{"id":"https://openalex.org/W4307226503","doi":"https://doi.org/10.1111/and.14616","title":"Targeting soluble guanylate cyclase with Riociguat has potency to alleviate testicular ischaemia reperfusion injury via regulating various cellular pathways","display_name":"Targeting soluble guanylate cyclase with Riociguat has potency to alleviate testicular ischaemia reperfusion injury via regulating various cellular pathways","publication_year":2022,"publication_date":"2022-10-25","ids":{"openalex":"https://openalex.org/W4307226503","doi":"https://doi.org/10.1111/and.14616","pmid":"https://pubmed.ncbi.nlm.nih.gov/36283690"},"language":"en","primary_location":{"id":"doi:10.1111/and.14616","doi":"https://doi.org/10.1111/and.14616","is_oa":true,"landing_page_url":"https://doi.org/10.1111/and.14616","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/and.14616","source":{"id":"https://openalex.org/S87865284","display_name":"Andrologia","issn_l":"0303-4569","issn":["0303-4569","1439-0272"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Andrologia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/and.14616","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051046633","display_name":"U\u011fur \u015eeker","orcid":"https://orcid.org/0000-0002-1693-6378","observed_orcids":["https://orcid.org/0000-0002-1693-6378"]},"institutions":[{"id":"https://openalex.org/I80538482","display_name":"Harran University","ror":"https://ror.org/057qfs197","country_code":"TR","type":"education","lineage":["https://openalex.org/I80538482"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Ugur Seker","raw_affiliation_strings":["Department of Histology and Embryology, School of Medicine, Harran University, Sanliurfa, Turkey"],"raw_orcid":"https://orcid.org/0000-0002-1693-6378","affiliations":[{"raw_affiliation_string":"Department of Histology and Embryology, School of Medicine, Harran University, Sanliurfa, Turkey","institution_ids":["https://openalex.org/I80538482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080982394","display_name":"Deniz Evrim Kavak","orcid":"https://orcid.org/0000-0002-9681-4468","observed_orcids":["https://orcid.org/0000-0002-9681-4468"]},"institutions":[{"id":"https://openalex.org/I193615760","display_name":"Dokuz Eyl\u00fcl University","ror":"https://ror.org/00dbd8b73","country_code":"TR","type":"education","lineage":["https://openalex.org/I193615760"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Deniz Evrim Kavak","raw_affiliation_strings":["Department of Medical Biology, School of Medicine, Dokuz Eylul University, Izmir, Turkey"],"raw_orcid":"https://orcid.org/0000-0002-9681-4468","affiliations":[{"raw_affiliation_string":"Department of Medical Biology, School of Medicine, Dokuz Eylul University, Izmir, Turkey","institution_ids":["https://openalex.org/I193615760"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084169596","display_name":"Bar\u0131\u015f Can G\u00fczel","orcid":"https://orcid.org/0000-0002-2504-120X","observed_orcids":["https://orcid.org/0000-0002-2504-120X"]},"institutions":[{"id":"https://openalex.org/I143396566","display_name":"F\u0131rat University","ror":"https://ror.org/05teb7b63","country_code":"TR","type":"education","lineage":["https://openalex.org/I143396566"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Baris Can Guzel","raw_affiliation_strings":["Department of Veterinary Anatomy, Faculty of Veterinary Medicine, Firat University, Elazig, Turkey"],"raw_orcid":"https://orcid.org/0000-0002-2504-120X","affiliations":[{"raw_affiliation_string":"Department of Veterinary Anatomy, Faculty of Veterinary Medicine, Firat University, Elazig, Turkey","institution_ids":["https://openalex.org/I143396566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011376444","display_name":"Saime Bet\u00fcl Baygeldi","orcid":"https://orcid.org/0000-0002-4403-8663","observed_orcids":["https://orcid.org/0000-0002-4403-8663"]},"institutions":[{"id":"https://openalex.org/I143396566","display_name":"F\u0131rat University","ror":"https://ror.org/05teb7b63","country_code":"TR","type":"education","lineage":["https://openalex.org/I143396566"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Saime Betul Baygeldi","raw_affiliation_strings":["Department of Veterinary Anatomy, Faculty of Veterinary Medicine, Firat University, Elazig, Turkey"],"raw_orcid":"https://orcid.org/0000-0002-4403-8663","affiliations":[{"raw_affiliation_string":"Department of Veterinary Anatomy, Faculty of Veterinary Medicine, Firat University, Elazig, Turkey","institution_ids":["https://openalex.org/I143396566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009088727","display_name":"Meral