{"id":"https://openalex.org/W4307210440","doi":"https://doi.org/10.3390/cells11213366","title":"Mesenchymal Stem Cell-Derived Extracellular Vesicles for Therapeutic Use and in Bioengineering Applications","display_name":"Mesenchymal Stem Cell-Derived Extracellular Vesicles for Therapeutic Use and in Bioengineering Applications","publication_year":2022,"publication_date":"2022-10-25","ids":{"openalex":"https://openalex.org/W4307210440","doi":"https://doi.org/10.3390/cells11213366","pmid":"https://pubmed.ncbi.nlm.nih.gov/36359762","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9657427"},"language":"en","primary_location":{"id":"doi:10.3390/cells11213366","doi":"https://doi.org/10.3390/cells11213366","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cells11213366","pdf_url":"https://www.mdpi.com/2073-4409/11/21/3366/pdf?version=1667967526","source":{"id":"https://openalex.org/S2736626452","display_name":"Cells","issn_l":"2073-4409","issn":["2073-4409"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2073-4409/11/21/3366/pdf?version=1667967526","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040597438","display_name":"Caroline McLaughlin","orcid":"https://orcid.org/0000-0003-1593-3121","observed_orcids":["https://orcid.org/0000-0003-1593-3121"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I82783531","display_name":"Penn State Milton S. Hershey Medical Center","ror":"https://ror.org/01h22ap11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I82783531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caroline McLaughlin","raw_affiliation_strings":["Department of Surgery, Penn State Health Milton S. Hershey Medical Center, Hershey, PA 17033, USA"],"raw_orcid":"https://orcid.org/0000-0003-1593-3121","affiliations":[{"raw_affiliation_string":"Department of Surgery, Penn State Health Milton S. Hershey Medical Center, Hershey, PA 17033, USA","institution_ids":["https://openalex.org/I130769515","https://openalex.org/I82783531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046111170","display_name":"Pallab Datta","orcid":"https://orcid.org/0000-0002-7404-4917","observed_orcids":["https://orcid.org/0000-0002-7404-4917"]},"institutions":[{"id":"https://openalex.org/I4210161501","display_name":"National Institute of Pharmaceutical Education and Research","ror":"https://ror.org/04t67vr60","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210161501"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Pallab Datta","raw_affiliation_strings":["Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER) Kolkata, West Bengal 700054, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER) Kolkata, West Bengal 700054, India","institution_ids":["https://openalex.org/I4210161501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089180739","display_name":"Yogendra Pratap Singh","orcid":"https://orcid.org/0000-0003-4941-9323","observed_orcids":["https://orcid.org/0000-0003-4941-9323"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yogendra P. Singh","raw_affiliation_strings":["Department of Biomedical Engineering, Materials Research Institute, The Huck Institutes of Life Sciences, Penn State University, University Park, PA 16802, USA"],"raw_orcid":"https://orcid.org/0000-0003-4941-9323","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Materials Research Institute, The Huck Institutes of Life Sciences, Penn State University, University Park, PA 16802, USA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112487416","display_name":"Alexis L. Lo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I82783531","display_name":"Penn State Milton S. Hershey Medical Center","ror":"https://ror.org/01h22ap11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I82783531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexis Lo","raw_affiliation_strings":["Department of Surgery, Penn State Health Milton S. Hershey Medical Center, Hershey, PA 17033, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Penn State Health Milton S. Hershey Medical Center, Hershey, PA 17033, USA","institution_ids":["https://openalex.org/I130769515","https://openalex.org/I82783531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090089041","display_name":"Summer Horchler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I82783531","display_name":"Penn State Milton S. Hershey Medical Center","ror":"https://ror.org/01h22ap11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I82783531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Summer Horchler","raw_affiliation_strings":["Department of Surgery, Penn State Health Milton S. Hershey Medical Center, Hershey, PA 17033, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Penn State Health Milton S. Hershey Medical Center, Hershey, PA 17033, USA","institution_ids":["https://openalex.org/I130769515","https://openalex.org/I82783531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034108846","display_name":"Irina A. Elcheva","orcid":"https://orcid.org/0000-0002-3992-2817","observed_orcids":["https://orcid.org/0000-0002-3992-2817"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Irina A. Elcheva","raw_affiliation_strings":["Department of Pediatrics, Hematology/Oncology, Penn State College of Medicine, Hershey, PA 17033, USA"],"raw_orcid":"https://orcid.org/0000-0002-3992-2817","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Hematology/Oncology, Penn