{"id":"https://openalex.org/W4308333979","doi":"https://doi.org/10.3390/bioengineering9110645","title":"Bioengineering of Hair Follicle-like Structure for Validation of Hair Growth Promoting Compounds","display_name":"Bioengineering of Hair Follicle-like Structure for Validation of Hair Growth Promoting Compounds","publication_year":2022,"publication_date":"2022-11-03","ids":{"openalex":"https://openalex.org/W4308333979","doi":"https://doi.org/10.3390/bioengineering9110645","pmid":"https://pubmed.ncbi.nlm.nih.gov/36354556"},"language":"en","primary_location":{"id":"doi:10.3390/bioengineering9110645","doi":"https://doi.org/10.3390/bioengineering9110645","is_oa":true,"landing_page_url":"https://doi.org/10.3390/bioengineering9110645","pdf_url":"https://www.mdpi.com/2306-5354/9/11/645/pdf?version=1667994613","source":{"id":"https://openalex.org/S4210179121","display_name":"Bioengineering","issn_l":"2306-5354","issn":["2306-5354"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioengineering","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2306-5354/9/11/645/pdf?version=1667994613","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082082248","display_name":"Hyun Woo Joo","orcid":"https://orcid.org/0000-0003-3024-0622","observed_orcids":["https://orcid.org/0000-0003-3024-0622"]},"institutions":[{"id":"https://openalex.org/I31419693","display_name":"Kyungpook National University","ror":"https://ror.org/040c17130","country_code":"KR","type":"education","lineage":["https://openalex.org/I31419693"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyun Woo Joo","raw_affiliation_strings":["BK21 FOUR KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents, Department of Biomedical Sciences, School of Medicine, Kyungpook National University, Daegu 41944, Korea","Department of Immunology, School of Medicine, Kyungpook National University, Daegu 41944, Korea"],"raw_orcid":"https://orcid.org/0000-0003-3024-0622","affiliations":[{"raw_affiliation_string":"BK21 FOUR KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents, Department of Biomedical Sciences, School of Medicine, Kyungpook National University, Daegu 41944, Korea","institution_ids":["https://openalex.org/I31419693"]},{"raw_affiliation_string":"Department of Immunology, School of Medicine, Kyungpook National University, Daegu 41944, Korea","institution_ids":["https://openalex.org/I31419693"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100773733","display_name":"Min Kyu Kim","orcid":"https://orcid.org/0000-0003-4609-1465","observed_orcids":["https://orcid.org/0000-0003-4609-1465"]},"institutions":[{"id":"https://openalex.org/I31419693","display_name":"Kyungpook National University","ror":"https://ror.org/040c17130","country_code":"KR","type":"education","lineage":["https://openalex.org/I31419693"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Min Kyu Kim","raw_affiliation_strings":["Department of Immunology, School of Medicine, Kyungpook National University, Daegu 41944, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, School of Medicine, Kyungpook National University, Daegu 41944, Korea","institution_ids":["https://openalex.org/I31419693"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103254302","display_name":"Soon\u2010Sun Bak","orcid":"https://orcid.org/0000-0002-4570-1383","observed_orcids":["https://orcid.org/0000-0002-4570-1383"]},"institutions":[{"id":"https://openalex.org/I31419693","display_name":"Kyungpook National University","ror":"https://ror.org/040c17130","country_code":"KR","type":"education","lineage":["https://openalex.org/I31419693"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Soon Sun Bak","raw_affiliation_strings":["Department of Immunology, School of Medicine, Kyungpook National University, Daegu 41944, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, School of Medicine, Kyungpook National University, Daegu 41944, Korea","institution_ids":["https://openalex.org/I31419693"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015079431","display_name":"Young Kwan Sung","orcid":"https://orcid.org/0000-0002-5122-4616","observed_orcids":["https://orcid.org/0000-0002-5122-4616"]},"institutions":[{"id":"https://openalex.org/I31419693","display_name":"Kyungpook National University","ror":"https://ror.org/040c17130","country_code":"KR","type":"education","lineage":["https://openalex.org/I31419693"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Young Kwan Sung","raw_affiliation_strings":["BK21 FOUR KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents, Department of Biomedical Sciences, School of Medicine, Kyungpook National University, Daegu 41944, Korea","Department of Immunology, School of Medicine, Kyungpook National University, Daegu 41944, Korea"],"raw_orcid":"https://orcid.org/0000-0002-5122-4616","affiliations":[{"raw_affiliation_string":"BK21 FOUR KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents, Department of Biomedical Sciences, School of Medicine, Kyungpook