{"id":"https://openalex.org/W4307545074","doi":"https://doi.org/10.7759/cureus.30718","title":"A Malignant Glomus Tumor of the Liver Harboring MIR143-NOTCH2 Rearrangement: From Diagnosis to Management","display_name":"A Malignant Glomus Tumor of the Liver Harboring MIR143-NOTCH2 Rearrangement: From Diagnosis to Management","publication_year":2022,"publication_date":"2022-10-26","ids":{"openalex":"https://openalex.org/W4307545074","doi":"https://doi.org/10.7759/cureus.30718","pmid":"https://pubmed.ncbi.nlm.nih.gov/36439569","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9696860"},"language":"en","primary_location":{"id":"doi:10.7759/cureus.30718","doi":"https://doi.org/10.7759/cureus.30718","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.30718","pdf_url":"https://assets.cureus.com/uploads/case_report/pdf/118163/20221125-25520-o4s4a7.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://assets.cureus.com/uploads/case_report/pdf/118163/20221125-25520-o4s4a7.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034824122","display_name":"Ruoyu Miao","orcid":"https://orcid.org/0000-0003-4286-5742","observed_orcids":["https://orcid.org/0000-0003-4286-5742"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruoyu Miao","raw_affiliation_strings":["Department of Hematology and Medical Oncology, Moffitt Cancer Center, Tampa, USA",". Department of Individualized Cancer Management, Moffitt Cancer Center, Tampa, USA",". Department of Pathology, Moffitt Cancer Center, Tampa, USA",". Department of Sarcoma, Moffitt Cancer Center, Tampa, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Medical Oncology, Moffitt Cancer Center, Tampa, USA","institution_ids":["https://openalex.org/I3019308854"]},{"raw_affiliation_string":". Department of Individualized Cancer Management, Moffitt Cancer Center, Tampa, USA","institution_ids":["https://openalex.org/I3019308854"]},{"raw_affiliation_string":". Department of Pathology, Moffitt Cancer Center, Tampa, USA","institution_ids":["https://openalex.org/I3019308854"]},{"raw_affiliation_string":". Department of Sarcoma, Moffitt Cancer Center, Tampa, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022728544","display_name":"Marilyn M. Bui","orcid":"https://orcid.org/0000-0003-4963-2255","observed_orcids":["https://orcid.org/0000-0003-4963-2255"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marilyn  M Bui","raw_affiliation_strings":["Department of Pathology, Moffitt Cancer Center, Tampa, USA",". Department of Hematology and Medical Oncology, Moffitt Cancer Center, Tampa, USA",". Department of Individualized Cancer Management, Moffitt Cancer Center, Tampa, USA",". Department of Sarcoma, Moffitt Cancer Center, Tampa, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Moffitt Cancer Center, Tampa, USA","institution_ids":["https://openalex.org/I3019308854"]},{"raw_affiliation_string":". Department of Hematology and Medical Oncology, Moffitt Cancer Center, Tampa, USA","institution_ids":["https://openalex.org/I3019308854"]},{"raw_affiliation_string":". Department of Individualized Cancer Management, Moffitt Cancer Center, Tampa, USA","institution_ids":["https://openalex.org/I3019308854"]},{"raw_affiliation_string":". Department of Sarcoma, Moffitt Cancer Center, Tampa, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025514406","display_name":"Christine Marie Walko","orcid":"https://orcid.org/0000-0001-8435-898X","observed_orcids":["https://orcid.org/0000-0001-8435-898X"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christine Walko","raw_affiliation_strings":["Department of Individualized Cancer Management, Moffitt Cancer Center, Tampa, USA",". Department of Hematology and Medical Oncology, Moffitt Cancer Center, Tampa, USA",". Department of Pathology, Moffitt Cancer Center, Tampa, USA",". Department of Sarcoma, Moffitt Cancer Center, Tampa, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Individualized Cancer Management, Moffitt Cancer Center, Tampa, USA","institution_ids":["https://openalex.org/I3019308854"]},{"raw_affiliation_string":". Department of Hematology and Medical Oncology, Moffitt Cancer Center, Tampa, USA","institution_ids":["https://openalex.org/I3019308854"]},{"raw_affiliation_string":". Department of Pathology, Moffitt Cancer Center, Tampa, USA","institution_ids":["https://openalex.org/I3019308854"]},{"raw_affiliation_string":". Department of Sarcoma, Moffitt Cancer Center, Tampa, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039971014","display_name":"John E. Mullinax","orcid":"https://orcid.org/0000-0002-9596-6785","observed_orcids":["https://orcid.org/0000-0002-9596-6785"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John E Mullinax","raw_affiliation_strings":["Department of Sarcoma, Moffitt Cancer Center, Tampa, USA",". Department of Hematology and Medical Oncology, Moffitt Cancer Center, Tampa, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Sarcoma, Moffitt Cancer Center, Tampa, USA","institution_ids":["https://openalex.org/I3019308854"]},{"raw_affiliation_string":". Department of Hematology and Medical Oncology, Moffitt Cancer Center, Tampa, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034066580","display_name":"Andrew Scott Brohl","orcid":"https://orcid.org/0000-0002-0071-0534","observed_orcids":["https://orcid.org/0000-0002-0071-0534"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andrew S Brohl","raw_affiliation_strings":["Department of Sarcoma, Moffitt Cancer Center, Tampa, USA",". Department of Hematology and Medical Oncology, Moffitt Cancer