{"id":"https://openalex.org/W4307229998","doi":null,"title":"Upfront immunotherapy leads to lower brain metastasis velocity in patients undergoing stereotactic radiosurgery for brain metastases.","display_name":"Upfront immunotherapy leads to lower brain metastasis velocity in patients undergoing stereotactic radiosurgery for brain metastases.","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4307229998","pmid":"https://pubmed.ncbi.nlm.nih.gov/36275134","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9489075"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9489075","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9489075","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Radiosurg SBRT","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9489075","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075170305","display_name":"Mohammed N. Abdulhaleem","orcid":"https://orcid.org/0000-0002-4429-2178","observed_orcids":["https://orcid.org/0000-0002-4429-2178"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohammed Abdulhaleem","raw_affiliation_strings":["Department of Medicine, Hematology and Oncology, Wake Forest School of Medicine, Winston-Salem, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Hematology and Oncology, Wake Forest School of Medicine, Winston-Salem, NC, USA","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011340484","display_name":"Emmanuel Scott","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emmanuel Scott","raw_affiliation_strings":["Department of Radiation Oncology, Wake Forest School of Medicine, Winston-Salem, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Wake Forest School of Medicine, Winston-Salem, NC, USA","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108771934","display_name":"Hannah E. Johnston","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hannah Johnston","raw_affiliation_strings":["Department of Radiation Oncology, Wake Forest School of Medicine, Winston-Salem, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Wake Forest School of Medicine, Winston-Salem, NC, USA","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079840473","display_name":"Scott P. Isom","orcid":"https://orcid.org/0000-0002-6658-3865","observed_orcids":["https://orcid.org/0000-0002-6658-3865"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott Isom","raw_affiliation_strings":["Deparment of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Deparment of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC, USA","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002293223","display_name":"C.M. Lanier","orcid":"https://orcid.org/0000-0003-0127-9253","observed_orcids":["https://orcid.org/0000-0003-0127-9253"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claire Lanier","raw_affiliation_strings":["Department of Radiation Oncology, Wake Forest School of Medicine, Winston-Salem, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Wake Forest School of Medicine, Winston-Salem, NC, USA","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062186012","display_name":"Michael C. LeCompte","orcid":"https://orcid.org/0000-0002-3116-007X","observed_orcids":["https://orcid.org/0000-0002-3116-007X"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael LeCompte","raw_affiliation_strings":["Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056464333","display_name":"Christina Kehl Cramer","orcid":"https://orcid.org/0000-0001-7618-3921","observed_orcids":["https://orcid.org/0000-0001-7618-3921"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina K Cramer","raw_affiliation_strings":["Department of Radiation Oncology, Wake Forest School of Medicine, Winston-Salem, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Wake Forest School of Medicine, Winston-Salem, NC, USA","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050923145","display_name":"Jimmy Ruiz","orcid":"https://orcid.org/0000-0002-7242-3315","observed_orcids":["https://orcid.org/0000-0002-7242-3315"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jimmy Ruiz","raw_affiliation_strings":["Department of Medicine, Hematology and Oncology, Wake Forest School of Medicine, Winston-Salem, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Hematology and Oncology, Wake Forest School of Medicine, Winston-Salem, NC, USA","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103025341","display_name":"Hui\u2010Wen Lo","orcid":"https://orcid.org/0000-0002-0681-7914","observed_orcids":["https://orcid.org/0000-0002-0681-7914"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hui-Wen Lo","raw_affiliation_strings":["Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC, USA","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023534649","display_name":"Kuonosuke