{"id":"https://openalex.org/W4308331306","doi":"https://doi.org/10.3390/medicina58111593","title":"Association of Polymorphism of the Methyl Tetrahydrofolate Reductase (MTHFR) Gene with Anti-Seizure Medication Response in Pediatric Patients in Jeddah, Saudi Arabia","display_name":"Association of Polymorphism of the Methyl Tetrahydrofolate Reductase (MTHFR) Gene with Anti-Seizure Medication Response in Pediatric Patients in Jeddah, Saudi Arabia","publication_year":2022,"publication_date":"2022-11-03","ids":{"openalex":"https://openalex.org/W4308331306","doi":"https://doi.org/10.3390/medicina58111593","pmid":"https://pubmed.ncbi.nlm.nih.gov/36363550","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9698893"},"language":"en","primary_location":{"id":"doi:10.3390/medicina58111593","doi":"https://doi.org/10.3390/medicina58111593","is_oa":true,"landing_page_url":"https://doi.org/10.3390/medicina58111593","pdf_url":"https://www.mdpi.com/1648-9144/58/11/1593/pdf?version=1668663157","source":{"id":"https://openalex.org/S1008817457","display_name":"Medicina","issn_l":"1010-660X","issn":["1010-660X","1648-9144"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4308331306"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1648-9144/58/11/1593/pdf?version=1668663157","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062979344","display_name":"Reem Abdullah Alyoubi","orcid":"https://orcid.org/0000-0001-8888-8435","observed_orcids":["https://orcid.org/0000-0001-8888-8435"]},"institutions":[{"id":"https://openalex.org/I185163786","display_name":"King Abdulaziz University","ror":"https://ror.org/02ma4wv74","country_code":"SA","type":"education","lineage":["https://openalex.org/I185163786"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Reem Alyoubi","raw_affiliation_strings":["Pediatric Department, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia"],"raw_orcid":"https://orcid.org/0000-0001-8888-8435","affiliations":[{"raw_affiliation_string":"Pediatric Department, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia","institution_ids":["https://openalex.org/I185163786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108783315","display_name":"Abdullah A Althomali","orcid":"https://orcid.org/0000-0002-0329-8776","observed_orcids":["https://orcid.org/0000-0002-0329-8776"]},"institutions":[{"id":"https://openalex.org/I185163786","display_name":"King Abdulaziz University","ror":"https://ror.org/02ma4wv74","country_code":"SA","type":"education","lineage":["https://openalex.org/I185163786"]},{"id":"https://openalex.org/I4210127754","display_name":"Ministry of Health","ror":"https://ror.org/030atj633","country_code":"SA","type":"government","lineage":["https://openalex.org/I4210127754"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Abdullah Althomali","raw_affiliation_strings":["Department of Clinical Pharmacy, King Faisal Medical Complex, Ministry of Health, Taif 26724, Saudi Arabia","Pharmacology Department, Faculty of Medicine, King Abdulaziz University, Jeddah 22254, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacy, King Faisal Medical Complex, Ministry of Health, Taif 26724, Saudi Arabia","institution_ids":["https://openalex.org/I4210127754"]},{"raw_affiliation_string":"Pharmacology Department, Faculty of Medicine, King Abdulaziz University, Jeddah 22254, Saudi Arabia","institution_ids":["https://openalex.org/I185163786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084003357","display_name":"Rania M. Magadmi","orcid":"https://orcid.org/0000-0003-0886-4068","observed_orcids":["https://orcid.org/0000-0003-0886-4068"]},"institutions":[{"id":"https://openalex.org/I185163786","display_name":"King Abdulaziz University","ror":"https://ror.org/02ma4wv74","country_code":"SA","type":"education","lineage":["https://openalex.org/I185163786"]}],"countries":["SA"],"is_corresponding":true,"raw_author_name":"Rania Magadmi","raw_affiliation_strings":["Pharmacology Department, Faculty of Medicine, King Abdulaziz University, Jeddah 22254, Saudi Arabia"],"raw_orcid":"https://orcid.org/0000-0003-0886-4068","affiliations":[{"raw_affiliation_string":"Pharmacology Department, Faculty of Medicine, King Abdulaziz University, Jeddah 22254, Saudi Arabia","institution_ids":["https://openalex.org/I185163786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034387560","display_name":"Hala Salah Abdel Kawy","orcid":"https://orcid.org/0000-0001-6994-8834","observed_orcids":["https://orcid.org/0000-0001-6994-8834"]},"institutions":[{"id":"https://openalex.org/I185163786","display_name":"King Abdulaziz