{"id":"https://openalex.org/W430788718","doi":"https://doi.org/10.1200/jco.2005.23.16_suppl.3552","title":"A randomized phase III intergroup study of perioperative fluorouracil (5-FU) in patients with resectable colon cancer","display_name":"A randomized phase III intergroup study of perioperative fluorouracil (5-FU) in patients with resectable colon cancer","publication_year":2005,"publication_date":"2005-06-01","ids":{"openalex":"https://openalex.org/W430788718","doi":"https://doi.org/10.1200/jco.2005.23.16_suppl.3552","mag":"430788718"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2005.23.16_suppl.3552","doi":"https://doi.org/10.1200/jco.2005.23.16_suppl.3552","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2005.23.16_suppl.3552","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110480246","display_name":"Margaret M. Kemeny","orcid":"https://orcid.org/0009-0006-2281-7750","observed_orcids":["https://orcid.org/0009-0006-2281-7750"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. M. Kemeny","raw_affiliation_strings":["Queens Hosp Ctr, Jamaica, NY; ECOG Statistical Ctr, Boston, MA; Univ of Texas Galveston, Galveston, TX; Brigham & Women\u2019s Hosp, Boston, MA; Regional Cancer Ctr, Eire, PA; Northwestern Univ, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queens Hosp Ctr, Jamaica, NY; ECOG Statistical Ctr, Boston, MA; Univ of Texas Galveston, Galveston, TX; Brigham & Women\u2019s Hosp, Boston, MA; Regional Cancer Ctr, Eire, PA; Northwestern Univ, Chicago, IL","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072507805","display_name":"Sara Eapen","orcid":"https://orcid.org/0000-0001-6549-8290","observed_orcids":["https://orcid.org/0000-0001-6549-8290"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Eapen","raw_affiliation_strings":["Queens Hosp Ctr, Jamaica, NY; ECOG Statistical Ctr, Boston, MA; Univ of Texas Galveston, Galveston, TX; Brigham & Women\u2019s Hosp, Boston, MA; Regional Cancer Ctr, Eire, PA; Northwestern Univ, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queens Hosp Ctr, Jamaica, NY; ECOG Statistical Ctr, Boston, MA; Univ of Texas Galveston, Galveston, TX; Brigham & Women\u2019s Hosp, Boston, MA; Regional Cancer Ctr, Eire, PA; Northwestern Univ, Chicago, IL","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075757534","display_name":"Robert P. Whitehead","orcid":"https://orcid.org/0000-0001-5780-3603","observed_orcids":["https://orcid.org/0000-0001-5780-3603"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. P. Whitehead","raw_affiliation_strings":["Queens Hosp Ctr, Jamaica, NY; ECOG Statistical Ctr, Boston, MA; Univ of Texas Galveston, Galveston, TX; Brigham & Women\u2019s Hosp, Boston, MA; Regional Cancer Ctr, Eire, PA; Northwestern Univ, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queens Hosp Ctr, Jamaica, NY; ECOG Statistical Ctr, Boston, MA; Univ of Texas Galveston, Galveston, TX; Brigham & Women\u2019s Hosp, Boston, MA; Regional Cancer Ctr, Eire, PA; Northwestern Univ, Chicago, IL","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032630006","display_name":"Ronald Bleday","orcid":"https://orcid.org/0000-0001-9861-7911","observed_orcids":["https://orcid.org/0000-0001-9861-7911"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Bleday","raw_affiliation_strings":["Queens Hosp Ctr, Jamaica, NY; ECOG Statistical Ctr, Boston, MA; Univ of Texas Galveston, Galveston, TX; Brigham & Women\u2019s Hosp, Boston, MA; Regional Cancer Ctr, Eire, PA; Northwestern Univ, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queens Hosp Ctr, Jamaica, NY; ECOG Statistical Ctr, Boston, MA; Univ of Texas Galveston, Galveston, TX; Brigham & Women\u2019s Hosp, Boston, MA; Regional Cancer Ctr, Eire, PA; Northwestern Univ, Chicago, IL","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028206850","display_name":"Roy E. Smith","orcid":"https://orcid.org/0000-0002-6018-250X","observed_orcids":["https://orcid.org/0000-0002-6018-250X"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. E. Smith","raw_affiliation_strings":["Queens Hosp Ctr, Jamaica, NY; ECOG Statistical Ctr, Boston, MA; Univ of Texas Galveston, Galveston, TX; Brigham & Women\u2019s Hosp, Boston, MA; Regional Cancer Ctr, Eire, PA; Northwestern Univ, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queens