{"id":"https://openalex.org/W4308142138","doi":"https://doi.org/10.1210/jendso/bvac150.1732","title":"PSAT356 Propranolol Improves Bulbar Dysfunction Seen in Hyperthyroidism","display_name":"PSAT356 Propranolol Improves Bulbar Dysfunction Seen in Hyperthyroidism","publication_year":2022,"publication_date":"2022-11-01","ids":{"openalex":"https://openalex.org/W4308142138","doi":"https://doi.org/10.1210/jendso/bvac150.1732"},"language":"en","primary_location":{"id":"doi:10.1210/jendso/bvac150.1732","doi":"https://doi.org/10.1210/jendso/bvac150.1732","is_oa":true,"landing_page_url":"https://doi.org/10.1210/jendso/bvac150.1732","pdf_url":"https://academic.oup.com/jes/article-pdf/6/Supplement_1/A838/46733433/bvac150.1732.pdf","source":{"id":"https://openalex.org/S2735747656","display_name":"Journal of the Endocrine Society","issn_l":"2472-1972","issn":["2472-1972"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315851","host_organization_name":"Endocrine Society","host_organization_lineage":["https://openalex.org/P4310315851"],"host_organization_lineage_names":["Endocrine Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Endocrine Society","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/jes/article-pdf/6/Supplement_1/A838/46733433/bvac150.1732.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026024349","display_name":"Robert A. Weinstein","orcid":"https://orcid.org/0000-0002-3390-858X","observed_orcids":["https://orcid.org/0000-0002-3390-858X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert Weinstein","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081455840","display_name":"Arwa Albashaireh","orcid":"https://orcid.org/0000-0002-5682-7352","observed_orcids":["https://orcid.org/0000-0002-5682-7352"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arwa Albashaireh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102017028","display_name":"Aashka Shah","orcid":"https://orcid.org/0009-0009-8379-4152","observed_orcids":["https://orcid.org/0009-0009-8379-4152"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aashka Shah","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002105917","display_name":"Sabah Syed","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sabah Syed","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Syeda Naqvi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Syeda Naqvi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2822,"currency":"USD","value_usd":2822},"apc_paid":{"value":2822,"currency":"USD","value_usd":2822},"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"6","issue":"Supplement_1","first_page":"A838","last_page":"A838"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11538","display_name":"Ophthalmology and Eye Disorders","score":0.007899999618530273,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11728","display_name":"Thyroid and Parathyroid Surgery","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/propranolol","display_name":"propranolol","score":0.9350000023841858},{"id":"https://openalex.org/keywords/hyperthyroidism","display_name":"hyperthyroidism","score":0.8799999952316284},{"id":"https://openalex.org/keywords/graves-disease","display_name":"Graves' disease","score":0.9470000267028809},{"id":"https://openalex.org/keywords/thyrotoxicosis","display_name":"thyrotoxicosis","score":0.8830000162124634},{"id":"https://openalex.org/keywords/dysphagia","display_name":"dysphagia","score":0.9279999732971191},{"id":"https://openalex.org/keywords/dysarthria","display_name":"dysarthria","score":0.8389999866485596},{"id":"https://openalex.org/keywords/bulbar-dysfunction","display_name":"bulbar dysfunction","score":0.8399999737739563},{"id":"https://openalex.org/keywords/beta-blockers","display_name":"beta-blockers","score":0.8820000290870667},{"id":"https://openalex.org/keywords/muscle-weakness","display_name":"muscle weakness","score":0.6060000061988831},{"id":"https://openalex.org/keywords/hypokalemia","display_name":"hypokalemia","score":0.6549999713897705},{"id":"https://openalex.org/keywords/methimazole","display_name":"methimazole","score":0.5889999866485596},{"id":"https://openalex.org/keywords/thyroid-nodules","display_name":"thyroid nodules","score":0.5960000157356262},{"id":"https://openalex.org/keywords/globus-sensation","display_name":"globus sensation","score":0.6660000085830688},{"id":"https://openalex.org/keywords/aspiration","display_name":"aspiration","score":0.609000027179718},{"id":"https://openalex.org/keywords/tsh-receptor-antibodies","display_name":"TSH