University","ror":"https://ror.org/02ma4wv74","country_code":"SA","type":"education","lineage":["https://openalex.org/I185163786"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Hala S. Abdel kawy","raw_affiliation_strings":["Pharmacology Department, Faculty of Medicine, King Abdulaziz University, Jeddah 22254, Saudi Arabia"],"raw_orcid":"https://orcid.org/0000-0001-6994-8834","affiliations":[{"raw_affiliation_string":"Pharmacology Department, Faculty of Medicine, King Abdulaziz University, Jeddah 22254, Saudi Arabia","institution_ids":["https://openalex.org/I185163786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018854166","display_name":"Hadiah Bassam Al Mahdi","orcid":"https://orcid.org/0000-0003-3483-9499","observed_orcids":["https://orcid.org/0000-0003-3483-9499"]},"institutions":[{"id":"https://openalex.org/I185163786","display_name":"King Abdulaziz University","ror":"https://ror.org/02ma4wv74","country_code":"SA","type":"education","lineage":["https://openalex.org/I185163786"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Hadiah Bassam Al Mahdi","raw_affiliation_strings":["Biological Sciences Department, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia","Princess Al Jawhara Albrahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah 21589, Saudi Arabia"],"raw_orcid":"https://orcid.org/0000-0003-3483-9499","affiliations":[{"raw_affiliation_string":"Biological Sciences Department, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia","institution_ids":["https://openalex.org/I185163786"]},{"raw_affiliation_string":"Princess Al Jawhara Albrahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah 21589, Saudi Arabia","institution_ids":["https://openalex.org/I185163786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086451269","display_name":"Fatemah O. Kamel","orcid":"https://orcid.org/0000-0002-7797-1492","observed_orcids":["https://orcid.org/0000-0002-7797-1492"]},"institutions":[{"id":"https://openalex.org/I185163786","display_name":"King Abdulaziz University","ror":"https://ror.org/02ma4wv74","country_code":"SA","type":"education","lineage":["https://openalex.org/I185163786"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Fatemah O. Kamel","raw_affiliation_strings":["Pharmacology Department, Faculty of Medicine, King Abdulaziz University, Jeddah 22254, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology Department, Faculty of Medicine, King Abdulaziz University, Jeddah 22254, Saudi Arabia","institution_ids":["https://openalex.org/I185163786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035173662","display_name":"Duaa Bakhshwin","orcid":"https://orcid.org/0000-0003-2371-9846","observed_orcids":["https://orcid.org/0000-0003-2371-9846"]},"institutions":[{"id":"https://openalex.org/I185163786","display_name":"King Abdulaziz University","ror":"https://ror.org/02ma4wv74","country_code":"SA","type":"education","lineage":["https://openalex.org/I185163786"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Duaa M. Bakhshwin","raw_affiliation_strings":["Pharmacology Department, Faculty of Medicine, King Abdulaziz University, Jeddah 22254, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology Department, Faculty of Medicine, King Abdulaziz University, Jeddah 22254, Saudi Arabia","institution_ids":["https://openalex.org/I185163786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071245982","display_name":"Maha Jamal","orcid":"https://orcid.org/0009-0007-9253-7620","observed_orcids":["https://orcid.org/0009-0007-9253-7620"]},"institutions":[{"id":"https://openalex.org/I185163786","display_name":"King Abdulaziz University","ror":"https://ror.org/02ma4wv74","country_code":"SA","type":"education","lineage":["https://openalex.org/I185163786"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Maha Jamal","raw_affiliation_strings":["Pharmacology Department, Faculty of Medicine, King Abdulaziz University, Jeddah 22254, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology Department, Faculty of Medicine, King Abdulaziz University, Jeddah 22254, Saudi Arabia","institution_ids":["https://openalex.org/I185163786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025434881","display_name":"Mohammed Alsieni","orcid":"https://orcid.org/0000-0002-2834-6041","observed_orcids":["https://orcid.org/0000-0002-2834-6041"]},"institutions":[{"id":"https://openalex.org/I185163786","display_name":"King Abdulaziz University","ror":"https://ror.org/02ma4wv74","country_code":"SA","type":"education","lineage":["https://openalex.org/I185163786"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Mohammed Alsieni","raw_affiliation_strings":["Pharmacology Department, Faculty of Medicine, King Abdulaziz University, Jeddah 22254, Saudi