{"id":"https://openalex.org/W4307634603","doi":"https://doi.org/10.3390/cancers14215244","title":"Molecular Engines, Therapeutic Targets, and Challenges in Pediatric Brain Tumors: A Special Emphasis on Hydrogen Sulfide and RNA-Based Nano-Delivery","display_name":"Molecular Engines, Therapeutic Targets, and Challenges in Pediatric Brain Tumors: A Special Emphasis on Hydrogen Sulfide and RNA-Based Nano-Delivery","publication_year":2022,"publication_date":"2022-10-26","ids":{"openalex":"https://openalex.org/W4307634603","doi":"https://doi.org/10.3390/cancers14215244","pmid":"https://pubmed.ncbi.nlm.nih.gov/36358663","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9657918"},"language":"en","primary_location":{"id":"doi:10.3390/cancers14215244","doi":"https://doi.org/10.3390/cancers14215244","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers14215244","pdf_url":"https://www.mdpi.com/2072-6694/14/21/5244/pdf?version=1666941559","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2072-6694/14/21/5244/pdf?version=1666941559","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008450363","display_name":"Sherif Ashraf Fahmy","orcid":"https://orcid.org/0000-0003-3056-8281","observed_orcids":["https://orcid.org/0000-0003-3056-8281"]},"institutions":[{"id":"https://openalex.org/I141584323","display_name":"University of Hertfordshire","ror":"https://ror.org/0267vjk41","country_code":"GB","type":"education","lineage":["https://openalex.org/I141584323"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sherif Ashraf Fahmy","raw_affiliation_strings":["Chemistry Department, School of Life and Medical Sciences, University of Hertfordshire Hosted by Global Academic Foundation, R5 New Capital City, Cairo 11835, Egypt"],"raw_orcid":"https://orcid.org/0000-0003-3056-8281","affiliations":[{"raw_affiliation_string":"Chemistry Department, School of Life and Medical Sciences, University of Hertfordshire Hosted by Global Academic Foundation, R5 New Capital City, Cairo 11835, Egypt","institution_ids":["https://openalex.org/I141584323"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031179826","display_name":"Alyaa Dawoud","orcid":"https://orcid.org/0000-0002-8140-1070","observed_orcids":["https://orcid.org/0000-0002-8140-1070"]},"institutions":[{"id":"https://openalex.org/I96823368","display_name":"German University in Cairo","ror":"https://ror.org/03rjt0z37","country_code":"EG","type":"education","lineage":["https://openalex.org/I96823368"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Alyaa Dawoud","raw_affiliation_strings":["Biochemistry Department, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt","Molecular Genetics Research Team (MGRT), Pharmaceutical Biology Department, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry Department, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt","institution_ids":["https://openalex.org/I96823368"]},{"raw_affiliation_string":"Molecular Genetics Research Team (MGRT), Pharmaceutical Biology Department, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt","institution_ids":["https://openalex.org/I96823368"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075771400","display_name":"Yousra Ahmed Zeinelabdeen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]},{"id":"https://openalex.org/I96823368","display_name":"German University in Cairo","ror":"https://ror.org/03rjt0z37","country_code":"EG","type":"education","lineage":["https://openalex.org/I96823368"]}],"countries":["EG","NL"],"is_corresponding":false,"raw_author_name":"Yousra Ahmed Zeinelabdeen","raw_affiliation_strings":["Faculty of Medical Sciences/UMCG, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands","Molecular Genetics Research Team (MGRT), Pharmaceutical Biology Department, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medical Sciences/UMCG, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]},{"raw_affiliation_string":"Molecular Genetics Research Team (MGRT), Pharmaceutical Biology Department, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt","institution_ids":["https://openalex.org/I96823368"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048714713","display_name":"Caroline