{"id":"https://openalex.org/W4307707362","doi":"https://doi.org/10.3389/fnut.2022.1014414","title":"Active fractions of golden-flowered tea (Camellia nitidissima Chi) inhibit epidermal growth factor receptor mutated non-small cell lung cancer via multiple pathways and targets in vitro and in vivo","display_name":"Active fractions of golden-flowered tea (Camellia nitidissima Chi) inhibit epidermal growth factor receptor mutated non-small cell lung cancer via multiple pathways and targets in vitro and in vivo","publication_year":2022,"publication_date":"2022-10-28","ids":{"openalex":"https://openalex.org/W4307707362","doi":"https://doi.org/10.3389/fnut.2022.1014414","pmid":"https://pubmed.ncbi.nlm.nih.gov/36386893","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9649924"},"language":"en","primary_location":{"id":"doi:10.3389/fnut.2022.1014414","doi":"https://doi.org/10.3389/fnut.2022.1014414","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnut.2022.1014414","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnut.2022.1014414/pdf","source":{"id":"https://openalex.org/S2596909297","display_name":"Frontiers in Nutrition","issn_l":"2296-861X","issn":["2296-861X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Nutrition","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fnut.2022.1014414/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101529535","display_name":"Ziling Wang","orcid":"https://orcid.org/0000-0002-1262-0341","observed_orcids":["https://orcid.org/0000-0002-1262-0341"]},"institutions":[{"id":"https://openalex.org/I205016115","display_name":"Hubei University of Chinese Medicine","ror":"https://ror.org/02my3bx32","country_code":"CN","type":"education","lineage":["https://openalex.org/I205016115"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ziling Wang","raw_affiliation_strings":["Key Laboratory of Traditional Chinese Medicine Resources and Chemistry of Hubei Province, School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Traditional Chinese Medicine Resources and Chemistry of Hubei Province, School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China","institution_ids":["https://openalex.org/I205016115"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087821382","display_name":"Xiaoying Hou","orcid":"https://orcid.org/0000-0002-9201-3970","observed_orcids":["https://orcid.org/0000-0002-9201-3970"]},"institutions":[{"id":"https://openalex.org/I31590910","display_name":"Jianghan University","ror":"https://ror.org/041c9x778","country_code":"CN","type":"education","lineage":["https://openalex.org/I31590910"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoying Hou","raw_affiliation_strings":["School of Medicine, Wuhan Institutes of Biomedical Sciences, Jianghan University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Wuhan Institutes of Biomedical Sciences, Jianghan University, Wuhan, China","institution_ids":["https://openalex.org/I31590910"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100400736","display_name":"Min Li","orcid":"https://orcid.org/0000-0002-3971-9130","observed_orcids":["https://orcid.org/0000-0002-3971-9130"]},"institutions":[{"id":"https://openalex.org/I180726961","display_name":"Shenzhen University","ror":"https://ror.org/01vy4gh70","country_code":"CN","type":"education","lineage":["https://openalex.org/I180726961"]},{"id":"https://openalex.org/I4210145330","display_name":"Shenzhen Luohu People's Hospital","ror":"https://ror.org/04bpt8p43","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210145330"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Li","raw_affiliation_strings":["Shenzhen Luohu Hospital Group Luohu People's Hospital, The Third Affiliated Hospital of Shenzhen University, Shenzhen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shenzhen Luohu Hospital Group Luohu People's Hospital, The Third Affiliated Hospital of Shenzhen University, Shenzhen, China","institution_ids":["https://openalex.org/I180726961","https://openalex.org/I4210145330"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Rongsheng Ji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205016115","display_name":"Hubei University of Chinese Medicine","ror":"https://ror.org/02my3bx32","country_code":"CN","type":"education","lineage":["https://openalex.org/I205016115"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rongsheng Ji","raw_affiliation_strings":["Key Laboratory of Traditional Chinese Medicine Resources and Chemistry of Hubei Province, School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Traditional Chinese Medicine Resources and Chemistry of Hubei Province, School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China","institution_ids":["https://openalex.org/I205016115"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107937407","display_name":"Zhouyuan Li","orcid":"https://orcid.org/0009-0000-0614-1275","observed_orcids":["https://orcid.org/0009-0000-0614-1275"]},"institutions":[{"id":"https://openalex.org/I205016115","display_name":"Hubei University of Chinese Medicine","ror":"https://ror.org/02my3bx32","country_code":"CN","type":"education","lineage":["https://openalex.org/I205016115"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhouyuan