{"id":"https://openalex.org/W4308138331","doi":"https://doi.org/10.1210/jendso/bvac150.1275","title":"OR14-5 Branched-chain Amino Acid and Tryptophan Metabolism and the Pathogenesis of Youth-Onset Type 2 Diabetes Mellitus (T2D)","display_name":"OR14-5 Branched-chain Amino Acid and Tryptophan Metabolism and the Pathogenesis of Youth-Onset Type 2 Diabetes Mellitus (T2D)","publication_year":2022,"publication_date":"2022-11-01","ids":{"openalex":"https://openalex.org/W4308138331","doi":"https://doi.org/10.1210/jendso/bvac150.1275"},"language":"en","primary_location":{"id":"doi:10.1210/jendso/bvac150.1275","doi":"https://doi.org/10.1210/jendso/bvac150.1275","is_oa":true,"landing_page_url":"https://doi.org/10.1210/jendso/bvac150.1275","pdf_url":"https://academic.oup.com/jes/article-pdf/6/Supplement_1/A614/46732451/bvac150.1275.pdf","source":{"id":"https://openalex.org/S2735747656","display_name":"Journal of the Endocrine Society","issn_l":"2472-1972","issn":["2472-1972"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315851","host_organization_name":"Endocrine Society","host_organization_lineage":["https://openalex.org/P4310315851"],"host_organization_lineage_names":["Endocrine Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Endocrine Society","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/jes/article-pdf/6/Supplement_1/A614/46732451/bvac150.1275.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069946238","display_name":"Sarah Armstrong","orcid":"https://orcid.org/0000-0003-4745-5646","observed_orcids":["https://orcid.org/0000-0003-4745-5646"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sarah Armstrong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029499930","display_name":"James Ralph Bain","orcid":"https://orcid.org/0000-0002-8917-9187","observed_orcids":["https://orcid.org/0000-0002-8917-9187"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James R Bain","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Matthew Crawford","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matthew Crawford","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080509236","display_name":"Michael Freemark","orcid":"https://orcid.org/0000-0001-5123-3531","observed_orcids":["https://orcid.org/0000-0001-5123-3531"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Freemark","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032081842","display_name":"Russell P. Grant","orcid":"https://orcid.org/0000-0001-9234-5433","observed_orcids":["https://orcid.org/0000-0001-9234-5433"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Russell P Grant","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041993578","display_name":"Pinar Gumus Balikcioglu","orcid":"https://orcid.org/0000-0002-5259-9196","observed_orcids":["https://orcid.org/0000-0002-5259-9196"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pinar Gumus Balikcioglu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018627458","display_name":"Daniel S. Hsia","orcid":"https://orcid.org/0000-0003-2832-3429","observed_orcids":["https://orcid.org/0000-0003-2832-3429"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel S Hsia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055488258","display_name":"Olga Ilkayeva","orcid":"https://orcid.org/0000-0002-9779-0883","observed_orcids":["https://orcid.org/0000-0002-9779-0883"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Olga Ilkayeva","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Nina Jain","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nina Jain","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006213707","display_name":"Michael J. Muehlbauer","orcid":"https://orcid.org/0000-0003-1501-0706","observed_orcids":["https://orcid.org/0000-0003-1501-0706"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Muehlbauer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062992566","display_name":"Christopher B. Newgard","orcid":"https://orcid.org/0000-0002-1293-691X","observed_orcids":["https://orcid.org/0000-0002-1293-691X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher Newgard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080242617","display_name":"Megan E. Ramaker","orcid":"https://orcid.org/0000-0003-2183-2319","observed_orcids":["https://orcid.org/0000-0003-2183-2319"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Megan Ramaker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Natalie Delgado","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Natalie Delgado","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2822,"currency":"USD","value_usd":2822},"apc_paid":{"value":2822,"currency":"USD","value_usd":2822},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.1142132,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"6","issue":"Supplement_1","first_page":"A614","last_page":"A615"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.41040000319480896,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.41040000319480896,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.22709999978542328,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.07490000128746033,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/youth-onset-type-2-diabetes","display_name":"youth-onset type 2 