{"id":"https://openalex.org/W4307439752","doi":"https://doi.org/10.1186/s10020-022-00556-8","title":"Inhibition of platelet activation suppresses reactive enteric glia and mitigates intestinal barrier dysfunction during sepsis","display_name":"Inhibition of platelet activation suppresses reactive enteric glia and mitigates intestinal barrier dysfunction during sepsis","publication_year":2022,"publication_date":"2022-10-27","ids":{"openalex":"https://openalex.org/W4307439752","doi":"https://doi.org/10.1186/s10020-022-00556-8","pmid":"https://pubmed.ncbi.nlm.nih.gov/36303116","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9615156"},"language":"en","primary_location":{"id":"doi:10.1186/s10020-022-00556-8","doi":"https://doi.org/10.1186/s10020-022-00556-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s10020-022-00556-8","pdf_url":"https://molmed.biomedcentral.com/counter/pdf/10.1186/s10020-022-00556-8","source":{"id":"https://openalex.org/S6769275","display_name":"Molecular Medicine","issn_l":"1076-1551","issn":["1076-1551","1528-3658"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://molmed.biomedcentral.com/counter/pdf/10.1186/s10020-022-00556-8","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Bo Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121771","display_name":"First Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/02tbvhh96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121771"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bo Cheng","raw_affiliation_strings":["Department of Anesthesiology & Center for Brain Science, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology & Center for Brain Science, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China","institution_ids":["https://openalex.org/I4210121771","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035780068","display_name":"Mengyu Du","orcid":"https://orcid.org/0000-0003-1900-1049","observed_orcids":["https://orcid.org/0000-0003-1900-1049"]},"institutions":[{"id":"https://openalex.org/I4210121771","display_name":"First Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/02tbvhh96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121771"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengyu Du","raw_affiliation_strings":["Department of Anesthesiology & Center for Brain Science, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology & Center for Brain Science, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China","institution_ids":["https://openalex.org/I4210121771","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087063886","display_name":"Shuxuan He","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121771","display_name":"First Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/02tbvhh96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121771"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuxuan He","raw_affiliation_strings":["Department of Anesthesiology & Center for Brain Science, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology & Center for Brain Science, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China","institution_ids":["https://openalex.org/I4210121771","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072256511","display_name":"Lan Yang","orcid":"https://orcid.org/0000-0002-5992-238X","observed_orcids":["https://orcid.org/0000-0002-5992-238X"]},"institutions":[{"id":"https://openalex.org/I4210121771","display_name":"First Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/02tbvhh96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121771"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lan Yang","raw_affiliation_strings":["Department of Anesthesiology & Center for Brain Science, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology & Center for Brain Science, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China","institution_ids":["https://openalex.org/I4210121771","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102026739","display_name":"Xi Wang","orcid":"https://orcid.org/0000-0002-5974-6363","observed_orcids":["https://orcid.org/0000-0002-5974-6363"]},"institutions":[{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xi Wang","raw_affiliation_strings":["Department of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China","institution_ids":["https://openalex.org/I2801769982"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hui Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121771","display_name":"First Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/02tbvhh96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121771"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Gao","raw_affiliation_strings":["Department of Anesthesiology & Center for Brain Science, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology & Center for Brain Science, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China","institution_ids":["https://openalex.org/I4210121771","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110961299","display_name":"Haiqing Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121771","display_name":"First Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/02tbvhh96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121771"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haiqing Chang","raw_affiliation_strings":["Department of Anesthesiology & Center for Brain Science, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology & Center for Brain