Watabe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kuonosuke Watabe","raw_affiliation_strings":["Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC, USA","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024176712","display_name":"Stacey S. O\u2019Neill","orcid":"https://orcid.org/0000-0002-7006-9615","observed_orcids":["https://orcid.org/0000-0002-7006-9615"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stacey O'Neill","raw_affiliation_strings":["Department of Pathology, Wake Forest School of Medicine, Winston-Salem, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Wake Forest School of Medicine, Winston-Salem, NC, USA","institution_ids":["https://openalex.org/I4405269449"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000092822","display_name":"Christopher T. Whitlow","orcid":"https://orcid.org/0000-0003-2392-8293","observed_orcids":["https://orcid.org/0000-0003-2392-8293"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Whitlow","raw_affiliation_strings":["Department of Radiology, Wake Forest School of Medicine, Winston-Salem, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Wake Forest School of Medicine, Winston-Salem, NC, USA","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059467122","display_name":"Stephen B. Tatter","orcid":"https://orcid.org/0000-0002-1063-0431","observed_orcids":["https://orcid.org/0000-0002-1063-0431"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen B Tatter","raw_affiliation_strings":["Department of Neurosurgery, Wake Forest School of Medicine, Winston-Salem, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Wake Forest School of Medicine, Winston-Salem, NC, USA","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053135133","display_name":"Adrian W. Laxton","orcid":"https://orcid.org/0000-0002-4631-5476","observed_orcids":["https://orcid.org/0000-0002-4631-5476"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adrian W Laxton","raw_affiliation_strings":["Department of Neurosurgery, Wake Forest School of Medicine, Winston-Salem, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Wake Forest School of Medicine, Winston-Salem, NC, USA","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034140883","display_name":"Jing Su","orcid":"https://orcid.org/0000-0003-4917-6173","observed_orcids":["https://orcid.org/0000-0003-4917-6173"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jing Su","raw_affiliation_strings":["Department of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053414244","display_name":"Michael David Chan","orcid":"https://orcid.org/0000-0002-5278-6709","observed_orcids":["https://orcid.org/0000-0002-5278-6709"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael D Chan","raw_affiliation_strings":["Department of Radiation Oncology, Wake Forest School of Medicine, Winston-Salem, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Wake Forest School of Medicine, Winston-Salem, NC, USA","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4609,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.61379976,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"8","issue":"2","first_page":"77","last_page":"83"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12108","display_name":"Management of metastatic bone disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brain-metastases","display_name":"brain metastases","score":0.9940000176429749},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.8399999737739563},{"id":"https://openalex.org/keywords/stereotactic-radiosurgery","display_name":"stereotactic radiosurgery","score":0.9800000190734863},{"id":"https://openalex.org/keywords/neurologic-death","display_name":"neurologic death","score":0.7519999742507935},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9620000123977661},{"id":"https://openalex.org/keywords/systemic-treatment","display_name":"systemic therapy","score":0.5260000228881836}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8769108057022095},{"id":"https://openalex.org/C2780387249","wikidata":"https://www.wikidata.org/wiki/Q973234","display_name":"Radiosurgery","level":3,"score":0.7976536750793457},{"id":"https://openalex.org/C2778164965","wikidata":"https://www.wikidata.org/wiki/Q1620196","display_name":"Brain metastasis","level":4,"score":0.790765643119812},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.7732417583465576},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.7090330719947815},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5589954853057861},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.48998966813087463},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.4298154413700104},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.4258314073085785},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.3471032381057739},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.1984153687953949},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.1782500445842743}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:9489075","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9489075","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Radiosurg