Joseph Kiriacos","orcid":"https://orcid.org/0000-0003-3535-9286","observed_orcids":["https://orcid.org/0000-0003-3535-9286"]},"institutions":[{"id":"https://openalex.org/I96823368","display_name":"German University in Cairo","ror":"https://ror.org/03rjt0z37","country_code":"EG","type":"education","lineage":["https://openalex.org/I96823368"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Caroline Joseph Kiriacos","raw_affiliation_strings":["Molecular Genetics Research Team (MGRT), Pharmaceutical Biology Department, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt"],"raw_orcid":"https://orcid.org/0000-0003-3535-9286","affiliations":[{"raw_affiliation_string":"Molecular Genetics Research Team (MGRT), Pharmaceutical Biology Department, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt","institution_ids":["https://openalex.org/I96823368"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052333837","display_name":"Kerolos Ashraf Daniel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141584323","display_name":"University of Hertfordshire","ror":"https://ror.org/0267vjk41","country_code":"GB","type":"education","lineage":["https://openalex.org/I141584323"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kerolos Ashraf Daniel","raw_affiliation_strings":["Biology and Biochemistry Department, School of Life and Medical Sciences, University of Hertfordshire Hosted by Global Academic Foundation, Cairo 11835, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology and Biochemistry Department, School of Life and Medical Sciences, University of Hertfordshire Hosted by Global Academic Foundation, Cairo 11835, Egypt","institution_ids":["https://openalex.org/I141584323"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074170856","display_name":"Omar Eltahtawy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96823368","display_name":"German University in Cairo","ror":"https://ror.org/03rjt0z37","country_code":"EG","type":"education","lineage":["https://openalex.org/I96823368"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Omar Eltahtawy","raw_affiliation_strings":["Molecular Genetics Research Team (MGRT), Pharmaceutical Biology Department, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Genetics Research Team (MGRT), Pharmaceutical Biology Department, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt","institution_ids":["https://openalex.org/I96823368"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024623600","display_name":"Miriam Mokhtar Abdelhalim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96823368","display_name":"German University in Cairo","ror":"https://ror.org/03rjt0z37","country_code":"EG","type":"education","lineage":["https://openalex.org/I96823368"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Miriam Mokhtar Abdelhalim","raw_affiliation_strings":["Molecular Genetics Research Team (MGRT), Pharmaceutical Biology Department, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Genetics Research Team (MGRT), Pharmaceutical Biology Department, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt","institution_ids":["https://openalex.org/I96823368"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023214943","display_name":"Maria Braoudaki","orcid":"https://orcid.org/0000-0003-4658-7225","observed_orcids":["https://orcid.org/0000-0003-4658-7225"]},"institutions":[{"id":"https://openalex.org/I141584323","display_name":"University of Hertfordshire","ror":"https://ror.org/0267vjk41","country_code":"GB","type":"education","lineage":["https://openalex.org/I141584323"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Maria Braoudaki","raw_affiliation_strings":["Clinical, Pharmaceutical, and Biological Science Department, School of Life and Medical Sciences, University of Hertfordshire, Hatfield AL10 9AB, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical, Pharmaceutical, and Biological Science Department, School of Life and Medical Sciences, University of Hertfordshire, Hatfield AL10 9AB, UK","institution_ids":["https://openalex.org/I141584323"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009963718","display_name":"Rana Ahmed