Li","raw_affiliation_strings":["Key Laboratory of Traditional Chinese Medicine Resources and Chemistry of Hubei Province, School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Traditional Chinese Medicine Resources and Chemistry of Hubei Province, School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China","institution_ids":["https://openalex.org/I205016115"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067124076","display_name":"Yuqiao Wang","orcid":"https://orcid.org/0000-0001-9281-3911","observed_orcids":["https://orcid.org/0000-0001-9281-3911","https://orcid.org/0009-0008-9468-5202"]},"institutions":[{"id":"https://openalex.org/I205016115","display_name":"Hubei University of Chinese Medicine","ror":"https://ror.org/02my3bx32","country_code":"CN","type":"education","lineage":["https://openalex.org/I205016115"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuqiao Wang","raw_affiliation_strings":["Key Laboratory of Traditional Chinese Medicine Resources and Chemistry of Hubei Province, School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Traditional Chinese Medicine Resources and Chemistry of Hubei Province, School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China","institution_ids":["https://openalex.org/I205016115"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101454323","display_name":"Yujie Guo","orcid":"https://orcid.org/0000-0002-2379-0725","observed_orcids":["https://orcid.org/0000-0002-2379-0725"]},"institutions":[{"id":"https://openalex.org/I205016115","display_name":"Hubei University of Chinese Medicine","ror":"https://ror.org/02my3bx32","country_code":"CN","type":"education","lineage":["https://openalex.org/I205016115"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yujie Guo","raw_affiliation_strings":["Key Laboratory of Traditional Chinese Medicine Resources and Chemistry of Hubei Province, School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Traditional Chinese Medicine Resources and Chemistry of Hubei Province, School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China","institution_ids":["https://openalex.org/I205016115"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032447446","display_name":"Dahui Liu","orcid":"https://orcid.org/0000-0001-6518-9068","observed_orcids":["https://orcid.org/0000-0001-6518-9068"]},"institutions":[{"id":"https://openalex.org/I205016115","display_name":"Hubei University of Chinese Medicine","ror":"https://ror.org/02my3bx32","country_code":"CN","type":"education","lineage":["https://openalex.org/I205016115"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dahui Liu","raw_affiliation_strings":["Key Laboratory of Traditional Chinese Medicine Resources and Chemistry of Hubei Province, School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Traditional Chinese Medicine Resources and Chemistry of Hubei Province, School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China","institution_ids":["https://openalex.org/I205016115"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102807127","display_name":"Bisheng Huang","orcid":"https://orcid.org/0000-0003-2735-6085","observed_orcids":["https://orcid.org/0000-0003-2735-6085"]},"institutions":[{"id":"https://openalex.org/I205016115","display_name":"Hubei University of Chinese Medicine","ror":"https://ror.org/02my3bx32","country_code":"CN","type":"education","lineage":["https://openalex.org/I205016115"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Bisheng Huang","raw_affiliation_strings":["Key Laboratory of Traditional Chinese Medicine Resources and Chemistry of Hubei Province, School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Traditional Chinese Medicine Resources and Chemistry of Hubei Province, School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China","institution_ids":["https://openalex.org/I205016115"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071288711","display_name":"Hongzhi Du","orcid":"https://orcid.org/0000-0002-3564-1874","observed_orcids":["https://orcid.org/0000-0002-3564-1874"]},"institutions":[{"id":"https://openalex.org/I205016115","display_name":"Hubei University of Chinese Medicine","ror":"https://ror.org/02my3bx32","country_code":"CN","type":"education","lineage":["https://openalex.org/I205016115"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hongzhi Du","raw_affiliation_strings":["Key Laboratory of Traditional Chinese Medicine Resources and Chemistry of Hubei Province, School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Traditional Chinese Medicine Resources and Chemistry of Hubei Province, School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China","institution_ids":["https://openalex.org/I205016115"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5071288711","https://openalex.org/A5102807127"],"corresponding_institution_ids":["https://openalex.org/I205016115"],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":1.9556,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.87749467,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"9","issue":null,"first_page":"1014414","last_page":"1014414"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11385","display_name":"Natural product