National University, Daegu 41944, Korea","institution_ids":["https://openalex.org/I31419693"]},{"raw_affiliation_string":"Department of Immunology, School of Medicine, Kyungpook National University, Daegu 41944, Korea","institution_ids":["https://openalex.org/I31419693"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5015079431"],"corresponding_institution_ids":["https://openalex.org/I31419693"],"apc_list":{"value":1700,"currency":"CHF","value_usd":1780},"apc_paid":{"value":1700,"currency":"CHF","value_usd":1780},"fwci":1.242,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.78768598,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"9","issue":"11","first_page":"645","last_page":"645"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hair-growth-promotion","display_name":"hair growth promotion","score":0.6389999985694885},{"id":"https://openalex.org/keywords/dermal-papilla-cells","display_name":"dermal papilla cells","score":0.9670000076293945},{"id":"https://openalex.org/keywords/keratinocytes","display_name":"keratinocytes","score":0.8169999718666077},{"id":"https://openalex.org/keywords/spheroids","display_name":"spheroids","score":0.7329999804496765},{"id":"https://openalex.org/keywords/immortalized-cell-lines","display_name":"immortalized cell lines","score":0.8730000257492065},{"id":"https://openalex.org/keywords/minoxidil","display_name":"minoxidil","score":0.8100000023841858},{"id":"https://openalex.org/keywords/tofacitinib","display_name":"tofacitinib","score":1.0},{"id":"https://openalex.org/keywords/vitamin-c","display_name":"vitamin C","score":1.0},{"id":"https://openalex.org/keywords/hair-care-products","display_name":"hair care products","score":0.4729999899864197},{"id":"https://openalex.org/keywords/screening-model","display_name":"screening model","score":0.5429999828338623}],"concepts":[{"id":"https://openalex.org/C2777216303","wikidata":"https://www.wikidata.org/wiki/Q866324","display_name":"Hair follicle","level":2,"score":0.8023543357849121},{"id":"https://openalex.org/C175369904","wikidata":"https://www.wikidata.org/wiki/Q208395","display_name":"Spheroid","level":3,"score":0.6336228251457214},{"id":"https://openalex.org/C2781085983","wikidata":"https://www.wikidata.org/wiki/Q505531","display_name":"Dermal papillae","level":3,"score":0.6035592555999756},{"id":"https://openalex.org/C2777074287","wikidata":"https://www.wikidata.org/wiki/Q1473931","display_name":"Keratinocyte","level":3,"score":0.5440589189529419},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5106199383735657},{"id":"https://openalex.org/C102570824","wikidata":"https://www.wikidata.org/wiki/Q147807","display_name":"Follicle","level":2,"score":0.5028333067893982},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46804237365722656},{"id":"https://openalex.org/C2778585322","wikidata":"https://www.wikidata.org/wiki/Q1566641","display_name":"Hair cell","level":3,"score":0.4397059977054596},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38661667704582214},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3264150619506836},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.19510072469711304},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.1795874536037445},{"id":"https://openalex.org/C2778500370","wikidata":"https://www.wikidata.org/wiki/Q212344","display_name":"Inner ear","level":2,"score":0.07647743821144104},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06146794557571411}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/bioengineering9110645","doi":"https://doi.org/10.3390/bioengineering9110645","is_oa":true,"landing_page_url":"https://doi.org/10.3390/bioengineering9110645","pdf_url":"https://www.mdpi.com/2306-5354/9/11/645/pdf?version=1667994613","source":{"id":"https://openalex.org/S4210179121","display_name":"Bioengineering","issn_l":"2306-5354","issn":["2306-5354"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioengineering","raw_type":"journal-article"},{"id":"pmid:36354556","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36354556","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioengineering (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9687544","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9687544","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioengineering (Basel)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:bb3b7cbea8ec44adb25b30bb26f4eca8","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/bb3b7cbea8ec44adb25b30bb26f4eca8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioengineering, Vol 9, Iss 11, p 645 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/bioengineering9110645","doi":"https://doi.org/10.3390/bioengineering9110645","is_oa":true,"landing_page_url":"https://doi.org/10.3390/bioengineering9110645","pdf_url":"https://www.mdpi.com/2306-5354/9/11/645/pdf?version=1667994613","source":{"id":"https://openalex.org/S4210179121","display_name":"Bioengineering","issn_l":"2306-5354","issn":["2306-5354"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioengineering","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1625442533","display_name":null,"funder_award_id":"2021N100","funder_id":"https://openalex.org/F4320332128","funder_display_name":"Commercializations