{"id":"https://openalex.org/W4307092425","doi":"https://doi.org/10.1111/all.15561","title":"Scalp biomarkers during dupilumab treatment support Th2 pathway pathogenicity in alopecia areata","display_name":"Scalp biomarkers during dupilumab treatment support Th2 pathway pathogenicity in alopecia areata","publication_year":2022,"publication_date":"2022-10-22","ids":{"openalex":"https://openalex.org/W4307092425","doi":"https://doi.org/10.1111/all.15561","pmid":"https://pubmed.ncbi.nlm.nih.gov/36271804"},"language":"en","primary_location":{"id":"doi:10.1111/all.15561","doi":"https://doi.org/10.1111/all.15561","is_oa":false,"landing_page_url":"https://doi.org/10.1111/all.15561","pdf_url":null,"source":{"id":"https://openalex.org/S68090385","display_name":"Allergy","issn_l":"0105-4538","issn":["0105-4538","1398-9995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11344221","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016998382","display_name":"Yael Renert\u2010Yuval","orcid":"https://orcid.org/0000-0002-2876-3048","observed_orcids":["https://orcid.org/0000-0002-2876-3048"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yael Renert\u2010Yuval","raw_affiliation_strings":["Laboratory for Investigative Dermatology Rockefeller University  New York New York USA","Laboratory of Inflammatory Skin Diseases, Department of Dermatology Icahn School of Medicine at Mount Sinai  New York New York USA"],"raw_orcid":"https://orcid.org/0000-0002-2876-3048","affiliations":[{"raw_affiliation_string":"Laboratory for Investigative Dermatology Rockefeller University  New York New York USA","institution_ids":["https://openalex.org/I83399316"]},{"raw_affiliation_string":"Laboratory of Inflammatory Skin Diseases, Department of Dermatology Icahn School of Medicine at Mount Sinai  New York New York USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032965176","display_name":"Ana Br\u00e2ndu\u015fa Pavel","orcid":"https://orcid.org/0000-0002-0497-8351","observed_orcids":["https://orcid.org/0000-0002-0497-8351","https://orcid.org/0000-0002-8155-8553"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ana B. Pavel","raw_affiliation_strings":["Laboratory of Inflammatory Skin Diseases, Department of Dermatology Icahn School of Medicine at Mount Sinai  New York New York USA"],"raw_orcid":"https://orcid.org/0000-0002-0497-8351","affiliations":[{"raw_affiliation_string":"Laboratory of Inflammatory Skin Diseases, Department of Dermatology Icahn School of Medicine at Mount Sinai  New York New York USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008637093","display_name":"Ester DEL DUCA","orcid":"https://orcid.org/0000-0001-7948-8536","observed_orcids":["https://orcid.org/0000-0001-7948-8536"]},"institutions":[{"id":"https://openalex.org/I36443711","display_name":"Magna Graecia University","ror":"https://ror.org/0530bdk91","country_code":"IT","type":"education","lineage":["https://openalex.org/I36443711"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"Ester Del Duca","raw_affiliation_strings":["Department of Dermatology University of Magna Graecia  Catanzaro Italy","Laboratory of Inflammatory Skin Diseases, Department of Dermatology Icahn School of Medicine at Mount Sinai  New York New York USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology University of Magna Graecia  Catanzaro Italy","institution_ids":["https://openalex.org/I36443711"]},{"raw_affiliation_string":"Laboratory of Inflammatory Skin Diseases, Department of Dermatology Icahn School of Medicine at Mount Sinai  New York New York USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019346097","display_name":"Paola Facheris","orcid":"https://orcid.org/0000-0002-5171-9854","observed_orcids":["https://orcid.org/0000-0002-5171-9854"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paola Facheris","raw_affiliation_strings":["Laboratory of Inflammatory Skin Diseases, Department of Dermatology Icahn School of Medicine at Mount Sinai  New York New York USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Inflammatory Skin Diseases, Department of Dermatology Icahn School of Medicine at Mount Sinai  New York New York USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023759240","display_name":"Angel D. Pagan","orcid":"https://orcid.org/0000-0002-4913-6705","observed_orcids":["https://orcid.org/0000-0002-4913-6705"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angel D. Pagan","raw_affiliation_strings":["Laboratory of Inflammatory Skin Diseases, Department of Dermatology Icahn School of Medicine at Mount Sinai  New York New York USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Inflammatory Skin Diseases, Department of Dermatology Icahn School of Medicine at Mount Sinai  New York New York USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025750733","display_name":"Swaroop N. Bose","orcid":"https://orcid.org/0000-0002-4337-9490","observed_orcids":["https://orcid.org/0000-0002-4337-9490"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Swaroop Bose","raw_affiliation_strings":["Laboratory of Inflammatory Skin Diseases, Department of Dermatology Icahn School of Medicine at Mount Sinai  New York New York USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Inflammatory Skin Diseases, Department of Dermatology Icahn