Arabia"],"raw_orcid":"https://orcid.org/0000-0002-2834-6041","affiliations":[{"raw_affiliation_string":"Pharmacology Department, Faculty of Medicine, King Abdulaziz University, Jeddah 22254, Saudi Arabia","institution_ids":["https://openalex.org/I185163786"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5084003357"],"corresponding_institution_ids":["https://openalex.org/I185163786"],"apc_list":{"value":1800,"currency":"CHF","value_usd":1885},"apc_paid":{"value":1800,"currency":"CHF","value_usd":1885},"fwci":0.4096,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.54337683,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"58","issue":"11","first_page":"1593","last_page":"1593"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.04309999942779541,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mthfr","display_name":"MTHFR","score":0.9070000052452087},{"id":"https://openalex.org/keywords/mthfr-c677t-polymorphism","display_name":"MTHFR C677T polymorphism","score":0.9200000166893005},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.8769999742507935},{"id":"https://openalex.org/keywords/pediatric-epilepsy","display_name":"pediatric epilepsy","score":0.7200000286102295},{"id":"https://openalex.org/keywords/pharmacogenetics","display_name":"pharmacogenetics","score":0.8809999823570251},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.7319999933242798},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.9319999814033508},{"id":"https://openalex.org/keywords/electrolyte-imbalance","display_name":"electrolyte imbalance","score":0.8899999856948853},{"id":"https://openalex.org/keywords/drug-gene-interactions","display_name":"drug-gene interactions","score":0.40400001406669617}],"concepts":[{"id":"https://openalex.org/C43563269","wikidata":"https://www.wikidata.org/wiki/Q424709","display_name":"Methylenetetrahydrofolate reductase","level":4,"score":0.9653098583221436},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7094940543174744},{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.6997301578521729},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.6746910810470581},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.5665539503097534},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.5512323975563049},{"id":"https://openalex.org/C55775858","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenetics","level":4,"score":0.5330281257629395},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.4820888340473175},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46908038854599},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4139351546764374},{"id":"https://openalex.org/C149737253","wikidata":"https://www.wikidata.org/wiki/Q3240252","display_name":"Polymorphism (computer science)","level":4,"score":0.4121185839176178},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.4109054207801819},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3756905794143677},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24627834558486938},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18299147486686707},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12101703882217407},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0915815532207489}],"mesh":[{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012529","descriptor_name":"Saudi Arabia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013763","descriptor_name":"Tetrahydrofolates","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D042965","descriptor_name":"Methylenetetrahydrofolate Reductase (NADPH2)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3390/medicina58111593","doi":"https://doi.org/10.3390/medicina58111593","is_oa":true,"landing_page_url":"https://doi.org/10.3390/medicina58111593","pdf_url":"https://www.mdpi.com/1648-9144/58/11/1593/pdf?version=1668663157","source":{"id":"https://openalex.org/S1008817457","display_name":"Medicina","issn_l":"1010-660X","issn":["1010-660X","1648-9144"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina","raw_type":"journal-article"},{"id":"pmid:36363550","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36363550","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina (Kaunas, Lithuania)","raw_type":"Multicenter Study"},{"id":"pmh:oai:pubmedcentral.nih.gov:9698893","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9698893/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina (Kaunas)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:7b5fe966169f4021a0235f12f368e720","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7b5fe966169f4021a0235f12f368e720","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Medicina, Vol 58, Iss 