Y\u00fcksel","orcid":"https://orcid.org/0000-0002-4760-3306","observed_orcids":["https://orcid.org/0000-0002-4760-3306"]},"institutions":[{"id":"https://openalex.org/I74897591","display_name":"Marmara University","ror":"https://ror.org/02kswqa67","country_code":"TR","type":"education","lineage":["https://openalex.org/I74897591"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Meral Yuksel","raw_affiliation_strings":["Department of Medical Laboratory, Vocational School of Health-Related Professions, Marmara University, Istanbul, Turkey"],"raw_orcid":"https://orcid.org/0000-0002-4760-3306","affiliations":[{"raw_affiliation_string":"Department of Medical Laboratory, Vocational School of Health-Related Professions, Marmara University, Istanbul, Turkey","institution_ids":["https://openalex.org/I74897591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067202925","display_name":"\u00d6zlem \u00dcnay Demirel","orcid":"https://orcid.org/0000-0002-3059-9398","observed_orcids":["https://orcid.org/0000-0002-3059-9398"]},"institutions":[{"id":"https://openalex.org/I128277893","display_name":"Bah\u00e7e\u015fehir University","ror":"https://ror.org/00yze4d93","country_code":"TR","type":"education","lineage":["https://openalex.org/I128277893"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ozlem Unay Demirel","raw_affiliation_strings":["Department of Medical Biochemistry, School of Medicine, Bahcesehir University, Istanbul, Turkey"],"raw_orcid":"https://orcid.org/0000-0002-3059-9398","affiliations":[{"raw_affiliation_string":"Department of Medical Biochemistry, School of Medicine, Bahcesehir University, Istanbul, Turkey","institution_ids":["https://openalex.org/I128277893"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050694300","display_name":"Sevgi \u0130rteg\u00fcn Kandemir","orcid":"https://orcid.org/0000-0001-6160-5626","observed_orcids":["https://orcid.org/0000-0001-6160-5626"]},"institutions":[{"id":"https://openalex.org/I123466251","display_name":"Dicle University","ror":"https://ror.org/0257dtg16","country_code":"TR","type":"education","lineage":["https://openalex.org/I123466251"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Sevgi Irtegun Kandemir","raw_affiliation_strings":["Department of Medical Biology, School of Medicine, Dicle University, Diyarbakir, Turkey"],"raw_orcid":"https://orcid.org/0000-0001-6160-5626","affiliations":[{"raw_affiliation_string":"Department of Medical Biology, School of Medicine, Dicle University, Diyarbakir, Turkey","institution_ids":["https://openalex.org/I123466251"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035444498","display_name":"Dila \u015eener","orcid":"https://orcid.org/0000-0001-9496-7324","observed_orcids":["https://orcid.org/0000-0001-9496-7324"]},"institutions":[{"id":"https://openalex.org/I128277893","display_name":"Bah\u00e7e\u015fehir University","ror":"https://ror.org/00yze4d93","country_code":"TR","type":"education","lineage":["https://openalex.org/I128277893"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Dila Sener","raw_affiliation_strings":["Department of Histology and Embryology, School of Medicine, Bahcesehir University, Istanbul, Turkey"],"raw_orcid":"https://orcid.org/0000-0001-9496-7324","affiliations":[{"raw_affiliation_string":"Department of Histology and Embryology, School of Medicine, Bahcesehir University, Istanbul, Turkey","institution_ids":["https://openalex.org/I128277893"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5051046633"],"corresponding_institution_ids":["https://openalex.org/I80538482"],"apc_list":{"value":3450,"currency":"USD","value_usd":3450},"apc_paid":null,"fwci":1.684,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.82556563,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"54","issue":"11","first_page":"e14616","last_page":"e14616"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.8428000211715698,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.8428000211715698,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.08950000256299973,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.009200000204145908,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/riociguat","display_name":"riociguat","score":0.8849999904632568},{"id":"https://openalex.org/keywords/soluble-guanylate-cyclase","display_name":"soluble guanylate cyclase","score":0.906000018119812},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8510000109672546},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8560000061988831},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.625},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.9229999780654907},{"id":"https://openalex.org/keywords/mtor","display_name":"mTOR","score":0.7590000033378601},{"id":"https://openalex.org/keywords/erk","display_name":"ERK","score":0.8619999885559082},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.8790000081062317},{"id":"https://openalex.org/keywords/caspases","display_name":"caspases","score":0.6610000133514404},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9039999842643738},{"id":"https://openalex.org/keywords/testicular-torsion","display_name":"testicular