{"id":"https://openalex.org/W4307618528","doi":null,"title":"Method of increasing radiation sensitivity by inhibition of beta one integrin","display_name":"Method of increasing radiation sensitivity by inhibition of beta one integrin","publication_year":2023,"publication_date":"2023-01-23","ids":{"openalex":"https://openalex.org/W4307618528"},"language":"en","primary_location":{"id":"pmh:oai:osti.gov:1015162","doi":null,"is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/1015162","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.osti.gov/biblio/1015162","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105462460","display_name":"Catherine Park","orcid":"https://orcid.org/0009-0009-6332-169X","observed_orcids":["https://orcid.org/0009-0009-6332-169X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Park, Catherine [San Francisco, CA]; Bissell, Mina J [Berkeley, CA]","raw_affiliation_strings":["San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"San Francisco, CA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5105462460"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0013683,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9355000257492065,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9355000257492065,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.02590000070631504,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.013500000350177288,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta1-integrin","display_name":"beta1 integrin","score":0.8410000205039978},{"id":"https://openalex.org/keywords/integrin-inhibition","display_name":"integrin inhibition","score":0.7110000252723694},{"id":"https://openalex.org/keywords/radiosensitivity","display_name":"radiosensitivity","score":0.6480000019073486},{"id":"https://openalex.org/keywords/ionizing-radiation","display_name":"ionizing radiation","score":0.8270000219345093},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8880000114440918},{"id":"https://openalex.org/keywords/cancer-cells","display_name":"cancer cells","score":0.9010000228881836},{"id":"https://openalex.org/keywords/anti-integrin-antibodies","display_name":"anti-integrin antibodies","score":0.7979999780654907},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.875},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8510000109672546},{"id":"https://openalex.org/keywords/radioimmunotherapy","display_name":"radioimmunotherapy","score":0.7720000147819519},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.5910000205039978}],"concepts":[{"id":"https://openalex.org/C2776174256","wikidata":"https://www.wikidata.org/wiki/Q830842","display_name":"BETA (programming language)","level":2,"score":0.6774227619171143},{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.6549712419509888},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.5109940767288208},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5077077150344849},{"id":"https://openalex.org/C153385146","wikidata":"https://www.wikidata.org/wiki/Q18335","display_name":"Radiation","level":2,"score":0.49433398246765137},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2179422378540039},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.17716681957244873},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.13866394758224487},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.09327930212020874},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.08548703789710999},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.05571678280830383},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:osti.gov:1015162","doi":null,"is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/1015162","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:osti.gov:1015162","doi":null,"is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/1015162","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2138952937","https://openalex.org/W1968324001","https://openalex.org/W2129087976","https://openalex.org/W2020904443","https://openalex.org/W6980216936","https://openalex.org/W1965469599","https://openalex.org/W2089700879","https://openalex.org/W2120982679","https://openalex.org/W2998993698","https://openalex.org/W2109930298"],"abstract_inverted_index":{"A":[0],"method":[1,75,97],"for":[2,104],"increasing":[3],"or":[4,61],"monitoring":[5],"apoptosis":[6,21],"in":[7,25,28,59,62,80],"tumor":[8,23,83],"cells":[9,84],"by":[10],"the":[11,38],"co-administration":[12],"of":[13,45,78,82],"ionizing":[14],"radiation":[15,90],"and":[16,27,42],"an":[17,52],"anti-integrin":[18],"antibody.":[19],"Increasing":[20],"reduces":[22],"growth":[24],"vivo":[26],"a":[29,100,111],"cell":[30],"culture":[31],"model.":[32],"The":[33,73,95],"antibody":[34,102],"is":[35,43,76,91],"directed":[36],"against":[37],"beta-1":[39,46,56],"integrin":[40,47],"subunit":[41],"inhibitory":[44,53],"signaling.":[48],"Other":[49],"molecules":[50],"having":[51],"effect":[54],"on":[55],"integrin,":[57],"either":[58],"signaling":[60],"binding":[63],"to":[64],"its":[65],"cognate":[66],"extracellular":[67],"receptors":[68],"may":[69,108],"also":[70],"be":[71],"used.":[72],"present":[74,96],"particularly":[77],"interest":[79],"treatment":[81],"associated":[85],"with":[86],"breast":[87],"cancer,":[88],"wherein":[89],"currently":[92],"used":[93],"alone.":[94],"further":[98,109],"contemplates":[99],"monoclonal":[101],"suitable":[103],"human":[105],"administration":[106],"that":[107],"comprise":[110],"radioisotope":[112],"attached":[113],"thereto.":[114]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2022-11-04T00:00:00"}