{"id":"https://openalex.org/W4307635379","doi":"https://doi.org/10.3389/fonc.2022.1013299","title":"MET-targeted therapies for the treatment of non-small-cell lung cancer: A systematic review and meta-analysis","display_name":"MET-targeted therapies for the treatment of non-small-cell lung cancer: A systematic review and meta-analysis","publication_year":2022,"publication_date":"2022-10-27","ids":{"openalex":"https://openalex.org/W4307635379","doi":"https://doi.org/10.3389/fonc.2022.1013299","pmid":"https://pubmed.ncbi.nlm.nih.gov/36387098","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9646943"},"language":"en","primary_location":{"id":"doi:10.3389/fonc.2022.1013299","doi":"https://doi.org/10.3389/fonc.2022.1013299","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2022.1013299","pdf_url":"https://www.frontiersin.org/articles/10.3389/fonc.2022.1013299/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fonc.2022.1013299/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068611268","display_name":"Linrui Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Linrui Xu","raw_affiliation_strings":["Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu, Sichuan, China","Department of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China","Laboratory of Pulmonary Immunology and Inflammation, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu, Sichuan, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"]},{"raw_affiliation_string":"Department of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"]},{"raw_affiliation_string":"Laboratory of Pulmonary Immunology and Inflammation, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060397974","display_name":"Faping Wang","orcid":"https://orcid.org/0000-0002-4473-1169","observed_orcids":["https://orcid.org/0000-0002-4473-1169"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Faping Wang","raw_affiliation_strings":["Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu, Sichuan, China","Department of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China","Laboratory of Pulmonary Immunology and Inflammation, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu, Sichuan, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"]},{"raw_affiliation_string":"Department of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"]},{"raw_affiliation_string":"Laboratory of Pulmonary Immunology and Inflammation, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101517322","display_name":"Fengming Luo","orcid":"https://orcid.org/0000-0002-7659-4621","observed_orcids":["https://orcid.org/0000-0002-7659-4621"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Fengming Luo","raw_affiliation_strings":["Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu, Sichuan, China","Department of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China","Laboratory of Pulmonary Immunology and Inflammation, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu, Sichuan, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"]},{"raw_affiliation_string":"Department of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"]},{"raw_affiliation_string":"Laboratory of Pulmonary Immunology and Inflammation, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101517322"],"corresponding_institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":0.5993,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.53395146,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"12","issue":null,"first_page":"1013299","last_page":"1013299"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.859000027179718},{"id":"https://openalex.org/keywords/met-inhibitors","display_name":"MET inhibitors","score":0.9120000004768372},{"id":"https://openalex.org/keywords/mesenchymal-epithelial-transition","display_name":"mesenchymal-epithelial transition","score":0.8479999899864197},{"id":"https://openalex.org/keywords/tepotinib","display_name":"tepotinib","score":0.781000018119812},{"id":"https://openalex.org/keywords/savolitinib","display_name":"savolitinib","score":1.0},{"id":"https://openalex.org/keywords/met-exon-14-skipping","display_name":"MET exon 14 skipping","score":0.8799999952316284},{"id":"https://openalex.org/keywords/met-amplification","display_name":"MET amplification","score":0.9649999737739563},{"id":"https://openalex.org/keywords/objective-response-rate","display_name":"objective response rate","score":0.9089999794960022},{"id":"https://openalex.org/keywords/disease-control-rate","display_name":"disease control rate","score":0.9639999866485596},{"id":"https://openalex.org/keywords/intracranial-response","display_name":"intracranial response","score":0.9750000238418579},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.8999999761581421},{"id":"https://openalex.org/keywords/lower-extremity-edema","display_name":"lower