{"id":"https://openalex.org/W4308135442","doi":"https://doi.org/10.1210/jendso/bvac150.403","title":"OR21-6 AZP-3601, a Long-Acting Parathyroid Hormone (PTH) Analog, Normalizes Blood Calcium in Thyroparathyroidectomized (TPTX) Rats Without Causing Deleterious Changes in Bone","display_name":"OR21-6 AZP-3601, a Long-Acting Parathyroid Hormone (PTH) Analog, Normalizes Blood Calcium in Thyroparathyroidectomized (TPTX) Rats Without Causing Deleterious Changes in Bone","publication_year":2022,"publication_date":"2022-11-01","ids":{"openalex":"https://openalex.org/W4308135442","doi":"https://doi.org/10.1210/jendso/bvac150.403"},"language":"en","primary_location":{"id":"doi:10.1210/jendso/bvac150.403","doi":"https://doi.org/10.1210/jendso/bvac150.403","is_oa":true,"landing_page_url":"https://doi.org/10.1210/jendso/bvac150.403","pdf_url":"https://academic.oup.com/jes/article-pdf/6/Supplement_1/A196/46734335/bvac150.403.pdf","source":{"id":"https://openalex.org/S2735747656","display_name":"Journal of the Endocrine Society","issn_l":"2472-1972","issn":["2472-1972"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315851","host_organization_name":"Endocrine Society","host_organization_lineage":["https://openalex.org/P4310315851"],"host_organization_lineage_names":["Endocrine Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Endocrine Society","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/jes/article-pdf/6/Supplement_1/A196/46734335/bvac150.403.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031937268","display_name":"Michael D. Culler","orcid":"https://orcid.org/0000-0001-5168-8739","observed_orcids":["https://orcid.org/0000-0001-5168-8739"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Culler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015542125","display_name":"Thomas James Gardella","orcid":"https://orcid.org/0000-0002-2163-5772","observed_orcids":["https://orcid.org/0000-0002-2163-5772"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas Gardella","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5051349655","display_name":"\u00c7a\u011fr\u0131 Aksu","orcid":"https://orcid.org/0000-0002-5828-5390","observed_orcids":["https://orcid.org/0000-0002-5828-5390"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cagri Aksu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2822,"currency":"USD","value_usd":2822},"apc_paid":{"value":2822,"currency":"USD","value_usd":2822},"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"6","issue":"Supplement_1","first_page":"A196","last_page":"A196"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11728","display_name":"Thyroid and Parathyroid Surgery","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parathyroid-hormone-analogues","display_name":"parathyroid hormone analog","score":0.8849999904632568},{"id":"https://openalex.org/keywords/teriparatide","display_name":"teriparatide","score":0.777999997138977},{"id":"https://openalex.org/keywords/hypoparathyroidism","display_name":"hypoparathyroidism","score":0.9660000205039978},{"id":"https://openalex.org/keywords/thyroparathyroidectomy","display_name":"thyroparathyroidectomy","score":0.9490000009536743},{"id":"https://openalex.org/keywords/bone-effects","display_name":"bone effects","score":0.46399998664855957},{"id":"https://openalex.org/keywords/continuous-infusion","display_name":"continuous infusion","score":0.7009999752044678},{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.5789999961853027}],"concepts":[{"id":"https://openalex.org/C2781208988","wikidata":"https://www.wikidata.org/wiki/Q202476","display_name":"Parathyroid