diabetes","score":0.8460000157356262},{"id":"https://openalex.org/keywords/branched-chain-amino-acids","display_name":"branched-chain amino acids","score":0.9779999852180481},{"id":"https://openalex.org/keywords/tryptophan-metabolism","display_name":"tryptophan metabolism","score":0.9900000095367432},{"id":"https://openalex.org/keywords/kynurenine-pathway","display_name":"kynurenine pathway","score":0.984000027179718},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.7070000171661377},{"id":"https://openalex.org/keywords/branched-chain-keto-acids","display_name":"branched-chain keto acids","score":0.8849999904632568},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.7319999933242798},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.527999997138977},{"id":"https://openalex.org/keywords/adolescents","display_name":"adolescents","score":0.7059999704360962},{"id":"https://openalex.org/keywords/urinary-metabolites","display_name":"urinary metabolites","score":0.675000011920929},{"id":"https://openalex.org/keywords/24-hour-urine","display_name":"24-hour urine","score":0.5929999947547913},{"id":"https://openalex.org/keywords/body-fat-percentage","display_name":"body fat percentage","score":0.5379999876022339},{"id":"https://openalex.org/keywords/pubertal-stage","display_name":"pubertal stage","score":0.5669999718666077},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.47999998927116394},{"id":"https://openalex.org/keywords/kynurenine-metabolites","display_name":"kynurenine metabolites","score":0.4650000035762787},{"id":"https://openalex.org/keywords/tryptophan-metabolites","display_name":"tryptophan metabolites","score":0.597000002861023},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.33000001311302185},{"id":"https://openalex.org/keywords/beta-cell-function","display_name":"beta-cell function","score":0.597000002861023}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7482759952545166},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7392970323562622},{"id":"https://openalex.org/C2777503454","wikidata":"https://www.wikidata.org/wiki/Q415768","display_name":"Kynurenine","level":4,"score":0.7182745337486267},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.5619713068008423},{"id":"https://openalex.org/C2776706248","wikidata":"https://www.wikidata.org/wiki/Q181003","display_name":"Tryptophan","level":3,"score":0.551113486289978},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4922544062137604},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.4620171785354614},{"id":"https://openalex.org/C96942376","wikidata":"https://www.wikidata.org/wiki/Q21130714","display_name":"Catabolism","level":3,"score":0.45571067929267883},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.4519975185394287},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4354782998561859},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.4276221990585327},{"id":"https://openalex.org/C2780586474","wikidata":"https://www.wikidata.org/wiki/Q332428","display_name":"Overweight","level":3,"score":0.412988543510437},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.4122239351272583},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.38234615325927734},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.37456589937210083},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35338810086250305},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.34018653631210327},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14878886938095093},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1210/jendso/bvac150.1275","doi":"https://doi.org/10.1210/jendso/bvac150.1275","is_oa":true,"landing_page_url":"https://doi.org/10.1210/jendso/bvac150.1275","pdf_url":"https://academic.oup.com/jes/article-pdf/6/Supplement_1/A614/46732451/bvac150.1275.pdf","source":{"id":"https://openalex.org/S2735747656","display_name":"Journal of the Endocrine Society","issn_l":"2472-1972","issn":["2472-1972"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315851","host_organization_name":"Endocrine Society","host_organization_lineage":["https://openalex.org/P4310315851"],"host_organization_lineage_names":["Endocrine Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Endocrine Society","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9625596","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9625596","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Endocr Soc","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1210/jendso/bvac150.1275","doi":"https://doi.org/10.1210/jendso/bvac150.1275","is_oa":true,"landing_page_url":"https://doi.org/10.1210/jendso/bvac150.1275","pdf_url":"https://academic.oup.com/jes/article-pdf/6/Supplement_1/A614/46732451/bvac150.1275.pdf","source":{"id":"https://openalex.org/S2735747656","display_name":"Journal of the Endocrine Society","issn_l":"2472-1972","issn":["2472-1972"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315851","host_organization_name":"Endocrine Society","host_organization_lineage":["https://openalex.org/P4310315851"],"host_organization_lineage_names":["Endocrine Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Endocrine Society","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4308138331.pdf","grobid_xml":"https://content.openalex.org/works/W4308138331.