State College of Medicine, Hershey, PA 17033, USA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083046197","display_name":"Ibrahim Tarik Ozbolat","orcid":"https://orcid.org/0000-0001-8328-4528","observed_orcids":["https://orcid.org/0000-0001-8328-4528"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ibrahim T. Ozbolat","raw_affiliation_strings":["Department of Biomedical Engineering, Materials Research Institute, The Huck Institutes of Life Sciences, Penn State University, University Park, PA 16802, USA"],"raw_orcid":"https://orcid.org/0000-0001-8328-4528","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Materials Research Institute, The Huck Institutes of Life Sciences, Penn State University, University Park, PA 16802, USA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056618662","display_name":"Dino J. Ravnic","orcid":"https://orcid.org/0000-0003-2261-5180","observed_orcids":["https://orcid.org/0000-0003-2261-5180"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I82783531","display_name":"Penn State Milton S. Hershey Medical Center","ror":"https://ror.org/01h22ap11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I82783531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dino J. Ravnic","raw_affiliation_strings":["Department of Surgery, Penn State Health Milton S. Hershey Medical Center, Hershey, PA 17033, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Penn State Health Milton S. Hershey Medical Center, Hershey, PA 17033, USA","institution_ids":["https://openalex.org/I130769515","https://openalex.org/I82783531"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072425635","display_name":"Srinivas V. Koduru","orcid":"https://orcid.org/0000-0001-6827-2908","observed_orcids":["https://orcid.org/0000-0001-6827-2908"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I82783531","display_name":"Penn State Milton S. Hershey Medical Center","ror":"https://ror.org/01h22ap11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I82783531"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Srinivas V. Koduru","raw_affiliation_strings":["Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, PA 17033, USA","Department of Surgery, Penn State Health Milton S. Hershey Medical Center, Hershey, PA 17033, USA"],"raw_orcid":"https://orcid.org/0000-0001-6827-2908","affiliations":[{"raw_affiliation_string":"Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, PA 17033, USA","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"Department of Surgery, Penn State Health Milton S. Hershey Medical Center, Hershey, PA 17033, USA","institution_ids":["https://openalex.org/I130769515","https://openalex.org/I82783531"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5072425635"],"corresponding_institution_ids":["https://openalex.org/I130769515","https://openalex.org/I82783531"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2303},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2303},"fwci":0.9716,"has_fulltext":true,"cited_by_count":58,"citation_normalized_percentile":{"value":0.7229465,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"11","issue":"21","first_page":"3366","last_page":"3366"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.921999990940094},{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"extracellular vesicles","score":0.9980000257492065},{"id":"https://openalex.org/keywords/paracrine-signaling","display_name":"paracrine signaling","score":0.9100000262260437},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.5690000057220459},{"id":"https://openalex.org/keywords/immunogenicity","display_name":"immunogenicity","score":0.703000009059906},{"id":"https://openalex.org/keywords/allogeneic-cell-transplantation","display_name":"allogeneic cell transplantation","score":0.7630000114440918},{"id":"https://openalex.org/keywords/ev-based-therapeutics","display_name":"EV-based therapeutics","score":0.5680000185966492},{"id":"https://openalex.org/keywords/3d-bioprinting","display_name":"3D bioprinting","score":0.9660000205039978},{"id":"https://openalex.org/keywords/tissue-engineering","display_name":"tissue engineering","score":0.5799999833106995}],"concepts":[{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.8144298791885376},{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.7137194871902466},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.6983093619346619},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6665008068084717},{"id":"https://openalex.org/C2781261824","wikidata":"https://www.wikidata.org/wiki/Q903634","display_name":"Exosome","level":5,"score":0.5547642111778259},{"id":"https://openalex.org/C2992929900","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicles","level":2,"score":0.545068621635437},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.50801682472229},{"id":"https://openalex.org/C2908689518","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicle","level":5,"score":0.4974527657032013},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.4399797320365906},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4393850862979889},{"id":"https://openalex.org/C2909763251","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicle","level":5,"score":0.4320881962776184},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4243234694004059},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1730523705482483},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07841339707374573},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07658055424690247},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D057005","descriptor_name":"Bioengineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D064987","descriptor_name":"Cell- and