{"id":"https://openalex.org/W4308331400","doi":"https://doi.org/10.3390/ijms232113477","title":"Trichostatin D as a Novel KLF2 Activator Attenuates TNF\u03b1-Induced Endothelial Inflammation","display_name":"Trichostatin D as a Novel KLF2 Activator Attenuates TNF\u03b1-Induced Endothelial Inflammation","publication_year":2022,"publication_date":"2022-11-03","ids":{"openalex":"https://openalex.org/W4308331400","doi":"https://doi.org/10.3390/ijms232113477","pmid":"https://pubmed.ncbi.nlm.nih.gov/36362263"},"language":"en","primary_location":{"id":"doi:10.3390/ijms232113477","doi":"https://doi.org/10.3390/ijms232113477","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms232113477","pdf_url":"https://www.mdpi.com/1422-0067/23/21/13477/pdf?version=1667886780","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/23/21/13477/pdf?version=1667886780","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101190548","display_name":"Lijuan Lei","orcid":"https://orcid.org/0009-0001-0460-4544","observed_orcids":["https://orcid.org/0009-0001-0460-4544"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lijuan Lei","raw_affiliation_strings":["NHC Key Laboratory of Biotechnology of Antibiotics, National Center for Screening Novel Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), 1# Tiantan Xili, Beijing 100050, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NHC Key Laboratory of Biotechnology of Antibiotics, National Center for Screening Novel Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), 1# Tiantan Xili, Beijing 100050, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100602644","display_name":"Minghua Chen","orcid":"https://orcid.org/0000-0001-5634-4599","observed_orcids":["https://orcid.org/0000-0001-5634-4599"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Minghua Chen","raw_affiliation_strings":["NHC Key Laboratory of Biotechnology of Antibiotics, National Center for Screening Novel Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), 1# Tiantan Xili, Beijing 100050, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NHC Key Laboratory of Biotechnology of Antibiotics, National Center for Screening Novel Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), 1# Tiantan Xili, Beijing 100050, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101974372","display_name":"Chenyin Wang","orcid":"https://orcid.org/0000-0002-4963-777X","observed_orcids":["https://orcid.org/0000-0002-4963-777X"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chenyin Wang","raw_affiliation_strings":["NHC Key Laboratory of Biotechnology of Antibiotics, National Center for Screening Novel Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), 1# Tiantan Xili, Beijing 100050, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NHC Key Laboratory of Biotechnology of Antibiotics, National Center for Screening Novel Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), 1# Tiantan Xili, Beijing 100050, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108823047","display_name":"Xinhai Jiang","orcid":"https://orcid.org/0000-0003-0585-215X","observed_orcids":["https://orcid.org/0000-0003-0585-215X"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinhai Jiang","raw_affiliation_strings":["NHC Key Laboratory of Biotechnology of Antibiotics, National Center for Screening Novel Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), 1# Tiantan Xili, Beijing 100050, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NHC Key Laboratory of Biotechnology of Antibiotics, National Center for Screening Novel Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), 1# Tiantan Xili, Beijing 100050, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101758673","display_name":"Yinghong Li","orcid":"https://orcid.org/0000-0002-3842-3127","observed_orcids":["https://orcid.org/0000-0002-3842-3127"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yinghong Li","raw_affiliation_strings":["NHC Key Laboratory of Biotechnology of Antibiotics, National Center for Screening Novel Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), 1# Tiantan Xili, Beijing 100050, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NHC Key Laboratory of Biotechnology of Antibiotics, National Center for Screening Novel Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), 1# Tiantan Xili, Beijing 100050, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Weizhi Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weizhi Wang","raw_affiliation_strings":["NHC Key Laboratory of Biotechnology of Antibiotics, National Center for Screening Novel Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), 1# Tiantan Xili, Beijing 100050, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NHC Key Laboratory of Biotechnology of Antibiotics, National Center for Screening Novel Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), 