Science, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China","institution_ids":["https://openalex.org/I4210121771","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000806510","display_name":"Wei Gao","orcid":"https://orcid.org/0000-0002-7889-1662","observed_orcids":["https://orcid.org/0000-0002-7889-1662"]},"institutions":[{"id":"https://openalex.org/I4210121771","display_name":"First Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/02tbvhh96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121771"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Gao","raw_affiliation_strings":["Department of Anesthesiology & Center for Brain Science, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology & Center for Brain Science, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China","institution_ids":["https://openalex.org/I4210121771","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059017864","display_name":"Yan Li","orcid":"https://orcid.org/0000-0002-7465-7705","observed_orcids":["https://orcid.org/0000-0002-7465-7705"]},"institutions":[{"id":"https://openalex.org/I4210121771","display_name":"First Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/02tbvhh96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121771"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yan Li","raw_affiliation_strings":["Department of Anesthesiology & Center for Brain Science, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China","Department of Anesthesiology & Center for Brain Science, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China. liyansong.inter@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology & Center for Brain Science, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China","institution_ids":["https://openalex.org/I4210121771","https://openalex.org/I87445476"]},{"raw_affiliation_string":"Department of Anesthesiology & Center for Brain Science, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China. liyansong.inter@163.com","institution_ids":["https://openalex.org/I4210121771","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100366972","display_name":"Qiang Wang","orcid":"https://orcid.org/0000-0002-3637-2063","observed_orcids":["https://orcid.org/0000-0002-3637-2063"]},"institutions":[{"id":"https://openalex.org/I4210121771","display_name":"First Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/02tbvhh96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121771"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiang Wang","raw_affiliation_strings":["Department of Anesthesiology & Center for Brain Science, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China"],"raw_orcid":"https://orcid.org/0000-0002-3637-2063","affiliations":[{"raw_affiliation_string":"Department of Anesthesiology & Center for Brain Science, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China","institution_ids":["https://openalex.org/I4210121771","https://openalex.org/I87445476"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086818325","display_name":"Yansong Li","orcid":"https://orcid.org/0000-0003-4949-0576","observed_orcids":["https://orcid.org/0000-0003-4949-0576"]},"institutions":[{"id":"https://openalex.org/I4210121771","display_name":"First Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/02tbvhh96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121771"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yansong Li","raw_affiliation_strings":["Department of Anesthesiology & Center for Brain Science, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China","Department of Anesthesiology & Center for Brain Science, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China. liyansong.inter@163.com"],"raw_orcid":"https://orcid.org/0000-0003-4949-0576","affiliations":[{"raw_affiliation_string":"Department of Anesthesiology & Center for Brain Science, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China","institution_ids":["https://openalex.org/I4210121771","https://openalex.org/I87445476"]},{"raw_affiliation_string":"Department of Anesthesiology & Center for Brain Science, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China. liyansong.inter@163.com","institution_ids":["https://openalex.org/I4210121771","https://openalex.org/I87445476"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5059017864","https://openalex.org/A5086818325"],"corresponding_institution_ids":["https://openalex.org/I4210121771","https://openalex.org/I87445476"],"apc_list":{"value":2890,"currency":"USD","value_usd":2890},"apc_paid":{"value":2890,"currency":"USD","value_usd":2890},"fwci":1.4425,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.80926343,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"28","issue":"1","first_page":"127","last_page":"127"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9491999745368958,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9491999745368958,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.021400000900030136,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.013399999588727951,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.9559999704360962},{"id":"https://openalex.org/keywords/platelet-activation","display_name":"platelet activation","score":0.921999990940094},{"id":"https://openalex.org/keywords/intestinal-barrier-dysfunction","display_name":"intestinal barrier dysfunction","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cd40-ligand","display_name":"CD40 