{"id":"https://openalex.org/W4307299833","doi":"https://doi.org/10.3389/fimmu.2022.1069232","title":"Editorial: Genetic basis of tolerance induction defects underlying the development of autoimmune pathologies","display_name":"Editorial: Genetic basis of tolerance induction defects underlying the development of autoimmune pathologies","publication_year":2022,"publication_date":"2022-10-26","ids":{"openalex":"https://openalex.org/W4307299833","doi":"https://doi.org/10.3389/fimmu.2022.1069232","pmid":"https://pubmed.ncbi.nlm.nih.gov/36389740","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9644883"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2022.1069232","doi":"https://doi.org/10.3389/fimmu.2022.1069232","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2022.1069232","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2022.1069232/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"editorial","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2022.1069232/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073737674","display_name":"Jeremy J. Racine","orcid":"https://orcid.org/0000-0001-5514-3074","observed_orcids":["https://orcid.org/0000-0001-5514-3074"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeremy J. Racine","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, ME, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, ME, United States","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102717548","display_name":"Laurence M Morel","orcid":"https://orcid.org/0000-0002-6622-1290","observed_orcids":["https://orcid.org/0000-0002-6622-1290"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laurence Morel","raw_affiliation_strings":["Department of Microbiology, Immunology & Molecular Genetics, The University of Texas Health Sciences Center at San Antonio, San Antonio, TX, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology & Molecular Genetics, The University of Texas Health Sciences Center at San Antonio, San Antonio, TX, United States","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102830191","display_name":"Yi\u2010Guang Chen","orcid":"https://orcid.org/0000-0001-9616-8841","observed_orcids":["https://orcid.org/0000-0001-9616-8841","https://orcid.org/0000-0002-1741-9719"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi-Guang Chen","raw_affiliation_strings":["Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, United States","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073755118","display_name":"DAVID V. SERREZE","orcid":"https://orcid.org/0000-0001-7614-5925","observed_orcids":["https://orcid.org/0000-0001-7614-5925"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David V. Serreze","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, ME, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, ME, United States","institution_ids":["https://openalex.org/I4210115256"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5073755118"],"corresponding_institution_ids":["https://openalex.org/I4210115256"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":null,"first_page":"1069232","last_page":"1069232"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immune-tolerance","display_name":"immune tolerance","score":0.7760000228881836},{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"autoimmune disease","score":0.6669999957084656},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.9110000133514404},{"id":"https://openalex.org/keywords/thymocyte-selection","display_name":"thymic selection","score":0.7269999980926514},{"id":"https://openalex.org/keywords/central-tolerance","display_name":"central tolerance","score":0.9549999833106995},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.968999981880188},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9070000052452087},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.7429999709129333},{"id":"https://openalex.org/keywords/regulatory-b-cells","display_name":"regulatory B cells","score":0.8629999756813049},{"id":"https://openalex.org/keywords/major-histocompatibility-complex","display_name":"major histocompatibility complex","score":0.47600001096725464},{"id":"https://openalex.org/keywords/ptpn22","display_name":"PTPN22","score":0.8619999885559082},{"id":"https://openalex.org/keywords/ctla-4","display_name":"CTLA-4","score":0.9559999704360962},{"id":"https://openalex.org/keywords/mda5","display_name":"MDA5","score":0.9610000252723694},{"id":"https://openalex.org/keywords/pad2","display_name":"PAD2","score":0.7459999918937683},{"id":"https://openalex.org/keywords/pad4","display_name":"PAD4","score":0.9980000257492065},{"id":"https://openalex.org/keywords/protein-citrullination","display_name":"citrullination","score":0.8199999928474426},{"id":"https://openalex.org/keywords/gene-environment-interaction","display_name":"gene-environment interaction","score":0.8050000071525574}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.529045045375824},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4872376024723053},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.4671717584133148},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.09620088338851929}],"mesh":[{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007108","descriptor_name":"Immune