{"id":"https://openalex.org/W4308058751","doi":"https://doi.org/10.1158/2326-6066.cir-22-0793","title":"The PO4-tential for Less Toxic CAR T-cell Therapies","display_name":"The PO4-tential for Less Toxic CAR T-cell Therapies","publication_year":2022,"publication_date":"2022-11-03","ids":{"openalex":"https://openalex.org/W4308058751","doi":"https://doi.org/10.1158/2326-6066.cir-22-0793","pmid":"https://pubmed.ncbi.nlm.nih.gov/36327248"},"language":"en","primary_location":{"id":"doi:10.1158/2326-6066.cir-22-0793","doi":"https://doi.org/10.1158/2326-6066.cir-22-0793","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2326-6066.cir-22-0793","pdf_url":"https://aacrjournals.org/cancerimmunolres/article-pdf/10/12/1422/3226533/1422.pdf","source":{"id":"https://openalex.org/S2765010658","display_name":"Cancer Immunology Research","issn_l":"2326-6066","issn":["2326-6066","2326-6074"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Immunology Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://aacrjournals.org/cancerimmunolres/article-pdf/10/12/1422/3226533/1422.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061323862","display_name":"Joshua W.D. Tobin","orcid":"https://orcid.org/0000-0003-4982-525X","observed_orcids":["https://orcid.org/0000-0003-4982-525X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU","US"],"is_corresponding":false,"raw_author_name":"Joshua W.D. Tobin","raw_affiliation_strings":["1Mater Research University of Queensland, Brisbane, Queensland, Australia","2MD Anderson Cancer Center, Houston, Texas"],"raw_orcid":"https://orcid.org/0000-0003-4982-525X","affiliations":[{"raw_affiliation_string":"1Mater Research University of Queensland, Brisbane, Queensland, Australia","institution_ids":["https://openalex.org/I165143802"]},{"raw_affiliation_string":"2MD Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael R. Green","orcid":"https://orcid.org/0000-0001-6309-9472","observed_orcids":["https://orcid.org/0000-0001-6309-9472"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael R. Green","raw_affiliation_strings":["2MD Anderson Cancer Center, Houston, Texas"],"raw_orcid":"https://orcid.org/0000-0001-6309-9472","affiliations":[{"raw_affiliation_string":"2MD Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020906373","display_name":"Maher K. Gandhi","orcid":"https://orcid.org/0000-0003-1000-5393","observed_orcids":["https://orcid.org/0000-0003-1000-5393"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I2801814493","display_name":"Princess Alexandra Hospital","ror":"https://ror.org/04mqb0968","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1302211766","https://openalex.org/I2801244131","https://openalex.org/I2801814493","https://openalex.org/I4210089726"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Maher K. Gandhi","raw_affiliation_strings":["1Mater Research University of Queensland, Brisbane, Queensland, Australia","3Princess Alexandra Hospital, Brisbane, Queensland, Australia"],"raw_orcid":"https://orcid.org/0000-0003-1000-5393","affiliations":[{"raw_affiliation_string":"1Mater Research University of Queensland, Brisbane, Queensland, Australia","institution_ids":["https://openalex.org/I165143802"]},{"raw_affiliation_string":"3Princess Alexandra Hospital, Brisbane, Queensland, Australia","institution_ids":["https://openalex.org/I2801814493"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5020906373"],"corresponding_institution_ids":["https://openalex.org/I165143802","https://openalex.org/I2801814493"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.17951836,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"10","issue":"12","first_page":"1422","last_page":"1422"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/car-t-cell-therapy","display_name":"CAR T-cell therapy","score":0.9739999771118164},{"id":"https://openalex.org/keywords/immune-effector-cell-associated-neurotoxicity-syndrome","display_name":"immune effector cell-associated neurotoxicity