Tissue-Based Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3390/cells11213366","doi":"https://doi.org/10.3390/cells11213366","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cells11213366","pdf_url":"https://www.mdpi.com/2073-4409/11/21/3366/pdf?version=1667967526","source":{"id":"https://openalex.org/S2736626452","display_name":"Cells","issn_l":"2073-4409","issn":["2073-4409"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9657427","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9657427","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"Text"},{"id":"pmid:36359762","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36359762","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:dc031809215140c2a1cdcfb62a5d81e3","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/dc031809215140c2a1cdcfb62a5d81e3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cells, Vol 11, Iss 21, p 3366 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/cells11213366","doi":"https://doi.org/10.3390/cells11213366","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cells11213366","pdf_url":"https://www.mdpi.com/2073-4409/11/21/3366/pdf?version=1667967526","source":{"id":"https://openalex.org/S2736626452","display_name":"Cells","issn_l":"2073-4409","issn":["2073-4409"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309370","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10"},{"id":"https://openalex.org/F4320310419","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231"},{"id":"https://openalex.org/F4320333195","display_name":"Penn State College of Medicine","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4307210440.pdf","grobid_xml":"https://content.openalex.org/works/W4307210440.grobid-xml"},"referenced_works_count":170,"referenced_works":["https://openalex.org/W144423133","https://openalex.org/W1525762980","https://openalex.org/W1612482630","https://openalex.org/W1615093431","https://openalex.org/W1632791076","https://openalex.org/W1832220924","https://openalex.org/W1888751811","https://openalex.org/W1922364744","https://openalex.org/W1967367827","https://openalex.org/W1969208019","https://openalex.org/W1977799997","https://openalex.org/W1989674299","https://openalex.org/W1990950572","https://openalex.org/W2003079057","https://openalex.org/W2005755533","https://openalex.org/W2007853610","https://openalex.org/W2018627432","https://openalex.org/W2021685339","https://openalex.org/W2021861291","https://openalex.org/W2054272773","https://openalex.org/W2055313665","https://openalex.org/W2055424631","https://openalex.org/W2057356848","https://openalex.org/W2059357290","https://openalex.org/W2062011959","https://openalex.org/W2066426973","https://openalex.org/W2072176858","https://openalex.org/W2093494581","https://openalex.org/W2094371980","https://openalex.org/W2098259366","https://openalex.org/W2108375854","https://openalex.org/W2119812304","https://openalex.org/W2121354606","https://openalex.org/W2122099309","https://openalex.org/W2122677163","https://openalex.org/W2128891846","https://openalex.org/W2135763340","https://openalex.org/W2145142940","https://openalex.org/W2154215235","https://openalex.org/W2154467674","https://openalex.org/W2157514094","https://openalex.org/W2163912530","https://openalex.org/W2169581526","https://openalex.org/W2170592926","https://openalex.org/W2170852633","https://openalex.org/W2171000684","https://openalex.org/W2185291866","https://openalex.org/W2207291742","https://openalex.org/W2218756943","https://openalex.org/W2235702117","https://openalex.org/W2254178765","https://openalex.org/W2277491622","https://openalex.org/W2281182212","https://openalex.org/W2286093957","https://openalex.org/W2309637019","https://openalex.org/W2325106937","https://openalex.org/W2417871706","https://openalex.org/W2419842412","https://openalex.org/W2466551530","https://openalex.org/W2472451784","https://openalex.org/W2487947432","https://openalex.org/W2504228461","https://openalex.org/W2519687050","https://openalex.org/W2519716821","https://openalex.org/W2520511021","https://openalex.org/W2529295635","https://openalex.org/W2566274288","https://openalex.org/W2586982562","https://openalex.org/W2601082158","https://openalex.org/W2611151408","https://openalex.org/W2613739181","https://openalex.org/W2620679532","https://openalex.org/W2626770589","https://openalex.org/W2662225365","https://openalex.org/W2748042710","https://openalex.org/W2761091945","https://openalex.org/W2761699988","https://openalex.org/W2765492673","https://openalex.org/W2767309788","https://openalex.org/W2767421147","https://openalex.org/W2768238755","https://openalex.org/W2770892112","https://openalex.org/W2779711953","https://openalex.org/W2780538963","https://openalex.org/W2786514708","https://openalex.org/W2789576140","https://openalex.org/W2790794891","https://openalex.org/W2793612642","https://openalex.org/W2795523469","https://openalex.org/W2796990186","https://openalex.org/W2799422921","https://openalex.org