Tolerance","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.3389/fimmu.2022.1069232","doi":"https://doi.org/10.3389/fimmu.2022.1069232","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2022.1069232","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2022.1069232/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9644883","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9644883","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmid:36389740","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36389740","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Editorial"},{"id":"pmh:oai:doaj.org/article:f7e21a43f9d84f5db260f1ece2729cff","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f7e21a43f9d84f5db260f1ece2729cff","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 13 (2022)","raw_type":"article"},{"id":"pmh:oai:mouseion.jax.org:stfb2022-1233","doi":null,"is_oa":true,"landing_page_url":"https://mouseion.jax.org/stfb2022/240","pdf_url":null,"source":{"id":"https://openalex.org/S4377196421","display_name":"The Mouseion at the JAXlibrary (Jackson Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115256","host_organization_name":"Jackson Laboratory","host_organization_lineage":["https://openalex.org/I4210115256"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty Research 2022","raw_type":"text"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2022.1069232","doi":"https://doi.org/10.3389/fimmu.2022.1069232","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2022.1069232","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2022.1069232/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5678835087","display_name":"Shaping diabetogenic T cells by IL-27 in type 1 diabetes","funder_award_id":"R01DK121747","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000872076","display_name":"B-lymphocyte Targeting Therapies for Autoimmune Diabetes","funder_award_id":"R01DK095735","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000901393","display_name":"Mechanistic and therapeutic role of the CD137-CD137L axis in Type 1 Diabetes","funder_award_id":"R01DK107541","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4307299833.pdf","grobid_xml":"https://content.openalex.org/works/W4307299833.grobid-xml"},"referenced_works_count":5,"referenced_works":["https://openalex.org/W1590974138","https://openalex.org/W2792081113","https://openalex.org/W3155677758","https://openalex.org/W3169707629","https://openalex.org/W4229042078"],"related_works":["https://openalex.org/W4289130226","https://openalex.org/W4313041771","https://openalex.org/W2519796613","https://openalex.org/W2121613610","https://openalex.org/W2094252521","https://openalex.org/W2162111800","https://openalex.org/W4313348254","https://openalex.org/W1866959257","https://openalex.org/W2053138569","https://openalex.org/W1560954102"],"abstract_inverted_index":{"Genetic":[0],"basis":[1,48,76,212],"of":[2,9,24,31,38,77,134,176,181,199,206,213,221,243],"tolerance":[3,50,217],"induction":[4,51],"defects":[5,52,214],"underlying":[6,53,218],"the":[7,19,29,75,121,125,147,177,219,241],"development":[8,90,220],"autoimmune":[10,58,79,95,108],"pathologiesIn":[11],"our":[12],"initial":[13],"call":[14,168],"for":[15,18,40,49,150,201,240],"review":[16,127],"articles":[17,128],"Research":[20,42],"Topic":[21],"\"Genetic":[22,179,211],"Basis":[23],"Tolerance":[25,186],"Induction":[26],"Defects":[27],"Underlying":[28],"Development":[30],"Autoimmune":[32],"Pathologies\"":[33],"we":[34,164],"envisioned":[35],"four":[36],"areas":[37],"interest":[39,200],"this":[41,135],"Topic:":[43,136],"Area":[44,61,83,99,132],"1":[45,133,189],"-the":[46,63],"genetic":[47],"any":[54],"single":[55],"or":[56,91],"multiple":[57],"disease":[59,96],"states;":[60,97],"2":[62],"controversy":[64],"concerning":[65],"how":[66],"well":[67],"some":[68],"animal":[69],"models,":[70],"in":[71,81,94,112,124,187,215,231,255],"particular":[72],"mice,":[73],"inform":[74],"various":[78,107],"pathologies":[80],"humans;":[82],"3":[84],"-how":[85],"gene":[86],"variants":[87,172,230],"disrupt":[88],"Treg/Breg":[89],"activity":[92],"resulting":[93],"and":[98,161,184,209,228,235],"4":[100],"-genes":[101],"x":[102],"environment":[103],"interactions":[104],"contributing":[105,148],"to":[106,119,146,167,174,245],"states.For":[109],"anyone":[110],"involved":[111],"autoimmunity":[113],"research,":[114],"it":[115],"is":[116],"not":[117],"surprising":[118],"find":[120],"usual":[122],"suspects":[123],"three":[126],"that":[129,250],"fall":[130],"under":[131],"MHCs/HLAs,":[137],"PTPN22,":[138],"PTPN2,":[139],"CTLA4,":[140],"IFIH1":[141],"etc.The":[142],"editors":[143],"are":[144,237],"grateful":[145],"authors":[149],"presenting":[151],"these":[152],"common":[153],"players":[154],"from":[155],"differing":[156],"perspectives":[157],"using":[158],"both":[159],"overlapping":[160],"unique":[162,173],"sources.Here,":[163],"would":[165],"like":[166],"out":[169],"discussed":[170],"allelic":[171],"each":[175],"reviews.Kissler's":[178],"Modifiers":[180],"Thymic":[182],"Selection":[183],"Central":[185],"Type":[188],"Diabetes\"":[190],"presents":[191,223],"a":[192,224],"section":[193,225],"on":[194,226],"TAGAP":[195],"which":[196],"may":[197],"be":[198],"those":[202],"studying":[203],"thymic":[204],"migration":[205],"developing":[207],"T-cells.Hocking":[208],"Buckner's":[210],"immune":[216],"autoimmunity\"":[222],"PADI2":[227],"PADI4":[229,236],"rheumatoid":[232],"arthritis":[233],"(RA).PADI2":[234],"enzymes":[238],"responsible":[239],"conversion":[242],"arginine":[244],"citrulline.Recent":[246],"work":[247],"has":[248],"indicated":[249],"post":[251],"translational":[252],"modifications":[253],"Frontiers":[254],"Immunology":[256],"frontiersin.":[257]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-10-31T00:00:00"}