Center, Tampa, USA",". Department of Individualized Cancer Management, Moffitt Cancer Center, Tampa, USA",". Department of Pathology, Moffitt Cancer Center, Tampa, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Sarcoma, Moffitt Cancer Center, Tampa, USA","institution_ids":["https://openalex.org/I3019308854"]},{"raw_affiliation_string":". Department of Hematology and Medical Oncology, Moffitt Cancer Center, Tampa, USA","institution_ids":["https://openalex.org/I3019308854"]},{"raw_affiliation_string":". Department of Individualized Cancer Management, Moffitt Cancer Center, Tampa, USA","institution_ids":["https://openalex.org/I3019308854"]},{"raw_affiliation_string":". Department of Pathology, Moffitt Cancer Center, Tampa, USA","institution_ids":["https://openalex.org/I3019308854"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5034066580"],"corresponding_institution_ids":["https://openalex.org/I3019308854"],"apc_list":null,"apc_paid":null,"fwci":0.9279,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.76276863,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"14","issue":"10","first_page":"e30718","last_page":"e30718"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13363","display_name":"Soft tissue tumors and treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13363","display_name":"Soft tissue tumors and treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/malignant-glomus-tumor","display_name":"malignant glomus tumor","score":0.9549999833106995},{"id":"https://openalex.org/keywords/liver-tumors","display_name":"liver tumors","score":0.7379999756813049},{"id":"https://openalex.org/keywords/soft-tissue-sarcoma","display_name":"soft tissue sarcoma","score":0.6949999928474426},{"id":"https://openalex.org/keywords/neoadjuvant-chemotherapy","display_name":"neoadjuvant chemotherapy","score":0.9470000267028809},{"id":"https://openalex.org/keywords/surgical-resection","display_name":"surgical resection","score":0.8360000252723694},{"id":"https://openalex.org/keywords/molecular-diagnosis","display_name":"molecular diagnosis","score":0.8140000104904175},{"id":"https://openalex.org/keywords/multimodal-treatment","display_name":"multimodal therapy","score":0.777999997138977}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9609978199005127},{"id":"https://openalex.org/C2778036477","wikidata":"https://www.wikidata.org/wiki/Q4139987","display_name":"Glomus tumor","level":2,"score":0.7510988712310791},{"id":"https://openalex.org/C136948725","wikidata":"https://www.wikidata.org/wiki/Q1458306","display_name":"Soft tissue","level":2,"score":0.4971642792224884},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3776536285877228}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.7759/cureus.30718","doi":"https://doi.org/10.7759/cureus.30718","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.30718","pdf_url":"https://assets.cureus.com/uploads/case_report/pdf/118163/20221125-25520-o4s4a7.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9696860","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9696860","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"Text"},{"id":"pmid:36439569","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36439569","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"Case Reports"}],"best_oa_location":{"id":"doi:10.7759/cureus.30718","doi":"https://doi.org/10.7759/cureus.30718","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.30718","pdf_url":"https://assets.cureus.com/uploads/case_report/pdf/118163/20221125-25520-o4s4a7.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4307545074.pdf","grobid_xml":"https://content.openalex.org/works/W4307545074.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W2066751347","https://openalex.org/W2103991610","https://openalex.org/W2414543224","https://openalex.org/W2595781410","https://openalex.org/W2802254308","https://openalex.org/W2810980858","https://openalex.org/W3008142836","https://openalex.org/W3040358148","https://openalex.org/W3096176191","https://openalex.org/W3175104119","https://openalex.org/W3179842366","https://openalex.org/W4206548629","https://openalex.org/W4220889808","https://openalex.org/W4282959530","https://openalex.org/W4283273933"],"related_works":["https://openalex.org/W1963593155","https://openalex.org/W7140092302","https://openalex.org/W116927409","https://openalex.org/W2810980858","https://openalex.org/W2151147142","https://openalex.org/W3025723111","https://openalex.org/W3029914435","https://openalex.org/W2103894658","https://openalex.org/W2269018035","https://openalex.org/W3044590040"],"abstract_inverted_index":{"A":[0],"primary":[1],"malignant":[2,68],"glomus":[3,69],"tumor":[4],"of":[5,19,44,52,65],"the":[6,42,50,63],"liver":[7],"is":[8],"extremely":[9],"rare":[10,53],"and":[11,57],"diagnostically":[12],"challenging.":[13],"We":[14],"present":[15],"an":[16],"exceptional":[17],"case":[18,29],"such":[20],"with":[21,33],"a":[22,59],"diagnosis":[23,51],"confirmed":[24],"by":[25,37],"MIR143-NOTCH2":[26],"rearrangement.":[27],"The":[28],"was":[30],"successfully":[31],"managed":[32],"neoadjuvant":[34],"chemotherapy":[35],"followed":[36],"surgery.":[38],"This":[39],"report":[40],"highlights":[41],"utilization":[43],"molecular":[45],"analysis":[46],"to":[47,62],"aid":[48],"in":[49],"soft":[54],"tissue":[55],"malignancies":[56],"supports":[58],"multimodality":[60],"approach":[61],"treatment":[64],"large,":[66],"high-grade":[67],"tumors.":[70]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2022-11-03T00:00:00"}