{"id":"https://openalex.org/W4307264702","doi":"https://doi.org/10.3389/fnut.2022.1019615","title":"A protein- and fiber-rich diet with astaxanthin alleviates high-fat diet-induced obesity in beagles","display_name":"A protein- and fiber-rich diet with astaxanthin alleviates high-fat diet-induced obesity in beagles","publication_year":2022,"publication_date":"2022-10-24","ids":{"openalex":"https://openalex.org/W4307264702","doi":"https://doi.org/10.3389/fnut.2022.1019615","pmid":"https://pubmed.ncbi.nlm.nih.gov/36352906","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9637869"},"language":"en","primary_location":{"id":"doi:10.3389/fnut.2022.1019615","doi":"https://doi.org/10.3389/fnut.2022.1019615","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnut.2022.1019615","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnut.2022.1019615/pdf","source":{"id":"https://openalex.org/S2596909297","display_name":"Frontiers in Nutrition","issn_l":"2296-861X","issn":["2296-861X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Nutrition","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fnut.2022.1019615/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004939804","display_name":"Jinhua Xue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113195","display_name":"Gannan Medical University","ror":"https://ror.org/01tjgw469","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210113195"]},{"id":"https://openalex.org/I4210133784","display_name":"First Affiliated Hospital of Gannan Medical University","ror":"https://ror.org/040gnq226","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133784"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinhua Xue","raw_affiliation_strings":["Department of Physiology, School of Basic Medicine, Gannan Medical University, Ganzhou, China","Gannan Innovation and Transformation Medical Research Institute, Key Laboratory of Cardiovascular Disease Prevention and Control, Ministry of Education, First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, School of Basic Medicine, Gannan Medical University, Ganzhou, China","institution_ids":["https://openalex.org/I4210113195"]},{"raw_affiliation_string":"Gannan Innovation and Transformation Medical Research Institute, Key Laboratory of Cardiovascular Disease Prevention and Control, Ministry of Education, First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, China","institution_ids":["https://openalex.org/I4210113195","https://openalex.org/I4210133784"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yuanyuan Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113195","display_name":"Gannan Medical University","ror":"https://ror.org/01tjgw469","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210113195"]},{"id":"https://openalex.org/I4210133784","display_name":"First Affiliated Hospital of Gannan Medical University","ror":"https://ror.org/040gnq226","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133784"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanyuan Lu","raw_affiliation_strings":["Gannan Innovation and Transformation Medical Research Institute, Key Laboratory of Cardiovascular Disease Prevention and Control, Ministry of Education, First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gannan Innovation and Transformation Medical Research Institute, Key Laboratory of Cardiovascular Disease Prevention and Control, Ministry of Education, First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, China","institution_ids":["https://openalex.org/I4210113195","https://openalex.org/I4210133784"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111041650","display_name":"Toujun Zou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Toujun Zou","raw_affiliation_strings":["Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I4210140357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100651619","display_name":"Wei Shi","orcid":"https://orcid.org/0000-0002-9924-8756","observed_orcids":["https://orcid.org/0000-0002-9924-8756"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Shi","raw_affiliation_strings":["School of Basic Medicine, Wuhan University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Basic Medicine, Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100375569","display_name":"Shuang Wang","orcid":"https://orcid.org/0000-0002-1726-8957","observed_orcids":["https://orcid.org/0000-0002-1726-8957"]},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuang Wang","raw_affiliation_strings":["College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008141343","display_name":"Xu Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113195","display_name":"Gannan Medical University","ror":"https://ror.org/01tjgw469","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210113195"]},{"id":"https://openalex.org/I4210133784","display_name":"First Affiliated Hospital of Gannan Medical University","ror":"https://ror.org/040gnq226","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133784"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xu Cheng","raw_affiliation_strings":["Gannan Innovation and Transformation Medical Research Institute, Key Laboratory of Cardiovascular Disease Prevention and Control, Ministry of Education, First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gannan Innovation and Transformation Medical Research