{"id":"https://openalex.org/W430807269","doi":null,"title":"Reconstruction de la voie de sortie du ventricule droit par un implant valve bior\u00e9sorbable cellularis\u00e9 autologue dans un mod\u00e8le animal en croissance","display_name":"Reconstruction de la voie de sortie du ventricule droit par un implant valve bior\u00e9sorbable cellularis\u00e9 autologue dans un mod\u00e8le animal en croissance","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W430807269","mag":"430807269"},"language":"fr","primary_location":{"id":"mag:430807269","doi":null,"is_oa":false,"landing_page_url":"https://www.theses.fr/2011PA05T024","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"dissertation","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018653856","display_name":"David M. Kalfa","orcid":"https://orcid.org/0000-0003-4324-6038","observed_orcids":["https://orcid.org/0000-0003-4324-6038"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"David Kalfa","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4324-6038","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5018653856"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.6996999979019165,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.6996999979019165,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10300","display_name":"Congenital Heart Disease Studies","score":0.21449999511241913,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.009999999776482582,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/right-ventricular-outflow-tract-reconstruction","display_name":"right ventricular outflow tract reconstruction","score":0.9070000052452087},{"id":"https://openalex.org/keywords/autologous-mesenchymal-stem-cells","display_name":"autologous mesenchymal stem cells","score":0.8560000061988831},{"id":"https://openalex.org/keywords/polydioxanone","display_name":"polydioxanone","score":0.7590000033378601},{"id":"https://openalex.org/keywords/poly-l-lactic-acid","display_name":"poly(L-lactic acid)","score":0.7509999871253967},{"id":"https://openalex.org/keywords/cell-seeding","display_name":"cell seeding","score":0.5680000185966492},{"id":"https://openalex.org/keywords/congenital-heart-disease","display_name":"congenital heart disease","score":0.6779999732971191},{"id":"https://openalex.org/keywords/sheep-model","display_name":"sheep model","score":0.460999995470047},{"id":"https://openalex.org/keywords/tissue-engineering","display_name":"tissue engineering","score":0.4429999887943268},{"id":"https://openalex.org/keywords/endothelialization","display_name":"endothelialization","score":0.6169999837875366},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.7059999704360962},{"id":"https://openalex.org/keywords/bioreactors","display_name":"bioreactors","score":0.5770000219345093},{"id":"https://openalex.org/keywords/quantum-dots","display_name":"quantum dots","score":0.722000002861023},{"id":"https://openalex.org/keywords/valve-degeneration","display_name":"valve degeneration","score":0.33899998664855957},{"id":"https://openalex.org/keywords/regenerative-medicine","display_name":"regenerative medicine","score":0.3449999988079071}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.619726836681366},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.5519284605979919}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:430807269","doi":null,"is_oa":false,"landing_page_url":"https://www.theses.fr/2011PA05T024","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2046012957","https://openalex.org/W7139213936","https://openalex.org/W7148582680","https://openalex.org/W2037791283","https://openalex.org/W777024463","https://openalex.org/W4392184180","https://openalex.org/W2384916157","https://openalex.org/W2802190374","https://openalex.org/W2065383576","https://openalex.org/W2356539745"],"abstract_inverted_index":{"Objectifs":[0],":":[1,47,113,116,212],"Les":[2,160],"moyens":[3],"utilises":[4],"en":[5,55,75,136,144,174,191,253,263,343],"pratique":[6],"clinique":[7,393],"pour":[8],"la":[9,13,49,68,148,327,348,367,370,375],"reparation":[10],"chirurgicale