Youness","orcid":"https://orcid.org/0000-0001-6268-7942","observed_orcids":["https://orcid.org/0000-0001-6268-7942"]},"institutions":[{"id":"https://openalex.org/I141584323","display_name":"University of Hertfordshire","ror":"https://ror.org/0267vjk41","country_code":"GB","type":"education","lineage":["https://openalex.org/I141584323"]},{"id":"https://openalex.org/I96823368","display_name":"German University in Cairo","ror":"https://ror.org/03rjt0z37","country_code":"EG","type":"education","lineage":["https://openalex.org/I96823368"]}],"countries":["EG","GB"],"is_corresponding":true,"raw_author_name":"Rana A. Youness","raw_affiliation_strings":["Biology and Biochemistry Department, School of Life and Medical Sciences, University of Hertfordshire Hosted by Global Academic Foundation, Cairo 11835, Egypt","Molecular Genetics Research Team (MGRT), Pharmaceutical Biology Department, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt"],"raw_orcid":"https://orcid.org/0000-0001-6268-7942","affiliations":[{"raw_affiliation_string":"Biology and Biochemistry Department, School of Life and Medical Sciences, University of Hertfordshire Hosted by Global Academic Foundation, Cairo 11835, Egypt","institution_ids":["https://openalex.org/I141584323"]},{"raw_affiliation_string":"Molecular Genetics Research Team (MGRT), Pharmaceutical Biology Department, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt","institution_ids":["https://openalex.org/I96823368"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5009963718"],"corresponding_institution_ids":["https://openalex.org/I141584323","https://openalex.org/I96823368"],"apc_list":{"value":2400,"currency":"CHF","value_usd":2513},"apc_paid":{"value":2400,"currency":"CHF","value_usd":2513},"fwci":1.2779,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.8262894,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"14","issue":"21","first_page":"5244","last_page":"5244"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.5630000233650208,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.5630000233650208,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11481","display_name":"Sulfur Compounds in Biology","score":0.382099986076355,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pediatric-brain-tumors","display_name":"pediatric brain tumors","score":0.972000002861023},{"id":"https://openalex.org/keywords/hydrogen-sulfide","display_name":"hydrogen sulfide","score":0.984000027179718},{"id":"https://openalex.org/keywords/gasotransmitters","display_name":"gasotransmitters","score":0.9940000176429749},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.8450000286102295},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6740000247955322},{"id":"https://openalex.org/keywords/drug-delivery-to-the-brain","display_name":"brain drug delivery","score":0.6470000147819519},{"id":"https://openalex.org/keywords/molecular-targeting","display_name":"molecular targeting","score":0.3779999911785126}],"concepts":[{"id":"https://openalex.org/C2780564542","wikidata":"https://www.wikidata.org/wiki/Q170591","display_name":"Hydrogen sulfide","level":3,"score":0.6158879399299622},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5200157165527344},{"id":"https://openalex.org/C2780357685","wikidata":"https://www.wikidata.org/wiki/Q154357","display_name":"Nano-","level":2,"score":0.49386125802993774},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.48315566778182983},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4512275457382202},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3922834098339081},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3728378713130951},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32688912749290466},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.32031136751174927},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2851281464099884},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2717553377151489},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20033422112464905},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1566418707370758},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.06551945209503174},{"id":"https://openalex.org/C518