Institute, Key Laboratory of Cardiovascular Disease Prevention and Control, Ministry of Education, First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, China","institution_ids":["https://openalex.org/I4210113195","https://openalex.org/I4210133784"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102805101","display_name":"Juan Wan","orcid":"https://orcid.org/0000-0003-4869-2459","observed_orcids":["https://orcid.org/0000-0003-4869-2459"]},"institutions":[{"id":"https://openalex.org/I4210113195","display_name":"Gannan Medical University","ror":"https://ror.org/01tjgw469","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210113195"]},{"id":"https://openalex.org/I4210133784","display_name":"First Affiliated Hospital of Gannan Medical University","ror":"https://ror.org/040gnq226","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133784"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Juan Wan","raw_affiliation_strings":["Gannan Innovation and Transformation Medical Research Institute, Key Laboratory of Cardiovascular Disease Prevention and Control, Ministry of Education, First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gannan Innovation and Transformation Medical Research Institute, Key Laboratory of Cardiovascular Disease Prevention and Control, Ministry of Education, First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, China","institution_ids":["https://openalex.org/I4210113195","https://openalex.org/I4210133784"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100416540","display_name":"Yun Chen","orcid":"https://orcid.org/0000-0002-3746-594X","observed_orcids":["https://orcid.org/0000-0002-3746-594X"]},"institutions":[{"id":"https://openalex.org/I4210162891","display_name":"Huanggang Central Hospital","ror":"https://ror.org/02sjdcn27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162891"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yun Chen","raw_affiliation_strings":["Department of Cardiology, Huanggang Central Hospital, Huanggang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Huanggang Central Hospital, Huanggang, China","institution_ids":["https://openalex.org/I4210162891"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Min Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Min Wang","raw_affiliation_strings":["Jiangxi Huichong Technology Co., Ltd., Ganzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangxi Huichong Technology Co., Ltd., Ganzhou, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Qingzheng Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113195","display_name":"Gannan Medical University","ror":"https://ror.org/01tjgw469","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210113195"]},{"id":"https://openalex.org/I4210133784","display_name":"First Affiliated Hospital of Gannan Medical University","ror":"https://ror.org/040gnq226","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133784"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qingzheng Wang","raw_affiliation_strings":["Department of Physiology, School of Basic Medicine, Gannan Medical University, Ganzhou, China","Gannan Innovation and Transformation Medical Research Institute, Key Laboratory of Cardiovascular Disease Prevention and Control, Ministry of Education, First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, School of Basic Medicine, Gannan Medical University, Ganzhou, China","institution_ids":["https://openalex.org/I4210113195"]},{"raw_affiliation_string":"Gannan Innovation and Transformation Medical Research Institute, Key Laboratory of Cardiovascular Disease Prevention and Control, Ministry of Education, First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, China","institution_ids":["https://openalex.org/I4210113195","https://openalex.org/I4210133784"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100415181","display_name":"Xia Yang","orcid":"https://orcid.org/0009-0006-7849-6394","observed_orcids":["https://orcid.org/0009-0006-7849-6394","https://orcid.org/0000-0003-2361-6003"]},"institutions":[{"id":"https://openalex.org/I4210113195","display_name":"Gannan Medical University","ror":"https://ror.org/01tjgw469","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210113195"]},{"id":"https://openalex.org/I4210133784","display_name":"First Affiliated Hospital of Gannan Medical University","ror":"https://ror.org/040gnq226","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133784"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xia Yang","raw_affiliation_strings":["Gannan Innovation and Transformation Medical Research Institute, Key Laboratory of Cardiovascular Disease Prevention and Control, Ministry of Education, First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gannan Innovation and Transformation Medical Research Institute, Key Laboratory of Cardiovascular Disease Prevention and Control, Ministry of Education, First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, China","institution_ids":["https://openalex.org/I4210113195","https://openalex.org/I4210133784"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038742224","display_name":"Mingxing Ding","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingxing Ding","raw_affiliation_strings":["College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107838448","display_name":"Zhili