1# Tiantan Xili, Beijing 100050, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085815024","display_name":"Shunwang Li","orcid":"https://orcid.org/0009-0000-4436-439X","observed_orcids":["https://orcid.org/0009-0000-4436-439X"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shunwang Li","raw_affiliation_strings":["NHC Key Laboratory of Biotechnology of Antibiotics, National Center for Screening Novel Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), 1# Tiantan Xili, Beijing 100050, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NHC Key Laboratory of Biotechnology of Antibiotics, National Center for Screening Novel Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), 1# Tiantan Xili, Beijing 100050, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101529825","display_name":"Liping Zhao","orcid":"https://orcid.org/0000-0002-5606-5562","observed_orcids":["https://orcid.org/0000-0002-5606-5562"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liping Zhao","raw_affiliation_strings":["NHC Key Laboratory of Biotechnology of Antibiotics, National Center for Screening Novel Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), 1# Tiantan Xili, Beijing 100050, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NHC Key Laboratory of Biotechnology of Antibiotics, National Center for Screening Novel Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), 1# Tiantan Xili, Beijing 100050, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ren Sheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ren Sheng","raw_affiliation_strings":["NHC Key Laboratory of Biotechnology of Antibiotics, National Center for Screening Novel Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), 1# Tiantan Xili, Beijing 100050, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NHC Key Laboratory of Biotechnology of Antibiotics, National Center for Screening Novel Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), 1# Tiantan Xili, Beijing 100050, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010982644","display_name":"Jiangxue Han","orcid":"https://orcid.org/0009-0000-9421-9924","observed_orcids":["https://orcid.org/0009-0000-9421-9924"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiangxue Han","raw_affiliation_strings":["NHC Key Laboratory of Biotechnology of Antibiotics, National Center for Screening Novel Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), 1# Tiantan Xili, Beijing 100050, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NHC Key Laboratory of Biotechnology of Antibiotics, National Center for Screening Novel Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), 1# Tiantan Xili, Beijing 100050, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100741682","display_name":"Yuyan Zhang","orcid":"https://orcid.org/0000-0002-2594-0918","observed_orcids":["https://orcid.org/0000-0002-2594-0918"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuyan Zhang","raw_affiliation_strings":["NHC Key Laboratory of Biotechnology of Antibiotics, National Center for Screening Novel Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), 1# Tiantan Xili, Beijing 100050, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NHC Key Laboratory of Biotechnology of Antibiotics, National Center for Screening Novel Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), 1# Tiantan Xili, Beijing 100050, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101628626","display_name":"Yu\u2010Chuan Chen","orcid":"https://orcid.org/0000-0003-1723-3567","observed_orcids":["https://orcid.org/0000-0003-1723-3567"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuchuan Chen","raw_affiliation_strings":["NHC Key Laboratory of Biotechnology of Antibiotics, National Center for Screening Novel Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), 1# Tiantan Xili, Beijing 100050, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NHC Key Laboratory of Biotechnology of Antibiotics, National Center for Screening Novel Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), 1# Tiantan Xili, Beijing 100050, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101188805","display_name":"Biying Yan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Biying Yan","raw_affiliation_strings":["NHC Key Laboratory of Biotechnology of Antibiotics, National Center for Screening Novel Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), 1# Tiantan Xili, Beijing 100050, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NHC Key Laboratory of Biotechnology of Antibiotics, National Center for Screening Novel Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), 1# Tiantan Xili, Beijing 100050, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104202766","display_name":"Yexiang Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yexiang Wu","raw_affiliation_strings":["NHC