Promotion Agency for R and D Outcomes"},{"id":"https://openalex.org/G1814706571","display_name":null,"funder_award_id":"2021N100","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G308334411","display_name":null,"funder_award_id":"KNU-2021","funder_id":"https://openalex.org/F4320321272","funder_display_name":"Kyungpook National University"},{"id":"https://openalex.org/G4140769166","display_name":null,"funder_award_id":"2021N100","funder_id":"https://openalex.org/F4320328359","funder_display_name":"Ministry of Science and ICT, South Korea"},{"id":"https://openalex.org/G7663981112","display_name":null,"funder_award_id":"NRF-2021R1A2C2003875","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320321272","display_name":"Kyungpook National University","ror":"https://ror.org/040c17130"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320322762","display_name":"Kyungpook National University Hospital","ror":"https://ror.org/04qn0xg47"},{"id":"https://openalex.org/F4320328359","display_name":"Ministry of Science and ICT, South Korea","ror":"https://ror.org/01wpjm123"},{"id":"https://openalex.org/F4320332128","display_name":"Commercializations Promotion Agency for R and D Outcomes","ror":"https://ror.org/05tz27s69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4308333979.pdf","grobid_xml":"https://content.openalex.org/works/W4308333979.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1545847816","https://openalex.org/W1969540624","https://openalex.org/W1999831098","https://openalex.org/W2023078673","https://openalex.org/W2034652807","https://openalex.org/W2038128569","https://openalex.org/W2039569972","https://openalex.org/W2051186877","https://openalex.org/W2101106024","https://openalex.org/W2107328147","https://openalex.org/W2111334492","https://openalex.org/W2130057699","https://openalex.org/W2155290753","https://openalex.org/W2177071410","https://openalex.org/W2626725994","https://openalex.org/W2893641631","https://openalex.org/W2897469437","https://openalex.org/W2904060869","https://openalex.org/W2922130354","https://openalex.org/W2966585674","https://openalex.org/W3015268941","https://openalex.org/W3032142305","https://openalex.org/W3098211307","https://openalex.org/W3107406176","https://openalex.org/W3119353425"],"related_works":["https://openalex.org/W1987407032","https://openalex.org/W3032256672","https://openalex.org/W2150518449","https://openalex.org/W2358021209","https://openalex.org/W2022967620","https://openalex.org/W4323642557","https://openalex.org/W2015770429","https://openalex.org/W2013584852","https://openalex.org/W2075925079","https://openalex.org/W2039077395"],"abstract_inverted_index":{"We":[0],"aimed":[1],"to":[2,39,164],"establish":[3],"screening":[4,175],"and":[5,32,63,88,96,150,176],"efficacy":[6],"test":[7],"techniques":[8],"for":[9,174],"use":[10],"in":[11,56,70,123,128,156,182],"the":[12,22,57,76,83,111,114,117,129,157,183],"development":[13],"of":[14,122],"hair-promoting":[15],"agents.":[16],"To":[17],"this":[18],"end,":[19],"we":[20,170],"used":[21,181],"dermal":[23,125],"papilla":[24],"cell":[25,28,36,54,78,98],"(DPc)-derived":[26],"immortalized":[27,42,97,162],"line":[29,37],"(SV40T-hTERT":[30],"DPc)":[31],"neonatal":[33],"foreskin-derived":[34],"keratinocyte":[35,108],"(Ker-CT)":[38],"form":[40,100],"an":[41],"cell-based":[43],"hair":[44,102,130,133,144],"follicle-like":[45,103,134,168],"structure.":[46],"The":[47,132],"SV40T-hTERT":[48,64],"DPc":[49,61,65,74],"spheroids":[50,58,68,115],"exhibited":[51],"a":[52,101,106,166],"higher":[53],"ratio":[55],"than":[59,72],"primary":[60,73,95],"spheroids,":[62],"aggregated":[66],"with":[67,105,141,154],"larger":[69],"diameter":[71,119],"when":[75],"same":[77,118],"number":[79],"was":[80,137],"seeded":[81],"into":[82],"low-adhesion":[84],"plate.":[85],"Microscopic":[86],"imaging":[87],"fluorescence":[89],"staining":[90],"results":[91],"indicated":[92],"that":[93,113,121,155],"both":[94],"combinations":[99],"structure":[104,135],"long-stretched":[107],"layer":[109],"under":[110],"condition":[112],"have":[116,171],"as":[120],"vivo":[124],"papillary":[126],"tissue":[127],"follicle.":[131],"elongation":[136],"increased":[138],"upon":[139],"treatment":[140],"three":[142],"known":[143],"follicle":[145],"growth-promoting":[146],"compounds":[147],"(minoxidil,":[148],"tofacitinib,":[149],"ascorbic":[151],"acid)":[152],"compared":[153],"control":[158],"group.":[159],"Therefore,":[160],"using":[161],"cells":[163],"generate":[165],"coherent":[167],"structure,":[169],"developed":[172],"models":[173],"evaluating":[177],"hair-care":[178],"materials":[179],"commonly":[180],"industry.":[184]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}