216],"support":[218],"growing":[220],"body":[221],"experimental":[223],"clinical":[225],"data":[226],"highlighting":[227],"specific":[228],"probiotic":[229],"strains":[230],"particular":[232],"components":[234],"preventing":[236],"via":[239]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-11-11T00:00:00"}