ligand","score":0.9120000004768372},{"id":"https://openalex.org/keywords/s-nitrosoglutathione","display_name":"S-nitrosoglutathione","score":0.8899999856948853},{"id":"https://openalex.org/keywords/tight-junction-proteins","display_name":"tight junction proteins","score":0.8130000233650208},{"id":"https://openalex.org/keywords/cecal-ligation-and-puncture","display_name":"cecal ligation and puncture","score":0.8299999833106995},{"id":"https://openalex.org/keywords/multiple-organ-failure","display_name":"multiple organ failure","score":0.7799999713897705},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.7689999938011169},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9850000143051147}],"concepts":[{"id":"https://openalex.org/C3018697912","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Platelet activation","level":3,"score":0.7699533700942993},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.730505108833313},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.7057226300239563},{"id":"https://openalex.org/C2775962179","wikidata":"https://www.wikidata.org/wiki/Q2013337","display_name":"Occludin","level":3,"score":0.6347116231918335},{"id":"https://openalex.org/C177779419","wikidata":"https://www.wikidata.org/wiki/Q1053832","display_name":"Tight junction","level":2,"score":0.4801994562149048},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.47701096534729004},{"id":"https://openalex.org/C39347974","wikidata":"https://www.wikidata.org/wiki/Q21135811","display_name":"CD40","level":4,"score":0.46222200989723206},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4252098798751831},{"id":"https://openalex.org/C51911345","wikidata":"https://www.wikidata.org/wiki/Q4863604","display_name":"Barrier function","level":2,"score":0.4229733347892761},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3796333074569702},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23222920298576355},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.22075378894805908},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1996956169605255},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.06424376368522644},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015539","descriptor_name":"Platelet Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017077","descriptor_name":"Culture Media, Conditioned","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018938","descriptor_name":"Caco-2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023201","descriptor_name":"CD40 Ligand","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D026422","descriptor_name":"S-Nitrosoglutathione","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048029","descriptor_name":"TNF Receptor-Associated Factor 6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062725","descriptor_name":"Tight Junction Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D062793","descriptor_name":"Occludin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s10020-022-00556-8","doi":"https://doi.org/10.1186/s10020-022-00556-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s10020-022-00556-8","pdf_url":"https://molmed.biomedcentral.com/counter/pdf/10.1186/s10020-022-00556-8","source":{"id":"https://openalex.org/S6769275","display_name":"Molecular Medicine","issn_l":"1076-1551","issn":["1076-1551","1528-3658"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9615156","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9615156","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Med","raw_type":"Text"},{"id":"pmid:36303116","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36303116","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular medicine (Cambridge, Mass.)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:8d4bb17259c24e08b6adac9d5cb2cedb","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8d4bb17259c24e08b6adac9d5cb2cedb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Medicine, Vol 28, Iss 1, Pp 1-18 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s10020-022-00556-8","doi":"https://doi.org/10.1186/s10020-022-00556-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s10020-022-00556-8","pdf_url":"https://molmed.biomedcentral.com/counter/pdf/10.1186/s10020-022-00556-8","source":{"id":"https://openalex.org/S6769275","display_name":"Molecular Medicine","issn_l":"1076-1551","issn":["1076-1551","1528-3658"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.7099999785423279,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6031809739","display_name":null,"funder_award_id":"81801899","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6207015428","display_name":null,"funder_award_id":"81974540","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8306855706","display_name":null,"funder_award_id":"81971290","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4307439752.pdf","grobid_xml":"https://content.openalex.org/works/W4307439752.grobid-xml"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W95996026","https://openalex.org/W269188746","https://openalex.org/W1485526722","https://openalex.org/W1496642521","https://openalex.org/W1880026441","https://openalex.org/W1981854425","https://openalex.org/W1986579965","https://openalex.org/W1993827036","https://openalex.org/W1996146242","https://openalex.org/W1996541643","https://openalex.org/W2004608935","https://openalex.org/W2018116362","https://openalex.org/W2018815492","https://openalex.org/W2019472123","https://openalex.org/W2023945291","https://openalex.org/W2032030580","https://openalex.org/W2032984191","https://openalex.org/W2034485512","https://openalex.org/W2035874302","https://openalex