Key Laboratory of Biotechnology of Antibiotics, National Center for Screening Novel Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), 1# Tiantan Xili, Beijing 100050, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NHC Key Laboratory of Biotechnology of Antibiotics, National Center for Screening Novel Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), 1# Tiantan Xili, Beijing 100050, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055091000","display_name":"Liyan Yu","orcid":"https://orcid.org/0000-0002-8861-9806","observed_orcids":["https://orcid.org/0000-0002-8861-9806"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liyan Yu","raw_affiliation_strings":["NHC Key Laboratory of Biotechnology of Antibiotics, National Center for Screening Novel Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), 1# Tiantan Xili, Beijing 100050, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NHC Key Laboratory of Biotechnology of Antibiotics, National Center for Screening Novel Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), 1# Tiantan Xili, Beijing 100050, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110875240","display_name":"Shuyi Si","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shuyi Si","raw_affiliation_strings":["NHC Key Laboratory of Biotechnology of Antibiotics, National Center for Screening Novel Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), 1# Tiantan Xili, Beijing 100050, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NHC Key Laboratory of Biotechnology of Antibiotics, National Center for Screening Novel Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), 1# Tiantan Xili, Beijing 100050, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102027775","display_name":"Yanni Xu","orcid":"https://orcid.org/0000-0003-1539-0606","observed_orcids":["https://orcid.org/0000-0003-1539-0606"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yanni Xu","raw_affiliation_strings":["NHC Key Laboratory of Biotechnology of Antibiotics, National Center for Screening Novel Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), 1# Tiantan Xili, Beijing 100050, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NHC Key Laboratory of Biotechnology of Antibiotics, National Center for Screening Novel Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), 1# Tiantan Xili, Beijing 100050, China","institution_ids":["https://openalex.org/I200296433"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5102027775","https://openalex.org/A5110875240"],"corresponding_institution_ids":["https://openalex.org/I200296433"],"apc_list":{"value":2300,"currency":"CHF","value_usd":2408},"apc_paid":{"value":2300,"currency":"CHF","value_usd":2408},"fwci":0.6224,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.60995454,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":98},"biblio":{"volume":"23","issue":"21","first_page":"13477","last_page":"13477"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13426","display_name":"Kruppel-like factors research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13426","display_name":"Kruppel-like factors research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/klf2","display_name":"KLF2","score":0.8240000009536743},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibition","display_name":"histone deacetylase inhibition","score":0.8309999704360962},{"id":"https://openalex.org/keywords/endothelial-inflammation","display_name":"endothelial inflammation","score":0.8870000243186951},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8069999814033508},{"id":"https://openalex.org/keywords/streptomyces","display_name":"Streptomyces","score":0.7870000004768372},{"id":"https://openalex.org/keywords/rice-fermentation","display_name":"rice fermentation","score":0.7269999980926514},{"id":"https://openalex.org/keywords/microbial-secondary-metabolites","display_name":"microbial secondary metabolites","score":0.8790000081062317},{"id":"https://openalex.org/keywords/nlrp3-inflammasome","display_name":"NLRP3 inflammasome","score":0.9100000262260437},{"id":"https://openalex.org/keywords/caspase-1","display_name":"caspase-1","score":0.8889999985694885},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9169999957084656},{"id":"https://openalex.org/keywords/monocyte-adhesion","display_name":"monocyte adhesion","score":0.9369999766349792},{"id":"https://openalex.org/keywords/vcam-1","display_name":"VCAM-1","score":0.9850000143051147},{"id":"https://openalex.org/keywords/icam-1","display_name":"ICAM-1","score":0.9860000014305115},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.8050000071525574}],"concepts":[{"id":"https://openalex.org/C2777350992","wikidata":"https://www.wikidata.org/wiki/Q18035329","display_name":"KLF2","level":4,"score":0.6584348678588867},{"id":"https://openalex.org/C2777865847","wikidata":"https://www.wikidata.org/wiki/Q425894","display_name":"Trichostatin