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4389499455","https://openalex.org/W4387379605","https://openalex.org/W4390818994","https://openalex.org/W1986797744","https://openalex.org/W4281652307","https://openalex.org/W2594111679","https://openalex.org/W1764778685","https://openalex.org/W2002364623","https://openalex.org/W4401330156","https://openalex.org/W3037825188"],"abstract_inverted_index":{"Abstract":[0],"Objectives":[1],"We":[2,194],"have":[3,65],"previously":[4],"demonstrated":[5],"that":[6,96],"insulin":[7,59],"resistance":[8],"(IR)":[9],"in":[10,82,90,112,134,141,218,317,327,336,372,426,432,448],"youth":[11,113,136,146,333,347,373,403],"is":[12],"associated":[13],"with":[14,24,114,137,139,158,163,268,334,348,374,404],"elevated":[15,97],"levels":[16,126,314,351],"of":[17,33,71,77,102,107,127,129,147,212,352,357,366,379,413,441],"branched-chain":[18,204],"amino":[19,26,46],"acids":[20,27],"(BCAAs).":[21],"BCAAs":[22,130],"compete":[23],"aromatic":[25],"(AAA)":[28],"including":[29,202,210],"tryptophan,":[30,311],"the":[31,43,72,203,213,354,364,377,390,417,421],"precursor":[32],"serotonin,":[34,358],"for":[35,248],"uptake":[36],"into":[37],"\u03b2-cells":[38],"and":[39,57,74,124,131,144,152,166,207,215,220,258,265,283,289,312,322,345,376,383,401,429,444],"other":[40,391],"tissues":[41],"via":[42],"large":[44],"neutral":[45],"acid":[47],"transporter.":[48],"Serotonin":[49],"has":[50],"been":[51],"reported":[52],"to":[53,232,389,420,439,446],"increase":[54],"\u03b2-cell":[55],"mass":[56],"glucose-dependent":[58],"secretion.":[60],"In":[61,306],"this":[62],"study":[63],"we":[64,94,119],"explored":[66],"how":[67],"BCAA,":[68],"tryptophan":[69,103,132,208,381,414],"(one":[70],"AAA),":[73],"a":[75],"subset":[76],"their":[78],"metabolites":[79,197],"are":[80,409],"modulated":[81],"youth-onset":[83,433],"T2D.":[84,115,434],"Based":[85],"on":[86],"our":[87],"prior":[88],"studies":[89],"neuronal":[91],"BCAA":[92,98,200,428],"metabolism,":[93,209],"hypothesized":[95],"could":[99,437],"induce":[100],"diversion":[101,412],"metabolism":[104,133,415,431],"towards":[105],"production":[106],"kynurenine":[108,216,313,422],"rather":[109],"than":[110,326],"serotonin":[111,418],"To":[116],"test":[117],"this,":[118],"analyzed":[120],"24-hour":[121,221,307],"urine":[122,222,233,308],"samples":[123,223],"compared":[125,388],"byproducts":[128],"obese":[135,143,278],"T2D":[138,164,254,269,297,318,375,447],"those":[140],"non-diabetic":[142,156,346,402],"lean":[145,259,301,329,343,399],"comparable":[148,247,360,397],"age,":[149],"pubertal":[150,263],"status":[151],"ethnicity.":[153,266],"Methods":[154],"56":[155],"adolescents":[157,162],"overweight/obesity":[159],"(\"obese\"),":[160],"42":[161],"(\"T2D\"),":[165],"43":[167],"normal":[168],"weight":[169],"controls":[170,330,344,400],"(\"lean\"),":[171],"ages":[172],"12-21":[173],"years-old":[174],"were":[175,181,230,237,246,270,315,339,359,386,396],"studied.":[176],"Weight,":[177],"height,":[178],"BMI,":[179],"BMI%":[180],"extracted":[182],"from":[183,199,416],"medical":[184],"charts.":[185],"Body":[186],"fat":[187],"percent":[188],"(BF%)":[189],"was":[190,368],"measured":[191,196],"by":[192,224,239,411],"TANITA.":[193],"also":[195],"derived":[198],"catabolism,":[201],"ketoacids":[205],"(BCKAs),":[206],"intermediates":[211],"serotonergic":[214],"pathways,":[217],"spot":[219],"liquid":[225],"chromatography/tandem-mass":[226],"spectrometry":[227],"(LC/MS-MS).":[228],"Levels":[229],"normalized":[231],"creatinine.":[234],"Group":[235],"differences":[236,341],"assessed":[238],"Kruskal":[240],"Wallis":[241],"or":[242,331],"ANOVA.":[243],"Results":[244],"Groups":[245],"age":[249],"(obese":[250,293],"14.8":[251],"+/-":[252,256,261,295,299,303],"1.9;":[253],"15.7":[255],"2.1":[257],"14.9":[260],"1.9-yr),":[262],"status,":[264],"Youth":[267],"predominantly":[271],"female":[272],"(T2D,":[273],"28":[274],"F,":[275,280,286],"14":[276],"M;":[277],"33":[279],"23":[281],"M":[282],"lean,":[284],"17":[285],"26":[287],"M),":[288],"had":[290],"highest":[291],"BF%":[292],"37.3":[294],"9.5;":[296],"42.9":[298],"9.9;":[300],"20.1":[302],"6.3%;":[304],"p=2.58e-22).":[305],"samples,":[309],"BCKAs,":[310],"higher":[316,369],"(p=0.0002,":[319],"p=":[320,323],"0.0045":[321],"0.00009":[324],"respectively)":[325],"either":[328],"nondiabetic":[332],"obesity;":[335],"contrast,":[337],"there":[338],"no":[340],"between":[342,398],"obesity.":[349,405],"The":[350],"5-HIAA,":[353],"principal":[355],"metabolite":[356],"across":[361],"groups;":[362],"however,":[363],"ratio":[365],"kynurenine/tryptophan":[367],"(p=":[370],"0.0112)":[371],"ratios":[378,395],"5-HIAA/":[380],"(p=0.027)":[382],"5-HIAA/Kynurenine":[384],"(p=0.0067)":[385],"lower":[387],"two":[392],"groups.":[393],"Those":[394],"Conclusions":[406],"Increased":[407],"BCKAs":[408],"accompanied":[410],"pathway":[419],"pathway,":[423],"suggesting":[424],"perturbations":[425],"both":[427],"AAA":[430],"These":[435],"alterations":[436],"contribute":[438],"development":[440],"beta-cell":[442],"dysfunction":[443],"progression":[445],"youth.":[449],"Presentation:":[450],"Sunday,":[451],"June":[452],"12,":[453],"2022":[454],"12:00":[455],"p.m.":[456,459],"-":[457],"12:15":[458]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2022-11-08T00:00:00"}