bioactivities and synthesis","score":0.31369999051094055,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11385","display_name":"Natural product bioactivities and synthesis","score":0.31369999051094055,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12215","display_name":"Phytochemical Studies and Bioactivities","score":0.25760000944137573,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.10660000145435333,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/camellia-nitidissima","display_name":"Camellia nitidissima","score":0.9629999995231628},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.8899999856948853},{"id":"https://openalex.org/keywords/egfr-mutant-lung-cancer","display_name":"EGFR-mutant lung cancer","score":0.7639999985694885},{"id":"https://openalex.org/keywords/polyphenols","display_name":"polyphenols","score":0.9359999895095825},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.9089999794960022},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cytokine-cytokine-receptor-interaction","display_name":"cytokine-cytokine receptor interaction","score":0.9649999737739563},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta2","display_name":"transforming growth factor-beta2","score":0.9779999852180481},{"id":"https://openalex.org/keywords/inhbb","display_name":"INHBB","score":0.9890000224113464},{"id":"https://openalex.org/keywords/pik3r3","display_name":"PIK3R3","score":0.9819999933242798},{"id":"https://openalex.org/keywords/itgb8","display_name":"ITGB8","score":0.8939999938011169},{"id":"https://openalex.org/keywords/trkb","display_name":"TrkB","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cacna1d","display_name":"CACNA1D","score":0.996999979019165},{"id":"https://openalex.org/keywords/medicine-food-homology","display_name":"medicine-food homology","score":0.8859999775886536}],"concepts":[{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.6414477825164795},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5125872492790222},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.5024597644805908},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.49510064721107483},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4941752254962921},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.46377959847450256},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.4429395794868469},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.43095824122428894},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3681163787841797},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3612930178642273},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3482553958892822},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28029173612594604},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.246902734041214},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.062747061252594}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fnut.2022.1014414","doi":"https://doi.org/10.3389/fnut.2022.1014414","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnut.2022.1014414","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnut.2022.1014414/pdf","source":{"id":"https://openalex.org/S2596909297","display_name":"Frontiers in Nutrition","issn_l":"2296-861X","issn":["2296-861X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Nutrition","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9649924","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9649924","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Nutr","raw_type":"Text"},{"id":"pmid:36386893","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36386893","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in nutrition","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:15c7bbec5e444d5dbad6b75331db9a47","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/15c7bbec5e444d5dbad6b75331db9a47","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Nutrition, Vol 9 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fnut.2022.1014414","doi":"https://doi.org/10.3389/fnut.2022.1014414","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnut.2022.1014414","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnut.2022.1014414/pdf","source":{"id":"https://openalex.org/S2596909297","display_name":"Frontiers in Nutrition","issn_l":"2296-861X","issn":["2296-861X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Nutrition","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2204764628","display_name":null,"funder_award_id":"81903845","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321542","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718"},{"id":"https://openalex.org/F4320323370","display_name":"Hainan University","ror":"https://ror.org/03q648j11"},{"id":"https://openalex.org/F4320329781","display_name":"Hubei University","ror":"https://ror.org/03a60m280"},{"id":"https://openalex.org/F4320330170","display_name":"Young Elite Scientists Sponsorship Program by Tianjin","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4307707362.pdf","grobid_xml":"https://content.openalex.org/works/W4307707362.