Qi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhili Qi","raw_affiliation_strings":["College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yi Ding","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Ding","raw_affiliation_strings":["College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029135732","display_name":"Manli Hu","orcid":"https://orcid.org/0000-0001-8318-0454","observed_orcids":["https://orcid.org/0000-0001-8318-0454"]},"institutions":[{"id":"https://openalex.org/I4210113195","display_name":"Gannan Medical University","ror":"https://ror.org/01tjgw469","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210113195"]},{"id":"https://openalex.org/I4210133784","display_name":"First Affiliated Hospital of Gannan Medical University","ror":"https://ror.org/040gnq226","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133784"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Manli Hu","raw_affiliation_strings":["Gannan Innovation and Transformation Medical Research Institute, Key Laboratory of Cardiovascular Disease Prevention and Control, Ministry of Education, First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gannan Innovation and Transformation Medical Research Institute, Key Laboratory of Cardiovascular Disease Prevention and Control, Ministry of Education, First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, China","institution_ids":["https://openalex.org/I4210113195","https://openalex.org/I4210133784"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100327390","display_name":"Xin Zhang","orcid":"https://orcid.org/0000-0001-9769-2856","observed_orcids":["https://orcid.org/0000-0001-9769-2856","https://orcid.org/0009-0000-3061-1417"]},"institutions":[{"id":"https://openalex.org/I4210113195","display_name":"Gannan Medical University","ror":"https://ror.org/01tjgw469","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210113195"]},{"id":"https://openalex.org/I4210133784","display_name":"First Affiliated Hospital of Gannan Medical University","ror":"https://ror.org/040gnq226","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133784"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Zhang","raw_affiliation_strings":["Gannan Innovation and Transformation Medical Research Institute, Key Laboratory of Cardiovascular Disease Prevention and Control, Ministry of Education, First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gannan Innovation and Transformation Medical Research Institute, Key Laboratory of Cardiovascular Disease Prevention and Control, Ministry of Education, First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, China","institution_ids":["https://openalex.org/I4210113195","https://openalex.org/I4210133784"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100442422","display_name":"Hongliang Li","orcid":"https://orcid.org/0000-0002-9821-0297","observed_orcids":["https://orcid.org/0000-0002-9821-0297"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]},{"id":"https://openalex.org/I4210113195","display_name":"Gannan Medical University","ror":"https://ror.org/01tjgw469","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210113195"]},{"id":"https://openalex.org/I4210133784","display_name":"First Affiliated Hospital of Gannan Medical University","ror":"https://ror.org/040gnq226","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133784"]},{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hongliang Li","raw_affiliation_strings":["Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China","Gannan Innovation and Transformation Medical Research Institute, Key Laboratory of Cardiovascular Disease Prevention and Control, Ministry of Education, First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, China","School of Basic Medicine, Wuhan University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I4210140357"]},{"raw_affiliation_string":"Gannan Innovation and Transformation Medical Research Institute, Key Laboratory of Cardiovascular Disease Prevention and Control, Ministry of Education, First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, China","institution_ids":["https://openalex.org/I4210113195","https://openalex.org/I4210133784"]},{"raw_affiliation_string":"School of Basic Medicine, Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082799922","display_name":"Yufeng Hu","orcid":"https://orcid.org/0000-0002-9416-262X","observed_orcids":["https://orcid.org/0000-0002-9416-262X"]},"institutions":[{"id":"https://openalex.org/I4210113195","display_name":"Gannan Medical University","ror":"https://ror.org/01tjgw469","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210113195"]},{"id":"https://openalex.org/I4210133784","display_name":"First Affiliated Hospital of Gannan Medical University","ror":"https://ror.org/040gnq226","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133784"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yufeng Hu","raw_affiliation_strings":["Gannan Innovation and Transformation Medical Research Institute, Key Laboratory of Cardiovascular Disease Prevention and Control, Ministry of Education, First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gannan Innovation and Transformation Medical Research Institute, Key Laboratory of Cardiovascular Disease Prevention and Control, Ministry of