receptor antibodies","score":0.550000011920929},{"id":"https://openalex.org/keywords/hypothyroidism","display_name":"hypothyroidism","score":0.38999998569488525}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8254777789115906},{"id":"https://openalex.org/C2776403943","wikidata":"https://www.wikidata.org/wiki/Q1123260","display_name":"Palpitations","level":2,"score":0.6550134420394897},{"id":"https://openalex.org/C2780596822","wikidata":"https://www.wikidata.org/wiki/Q623289","display_name":"Dysphagia","level":2,"score":0.644517719745636},{"id":"https://openalex.org/C2778151854","wikidata":"https://www.wikidata.org/wiki/Q423364","display_name":"Propranolol","level":2,"score":0.5425328612327576},{"id":"https://openalex.org/C2779744641","wikidata":"https://www.wikidata.org/wiki/Q9614","display_name":"Tongue","level":2,"score":0.48745250701904297},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.4724082350730896},{"id":"https://openalex.org/C2777195454","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Euthyroid","level":3,"score":0.4570598006248474},{"id":"https://openalex.org/C112497637","wikidata":"https://www.wikidata.org/wiki/Q211669","display_name":"Swallowing","level":2,"score":0.4438855051994324},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.42960628867149353},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33726024627685547},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.31282538175582886},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1210/jendso/bvac150.1732","doi":"https://doi.org/10.1210/jendso/bvac150.1732","is_oa":true,"landing_page_url":"https://doi.org/10.1210/jendso/bvac150.1732","pdf_url":"https://academic.oup.com/jes/article-pdf/6/Supplement_1/A838/46733433/bvac150.1732.pdf","source":{"id":"https://openalex.org/S2735747656","display_name":"Journal of the Endocrine Society","issn_l":"2472-1972","issn":["2472-1972"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315851","host_organization_name":"Endocrine Society","host_organization_lineage":["https://openalex.org/P4310315851"],"host_organization_lineage_names":["Endocrine Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Endocrine Society","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9627925","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9627925","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Endocr Soc","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1210/jendso/bvac150.1732","doi":"https://doi.org/10.1210/jendso/bvac150.1732","is_oa":true,"landing_page_url":"https://doi.org/10.1210/jendso/bvac150.1732","pdf_url":"https://academic.oup.com/jes/article-pdf/6/Supplement_1/A838/46733433/bvac150.1732.pdf","source":{"id":"https://openalex.org/S2735747656","display_name":"Journal of the Endocrine Society","issn_l":"2472-1972","issn":["2472-1972"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315851","host_organization_name":"Endocrine Society","host_organization_lineage":["https://openalex.org/P4310315851"],"host_organization_lineage_names":["Endocrine Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Endocrine Society","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4308142138.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2082074660","https://openalex.org/W1968778842","https://openalex.org/W267534826","https://openalex.org/W30548580","https://openalex.org/W4249161445","https://openalex.org/W2063207562","https://openalex.org/W2028404398","https://openalex.org/W2424516953","https://openalex.org/W2042809455","https://openalex.org/W2009282640"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Many":[2],"symptoms":[3,19,39,350,417],"of":[4,12,20,70,84,120,165,175,187,214,219,254,283,306,326,374,379,407,412,418],"hyperthyroidism":[5,329,390],"are":[6,23,43],"mediated":[7],"by":[8],"the":[9,13,55,104,145,188,203,230,235,281,321,365,393,410,436],"augmented":[10],"activity":[11],"adrenergic":[14,375],"central":[15],"nervous":[16],"system.":[17,323],"Rarely,":[18],"bulbar":[21,419],"dysfunction":[22],"seen":[24],"with":[25,49,58,198,299,345,354],"thyrotoxicosis":[26],"such":[27],"as":[28,68],"dysphagia":[29,244,307],"and":[30,51,62,82,86,98,131,150,192,233,245,258,265,275,280,308,341,363,391,435],"dysarthria.":[31],"Beta":[32],"blockers":[33,414],"can":[34,415],"abort":[35],"or":[36,129,156],"reduce":[37],"these":[38],"before":[40,364],"anti-thyroid":[41],"drugs":[42],"used.":[44],"Case":