torsion","score":0.671999990940094},{"id":"https://openalex.org/keywords/male-infertility","display_name":"male infertility","score":0.5189999938011169}],"concepts":[{"id":"https://openalex.org/C2776304953","wikidata":"https://www.wikidata.org/wiki/Q2154494","display_name":"Riociguat","level":4,"score":0.8811139464378357},{"id":"https://openalex.org/C2778401633","wikidata":"https://www.wikidata.org/wiki/Q418661","display_name":"Malondialdehyde","level":3,"score":0.5883815288543701},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5399878025054932},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5268308520317078},{"id":"https://openalex.org/C2780114680","wikidata":"https://www.wikidata.org/wiki/Q1413991","display_name":"Reperfusion injury","level":3,"score":0.5089230537414551},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.46240121126174927},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.45183122158050537},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.42481529712677},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4104938507080078},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40982869267463684},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39673835039138794},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2690078318119049},{"id":"https://openalex.org/C173803235","wikidata":"https://www.wikidata.org/wiki/Q419566","display_name":"Guanylate cyclase","level":3,"score":0.20234021544456482},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.1618424654006958},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13771218061447144}],"mesh":[{"descriptor_ui":"D000071756","descriptor_name":"Soluble Guanylyl Cyclase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007511","descriptor_name":"Ischemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D007511","descriptor_name":"Ischemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007511","descriptor_name":"Ischemia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/and.14616","doi":"https://doi.org/10.1111/and.14616","is_oa":true,"landing_page_url":"https://doi.org/10.1111/and.14616","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/and.14616","source":{"id":"https://openalex.org/S87865284","display_name":"Andrologia","issn_l":"0303-4569","issn":["0303-4569","1439-0272"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Andrologia","raw_type":"journal-article"},{"id":"pmid:36283690","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36283690","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Andrologia","raw_type":"Journal Article"},{"id":"pmh:oai:openaccess.firat.edu.tr:11508/53609","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11508/53609","pdf_url":null,"source":{"id":"https://openalex.org/S4377196733","display_name":"DSpace - FIRAT (F\u0131rat University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143396566","host_organization_name":"F\u0131rat University","host_organization_lineage":["https://openalex.org/I143396566"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:openaccess.marmara.edu.tr:11424/284067","doi":null,"is_oa":true,"landing_page_url":"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85140399446&origin=inward","pdf_url":null,"source":{"id":"https://openalex.org/S4306401380","display_name":"Dspace Repository (Marmara \u00dcniversitesi)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I74897591","host_organization_name":"Marmara University","host_organization_lineage":["https://openalex.org/I74897591"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":{"id":"doi:10.1111/and.14616","doi":"https://doi.org/10.1111/and.14616","is_oa":true,"landing_page_url":"https://doi.org/10.1111/and.14616","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/and.14616","source":{"id":"https://openalex.org/S87865284","display_name":"Andrologia","issn_l":"0303-4569","issn":["0303-4569","1439-0272"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Andrologia","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9907000064849854,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7699999809265137,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4307226503.pdf","grobid_xml":"https://content.openalex.org/works/W4307226503.