881349","wikidata":"https://www.wikidata.org/wiki/Q682","display_name":"Sulfur","level":2,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0}],"mesh":[],"locations_count":8,"locations":[{"id":"doi:10.3390/cancers14215244","doi":"https://doi.org/10.3390/cancers14215244","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers14215244","pdf_url":"https://www.mdpi.com/2072-6694/14/21/5244/pdf?version=1666941559","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},{"id":"pmid:36358663","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36358663","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9657918","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9657918/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers (Basel)","raw_type":"Text"},{"id":"pmh:oai:uhra.herts.ac.uk:10056","doi":null,"is_oa":true,"landing_page_url":"https://uhra.herts.ac.uk/view/author_id/m=2Ebraoudaki=40herts=2Eac=2Euk.html>","pdf_url":"https://uhra.herts.ac.uk/id/eprint/10056/1/cancers-14-05244-v3.pdf","source":{"id":"https://openalex.org/S4306400241","display_name":"University of Hertfordshire Research Archive (University of Hertfordshire)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I141584323","host_organization_name":"University of Hertfordshire","host_organization_lineage":["https://openalex.org/I141584323"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:8c993bdab4f5477faabb710d958224ad","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8c993bdab4f5477faabb710d958224ad","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancers, Vol 14, Iss 5244, p 5244 (2022)","raw_type":"article"},{"id":"pmh:oai:pure.rug.nl:openaire/d846346f-e5b0-47de-992b-e0a8baf48a71","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11370/d846346f-e5b0-47de-992b-e0a8baf48a71","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Fahmy, S A, Dawoud, A, Zeinelabdeen, Y A, Kiriacos, C J, Daniel, K A, Eltahtawy, O, Abdelhalim, M M, Braoudaki, M & Youness, R A 2022, 'Molecular Engines, Therapeutic Targets, and Challenges in Pediatric Brain Tumors : A Special Emphasis on Hydrogen Sulfide and RNA-Based Nano-Delivery', Cancers, vol. 14, no. 21, 5244. https://doi.org/10.3390/cancers14215244","raw_type":"info:eu-repo/semantics/review"},{"id":"pmh:oai:uhra.herts.ac.uk:2299/25870","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2299/25870","pdf_url":null,"source":{"id":"https://openalex.org/S4306400241","display_name":"University of Hertfordshire Research Archive (University of Hertfordshire)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I141584323","host_organization_name":"University of Hertfordshire","host_organization_lineage":["https://openalex.org/I141584323"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:rug:oai:pure.rug.nl:publications/d846346f-e5b0-47de-992b-e0a8baf48a71","doi":null,"is_oa":true,"landing_page_url":"https://research.rug.nl/en/publications/d846346f-e5b0-47de-992b-e0a8baf48a71","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancers, 14(21):5244. MDPI AG","raw_type":"info:eu-repo/semantics/other"}],"best_oa_location":{"id":"doi:10.3390/cancers14215244","doi":"https://doi.org/10.3390/cancers14215244","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers14215244","pdf_url":"https://www.mdpi.com/2072-6694/14/21/5244/pdf?version=1666941559","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4307634603.pdf","grobid_xml":"https://content.openalex.org/works/W4307634603.grobid-xml"},"referenced_works_count":180,"referenced_works":["https://openalex.org/W23556053","https://openalex.org/W874697581","https://openalex.org/W1510366577","https://openalex.org/W1535135245","https://openalex.org/W1541949755","https://openalex.org/W1559064733","https://openalex.org/W1575310353","https://openalex.org/W1586592493","https://openalex.org/W1674148475","https://openalex.org/W1805462004","https://openalex.org/W1880621477","https://openalex.org/W1926220930","https://openalex.org/W1964527234","https://openalex.org/W1967744161","https://openalex.org/W1968793863","https://openalex.org/W1973017725","https://openalex.org/W1977181728","https://openalex.org/W1980063823","https://openalex.org/W1982188223","https