hormone","level":3,"score":0.7078340649604797},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6049172878265381},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5882933139801025},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46344876289367676},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.45473700761795044},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3870912790298462}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1210/jendso/bvac150.403","doi":"https://doi.org/10.1210/jendso/bvac150.403","is_oa":true,"landing_page_url":"https://doi.org/10.1210/jendso/bvac150.403","pdf_url":"https://academic.oup.com/jes/article-pdf/6/Supplement_1/A196/46734335/bvac150.403.pdf","source":{"id":"https://openalex.org/S2735747656","display_name":"Journal of the Endocrine Society","issn_l":"2472-1972","issn":["2472-1972"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315851","host_organization_name":"Endocrine Society","host_organization_lineage":["https://openalex.org/P4310315851"],"host_organization_lineage_names":["Endocrine Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Endocrine Society","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9624649","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9624649","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Endocr Soc","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1210/jendso/bvac150.403","doi":"https://doi.org/10.1210/jendso/bvac150.403","is_oa":true,"landing_page_url":"https://doi.org/10.1210/jendso/bvac150.403","pdf_url":"https://academic.oup.com/jes/article-pdf/6/Supplement_1/A196/46734335/bvac150.403.pdf","source":{"id":"https://openalex.org/S2735747656","display_name":"Journal of the Endocrine Society","issn_l":"2472-1972","issn":["2472-1972"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315851","host_organization_name":"Endocrine Society","host_organization_lineage":["https://openalex.org/P4310315851"],"host_organization_lineage_names":["Endocrine Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Endocrine Society","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4308135442.pdf","grobid_xml":"https://content.openalex.org/works/W4308135442.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4229440324","https://openalex.org/W3158744215","https://openalex.org/W2282509280","https://openalex.org/W2157623836","https://openalex.org/W7213320395","https://openalex.org/W1604624179","https://openalex.org/W4387379972","https://openalex.org/W2062496249","https://openalex.org/W2011033582","https://openalex.org/W7099117954"],"abstract_inverted_index":{"Abstract":[0],"PTH":[1,58],"peptides":[2,115],"can":[3],"be":[4],"effective":[5],"in":[6,12,67,76,102,106,265,275,343,389,424],"normalizing":[7],"blood":[8,141,205,237],"calcium":[9],"(Ca++)":[10],"levels":[11,249,270,350],"cases":[13],"of":[14,56,90,168,176,191,351,363,426,439],"hypoparathyroidism":[15],"(HP),":[16],"but":[17,368],"long-term":[18,118,377,445],"effects":[19,105,392],"on":[20,208,228,250,393,429],"bone":[21,107,300,347,353,394,430],"are":[22,116],"not":[23,370],"well":[24,70,328],"understood.":[25],"AZP-3601":[26,47,100,164,337,411,420],"is":[27],"a":[28,36,80,166,174,189,444],"long-acting":[29],"PTH/PTHrP(1-36)":[30],"analog":[31],"currently":[32],"being":[33],"investigated":[34,93],"as":[35,69,71,202,327,329,443],"potential":[37],"treatment":[38,380,446],"option":[39],"for":[40,222,241,397,403,410,447],"HP.":[41,448],"As":[42],"compared":[43],"to":[44,52,138,253,269,288,303],"conventional":[45],"PTH1-34,":[46,112],"binds":[48],"with":[49,162,186],"higher":[50,272],"affinity":[51],"the":[53,57,86,95,114,257,352],"R0":[54],"conformation":[55],"receptor":[59],"and":[60,127,134,