/W2800052928","https://openalex.org/W2800659616","https://openalex.org/W2801497388","https://openalex.org/W2804234549","https://openalex.org/W2810276296","https://openalex.org/W2883760436","https://openalex.org/W2884360701","https://openalex.org/W2887684893","https://openalex.org/W2887699894","https://openalex.org/W2896958491","https://openalex.org/W2899470782","https://openalex.org/W2899589061","https://openalex.org/W2900713991","https://openalex.org/W2901596366","https://openalex.org/W2910846482","https://openalex.org/W2914950976","https://openalex.org/W2915270257","https://openalex.org/W2922102878","https://openalex.org/W2922151254","https://openalex.org/W2923687733","https://openalex.org/W2926951419","https://openalex.org/W2937031136","https://openalex.org/W2942913826","https://openalex.org/W2946299561","https://openalex.org/W2949166959","https://openalex.org/W2954174412","https://openalex.org/W2954862425","https://openalex.org/W2969000338","https://openalex.org/W2969502145","https://openalex.org/W2974626482","https://openalex.org/W2980312160","https://openalex.org/W2980461543","https://openalex.org/W2989661489","https://openalex.org/W2990542915","https://openalex.org/W2991481938","https://openalex.org/W2995856749","https://openalex.org/W2996006773","https://openalex.org/W2999225761","https://openalex.org/W2999723972","https://openalex.org/W3000006678","https://openalex.org/W3011174573","https://openalex.org/W3012118032","https://openalex.org/W3013030854","https://openalex.org/W3016824415","https://openalex.org/W3022155704","https://openalex.org/W3023928131","https://openalex.org/W3026908933","https://openalex.org/W3033438356","https://openalex.org/W3034995811","https://openalex.org/W3036058549","https://openalex.org/W3036502321","https://openalex.org/W3037901058","https://openalex.org/W3045339283","https://openalex.org/W3047270100","https://openalex.org/W3081043758","https://openalex.org/W3091906536","https://openalex.org/W3096447928","https://openalex.org/W3105994575","https://openalex.org/W3107027596","https://openalex.org/W3112286367","https://openalex.org/W3118512931","https://openalex.org/W3120552248","https://openalex.org/W3133158427","https://openalex.org/W3147904318","https://openalex.org/W3156656062","https://openalex.org/W3157681989","https://openalex.org/W3157812232","https://openalex.org/W3182697056","https://openalex.org/W3184819565","https://openalex.org/W3193298036","https://openalex.org/W3193915397","https://openalex.org/W3195543111","https://openalex.org/W3203866006","https://openalex.org/W3204953928","https://openalex.org/W3205847423","https://openalex.org/W3212500339","https://openalex.org/W4220679639","https://openalex.org/W6750944199","https://openalex.org/W6760680968"],"related_works":["https://openalex.org/W3080886266","https://openalex.org/W2054939463","https://openalex.org/W2756291141","https://openalex.org/W4406920578","https://openalex.org/W2991481938","https://openalex.org/W1967270924","https://openalex.org/W3032530697","https://openalex.org/W2976429808","https://openalex.org/W3022816938","https://openalex.org/W2793612642"],"abstract_inverted_index":{"Extracellular":[0],"vesicles":[1],"(EVs)":[2],"are":[3,9,106],"small":[4],"lipid":[5],"bilayer-delimited":[6],"particles":[7],"that":[8],"naturally":[10],"released":[11],"from":[12,142],"cells":[13,75,94],"into":[14],"body":[15],"fluids,":[16],"and":[17,21,48,60,83,109,147],"therefore":[18],"can":[19,33,110],"travel":[20,64],"convey":[22],"regulatory":[23],"functions":[24],"in":[25],"the":[26,30,89,128,137],"distal":[27],"parts":[28],"of":[29,86,92,127,139,145,153],"body.":[31,129],"EVs":[32,63,105,140],"transmit":[34],"paracrine":[35],"signaling":[36,120],"by":[37,98,118],"carrying":[38],"over":[39],"cytokines,":[40],"chemokines,":[41],"growth":[42],"factors,":[43,47],"interleukins":[44],"(ILs),":[45],"transcription":[46],"nucleic":[49],"acids":[50],"such":[51,156],"as":[52,112,157],"DNA,":[53],"mRNAs,":[54],"microRNAs,":[55],"piRNAs,":[56],"lncRNAs,":[57],"sn/snoRNAs,":[58],"mtRNAs":[59],"circRNAs;":[61],"these":[62,93],"to":[65,68,80,115,124,160],"predecided":[66],"destinations":[67],"perform":[69],"their":[70],"functions.":[71],"While":[72],"mesenchymal":[73],"stem":[74],"(MSCs)":[76],"have":[77],"been":[78],"shown":[79],"improve":[81],"healing":[82],"facilitate":[84],"treatments":[85],"various":[87],"diseases,":[88],"allogenic":[90],"use":[91],"is":[95,133,164],"often":[96],"accompanied":[97],"serious":[99],"adverse":[100],"effects":[101],"after":[102],"transplantation.":[103],"MSC-produced":[104],"less":[107],"immunogenic":[108],"serve":[111],"an":[113],"alternative":[114],"cellular":[116],"therapies":[117,163],"transmitting":[119],"or":[121],"delivering":[122],"biomaterials":[123],"diseased":[125],"areas":[126],"This":[130],"review":[131],"article":[132],"focused":[134],"on":[135],"understanding":[136],"properties":[138],"derived":[141],"different":[143],"types":[144],"MSCs":[146],"MSC-EV-based":[148],"therapeutic":[149],"options.":[150],"The":[151],"potential":[152],"modern":[154],"technologies":[155],"3D":[158],"bioprinting":[159],"advance":[161],"EV-based":[162],"also":[165],"discussed.":[166]},"counts_by_year":[{"year":2026,"cited_by_count":21},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":18},{"year":2023,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-10-30T00:00:00"}