Education, First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, China","institution_ids":["https://openalex.org/I4210113195","https://openalex.org/I4210133784"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5082799922","https://openalex.org/A5100442422"],"corresponding_institution_ids":["https://openalex.org/I37461747","https://openalex.org/I4210113195","https://openalex.org/I4210133784","https://openalex.org/I4210140357"],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":2.6262,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.88752349,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"9","issue":null,"first_page":"1019615","last_page":"1019615"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11580","display_name":"Veterinary Medicine and Surgery","score":0.8403000235557556,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11580","display_name":"Veterinary Medicine and Surgery","score":0.8403000235557556,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.01590000092983246,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.012900000438094139,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/canine-obesity","display_name":"canine obesity","score":0.8090000152587891},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.7990000247955322},{"id":"https://openalex.org/keywords/weight-loss-diet","display_name":"weight loss diet","score":0.9539999961853027},{"id":"https://openalex.org/keywords/astaxanthin","display_name":"astaxanthin","score":0.871999979019165},{"id":"https://openalex.org/keywords/high-protein-diet","display_name":"high-protein diet","score":0.8799999952316284},{"id":"https://openalex.org/keywords/dietary-fiber","display_name":"dietary fiber","score":0.8579999804496765},{"id":"https://openalex.org/keywords/adipose-tissue-transcriptome","display_name":"adipose tissue transcriptome","score":0.6290000081062317},{"id":"https://openalex.org/keywords/energy-metabolism","display_name":"energy metabolism","score":0.8330000042915344},{"id":"https://openalex.org/keywords/lipogenesis","display_name":"lipogenesis","score":0.9399999976158142},{"id":"https://openalex.org/keywords/adipocyte-size","display_name":"adipocyte size","score":0.6840000152587891},{"id":"https://openalex.org/keywords/serum-lipids","display_name":"serum lipids","score":0.7379999756813049},{"id":"https://openalex.org/keywords/body-condition-score","display_name":"body condition score","score":0.4970000088214874},{"id":"https://openalex.org/keywords/pet-nutrition","display_name":"pet nutrition","score":0.5879999995231628},{"id":"https://openalex.org/keywords/beagle-dog-model","display_name":"beagle dog model","score":0.6290000081062317}],"concepts":[{"id":"https://openalex.org/C544821477","wikidata":"https://www.wikidata.org/wiki/Q718113","display_name":"Weight loss","level":3,"score":0.84831702709198},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.6683056950569153},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6283450722694397},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.6149300336837769},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.609980046749115},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5967966914176941},{"id":"https://openalex.org/C2776820430","wikidata":"https://www.wikidata.org/wiki/Q21102","display_name":"Beagle","level":2,"score":0.5167900323867798},{"id":"https://openalex.org/C2780586474","wikidata":"https://www.wikidata.org/wiki/Q332428","display_name":"Overweight","level":3,"score":0.4824029207229614},{"id":"https://openalex.org/C40438245","wikidata":"https://www.wikidata.org/wiki/Q130964","display_name":"Calorie","level":2,"score":0.45705342292785645}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fnut.2022.1019615","doi":"https://doi.org/10.3389/fnut.2022.1019615","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnut.2022.1019615","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnut.2022.1019615/pdf","source":{"id":"https://openalex.org/S2596909297","display_name":"Frontiers in Nutrition","issn_l":"2296-861X","issn":["2296-861X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Nutrition","raw_type":"journal-article"},{"id":"pmid:36352906","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36352906","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in nutrition","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9637869","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9637869/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Nutr","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:581f0d82bd1d4e58ad8552daac67f865","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/581f0d82bd1d4e58ad8552daac67f865","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Nutrition, Vol 9 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fnut.2022.1019615","doi":"https://doi.org/10.3389/fnut.2022.1019615","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnut.2022.1019615","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnut.2022.1019615/pdf","source":{"id":"https://openalex.org/S2596909297","display_name":"Frontiers in Nutrition","issn_l":"2296-861X","issn":["2296-861X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Nutrition","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"},{"id":"https://metadata.un.org/sdg/2","score":0.40450000762939453,"display_name":"Zero hunger"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3622201003","display_name":null,"funder_award_id":"82100086","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4307264702.pdf","grobid_xml":"https://content.openalex.org/works/W4307264702.