153,196,214,220,236,238,268,310,325,381,408],"thereby":[61],"induces":[62],"more":[63,72],"sustained":[64],"signaling":[65],"responses":[66,75],"cells":[68],"prolonged":[73],"calcemic":[74],"vivo,":[77],"despite":[78],"having":[79],"very":[81],"short":[82],"circulating":[83],"half-life.":[84],"Using":[85],"TPTX":[87,146,157,277,390],"rat":[88],"model":[89],"HP,":[91],"we":[92],"whether":[94],"distinct":[96,416],"mode-of-action":[97],"used":[98,201,418,442],"by":[99,111,122,130,360,372,399,405,412,419],"results":[101],"different":[103],"down-stream":[104],"than":[108,273,431],"those":[109,274],"induced":[110],"when":[113,441],"administered":[117],"(31":[119,378],"days)":[120,379],"either":[121,163,432],"daily":[123,161,316,338,361,406,413,433],"sc":[124],"injection":[125,317,339,362,434],"(AZP-3601":[126],"PTH1-34)":[128],"or":[129,171,179,255,345,435],"continuous":[131,292,400,437],"infusion":[132,293],"(PTH1-34),":[133],"at":[135,165,173,188,216,382],"doses":[136,383],"aimed":[137],"optimally":[139],"normalize":[140],"Ca++":[142,248,388],"levels.":[143],"Methods":[144],"Male":[145],"rats":[147,199,278],"(strain":[148],"S-D,":[149],"age":[150],"9":[151],"weeks,":[152],"2":[154],"weeks":[155],"post":[156],"surgery)":[158],"were":[159,180,200,226,357,369,395],"injected":[160],"dose":[167,175,190],"0.7":[169],"nmol/kg":[170],"PTH1-34":[172,187,291,315,364,398,404],"50":[177],"nmol/kg,":[178],"continuously":[181],"infused":[182],"via":[183],"Alzet":[184],"mini-pump":[185],"3.0":[192],"nmol/kg/day.":[193],"Vehicle":[194],"treatments":[195],"sham":[197],"surgery":[198],"controls.":[203],"Tail-vein":[204],"was":[206],"collected":[207,240],"days":[209,251],"1,":[210],"7":[211],"14,":[212],"21":[213],"28":[215],"6":[217],"hours":[218,232],"post-injection":[219],"analyzed":[221],"total":[223],"Ca++.":[224],"Rats":[225],"euthanized":[227],"day":[229],"31":[230],"(24":[231],"after":[233],"last":[234],"injection)":[235],"femurs":[239],"analysis.":[242],"Results":[243],"All":[244],"peptide-treatments":[245],"increased":[246,319,359],"serum":[247,387],"7-21":[252],"within":[254],"near":[256],"normal":[258],"range":[259],"(8.8-11.7":[260],"mg/dL":[261,264],"versus":[262],"10.8-11.9":[263],"sham-operated":[266],"rats)":[267],"significantly":[271,294,318,358],"vehicle-treated":[276],"(6.9-7.9":[279],"mg/dL,":[280],"P<0.01).":[281],"Bone":[282],"mCT":[283],"analysis":[284],"revealed":[285],"that":[286,384],"relative":[287,302],"TPTX-vehicle":[289],"controls,":[290],"decreased":[295],"(p<0.001)":[296],"distal":[297,321],"femur":[298,322],"trabecular":[299,307,311,344],"volume":[301,305],"tissue":[304],"(BV/TV),":[306],"number":[308],"(Tb.N)":[309],"thickness":[312,332],"(Tb.Th),":[313],"while":[314],"(P<0.001)":[320],"BV/TV,":[323],"Tb.Th":[324],"Tb.N,":[326],"mid-femur":[330],"cortical":[331,346],"(Ct.Th,":[333],"P<0.001).":[334],"In":[335],"contrast,":[336],"caused":[340],"no":[341],"change":[342],"parameters.":[348],"Serum":[349],"formation":[354],"marker":[355],"P1NP":[356],"(P<0.001":[365],"vs.":[366],"TPTX-vehicle)":[367],"changed":[371],"other":[373],"treatments.":[374],"Conclusion":[375],"With":[376],"similarly":[385],"normalized":[386],"rats,":[391],"catabolic":[396],"infusion,":[401],"anabolic":[402],"injection,":[407],"neutral":[409],"injection.":[414],"The":[415],"MOA":[417],"may":[421],"thus":[422],"result":[423],"less":[425],"an":[427],"impact":[428],"sustained,":[436],"delivery":[438],"PTH(1-34),":[440],"Presentation:":[449],"Monday,":[450],"June":[451],"13,":[452],"2022":[453],"12:15":[454],"p.m.":[455,458],"-":[456],"12:30":[457]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2022-11-08T00:00:00"}