Hosp Ctr, Jamaica, NY; ECOG Statistical Ctr, Boston, MA; Univ of Texas Galveston, Galveston, TX; Brigham & Women\u2019s Hosp, Boston, MA; Regional Cancer Ctr, Eire, PA; Northwestern Univ, Chicago, IL","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029706633","display_name":"Al B. Benson","orcid":"https://orcid.org/0000-0001-5485-7227","observed_orcids":["https://orcid.org/0000-0001-5485-7227"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. B. Benson","raw_affiliation_strings":["Queens Hosp Ctr, Jamaica, NY; ECOG Statistical Ctr, Boston, MA; Univ of Texas Galveston, Galveston, TX; Brigham & Women\u2019s Hosp, Boston, MA; Regional Cancer Ctr, Eire, PA; Northwestern Univ, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queens Hosp Ctr, Jamaica, NY; ECOG Statistical Ctr, Boston, MA; Univ of Texas Galveston, Galveston, TX; Brigham & Women\u2019s Hosp, Boston, MA; Regional Cancer Ctr, Eire, PA; Northwestern Univ, Chicago, IL","institution_ids":["https://openalex.org/I1283280774"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1283280774"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"23","issue":"16_suppl","first_page":"3552","last_page":"3552"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.8295999765396118,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.8295999765396118,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.1639000028371811,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/perioperative-chemotherapy","display_name":"perioperative chemotherapy","score":0.8360000252723694},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.9639999866485596},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.7179999947547913},{"id":"https://openalex.org/keywords/continuous-infusion","display_name":"continuous infusion","score":0.6079999804496765},{"id":"https://openalex.org/keywords/colectomy","display_name":"colectomy","score":0.7360000014305115},{"id":"https://openalex.org/keywords/dukes-classification","display_name":"Dukes classification","score":0.5730000138282776},{"id":"https://openalex.org/keywords/adjuvant-chemotherapy","display_name":"adjuvant chemotherapy","score":0.8190000057220459},{"id":"https://openalex.org/keywords/leucovorin","display_name":"leucovorin","score":0.925000011920929},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7369999885559082},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9679999947547913},{"id":"https://openalex.org/keywords/levamisole","display_name":"levamisole","score":0.8560000061988831},{"id":"https://openalex.org/keywords/postoperative-chemotherapy","display_name":"postoperative chemotherapy","score":0.35100001096725464},{"id":"https://openalex.org/keywords/intergroup-trial","display_name":"intergroup trial","score":0.4819999933242798},{"id":"https://openalex.org/keywords/metastatic-colon-cancer","display_name":"metastatic colon cancer","score":0.597000002861023}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9641526937484741},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6926023960113525},{"id":"https://openalex.org/C2780456651","wikidata":"https://www.wikidata.org/wiki/Q238512","display_name":"Fluorouracil","level":3,"score":0.6829228401184082},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6625818014144897},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.6206845045089722},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.5832585096359253},{"id":"https://openalex.org/C31174226","wikidata":"https://www.wikidata.org/wiki/Q64855140","display_name":"Perioperative","level":2,"score":0.554768443107605},{"id":"https://openalex.org/C204243189","wikidata":"https://www.wikidata.org/wiki/Q1363085","display_name":"Randomization","level":3,"score":0.5269162058830261},{"id":"https://openalex.org/C2778336483","wikidata":"https://www.wikidata.org/wiki/Q5090632","display_name":"Chemotherapy