://openalex.org/W1985050049","https://openalex.org/W1988817734","https://openalex.org/W1989891384","https://openalex.org/W1993504367","https://openalex.org/W1993760429","https://openalex.org/W2001764001","https://openalex.org/W2005133500","https://openalex.org/W2007549861","https://openalex.org/W2009743408","https://openalex.org/W2012526118","https://openalex.org/W2016042686","https://openalex.org/W2019219919","https://openalex.org/W2020915539","https://openalex.org/W2021448795","https://openalex.org/W2028606217","https://openalex.org/W2032765695","https://openalex.org/W2035346960","https://openalex.org/W2039240944","https://openalex.org/W2043289157","https://openalex.org/W2044616474","https://openalex.org/W2046603817","https://openalex.org/W2048397378","https://openalex.org/W2048944816","https://openalex.org/W2053104328","https://openalex.org/W2053393698","https://openalex.org/W2056769172","https://openalex.org/W2057666061","https://openalex.org/W2059917368","https://openalex.org/W2063207603","https://openalex.org/W2065169211","https://openalex.org/W2074868130","https://openalex.org/W2076910437","https://openalex.org/W2078210300","https://openalex.org/W2080664438","https://openalex.org/W2080713919","https://openalex.org/W2081291037","https://openalex.org/W2083904945","https://openalex.org/W2084654503","https://openalex.org/W2084667421","https://openalex.org/W2084878154","https://openalex.org/W2085752747","https://openalex.org/W2086059554","https://openalex.org/W2093374499","https://openalex.org/W2096680263","https://openalex.org/W2099469211","https://openalex.org/W2105414327","https://openalex.org/W2110529088","https://openalex.org/W2116997946","https://openalex.org/W2118097751","https://openalex.org/W2120452752","https://openalex.org/W2121017846","https://openalex.org/W2127463721","https://openalex.org/W2132456479","https://openalex.org/W2134479723","https://openalex.org/W2139787372","https://openalex.org/W2141078839","https://openalex.org/W2141541918","https://openalex.org/W2145685571","https://openalex.org/W2148504560","https://openalex.org/W2153398041","https://openalex.org/W2154951934","https://openalex.org/W2157215000","https://openalex.org/W2158233796","https://openalex.org/W2162245571","https://openalex.org/W2164137184","https://openalex.org/W2166439489","https://openalex.org/W2169346737","https://openalex.org/W2180293476","https://openalex.org/W2197175751","https://openalex.org/W2216033157","https://openalex.org/W2252539153","https://openalex.org/W2300229781","https://openalex.org/W2323317437","https://openalex.org/W2338116242","https://openalex.org/W2366536035","https://openalex.org/W2392755478","https://openalex.org/W2404448121","https://openalex.org/W2405573244","https://openalex.org/W2417217560","https://openalex.org/W2461594815","https://openalex.org/W2507879231","https://openalex.org/W2515804433","https://openalex.org/W2550983153","https://openalex.org/W2561615666","https://openalex.org/W2575515814","https://openalex.org/W2592279845","https://openalex.org/W2598840959","https://openalex.org/W2748787958","https://openalex.org/W2762193043","https://openalex.org/W2767490762","https://openalex.org/W2769002364","https://openalex.org/W2783435080","https://openalex.org/W2793428109","https://openalex.org/W2794886527","https://openalex.org/W2797089132","https://openalex.org/W2803166719","https://openalex.org/W2803997671","https://openalex.org/W2804063822","https://openalex.org/W2884741638","https://openalex.org/W2885370926","https://openalex.org/W2887691183","https://openalex.org/W2892282588","https://openalex.org/W2897666582","https://openalex.org/W2899298864","https://openalex.org/W2903239508","https://openalex.org/W2904434513","https://openalex.org/W2914875381","https://openalex.org/W2921633429","https://openalex.org/W2943067025","https://openalex.org/W2963723666","https://openalex.org/W2968139886","https://openalex.org/W2971678986","https://openalex.org/W2972260742","https://openalex.org/W2982160786","https://openalex.org/W2983019152","https://openalex.org/W2988131634","https://openalex.org/W2989425431","https://openalex.org/W2995361768","https://openalex.org/W2996416950","https://openalex.org/W2997244