limb edema","score":0.8500000238418579},{"id":"https://openalex.org/keywords/alanine-aminotransferase-elevation","display_name":"alanine aminotransferase elevation","score":0.8399999737739563}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8641963005065918},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.7350802421569824},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7160167694091797},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6342999935150146},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6004937887191772},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5925242900848389},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5820249915122986},{"id":"https://openalex.org/C2776478404","wikidata":"https://www.wikidata.org/wiki/Q1105187","display_name":"Cochrane Library","level":3,"score":0.5445809364318848}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fonc.2022.1013299","doi":"https://doi.org/10.3389/fonc.2022.1013299","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2022.1013299","pdf_url":"https://www.frontiersin.org/articles/10.3389/fonc.2022.1013299/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},{"id":"pmid:36387098","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36387098","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in oncology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9646943","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9646943/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Oncol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:cff2ee1b355646528ed4ae0d24bdc473","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/cff2ee1b355646528ed4ae0d24bdc473","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Oncology, Vol 12 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fonc.2022.1013299","doi":"https://doi.org/10.3389/fonc.2022.1013299","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2022.1013299","pdf_url":"https://www.frontiersin.org/articles/10.3389/fonc.2022.1013299/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[{"id":"https://openalex.org/G1151443205","display_name":null,"funder_award_id":"ZYJC18021","funder_id":"https://openalex.org/F4320322990","funder_display_name":"Sichuan University"},{"id":"https://openalex.org/G2817020326","display_name":null,"funder_award_id":"2021HXBH074","funder_id":"https://openalex.org/F4320336042","funder_display_name":"West China Hospital, Sichuan University"},{"id":"https://openalex.org/G3747040185","display_name":null,"funder_award_id":"ZYJC18021","funder_id":"https://openalex.org/F4320336042","funder_display_name":"West China Hospital, Sichuan University"},{"id":"https://openalex.org/G5327689620","display_name":null,"funder_award_id":"1.3.5 project","funder_id":"https://openalex.org/F4320336042","funder_display_name":"West China Hospital, Sichuan University"},{"id":"https://openalex.org/G7899741169","display_name":null,"funder_award_id":"1.3.5","funder_id":"https://openalex.org/F4320336042","funder_display_name":"West China Hospital, Sichuan University"}],"funders":[{"id":"https://openalex.org/F4320322990","display_name":"Sichuan University","ror":"https://ror.org/011ashp19"},{"id":"https://openalex.org/F4320336042","display_name":"West China Hospital, Sichuan University","ror":"https://ror.org/007mrxy13"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4307635379.pdf","grobid_xml":"https://content.openalex.org/works/W4307635379.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W1892652546","https://openalex.org/W1964127544","https://openalex.org/W1965438158","https://openalex.org/W1974058738","https://openalex.org/W1985264867","https://openalex.org/W1992399396","https://openalex.org/W1994912526","https://openalex.org/W1998971866","https://openalex.org/W2012642473","https://openalex.org/W2017044005","https://openalex.org/W2017352677","https://openalex.org/W2019607817","https://openalex.org/W2021452013","https://openalex.org/W2026805792","https://openalex.org/W2056837471","https://openalex.org/W2077595209","https://openalex.org/W2101581271","https://openalex.org/W2106915761","https://openalex.org/W2125435699","https://openalex.org/W2128696591","https://openalex.org/W2138309116","https://openalex.org/W2140334822","https://openalex.org/W2151512523","https://openalex.org/W2154402764","https://openalex.org/W2157823046","https://openalex.org/W2160212814","https://openalex.org/W2169624569","https://openalex.org/W2228221433","https://openalex.org/W2230948985","https://openalex.org/W2253815799","https://openalex.org/W2272081149","https://openalex.org/W2281622498","https://openalex.org/W2544185683","https://openalex.org/W2545600847","https://openalex.org/W2562169753","https://openalex.org/W2739028852","https://openalex.org/W2746069565","https