syndrome","score":0.9539999961853027},{"id":"https://openalex.org/keywords/hypophosphatemia","display_name":"hypophosphatemia","score":0.949999988079071},{"id":"https://openalex.org/keywords/phosphate-monitoring","display_name":"phosphate monitoring","score":0.8320000171661377},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.5759999752044678},{"id":"https://openalex.org/keywords/toxicity-prevention","display_name":"toxicity prevention","score":0.4189999997615814}],"concepts":[{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.31268227100372314},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23872503638267517},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1872403621673584}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010710","descriptor_name":"Phosphates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016219","descriptor_name":"Immunotherapy, Adoptive","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1158/2326-6066.cir-22-0793","doi":"https://doi.org/10.1158/2326-6066.cir-22-0793","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2326-6066.cir-22-0793","pdf_url":"https://aacrjournals.org/cancerimmunolres/article-pdf/10/12/1422/3226533/1422.pdf","source":{"id":"https://openalex.org/S2765010658","display_name":"Cancer Immunology Research","issn_l":"2326-6066","issn":["2326-6066","2326-6074"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Immunology Research","raw_type":"journal-article"},{"id":"pmid:36327248","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36327248","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer immunology research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1158/2326-6066.cir-22-0793","doi":"https://doi.org/10.1158/2326-6066.cir-22-0793","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2326-6066.cir-22-0793","pdf_url":"https://aacrjournals.org/cancerimmunolres/article-pdf/10/12/1422/3226533/1422.pdf","source":{"id":"https://openalex.org/S2765010658","display_name":"Cancer Immunology Research","issn_l":"2326-6066","issn":["2326-6066","2326-6074"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Immunology Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4308058751.pdf","grobid_xml":"https://content.openalex.org/works/W4308058751.grobid-xml"},"referenced_works_count":4,"referenced_works":["https://openalex.org/W3081041696","https://openalex.org/W3089967262","https://openalex.org/W4200014243","https://openalex.org/W4306773893"],"related_works":["https://openalex.org/W4306773893","https://openalex.org/W4402517785","https://openalex.org/W7128821253","https://openalex.org/W4415475354","https://openalex.org/W4282930031","https://openalex.org/W4379283607","https://openalex.org/W4389234700","https://openalex.org/W4385809811","https://openalex.org/W4310730643","https://openalex.org/W7207846743"],"abstract_inverted_index":{"Chimeric":[0],"antigen":[1],"receptor":[2],"(CAR)":[3],"T-cell":[4],"therapy":[5],"has":[6,79],"yielded":[7],"remarkable":[8],"and":[9,17,45,52,73],"durable":[10],"responses":[11],"for":[12,35,70],"some":[13],"patients":[14],"with":[15],"relapsed":[16],"refractory":[18],"blood":[19],"cancers.":[20],"However,":[21],"life-threatening":[22],"toxicities":[23],"such":[24,39],"as":[25,82],"immune":[26],"effector":[27],"cell-associated":[28],"neurotoxicity":[29],"syndrome":[30],"(ICANS)":[31],"remain":[32],"a":[33,80,83],"challenge":[34],"broad":[36],"delivery":[37],"of":[38,76],"therapies.":[40],"In":[41],"this":[42],"issue,":[43],"Tang":[44,90],"colleagues":[46],"demonstrate":[47],"an":[48,67],"association":[49],"between":[50],"hypophosphatemia":[51],"CAR":[53],"T":[54],"cell-induced":[55],"ICANS.":[56],"Prospective":[57],"studies":[58],"are":[59],"required":[60],"to":[61],"establish":[62],"if":[63,74],"phosphate":[64,77],"monitoring":[65],"is":[66],"early":[68],"predictor":[69],"ICANS":[71],"occurrence":[72],"maintenance":[75],"levels":[78],"role":[81],"preventative":[84],"strategy.":[85],"See":[86],"related":[87],"article":[88],"by":[89],"et":[91],"al.,":[92],"p.":[93],"1433":[94],"(4).":[95]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-11-07T00:00:00"}