11, p 1593 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/medicina58111593","doi":"https://doi.org/10.3390/medicina58111593","is_oa":true,"landing_page_url":"https://doi.org/10.3390/medicina58111593","pdf_url":"https://www.mdpi.com/1648-9144/58/11/1593/pdf?version=1668663157","source":{"id":"https://openalex.org/S1008817457","display_name":"Medicina","issn_l":"1010-660X","issn":["1010-660X","1648-9144"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2593647585","display_name":null,"funder_award_id":"G-677-140-1441","funder_id":"https://openalex.org/F4320322322","funder_display_name":"King Abdulaziz University"}],"funders":[{"id":"https://openalex.org/F4320322322","display_name":"King Abdulaziz University","ror":"https://ror.org/02ma4wv74"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4308331306.pdf","grobid_xml":"https://content.openalex.org/works/W4308331306.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W842024258","https://openalex.org/W1848079371","https://openalex.org/W1920696238","https://openalex.org/W2003634197","https://openalex.org/W2016854448","https://openalex.org/W2017894490","https://openalex.org/W2023544660","https://openalex.org/W2033976133","https://openalex.org/W2052211882","https://openalex.org/W2052680645","https://openalex.org/W2061230148","https://openalex.org/W2072542357","https://openalex.org/W2075119373","https://openalex.org/W2079919793","https://openalex.org/W2141322774","https://openalex.org/W2148259440","https://openalex.org/W2154130708","https://openalex.org/W2405066962","https://openalex.org/W2411797490","https://openalex.org/W2507701231","https://openalex.org/W2525564551","https://openalex.org/W2587084013","https://openalex.org/W2594644573","https://openalex.org/W2767852319","https://openalex.org/W2948295112","https://openalex.org/W2993293913","https://openalex.org/W3092259116","https://openalex.org/W3137221047"],"related_works":["https://openalex.org/W2948295112","https://openalex.org/W4385423648","https://openalex.org/W3093191471","https://openalex.org/W4386608068","https://openalex.org/W2131815155","https://openalex.org/W3206069539","https://openalex.org/W4407262366","https://openalex.org/W3164134524","https://openalex.org/W2014227362","https://openalex.org/W2025225413"],"abstract_inverted_index":{"Background":[0],"and":[1,11,38,45,54,68,96,100,122,138,160,191,194],"Objectives:":[2],"Epilepsy":[3],"is":[4,167,201],"a":[5,58,128],"chronic":[6],"brain":[7],"disease,":[8],"with":[9,51,66,93,152,176],"inherent":[10],"noninherent":[12],"factors.":[13],"Although":[14],"over":[15],"20":[16],"anti-seizure":[17],"medications":[18],"(ASMs)":[19],"are":[20],"commercially":[21],"available,":[22],"nearly":[23],"one-third":[24],"of":[25,63,135,155,172],"patients":[26,50,92,175],"develop":[27],"drug-resistant":[28],"epilepsy.":[29,52],"We":[30],"evaluated":[31],"the":[32,35,39,81,91,113,119,123,153,168,187,208],"association":[33,109,130,185],"between":[34,112,133,186],"clinical":[36],"features":[37],"methyl":[40],"tetrahydrofolate":[41],"(MTHFR)":[42],"rs1801133":[43,76,117,147,190],"polymorphism":[44,77,115],"ASMs":[46],"response":[47,124],"among":[48,158],"pediatric":[49],"Materials":[53],"Methods:":[55],"This":[56,166],"was":[57,78,110,131,149],"multicenter,":[59],"retrospective,":[60],"case\u2013control":[61],"study":[62,171],"101":[64],"children":[65,71],"epilepsy":[67,177],"59":[69],"healthy":[70],"in":[72,141,174,178,207],"Jeddah.":[73],"The":[74,145],"MTHFR":[75,120,146,173,188],"genotyped":[79],"using":[80],"real-time":[82],"polymerase":[83],"chain":[84],"reaction":[85],"TaqMan":[86],"Genotyping":[87],"Assay.":[88],"Results:":[89],"Among":[90],"epilepsy,":[94],"56":[95],"45":[97],"showed":[98],"good":[99,159],"poor":[101,161],"responses":[102],"to":[103,125,163],"ASMs,":[104],"respectively.":[105],"No":[106],"significant":[107,129,184],"genetic":[108],"noted":[111,132],"single-nucleotide":[114],"(SNP)":[116],"within":[118],"gene":[121,192,205],"ASMs.":[126,164],"However,":[127],"reports":[134],"drug-induced":[136],"toxicity":[137],"an":[139],"increase":[140],"allele":[142],"A":[143,197],"frequencies.":[144],"genotype":[148],"significantly":[150],"associated":[151],"development":[154],"electrolyte":[156],"disturbance":[157],"responders":[162],"Conclusions:":[165],"first":[169],"pharmacogenetic":[170],"Saudi":[179],"Arabia":[180],"that":[181],"found":[182],"no":[183],"SNP":[189],"susceptibility":[193],"drug":[195],"responsiveness.":[196],"larger":[198],"sample":[199],"size":[200],"needed":[202],"for":[203],"testing":[204],"polymorphisms":[206],"future.":[209]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2022-11-11T00:00:00"}