A","level":5,"score":0.5885988473892212},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5719041228294373},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5313950777053833},{"id":"https://openalex.org/C2778942008","wikidata":"https://www.wikidata.org/wiki/Q305004","display_name":"Sodium butyrate","level":3,"score":0.4508209526538849},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.4472172260284424},{"id":"https://openalex.org/C71723506","wikidata":"https://www.wikidata.org/wiki/Q18026859","display_name":"Histone deacetylase 2","level":5,"score":0.44140470027923584},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.4253655672073364},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4151734411716461},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.40027284622192383},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3425743579864502},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2961345911026001},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2816695272922516},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.17341271042823792},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.1631493866443634},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.14376336336135864},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000071199","descriptor_name":"NLR Family, Pyrin Domain-Containing 3 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000071199","descriptor_name":"NLR Family, Pyrin Domain-Containing 3 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000071199","descriptor_name":"NLR Family, Pyrin Domain-Containing 3 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006877","descriptor_name":"Hydroxamic Acids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019010","descriptor_name":"Vascular Cell Adhesion Molecule-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019010","descriptor_name":"Vascular Cell Adhesion Molecule-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019010","descriptor_name":"Vascular Cell Adhesion Molecule-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051741","descriptor_name":"Kruppel-Like Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051741","descriptor_name":"Kruppel-Like Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051741","descriptor_name":"Kruppel-Like Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051741","descriptor_name":"Kruppel-Like Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051741","descriptor_name":"Kruppel-Like Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051741","descriptor_name":"Kruppel-Like Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3390/ijms232113477","doi":"https://doi.org/10.3390/ijms232113477","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms232113477","pdf_url":"https://www.mdpi.com/1422-0067/23/21/13477/pdf?version=1667886780","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmid:36362263","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36362263","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9656815","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9656815","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:a5bc2f3284b24ae686783a093cd02e93","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a5bc2f3284b24ae686783a093cd02e93","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences, Vol 23, Iss 13477, p 13477 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ijms232113477","doi":"https://doi.org/10.3390/ijms232113477","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms232113477","pdf_url":"https://www.mdpi.com/1422-0067/23/21/13477/pdf?version=1667886780","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1723267959","display_name":null,"funder_award_id":"81973328","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320310246","display_name":"University of Rochester","ror":"https://ror.org/022kthw22"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322647","display_name":"Chinese Pharmaceutical Association","ror":"https://ror.org/023q20n38"},{"id":"https://openalex.org/F4320326853","display_name":"Peking Union Medical College","ror":"https://ror.org/02drdmm93"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4308331400.pdf","grobid_xml":"https://content.openalex.org/works/W4308331400.