036","https://openalex.org/W2999417355","https://openalex.org/W2999586401","https://openalex.org/W3010860768","https://openalex.org/W3011571903","https://openalex.org/W3012102028","https://openalex.org/W3021131914","https://openalex.org/W3023816032","https://openalex.org/W3035419715","https://openalex.org/W3042737539","https://openalex.org/W3045130184","https://openalex.org/W3083603751","https://openalex.org/W3083807426","https://openalex.org/W3092502795","https://openalex.org/W3093218751","https://openalex.org/W3097119555","https://openalex.org/W3114049193","https://openalex.org/W3119077889","https://openalex.org/W3126683281","https://openalex.org/W3134074724","https://openalex.org/W3135517628","https://openalex.org/W3151237903","https://openalex.org/W3152700007","https://openalex.org/W3153985560","https://openalex.org/W3157163175","https://openalex.org/W3193929510","https://openalex.org/W3195061573","https://openalex.org/W3203107563","https://openalex.org/W3205209468","https://openalex.org/W3205331485","https://openalex.org/W3205722390","https://openalex.org/W3210931446","https://openalex.org/W3215999777","https://openalex.org/W4200308149","https://openalex.org/W4200351747","https://openalex.org/W4213275074","https://openalex.org/W4221024547","https://openalex.org/W4229538388","https://openalex.org/W4296127374","https://openalex.org/W6718699750","https://openalex.org/W6755775125","https://openalex.org/W6769873251"],"related_works":["https://openalex.org/W2105347809","https://openalex.org/W2040711273","https://openalex.org/W191781817","https://openalex.org/W4224274633","https://openalex.org/W4413816765","https://openalex.org/W2308937662","https://openalex.org/W2595613950","https://openalex.org/W7222727892","https://openalex.org/W2765308886","https://openalex.org/W7208740160"],"abstract_inverted_index":{"Pediatric":[0],"primary":[1,57,113],"brain":[2,16,58,114,146,157,189],"tumors":[3,17,59],"represent":[4],"a":[5,45,48,90,141,153],"real":[6],"challenge":[7],"in":[8,37,56,112,144],"the":[9,13,22,35,40,52,64,67,71,76,93,127,130,133,161,166,181],"oncology":[10],"arena.":[11],"Besides":[12],"psychosocial":[14],"burden,":[15],"are":[18],"considered":[19],"one":[20],"of":[21,51,70,78,92,136,170,183],"most":[23],"difficult-to-treat":[24],"malignancies":[25],"due":[26],"to":[27,43],"their":[28],"sophisticated":[29],"cellular":[30],"and":[31,39,96,117,149,168,175],"molecular":[32,53,83,103,172],"pathophysiology.":[33],"Notwithstanding":[34],"advances":[36],"research":[38],"substantial":[41],"efforts":[42],"develop":[44],"suitable":[46],"therapy,":[47],"full":[49],"understanding":[50],"pathways":[54],"involved":[55],"is":[60,121],"still":[61],"demanded.":[62],"On":[63],"other":[65],"hand,":[66],"physiological":[68],"nature":[69],"blood\u2013brain":[72],"barrier":[73],"(BBB)":[74],"limits":[75],"efficiency":[77],"many":[79],"available":[80],"treatments,":[81],"including":[82],"therapeutic":[84,154,186],"approaches.":[85],"Hydrogen":[86],"Sulfide":[87],"(H2S),":[88],"as":[89,140,152],"member":[91],"gasotransmitters":[94],"family,":[95],"its":[97,110,150],"synthesizing":[98],"machinery":[99],"have":[100],"represented":[101],"promising":[102,177],"targets":[104],"for":[105,156,180,188],"plentiful":[106],"cancer":[107],"types.":[108],"However,":[109],"role":[111,135],"tumors,":[115],"generally,":[116],"pediatric":[118,145],"types,":[119],"particularly,":[120],"barely":[122],"investigated.":[123],"In":[124,159],"this":[125],"review,":[126],"authors":[128],"shed":[129],"light":[131],"on":[132,165],"novel":[134],"hydrogen":[137],"sulfide":[138],"(H2S)":[139],"prominent":[142],"player":[143],"tumor":[147,190],"pathophysiology":[148],"potential":[151],"avenue":[155],"tumors.":[158],"addition,":[160],"review":[162],"also":[163],"focuses":[164],"challenges":[167],"opportunities":[169],"several":[171],"targeting":[173],"approaches":[174],"proposes":[176],"brain-delivery":[178],"strategies":[179],"sake":[182],"achieving":[184],"better":[185],"results":[187],"patients.":[191]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":20},{"year":2023,"cited_by_count":10}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-11-04T00:00:00"}