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W1529003705","https://openalex.org/W1988539624","https://openalex.org/W2007096141","https://openalex.org/W2089808574","https://openalex.org/W2097337885","https://openalex.org/W2111689182","https://openalex.org/W2145835533","https://openalex.org/W2160566324","https://openalex.org/W2322510095","https://openalex.org/W2570763587","https://openalex.org/W2598381831","https://openalex.org/W2783258028","https://openalex.org/W2784371446","https://openalex.org/W2791120762","https://openalex.org/W2798217573","https://openalex.org/W2907026587","https://openalex.org/W2916508569","https://openalex.org/W2917248207","https://openalex.org/W2950538187","https://openalex.org/W2987525868","https://openalex.org/W2989919747","https://openalex.org/W2994249217","https://openalex.org/W2995487304","https://openalex.org/W2996272498","https://openalex.org/W2996973801","https://openalex.org/W2999417355","https://openalex.org/W3005196658","https://openalex.org/W3009796018","https://openalex.org/W3021300528","https://openalex.org/W3024828685","https://openalex.org/W3045399298","https://openalex.org/W3085617236","https://openalex.org/W3097169522","https://openalex.org/W3107263663","https://openalex.org/W3110833960","https://openalex.org/W3115667040","https://openalex.org/W3119005666","https://openalex.org/W3130058826","https://openalex.org/W3132271411","https://openalex.org/W3133654640","https://openalex.org/W3137009087","https://openalex.org/W3180870360","https://openalex.org/W3189362816","https://openalex.org/W3199679779","https://openalex.org/W3205685501","https://openalex.org/W3209791820","https://openalex.org/W4200576251","https://openalex.org/W4210755799"],"related_works":["https://openalex.org/W3209791820","https://openalex.org/W4367669860","https://openalex.org/W2769971892","https://openalex.org/W3131467242","https://openalex.org/W4383999140","https://openalex.org/W3015545969","https://openalex.org/W4403701320","https://openalex.org/W7133193402","https://openalex.org/W2791120762","https://openalex.org/W2102851694"],"abstract_inverted_index":{"As":[0],"a":[1,250],"medicine-food":[2],"homology":[3],"(MFH)":[4],"plant,":[5],"golden-flowered":[6,244],"tea":[7,25,245,252],"(Camellia":[8],"nitidissima":[9],"Chi,":[10],"CNC)":[11],"has":[12,69],"many":[13],"different":[14],"pharmacologic":[15,39],"activities":[16],"and":[17,27,48,61,119,133,186,195,205,231],"is":[18],"known":[19],"as":[20,207,249],"\u201cthe":[21,28],"queen":[22],"of":[23,30,41,63,85,89,98,103,141,168,215],"the":[24,31,38,57,66,78,94,99,121,149,166,208,212,220,232],"family\u201d":[26],"Panda":[29],"Plant":[32],"world\u201d.":[33],"Several":[34],"studies":[35,55],"have":[36],"revealed":[37,164,199],"effects":[40,84,214],"CNC":[42,104,142],"crude":[43],"extract,":[44],"including":[45,179],"anti-tumor,":[46],"anti-oxidative":[47],"hepatoprotective":[49],"activity.":[50],"However,":[51],"there":[52],"are":[53],"few":[54],"on":[56,146,155],"anti-tumor":[58,213],"active":[59,87,101],"fractions":[60,88,102,140],"components":[62],"CNC,":[64],"yet":[65],"underlying":[67],"mechanism":[68,261],"not":[70],"been":[71],"investigated.":[72],"Thus,":[73],"we":[74,92],"sought":[75],"to":[76],"verify":[77],"anti-non-small":[79],"cell":[80,159,170],"lung":[81],"cancer":[82],"(NSCLC)":[83],"four":[86,100],"CNC.":[90],"Firstly,":[91],"determined":[93],"pharmacodynamic":[95],"material":[96],"basis":[97],"(Camellia.":[105],"leave.":[106,109,151],"saponins,":[107,113],"Camellia.":[108,111,114,150],"polyphenols,":[110],"flower.":[112,115],"polyphenols)":[116],"by":[117,172],"UPLC-Q-TOF-MS/MS":[118],"confirmed":[120,137,223],"differences":[122],"in":[123,217,238],"their":[124],"specific":[125],"compound":[126],"contents.":[127],"Then,":[128],"MTT,":[129],"colony":[130],"formation":[131],"assay":[132,136],"EdU":[134],"incorporation":[135],"that":[138,165,224,243],"all":[139],"exhibit":[143],"significant":[144],"inhibitory":[145],"NSCLC,":[147],"especially":[148],"saponins":[152],"(CLS)":[153],"fraction":[154],"EGFR":[156],"mutated":[157],"NSCLC":[158,169],"lines.":[160],"Moreover,":[161],"transcriptome":[162],"analysis":[163],"inhibition":[167],"growth":[171],"CLS":[173,216,225],"may":[174],"be":[175,247],"via":[176],"three":[177],"pathways,":[178],"\u201cCytokine-cytokine":[180],"receptor":[181],"interaction,\u201d":[182],"\u201cPI3K-Akt":[183],"signaling":[184,188],"pathway\u201d":[185],"\u201cMAPK":[187],"pathway.\u201d":[189],"Subsequently,":[190],"quantitative":[191],"real-time":[192],"PCR":[193],"(RT-qPCR)":[194],"Western":[196],"blot":[197],"(WB)":[198],"TGFB2,":[200],"INHBB,":[201],"PIK3R3,":[202],"ITGB8,":[203],"TrkB":[204],"CACNA1D":[206],"critical":[209],"targets":[210,234],"for":[211,263],"vitro.":[218],"Finally,":[219],"xenograft":[221],"models":[222],"treatment":[226],"effectively":[227],"suppressed":[228],"tumor":[229],"growth,":[230],"key":[233],"were":[235],"also":[236],"verified":[237],"vivo.":[239],"These":[240],"observations":[241],"suggest":[242],"could":[246],"developed":[248],"functional":[251],"drink":[253],"with":[254],"anti-cancer":[255],"ability,":[256],"providing":[257],"an":[258],"essential":[259],"molecular":[260],"foundation":[262],"MFH":[264],"medicine":[265],"treating":[266],"NSCLC.":[267]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-11-05T00:00:00"}