":[11],"de":[12,15,30,33,58,63,80,85,90,104,108,150,157,178,220,226,228,230,233,243,274,276,281,284,287,294,299,301,312,323,326,335,355,363,387],"voie":[14,354],"sortie":[16,356],"ventriculaire":[17],"droite":[18,357],"(RVOT)":[19],"dans":[20,266],"les":[21],"cardiopathies":[22],"congenitales":[23],"sont":[24],"des":[25,38,117,385],"materiaux":[26],"inertes":[27],"sans":[28],"potentiel":[29,103,283,362],"croissance":[31,105,285],"ni":[32],"regeneration":[34],"et":[35,96,106,111,169,184,194,196,286,369,382],"conduisant":[36],"a":[37,181,187,197,205,315,346,374],"reprises":[39],"chirurgicales":[40],"multiples.":[41],"Notre":[42],"travail":[43],"comporte":[44],"2":[45,211,313],"etapes":[46],"1)":[48],"creation":[50,69],"d\u2019un":[51,70,361],"patch":[52,135,173],"monovalve":[53],"bioresorbable":[54,74,217,333],"polydioxanone":[56],"ensemence":[57,79,334],"cellules":[59,81],"souches":[60,82],"mesenchymateuses":[61,83],"autologues":[62,84,119,238,304],"sang":[64],"peripherique":[65],";":[66],"2)":[67],"tube":[71,214,248,279,331],"valve":[72,215,332],"trifolie":[73],"acide":[76],"poly-lactique":[77],"levogyre":[78],"cordon":[86,241,302,388],"ombilical.":[87],"L\u2019objectif":[88],"est":[89,176,345],"restaurer":[91],"une":[92,99,198,391],"RVOT":[93,149,328],"valvee":[94],"autologue":[95],"vivante,":[97,359],"presentant":[98],"competence":[100,289],"valvulaire,":[101],"un":[102,134,154,188,224,267,310,330],"l\u2019absence":[107,275],"degenerescence.":[109],"Methodologie":[110],"Resultats":[112,318],"Etape":[114,210],"1":[115],"MSC":[118,237,257,300,336,386],"circulantes":[120],"furent":[121,142,162],"isolees,":[122],"cultivees,":[123],"phenotypees,":[124],"marquees":[125],"par":[126,164,329],"quantum":[127],"dots,":[128],"ensemencees":[129,252],"pendant":[130,259,269],"6":[131,151],"jours":[132],"sur":[133,147,292],"PDO":[137,175],"biodegradable":[138],"valve.":[139],"Ces":[140],"patchs":[141],"implantes":[143,305],"position":[145],"transannulaire":[146],"agneaux":[152],"avec":[153,223,309],"suivi":[155,311],"maximal":[156],"8":[158],"mois.":[159,235],"resultats":[161],"evalues":[163],"echocardiographie,":[165],"IRM,":[166],"histologie,":[167],"immunohistochimie":[168],"dosage":[170],"calcique.":[171],"Le":[172,213,320,378],"degrade":[177],"maniere":[179],"complete":[180],"4":[182,260,270],"mois":[183,314],"laisse":[185],"place":[186],"neo-tissu":[189],"organise":[190],"3":[192,316],"couches":[193],"endothelialise":[195],"neo-matrice":[199],"extracellulaire":[200],"(avec":[201],"fibres":[202],"elastiques)":[203],"comparable":[204],"celle":[206],"du":[207,240,278],"tissu":[208],"natif.":[209],"polymerique":[216],"sera":[218,249],"constitue":[219],"PLLA":[221],"tisse,":[222],"delai":[225],"perte":[227],"50%":[229],"resistance":[231],"mecanique":[232],"12":[234],"Des":[236],"issues":[239],"ombilical":[242,303,389],"l\u2019agneau":[244,307],"chez":[245,306,338,398],"qui":[246],"le":[247,399],"implante":[250],"seront":[251],"conditions":[254,264],"statiques":[255],"(3,5x106":[256],"/cm\u00b2":[258],"jours),":[261],"puis":[262],"dynamiques":[265],"bioreacteur":[268],"semaines.":[271],"L\u2019evaluation":[272],"preclinique":[273],"degenerescence":[277],"valve,":[280],"son":[282],"sa":[288],"valvulaire":[290],"reposera":[291],"l\u2019etude":[293],"20":[295],"tubes":[296],"valves":[297],"ensemences":[298],"nouveau-ne,":[308],"ans.":[317],"attendus:":[319],"resultat":[321],"espere":[322],"ce":[324,339],"remplacement":[325],"autologues,":[337],"modele":[340],"animal":[341],"neonatal":[342],"croissance,":[344,364],"terme":[347],"restitution":[349],"ad":[350],"integrum":[351],"d\u2019une":[352],"neo":[353],"autologue,":[358],"douee":[360],"evitant":[365],"ainsi":[366],"morbidite":[368],"mortalite":[371],"majeures":[372],"inherentes":[373],"chirurgie":[376],"actuelle.":[377],"caractere":[379],"non":[380],"invasif":[381],"immediatement":[383],"disponible":[384],"rend":[390],"application":[392],"potentielle":[394],"d\u2019autant":[395],"plus":[396],"pertinente":[397],"nouveau-ne.":[400]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}