://openalex.org/W2770145709","https://openalex.org/W2802552316","https://openalex.org/W2889373434","https://openalex.org/W2889646458","https://openalex.org/W2894761459","https://openalex.org/W2917837889","https://openalex.org/W2954589648","https://openalex.org/W2964471257","https://openalex.org/W2967992516","https://openalex.org/W2970196241","https://openalex.org/W2978886033","https://openalex.org/W2989605641","https://openalex.org/W3000668520","https://openalex.org/W3004715000","https://openalex.org/W3004905091","https://openalex.org/W3013425984","https://openalex.org/W3029971508","https://openalex.org/W3033982788","https://openalex.org/W3035138898","https://openalex.org/W3082015854","https://openalex.org/W3108770517","https://openalex.org/W3110833960","https://openalex.org/W3118615836","https://openalex.org/W3118874405","https://openalex.org/W3128342266","https://openalex.org/W3133838590","https://openalex.org/W3175096644","https://openalex.org/W3184303806","https://openalex.org/W3188690607","https://openalex.org/W3194878909","https://openalex.org/W3214261332","https://openalex.org/W4289335944","https://openalex.org/W4322696732"],"related_works":["https://openalex.org/W4396838033","https://openalex.org/W4388046112","https://openalex.org/W4220957917","https://openalex.org/W7131818085","https://openalex.org/W3130463127","https://openalex.org/W2904071455","https://openalex.org/W2545600847","https://openalex.org/W3127624579","https://openalex.org/W4406755930","https://openalex.org/W4306969221"],"abstract_inverted_index":{"Background:":[0],"Dysregulation":[1],"of":[2,33,48,117,177,226,269],"the":[3,34,44,77,90,218,267],"mesenchymal":[4],"epithelial":[5],"transition":[6],"(MET)":[7],"pathway":[8],"contributes":[9],"to":[10,41,173,256,265],"poor":[11],"clinical":[12,23],"outcomes":[13],"in":[14,51,66,76,175,217,232,241,273],"patients":[15,52,233],"with":[16,53,121,123,142,234,243,275],"non-small":[17],"cell":[18],"lung":[19],"cancer":[20],"(NSCLC).":[21],"Numerous":[22],"trials":[24,253],"are":[25,254],"currently":[26],"investigating":[27],"several":[28],"therapies":[29,263],"based":[30,61],"on":[31,62],"modulation":[32],"MET":[35,49,118,143,209,230,262,271,276],"pathway.":[36],"Objectives:":[37],"This":[38],"study":[39],"aimed":[40],"systematically":[42],"evaluate":[43],"activity":[45],"and":[46,107,134,151,161,201,239,249,264],"safety":[47,215],"inhibitors":[50,272],"NSCLC.":[54],"Methods:":[55],">50%).":[56],"Safety":[57],"analysis":[58],"was":[59,82,93],"performed":[60],"adverse":[63,180],"events":[64,168,181],"reported":[65],"all":[67],"studies.":[68],"Results:":[69],"Eleven":[70],"studies":[71],"(882":[72],"patients)":[73],"were":[74,99,156,169],"included":[75,185],"meta-analysis.":[78],"The":[79],"pooled":[80,91],"ORR":[81],"28.1%":[83],"(95%":[84,95,131,137,158,163],"confidence":[85],"interval":[86],"[CI],":[87],"0.223-0.354),":[88],"while":[89],"DCR":[92],"69.1%":[94],"CI,":[96,105,111,132,138,159,164,191,199,206],"0.631-0.756).":[97],"ORRs":[98,129],"higher":[100,128],"for":[101,114,228,261],"tepotinib":[102],"(44.7%":[103],"[95%":[104,110,190,198,205],"0.365-0.530])":[106],"savolitinib":[108,248],"(42.9%":[109],"0.311-0.553])":[112],"than":[113,140],"other":[115],"types":[116],"inhibitors.":[119],"Patients":[120],"NSCLC":[122,274],"exon":[124],"14":[125],"skipping":[126],"exhibited":[127,212],"(39.3%":[130],"0.296-0.522))":[133],"DCRs":[135],"(77.8%":[136],"0.714-0.847))":[139],"those":[141,242],"protein":[144],"overexpression":[145],"or":[146,236],"amplification.":[147],"Intracranial":[148],"response":[149],"rate":[150],"intracranial":[152],"disease":[153],"control":[154],"rates":[155],"40.1%":[157],"0.289-0.556)":[160],"95.4%":[162],"0.892-0.100),":[165],"respectively.":[166],"Adverse":[167],"mild":[170],"(grade":[171],"1":[172],"2)":[174],"87.2%":[176],"patients.":[178],"Common":[179],"above":[182],"grade":[183],"3":[184],"lower":[186],"extremity":[187],"edema":[188],"(3.5%":[189],"0.027-0.044]),":[192],"alanine":[193],"aminotransferase":[194],"(ALT)":[195],"elevation":[196,203],"(2.4%":[197],"0.014-0.033]),":[200],"lipase":[202],"(2.2%":[204],"0.016-0.031]).":[207],"Conclusion:":[208],"inhibitors,":[210],"which":[211],"a":[213,223],"satisfactory":[214],"profile":[216],"current":[219],"study,":[220],"may":[221],"become":[222],"new":[224],"standard":[225,258],"care":[227],"addressing":[229],"dysregulation":[231],"advanced":[235],"metastatic":[237],"NSCLC,":[238],"even":[240],"brain":[244],"metastases,":[245],"particularly":[246],"tepotinib,":[247],"capmatinib.":[250],"Further":[251],"randomized":[252],"required":[255],"establish":[257],"predictive":[259],"biomarkers":[260],"compare":[266],"effects":[268],"different":[270],"dysregulation.":[277]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-11-04T00:00:00"}