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1989642339","https://openalex.org/W2012803307","https://openalex.org/W2033109099","https://openalex.org/W2067673762","https://openalex.org/W2073140562","https://openalex.org/W2084807681","https://openalex.org/W2112399243","https://openalex.org/W2130319273","https://openalex.org/W2131122125","https://openalex.org/W2132103709","https://openalex.org/W2161449776","https://openalex.org/W2165803417","https://openalex.org/W2188101933","https://openalex.org/W2198352492","https://openalex.org/W2504893897","https://openalex.org/W2518098391","https://openalex.org/W2585282622","https://openalex.org/W2885709209","https://openalex.org/W2893673243","https://openalex.org/W2904339813","https://openalex.org/W2912395967","https://openalex.org/W2917520831","https://openalex.org/W3004349582","https://openalex.org/W3021512157","https://openalex.org/W3042932679","https://openalex.org/W3062521503","https://openalex.org/W3135278976","https://openalex.org/W3180573026","https://openalex.org/W3181760337","https://openalex.org/W3197299683","https://openalex.org/W4200227945","https://openalex.org/W4210724273","https://openalex.org/W4230805141","https://openalex.org/W4280547849"],"related_works":["https://openalex.org/W3109436653","https://openalex.org/W4200227945","https://openalex.org/W2092989600","https://openalex.org/W4293796498","https://openalex.org/W2282280560","https://openalex.org/W4379599078","https://openalex.org/W2307255800","https://openalex.org/W2081158219","https://openalex.org/W4283644809","https://openalex.org/W2165803417"],"abstract_inverted_index":{"Background":[0],"and":[1,17,23,28,42,60,63,86,98,127,144,146,154,159,214,220,265,285,295],"aims:":[2],"Overweight":[3],"or":[4,121],"obesity":[5,54,92,201],"is":[6],"one":[7],"of":[8,72,168,175,183,195,223,251,292],"the":[9,73,176,180,224,245],"most":[10],"prevalent":[11],"health":[12],"burdens":[13],"in":[14,80,202,278,301],"companion":[15,302],"pets":[16],"predisposes":[18],"subjects":[19],"to":[20,50,110],"multiple":[21],"comorbidities":[22],"reduced":[24],"longevity.":[25],"Dietary":[26],"management":[27,281,294],"sufficient":[29],"exercise":[30],"are":[31],"effective":[32,290],"options":[33],"for":[34,91,298],"weight":[35,126,246,280,299],"loss":[36,247],"but":[37],"challenged":[38],"by":[39,58,93,188,206,230],"modern":[40],"lifestyle":[41],"calorie":[43],"control-triggered":[44],"malnutrition.":[45],"Therefore,":[46],"this":[47],"study":[48],"aimed":[49],"develop":[51],"a":[52,94,117,257],"formulated":[53,118,177],"control":[55,122,300],"diet":[56,62,76,120,170,178,234,259,274],"characterized":[57],"protein-":[59],"fiber-rich":[61],"supplemented":[64],"with":[65,116,282],"astaxanthin.":[66],"We":[67],"systemically":[68],"evaluated":[69],"global":[70,173],"influences":[71],"designed":[74],"weight-loss":[75,102,119,169,233,258,273],"on":[77,179],"metabolic":[78,221],"homeostasis":[79],"an":[81,231],"obese":[82,105,219],"beagle":[83],"model.":[84],"Materials":[85],"methods:":[87],"Beagles":[88],"were":[89,107,114,132,150,162,186,227],"induced":[90,200],"24-week":[95],"HFD":[96,197],"treatment":[97],"then":[99],"included":[100],"into":[101],"programs.":[103],"Briefly,":[104],"beagles":[106],"randomly":[108],"assigned":[109],"two":[111],"groups":[112],"that":[113,256],"fed":[115],"diet,":[123],"respectively.":[124],"Body":[125],"body":[128,208],"condition":[129,222],"scoring":[130],"(BCS)":[131],"analyzed":[133],"biweekly.":[134],"Computed":[135],"tomography":[136],"(CT),":[137],"nuclear":[138],"magnetic":[139],"resonance":[140],"imaging":[141],"(MRI)":[142],"measurements,":[143],"blood":[145],"adipose":[147,189,252],"tissue":[148],"biopsies":[149],"collected":[151],"at":[152],"0":[153],"8":[155,166],"weeks.":[156],"Plasma":[157],"lipids":[158],"adipocyte":[160],"size":[161],"also":[163],"measured":[164],"after":[165],"weeks":[167,194],"feeding.":[171],"The":[172,218,271],"influence":[174],"whole":[181],"spectrum":[182],"gene":[184],"panels":[185],"examined":[187],"RNA":[190],"assays.":[191],"Results:":[192],"Twenty-four":[193],"continuous":[196],"feeding":[198],"significantly":[199,260],"beagles,":[203],"as":[204],"evidenced":[205],"increased":[207,261],"weight,":[209],"BCS,":[210],"abdominal":[211],"fat":[212],"mass,":[213],"serum":[215],"lipid":[216,267],"levels.":[217],"modeled":[225],"canine":[226,279],"effectively":[228],"improved":[229],"8-week":[232],"administration.":[235],"Importantly,":[236],"we":[237],"did":[238],"not":[239],"observe":[240],"any":[241],"side":[242],"effects":[243],"during":[244],"duration.":[248],"Transcriptional":[249],"analysis":[250],"tissues":[253],"further":[254],"supported":[255],"energy":[262],"metabolism-related":[263],"pathways":[264],"decreased":[266],"synthesis-related":[268],"pathways.":[269],"Conclusion:":[270],"prescribed":[272],"exhibited":[275],"profound":[276],"benefits":[277],"well":[283],"safety":[284],"palatability.":[286],"These":[287],"findings":[288],"support":[289],"strategies":[291],"nutritional":[293],"supplementation":[296],"approaches":[297],"animals.":[303]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-10-31T00:00:00"}