[45],"A":[46,381],"59-year-old":[47],"woman":[48],"hypertension":[50],"gout,":[52],"presented":[53],"to":[54,77,154,223,385,395,405,438],"emergency":[56],"department":[57],"poor":[59],"oral":[60],"intake":[61],"difficulties":[63,80],"swallowing.":[64],"Symptoms":[65],"initially":[66],"started":[67],"hoarseness":[69],"voice":[71],"for":[72],"3":[73,290],"weeks":[74,291],"then":[75],"progressed":[76],"Globus":[78],"sensation,":[79],"swallowing":[81],"aspiration":[83],"solids":[85],"liquids.":[87],"She":[88,248,302],"also":[89],"reported":[90,240,303],"generalized":[91],"muscle":[92,246],"weakness,":[93],"palpitations,":[94],"increased":[95],"sweating,":[96],"tremors":[97],"20":[99],"pounds":[100],"weight":[101],"loss":[102],"in":[103,144,202,243,310,328,377,389],"preceding":[105],"2":[106],"months.":[107],"Physical":[108],"exam":[109],"showed":[110,117,163],"an":[111,118],"ill-appearing,":[112],"catechetic":[113],"woman.":[114],"Luedde":[115],"exophthalmometry":[116],"absence":[119],"proptosis":[121],"measuring":[122],"15":[123,252],"mm":[124],"bilaterally":[125],"without":[126,140,212],"lid":[127],"lag":[128],"stare":[130],"extraocular":[132],"muscles":[133],"were":[134,200,221,267],"intact.":[135],"The":[136,142,324],"skin":[137],"was":[138,148,152,190,210,249,286,295,368,383],"silky":[139],"edema.":[141],"strength":[143],"lower":[146,311],"extremities":[147,312],"decreased":[149],"she":[151,239],"unable":[153],"squat":[155],"raise":[157],"from":[158],"a":[159,372],"seated":[160],"position.":[161],"Labs":[162],"creatinine":[164],"2.7":[166],"mg/dL":[167],"(0.4\u20131":[168],"mg/dL),":[169,173],"BUN":[170],"49":[171],"(6\u201320":[172],"potassium":[174,208,346,355],"3.1":[176],"(3.5\u20135.1":[177],"mmol/L),":[178],"TSH":[179,294],"<":[180,272],"0.02":[181],"(0.34\u20135.60":[182,297],"uIU/mL),":[183],"FT4:":[184],"3.72.":[185],"CT":[186],"neck":[189],"obtained":[191],"multiple":[193],"sub-centimetric":[194],"hypodense":[195],"thyroid":[196,205,366,408],"nodules":[197],"calcifications":[199],"noted":[201],"left":[204],"lobe.":[206],"Intravenous":[207],"chloride":[209],"given":[211,225],"improvement":[213,242,309],"dysphagia.":[215],"10":[216,260],"milligrams":[217],"(mg)":[218],"propranolol":[220,259,361,399],"ordered":[222],"be":[224],"every":[226],"8":[227],"hours.":[228],"After":[229],"first":[231],"dose":[232],"over":[234],"next":[236],"24":[237],"hours":[238],"rapid":[241],"weakness.":[247,313,402],"discharged":[250],"on":[251,320],"mg":[253,261],"methimazole":[255],"twice":[256],"daily":[257],"thrice":[262],"daily.":[263],"TSI":[264],"TRAB":[266],"elevated":[268],"at":[269],"1.03":[270],"(normal":[271],"0.54":[273],"IU/L)":[274,278],"2.20":[276],"(normal<1.75":[277],"respectively":[279],"diagnosis":[282],"Graves\u2019":[284],"disease":[285],"made.":[287],"At":[288],"her":[289],"follow":[292],"up,":[293],"<0.02":[296],"uIU/mL)":[298],"normal":[300],"FT4.":[301],"complete":[304],"resolution":[305],"Discussion":[314],"Hyperthyroidism":[315],"may":[316],"exert":[317],"powerful":[318],"effects":[319],"neuro-muscular":[322],"pathogenesis":[325],"myopathy":[327,378,434],"is":[330,339,343],"not":[331,352],"fully":[332],"understood.":[333],"In":[334],"hyperthyroid":[335],"periodic":[336],"paralysis,":[337],"hypokalemia":[338],"present,":[340],"paresis":[342],"corrected":[344],"supplementation.":[347],"Our":[348],"patient's":[349],"did":[351],"improve":[353],"supplement":[356],"but":[357],"dramatically":[358],"improved":[359],"after":[360],"use":[362,411],"function":[367],"normalized.":[369],"This":[370],"implies":[371],"role":[373],"overactivity":[376],"hyperthyroidism.":[380],"study1":[382],"conducted":[384],"quantify":[386],"muscular":[387,401],"weakness":[388],"assess":[392],"response":[394,437],"therapy":[396],"concluded":[397],"that":[398],"improves":[400],"Conclusion":[403],"Prior":[404],"normalization":[406],"function,":[409],"beta":[413],"alleviate":[416],"dysfunction.":[420],"(1)Olson":[421],"BR,":[422],"Klein":[423],"I,":[424],"Benner":[425],"R,":[426,428],"Burdett":[427],"Trzepacz":[429],"P,":[430],"Levey":[431],"GS.":[432],"Hyperthyroid":[433],"treatment.":[439],"Thyroid.":[440],"1991;1(2):":[441],"137-41.":[442],"doi:":[443],"10.1089/thy.1991.1.137.":[444],"PMID:":[445],"1688015.":[446],"Presentation:":[447],"Saturday,":[448],"June":[449],"11,":[450],"2022":[451],"1:00":[452],"p.m.":[453,456],"-":[454],"3:00":[455]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2022-11-08T00:00:00"}