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W51382797","https://openalex.org/W182778844","https://openalex.org/W1530421518","https://openalex.org/W2009001450","https://openalex.org/W2028597443","https://openalex.org/W2075282777","https://openalex.org/W2094051883","https://openalex.org/W2124393451","https://openalex.org/W2151493966","https://openalex.org/W2316225064","https://openalex.org/W2531712020","https://openalex.org/W2563703915","https://openalex.org/W2598678077","https://openalex.org/W2753147441","https://openalex.org/W2761909394","https://openalex.org/W2767765728","https://openalex.org/W2781852782","https://openalex.org/W2793448482","https://openalex.org/W2808584198","https://openalex.org/W2832545210","https://openalex.org/W2885478105","https://openalex.org/W2898359156","https://openalex.org/W2909214678","https://openalex.org/W2915432665","https://openalex.org/W2949714132","https://openalex.org/W2966115229","https://openalex.org/W2967476539","https://openalex.org/W2969802327","https://openalex.org/W2972217041","https://openalex.org/W2998117498","https://openalex.org/W3033364661","https://openalex.org/W3047498876","https://openalex.org/W3090104643","https://openalex.org/W3091713160","https://openalex.org/W3101072710","https://openalex.org/W3107402251","https://openalex.org/W3114952911","https://openalex.org/W3137764324","https://openalex.org/W3152961402","https://openalex.org/W3157030715","https://openalex.org/W3164610060","https://openalex.org/W3166168423","https://openalex.org/W3185437220","https://openalex.org/W3194984079","https://openalex.org/W3196036761","https://openalex.org/W4210521722","https://openalex.org/W4220923512","https://openalex.org/W4225258033","https://openalex.org/W4247766583"],"related_works":["https://openalex.org/W2783560067","https://openalex.org/W2078735261","https://openalex.org/W3128190703","https://openalex.org/W4394861584","https://openalex.org/W2990297874","https://openalex.org/W2019339754","https://openalex.org/W4285523872","https://openalex.org/W2994923811","https://openalex.org/W4402313115","https://openalex.org/W4240218695"],"abstract_inverted_index":{"Testicular":[0],"ischaemia":[1],"reperfusion":[2,97],"(I/R)":[3],"injury":[4,28,173,219],"results":[5],"with":[6],"serious":[7],"dysfunctions":[8],"in":[9,29,62,74,147,154,194,216,246],"testis.":[10],"This":[11],"study":[12],"aims":[13],"to":[14,49,68,81,91,126,236],"explore":[15,237],"effects":[16],"of":[17,84,104,241],"soluble":[18],"guanylate":[19],"cyclase":[20],"(sGC)":[21],"stimulator":[22],"Riociguat":[23,88,116,155,161,201,242],"on":[24],"experimental":[25,70],"testicular":[26,71,217,247],"I/R":[27,218,248],"rats.":[30],"Twenty-one":[31],"male":[32],"rats":[33],"were":[34,59,79,89,107,112,151],"divided":[35],"into":[36],"three":[37],"groups":[38,78],"(Control,":[39],"IR":[40,55,75,128,149,195],"and":[41,56,76,87,109,122,141,144,180,190,225,243],"IRR).":[42],"The":[43,133],"control":[44],"group":[45,129,150,196],"was":[46,163],"not":[47],"exposed":[48],"any":[50],"application.":[51],"Bilateral":[52],"testis":[53],"from":[54],"IRR":[57,77],"animals":[58,93,106,157],"rotated":[60],"720\u00b0":[61],"opposite":[63],"directions":[64],"for":[65,114],"3":[66,82],"h":[67,83],"induce":[69],"ischaemia.":[72],"Animals":[73],"subjected":[80],"reperfusion.":[85],"Isotonic":[86],"administered":[90],"the":[92,102,127,148,238],"30":[94],"min":[95],"prior":[96],"by":[98,220],"oral":[99],"gavage.":[100],"At":[101],"end":[103],"experiment,":[105],"sacrificed":[108],"tissue":[110,120,172],"samples":[111],"used":[113],"analyses.":[115],"treatment":[117,162,202],"significantly":[118,165,181],"decreased":[119],"malondialdehyde":[121],"Luminol":[123],"levels":[124,179],"compared":[125],"(p":[130,158,182,197],"<":[131,159,183,198],"0.05).":[132,160],"pathological":[134],"changes,":[135],"pro-apoptotic":[136],"proteins":[137],"(Bax,":[138],"Caspase":[139,142],"3,":[140],"9)":[143],"apoptotic":[145,226],"index":[146],"down":[152],"regulated":[153],"treated":[156],"also":[164],"increased":[166,193],"anti-apoptotic":[167],"Bcl-2":[168],"expression,":[169],"but":[170,200,230],"alleviated":[171],"via":[174],"modulating":[175,221],"pro-inflammatory":[176],"cytokine":[177],"IL-1\u03b2":[178],"0.05)":[184],"down-regulating":[185],"NF-\u03baB":[186],"activity.":[187],"Moreover,":[188],"mTOR":[189],"ERK":[191],"phosphorylation":[192],"0.05),":[199],"reduced":[203],"protein":[204,227],"phosphorylation.":[205],"Our":[206],"experiment":[207],"indicated":[208],"that":[209],"targeting":[210],"sGC":[211],"might":[212],"support":[213],"surgical":[214],"interventions":[215],"oxidative":[222],"stress,":[223],"inflammation,":[224],"expression":[228],"levels,":[229],"more":[231],"detailed":[232],"studies":[233],"are":[234],"required":[235],"protective":[239],"activity":[240],"underlying":[244],"mechanisms":[245],"injury.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-10-30T00:00:00"}