regimen","level":3,"score":0.48149073123931885},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4442899823188782},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3524664342403412},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3344678282737732}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2005.23.16_suppl.3552","doi":"https://doi.org/10.1200/jco.2005.23.16_suppl.3552","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2005.23.16_suppl.3552","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4307503744","https://openalex.org/W1976587760","https://openalex.org/W7097032077","https://openalex.org/W2044696791","https://openalex.org/W2121681083","https://openalex.org/W2398756450","https://openalex.org/W1840481440","https://openalex.org/W1795564265","https://openalex.org/W2047166060","https://openalex.org/W2302360530"],"abstract_inverted_index":{"3552":[0],"Background:":[1],"Data":[2],"from":[3],"previous":[4],"trials":[5],"suggest":[6],"that":[7],"a":[8,28,337,346,351],"weeklong":[9],"continuous":[10,29,338],"infusion":[11,30,339],"of":[12,31,42,45,119,131,145],"5FU":[13,32,114,132],"started":[14],"24":[15,40],"hours":[16,41],"after":[17,345],"colon":[18,47,70,347],"resection":[19,48],"may":[20],"improve":[21],"survival.":[22],"Methods:":[23],"Patients":[24,56,76],"were":[25,72,105,155,177,185,189,197,213,284],"randomized":[26,195],"to":[27,50,126,150,168,386],"at":[33,61,157],"600mg/m2/day":[34],"for":[35,107,260,309],"7":[36],"days":[37],"starting":[38],"within":[39],"the":[43,82,100,121,127,146,173,193,217,222,234,242,264,273,292,296,310,317,323,341,357,363,376],"end":[44],"curative":[46],"or":[49,63,68,103],"no":[51,85,235,265,282,318],"peri-operative":[52,101,218],"chemotherapy(POC)":[53],"(Step":[54,111],"1).":[55],"who":[57,64],"had":[58,65],"metastatic":[59],"disease":[60],"operation":[62],"Dukes":[66,78,92,178,181,186,203],"A":[67],"B1":[69,182],"lesion":[71],"placed":[73],"off":[74],"study.":[75],"with":[77,91,113],"B2":[79,298,312,364],"lesions":[80],"received":[81,99],"POC,":[83,360],"but":[84,366],"post":[86],"operative":[87],"chemotherapy.":[88],"All":[89],"patients":[90,143,149,194,247,262,313,358],"B3":[93,200,244],"and":[94,115,133,153,183,201,229,238,245,252,270,288,301,321],"C":[95,246],"lesions,":[96],"whether":[97],"they":[98],"treatment":[102],"not,":[104],"reentered":[106],"standard":[108],"postoperative":[109,343],"chemotherapy":[110,123,223],"2),":[112],"levamisole.":[116],"In":[117],"August":[118,139],"1997":[120],"adjuvant":[122],"was":[124,162,248],"changed":[125],"Mayo":[128],"Clinic":[129],"regimen":[130],"leucovorin.":[134],"The":[135,160,205,225,255,304],"protocol,":[136],"activated":[137],"in":[138,164,216,221,227,263,272,286,295,316,340,356,362],"1993,":[140],"accrued":[141],"858":[142],"out":[144],"targeted":[147],"2000":[148,166],"Step":[151,158],"1":[152],"604":[154],"re-registered":[156],"2.":[159],"study":[161,377],"closed":[163],"May":[165],"due":[167],"insufficient":[169],"accrual.":[170],"Results:":[171],"Of":[172],"total":[174],"cases":[175],"7%":[176,184],"A,":[179],"14%":[180],"D;":[187],"all":[188],"not":[190,249,371,379],"re-registered.":[191],"For":[192],"35%":[196],"B2,":[198],"4%":[199],"33%":[202],"C.":[204],"median":[206],"follow-up":[207],"time":[208],"is":[209,268,314,350],"7.4":[210],"years.":[211],"There":[212,349],"4":[214],"deaths":[215],"period,":[219],"3":[220],"arm.":[224],"difference":[226],"overall":[228,258,287,307],"progression":[230],"free":[231],"survival":[232,259,290,308,355],"between":[233,291],"POC":[236,239,266,274,319,324],"arm":[237,240,267,275,320],"among":[241],"Dukes\u2019":[243,297,311],"significant,":[250],"p-value=0.37":[251],"0.72,":[253],"respectively.":[254,303],"5":[256,305],"year":[257,306],"these":[261],"65%":[269],"68%":[271],"(log":[276],"rank":[277,326],"p-value":[278,327],"=":[279,328],"0.74).":[280],"Similarly,":[281],"differences":[283],"seen":[285],"progression-free":[289],"two":[293],"arms":[294],"patients,":[299,365],"p-value=0.14":[300],"0.17,":[302],"77%":[315],"86%in":[322],"arm(log":[325],"0.068).":[329],"Conclusions:":[330],"Fluorouracil":[331],"can":[332],"be":[333],"safely":[334],"given":[335],"as":[336],"immediate":[342],"period":[344],"resection.":[348],"trend":[352],"toward":[353],"increased":[354],"receiving":[359],"especially":[361],"since":[367],"this":[368],"trial":[369],"did":[370,378],"achieve":[372],"its":[373],"accrual":[374],"goal,":[375],"reach":[380],"significance.":[381],"No":[382],"significant":[383],"financial":[384],"relationships":[385],"disclose.":[387]},"counts_by_year":[],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2016-06-24T00:00:00"}