SBRT","raw_type":"Text"},{"id":"pmid:36275134","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36275134","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of radiosurgery and SBRT","raw_type":"Journal Article"},{"id":"pmh:oai:scholarworks.indianapolis.iu.edu:1805/36512","doi":null,"is_oa":false,"landing_page_url":"https://scholarworks.indianapolis.iu.edu/bitstreams/70c78d70-d004-49cd-bb9f-63723c8b7ebb/download","pdf_url":null,"source":{"id":"https://openalex.org/S4306400987","display_name":"IUScholarWorks (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PMC","raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9489075","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9489075","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Radiosurg SBRT","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1505561455","https://openalex.org/W2015998836","https://openalex.org/W2060654645","https://openalex.org/W2083128109","https://openalex.org/W2116478428","https://openalex.org/W2169923878","https://openalex.org/W2416791964","https://openalex.org/W2511092051","https://openalex.org/W2581511343","https://openalex.org/W2582449552","https://openalex.org/W2753432434","https://openalex.org/W2769596292","https://openalex.org/W2796582438","https://openalex.org/W2888298425","https://openalex.org/W2899466595","https://openalex.org/W2913745075","https://openalex.org/W2914101161","https://openalex.org/W2973080678","https://openalex.org/W2998688399","https://openalex.org/W3043703771","https://openalex.org/W3095969107"],"related_works":["https://openalex.org/W3210818789","https://openalex.org/W2895957448","https://openalex.org/W2914101161","https://openalex.org/W2998688399","https://openalex.org/W2767873363","https://openalex.org/W3024540877","https://openalex.org/W2767589998","https://openalex.org/W4313583801","https://openalex.org/W4212871392","https://openalex.org/W2529617884"],"abstract_inverted_index":{"Background:":[0],"While":[1,216],"immunotherapy":[2,59,86,117,142,160,191,203,233],"has":[3],"been":[4],"shown":[5],"to":[6,26,31,70,84,101,119,131,205,213,220],"improve":[7,206],"survival":[8,108,208],"and":[9,54,66,98,144,193,209],"decrease":[10,210],"neurologic":[11,181],"death":[12,182],"in":[13,112,157,168,188,195],"patients":[14,41,114,228],"with":[15,43,47,57,78,91,99,234],"brain":[16,44,72,103,133,226],"metastases,":[17],"it":[18],"remains":[19],"unclear":[20],"whether":[21],"this":[22,76],"improvement":[23],"is":[24],"due":[25],"prevention":[27],"of":[28,40,51,62,94,180],"new":[29],"metastasis":[30,153,227],"the":[32,48,71,85,102,113,120,140,158,169,189,196],"brain.":[33],"Method:":[34],"We":[35,74],"performed":[36],"a":[37,79],"retrospective":[38],"review":[39],"presenting":[42],"metastases":[45,164,174],"simultaneously":[46],"first":[49],"diagnosis":[50],"metastatic":[52],"disease":[53],"were":[55,89],"treated":[56,90],"upfront":[58,116,141,159,190],"as":[60],"part":[61],"their":[63],"treatment":[64],"regimen":[65],"stereotactic":[67],"radiosurgery":[68],"(SRS)":[69],"metastases.":[73,104],"compared":[75,118,212],"cohort":[77,122,143,147,161,192,199],"historical":[80,121,145,170,197,214],"control":[81,146,198],"population":[82],"(prior":[83],"era)":[87],"who":[88],"pre-immunotherapy":[92],"standard":[93],"care":[95],"systemic":[96],"therapy":[97],"SRS":[100],"Results:":[105],"Median":[106,129],"overall":[107,207],"time":[109,130],"was":[110,135,155,186],"improved":[111],"receiving":[115],"(48":[123],"months":[124],"vs":[125,149],"8.4":[126],"months,":[127],"p=0.001).":[128,177],"distant":[132],"failure":[134],"statistically":[136],"equivalent":[137],"(p=0.3)":[138],"between":[139],"(10.3":[148],"12.6":[150],"months).":[151],"Brain":[152],"velocity":[154],"lower":[156],"(median":[162,172],"3.72":[163],"per":[165,175],"year)":[166],"than":[167],"controls":[171],"9.48":[173],"year,":[176],"Cumulative":[178],"incidence":[179],"at":[183],"one":[184],"year":[185],"12%":[187],"28%":[194],"(p=0.1).":[200],"Conclusions:":[201],"Upfront":[202],"appears":[204],"BMV":[211],"controls.":[215],"these":[217],"data":[218],"remain":[219],"be":[221],"validated,":[222],"they":[223],"suggest":[224],"that":[225],"may":[229],"benefit":[230],"from":[231],"concurrent":[232],"SRS.":[235]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2022-10-30T00:00:00"}