.org/W2050611911","https://openalex.org/W2060544572","https://openalex.org/W2072950950","https://openalex.org/W2076872340","https://openalex.org/W2085062842","https://openalex.org/W2092322285","https://openalex.org/W2111290351","https://openalex.org/W2113285613","https://openalex.org/W2122292170","https://openalex.org/W2127109571","https://openalex.org/W2131071041","https://openalex.org/W2164231091","https://openalex.org/W2166190627","https://openalex.org/W2284900346","https://openalex.org/W2293520315","https://openalex.org/W2339849544","https://openalex.org/W2471204086","https://openalex.org/W2482048902","https://openalex.org/W2522591839","https://openalex.org/W2619603312","https://openalex.org/W2620241325","https://openalex.org/W2734473385","https://openalex.org/W2769341285","https://openalex.org/W2772324540","https://openalex.org/W2777908013","https://openalex.org/W2793282900","https://openalex.org/W2796624603","https://openalex.org/W2808407204","https://openalex.org/W2885093728","https://openalex.org/W2896909471","https://openalex.org/W2896959233","https://openalex.org/W2899188916","https://openalex.org/W2911613746","https://openalex.org/W2921822951","https://openalex.org/W2981311241","https://openalex.org/W2984551404","https://openalex.org/W2995821584","https://openalex.org/W3040965153","https://openalex.org/W3094495571","https://openalex.org/W3114196093","https://openalex.org/W3129434526","https://openalex.org/W3133544828","https://openalex.org/W3188066578","https://openalex.org/W3199203187","https://openalex.org/W4294011912","https://openalex.org/W4297704090"],"related_works":["https://openalex.org/W7160965157","https://openalex.org/W2810171846","https://openalex.org/W3204934525","https://openalex.org/W3035808854","https://openalex.org/W4411847242","https://openalex.org/W4313263809","https://openalex.org/W2782626594","https://openalex.org/W4402890755","https://openalex.org/W2543706771","https://openalex.org/W7163568441"],"abstract_inverted_index":{"BACKGROUND:":[0],"Intestinal":[1],"barrier":[2,54,107,152,308],"dysfunction,":[3],"which":[4,273,305],"is":[5,13,60,109,290],"associated":[6,110],"with":[7,111,217],"reactive":[8,113],"enteric":[9],"glia":[10],"cells":[11,183,267],"(EGCs),":[12],"not":[14],"only":[15],"a":[16,23,38,71,76,220,319,324],"result":[17],"of":[18,25,31,45,73,79,87,138,143,147,157,187,194,209,222,243,251,261,287,295,302],"early":[19],"sepsis":[20,80,130,313],"but":[21],"also":[22],"cause":[24],"multiple":[26],"organ":[27,51],"dysfunction":[28,108],"syndrome.":[29],"Inhibition":[30],"platelet":[32,57,67,74,103,288],"activation":[33,75,104,208,289],"has":[34],"been":[35],"proposed":[36],"as":[37,70],"potential":[39,320],"treatment":[40,216],"for":[41,173,181,327],"septic":[42,158],"patients":[43],"because":[44],"its":[46,116],"efficacy":[47],"in":[48,233,236,312],"ameliorating":[49],"the":[50,66,88,95,129,136,141,145,150,207,249,259,293,300],"damage":[52,156,231],"and":[53,115,122,154,171,176,190,205,235,245,263,268,279,299,310,323],"dysfunction.":[55],"During":[56],"activation,":[58,304],"CD40L":[59,90,170,240],"translocated":[61],"from":[62,92,253],"\u03b1":[63],"granules":[64],"to":[65,99,127,292],"surface,":[68],"serving":[69],"biomarker":[72],"reliable":[77],"predictor":[78],"prognosis.":[81],"Given":[82],"that":[83],"more":[84],"than":[85],"95%":[86],"circulating":[89],"originate":[91],"activated":[93,139],"platelets,":[94,140],"present":[96],"study":[97],"aimed":[98],"investigate":[100],"if":[101],"inhibiting":[102],"mitigates":[105],"intestinal":[106,151,230,307],"suppressing":[112],"EGCs":[114,166,303],"underlying":[117],"mechanism.":[118],"METHODS:":[119],"Cecal":[120],"ligation":[121],"puncture":[123],"(CLP)":[124],"was":[125],"performed":[126],"establish":[128],"model.":[131],"24":[132,174],"h":[133,175],"after":[134],"CLP,":[135],"proportion":[137],"level":[142],"sCD40L,":[144],"expression":[146,186,260],"tight-junction":[148,188],"proteins,":[149],"function":[153,309],"histological":[155],"mice":[159],"were":[160,167,179,197,213],"analyzed.":[161],"In":[162,238],"vitro,":[163],"primary":[164],"cultured":[165],"stimulated":[168],"by":[169,277],"LPS":[172],"EGCs-conditioned":[177,256],"medium":[178,257],"collected":[180],"Caco-2":[182,195,266],"treatment.":[184],"The":[185,285],"proteins":[189],"transepithelial":[191,270],"electrical":[192,271],"resistance":[193],"cell":[196],"evaluated.":[198],"RESULTS:":[199],"platelets":[200],"proportion,":[201],"decreased":[202],"sCD40L":[203],"concentration,":[204],"suppressed":[206,248],"EGCs.":[210,254,283],"Comparable":[211],"results":[212,316],"observed":[214],"upon":[215],"compound":[218],"6,877,002,":[219],"blocker":[221],"CD40L-CD40-TRAF6":[223,296],"signaling":[224,297],"pathway.":[225],"Also,":[226],"S-nitrosoglutathione":[227,252],"supplement":[228],"reduced":[229,258],"both":[232],"vivo":[234],"vitro.":[237],"addition,":[239],"increased":[241],"release":[242,250],"TNF-\u03b1":[244],"IL-1\u03b2":[246],"while":[247],"These":[255,315],"ZO-1":[262],"occludin":[264],"on":[265,282],"their":[269],"resistance,":[272],"could":[274],"be":[275],"reversed":[276],"CD40-siRNA":[278],"TRAF6-siRNA":[280],"transfection":[281],"CONCLUSIONS:":[284],"inhibition":[286],"related":[291],"suppression":[294],"pathway":[298],"reduction":[301],"promotes":[306],"survival":[311],"mice.":[314],"might":[317],"provide":[318],"therapeutic":[321],"strategy":[322],"promising":[325],"target":[326],"sepsis.":[328]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-11-01T00:00:00"}