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W1996917210","https://openalex.org/W2041986831","https://openalex.org/W2119129191","https://openalex.org/W2144993269","https://openalex.org/W2155086974","https://openalex.org/W2275204317","https://openalex.org/W2279717914","https://openalex.org/W2400167361","https://openalex.org/W2564313823","https://openalex.org/W2586435916","https://openalex.org/W2739020588","https://openalex.org/W2745487428","https://openalex.org/W2751157908","https://openalex.org/W2765749162","https://openalex.org/W2775506761","https://openalex.org/W2793675081","https://openalex.org/W2794169913","https://openalex.org/W2800009248","https://openalex.org/W2803038140","https://openalex.org/W2803047725","https://openalex.org/W2809703637","https://openalex.org/W2884649359","https://openalex.org/W2887426837","https://openalex.org/W2888679536","https://openalex.org/W2891701191","https://openalex.org/W2902345322","https://openalex.org/W2936977021","https://openalex.org/W2963853336","https://openalex.org/W2964584906","https://openalex.org/W2974408969","https://openalex.org/W2983871227","https://openalex.org/W2990498378","https://openalex.org/W2994142215","https://openalex.org/W3006888458","https://openalex.org/W3038833640","https://openalex.org/W3088268138","https://openalex.org/W3109251337","https://openalex.org/W3137230464","https://openalex.org/W3156151565","https://openalex.org/W3178353996","https://openalex.org/W3203845560","https://openalex.org/W3216605022","https://openalex.org/W4210532486","https://openalex.org/W4220713736","https://openalex.org/W4220787494","https://openalex.org/W4220896600","https://openalex.org/W4224470045","https://openalex.org/W4225091483","https://openalex.org/W4226382238","https://openalex.org/W4226397967","https://openalex.org/W4280542460","https://openalex.org/W6771583775","https://openalex.org/W6810399050"],"related_works":["https://openalex.org/W2392327783","https://openalex.org/W2060017122","https://openalex.org/W2053139375","https://openalex.org/W2083299719","https://openalex.org/W2362857891","https://openalex.org/W2334168046","https://openalex.org/W2080624633","https://openalex.org/W3030950996","https://openalex.org/W2003519583","https://openalex.org/W2029788469"],"abstract_inverted_index":{"Kr\u00fcppel-like":[0],"factor":[1,9,140],"2":[2],"(KLF2)":[3],"is":[4],"an":[5,134],"atherosclerotic":[6],"protective":[7],"transcription":[8],"that":[10,96,110,154,197],"maintains":[11],"endothelial":[12,105,116,143,165,248],"cell":[13,120],"homeostasis":[14],"through":[15,148],"its":[16],"anti-inflammatory,":[17],"anti-oxidant,":[18],"and":[19,36,63,82,125,132,150,162,174,191,207,222,244,246],"antithrombotic":[20],"properties.":[21],"The":[22],"aim":[23],"of":[24,78,102,157,218,229,252],"this":[25,232],"study":[26],"was":[27,72,213],"to":[28,115],"discover":[29],"KLF2":[30,51,87,103,172,200,230,237],"activators":[31],"from":[32,74,215],"microbial":[33],"secondary":[34],"metabolites":[35],"explore":[37],"their":[38],"potential":[39,227],"molecular":[40,192],"mechanisms.":[41],"By":[42],"using":[43],"a":[44,50,85,226],"high-throughput":[45],"screening":[46],"model":[47],"based":[48],"on":[49,159,170],"promoter":[52],"luciferase":[53],"reporter":[54],"assay,":[55],"column":[56],"chromatography,":[57],"electrospray":[58],"ionization":[59],"mass":[60],"spectrometry":[61],"(ESI-MS),":[62],"nuclear":[64],"magnetic":[65],"resonance":[66],"(NMR)":[67],"spectra,":[68],"trichostatin":[69],"D":[70],"(TSD)":[71],"isolated":[73,214],"the":[75,99,155,177,216,253],"rice":[76],"fermentation":[77,217],"Streptomyces":[79,219],"sp.":[80,220],"CPCC203909":[81,221],"identified":[83],"as":[84,225],"novel":[86],"activator.":[88],"Real-time-quantitative":[89],"polymerase":[90],"chain":[91],"reaction":[92],"(RT-qPCR)":[93],"results":[94,195],"showed":[95,109,196],"TSD":[97,111,158,198,212,235],"upregulated":[98,199,236],"mRNA":[100],"level":[101],"in":[104,137,164,231],"cells.":[106,144],"Functional":[107],"assays":[108,153],"attenuated":[112,247],"monocyte":[113,160],"adhesion":[114,121,127,161],"cells,":[117],"decreased":[118],"vascular":[119],"protein":[122,180],"1":[123,129],"(VCAM-1)":[124],"intercellular":[126],"molecule":[128],"(ICAM-1)":[130],"expression,":[131],"exhibited":[133],"anti-inflammatory":[135],"effect":[136],"tumor":[138],"necrosis":[139],"alpha":[141],"(TNF\u03b1)-induced":[142],"We":[145],"further":[146],"demonstrated":[147],"siRNA":[149],"western":[151],"blot":[152],"effects":[156],"inflammation":[163,249],"cells":[166],"were":[167],"partly":[168],"dependent":[169],"upregulating":[171],"expression":[173,201,238],"then":[175],"inhibiting":[176,203,240],"NOD-like":[178],"receptor":[179],"3":[181],"(NLRP3)/Caspase-1/interleukin-1beta":[182],"(IL-1\u03b2)":[183],"signaling":[184,255],"pathway.":[185,256],"Furthermore,":[186,234],"histone":[187],"deacetylase":[188],"(HDAC)":[189],"overexpression":[190],"docking":[193],"analysis":[194],"by":[202,239],"HDAC":[204,241],"4,":[205,242],"5,":[206,243],"7":[208,245],"activities.":[209],"Taken":[210],"together,":[211],"first":[223],"reported":[224],"activator":[228],"study.":[233],"via":[250],"regulation":[251],"KLF2/NLRP3/Caspase-1/IL-1\u03b2":[254]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":6}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}