School of Medicine at Mount Sinai  New York New York USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081438744","display_name":"Pedro J. G\u00f3mez\u2010Arias","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pedro J. G\u00f3mez\u2010Arias","raw_affiliation_strings":["Laboratory of Inflammatory Skin Diseases, Department of Dermatology Icahn School of Medicine at Mount Sinai  New York New York USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Inflammatory Skin Diseases, Department of Dermatology Icahn School of Medicine at Mount Sinai  New York New York USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015278488","display_name":"Michael Angelov","orcid":"https://orcid.org/0000-0001-7272-7143","observed_orcids":["https://orcid.org/0000-0001-7272-7143"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Angelov","raw_affiliation_strings":["Laboratory of Inflammatory Skin Diseases, Department of Dermatology Icahn School of Medicine at Mount Sinai  New York New York USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Inflammatory Skin Diseases, Department of Dermatology Icahn School of Medicine at Mount Sinai  New York New York USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032316948","display_name":"Jennifer Bares","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Bares","raw_affiliation_strings":["Laboratory of Inflammatory Skin Diseases, Department of Dermatology Icahn School of Medicine at Mount Sinai  New York New York USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Inflammatory Skin Diseases, Department of Dermatology Icahn School of Medicine at Mount Sinai  New York New York USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112250931","display_name":"Margot Chima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margo Chima","raw_affiliation_strings":["Laboratory of Inflammatory Skin Diseases, Department of Dermatology Icahn School of Medicine at Mount Sinai  New York New York USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Inflammatory Skin Diseases, Department of Dermatology Icahn School of Medicine at Mount Sinai  New York New York USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035849206","display_name":"Yeriel D. Estrada","orcid":"https://orcid.org/0000-0002-5172-6747","observed_orcids":["https://orcid.org/0000-0002-5172-6747"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yeriel D. Estrada","raw_affiliation_strings":["Laboratory of Inflammatory Skin Diseases, Department of Dermatology Icahn School of Medicine at Mount Sinai  New York New York USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Inflammatory Skin Diseases, Department of Dermatology Icahn School of Medicine at Mount Sinai  New York New York USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067348327","display_name":"Sandra Garcet","orcid":"https://orcid.org/0000-0002-4465-8547","observed_orcids":["https://orcid.org/0000-0002-4465-8547"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandra Garcet","raw_affiliation_strings":["Laboratory for Investigative Dermatology Rockefeller University  New York New York USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Investigative Dermatology Rockefeller University  New York New York USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038505651","display_name":"Mark Lebwohl","orcid":"https://orcid.org/0000-0002-4705-5303","observed_orcids":["https://orcid.org/0000-0002-4705-5303"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark G. Lebwohl","raw_affiliation_strings":["Laboratory of Inflammatory Skin Diseases, Department of Dermatology Icahn School of Medicine at Mount Sinai  New York New York USA"],"raw_orcid":"https://orcid.org/0000-0002-4705-5303","affiliations":[{"raw_affiliation_string":"Laboratory of Inflammatory Skin Diseases, Department of Dermatology Icahn School of Medicine at Mount Sinai  New York New York USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080337749","display_name":"James G. Krueger","orcid":"https://orcid.org/0000-0002-3775-1778","observed_orcids":["https://orcid.org/0000-0002-3775-1778"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James G. Krueger","raw_affiliation_strings":["Laboratory for Investigative Dermatology Rockefeller University  New York New York USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Investigative Dermatology Rockefeller University  New York New York USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024365532","display_name":"Emma Guttman\u2010Yassky","orcid":"https://orcid.org/0000-0002-9363-324X","observed_orcids":["https://orcid.org/0000-0002-9363-324X"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emma Guttman\u2010Yassky","raw_affiliation_strings":["Laboratory of Inflammatory Skin Diseases, Department of Dermatology Icahn School of Medicine at Mount Sinai  New York New York USA"],"raw_orcid":"https://orcid.org/0000-0002-9363-324X","affiliations":[{"raw_affiliation_string":"Laboratory of Inflammatory Skin Diseases, Department of Dermatology Icahn School of Medicine at Mount Sinai  New York New York USA","institution_ids":["https://openalex.org/I98704320"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4900,"currency":"USD","value_usd":4900},"apc_paid":null,"fwci":12.172,"has_fulltext":false,"cited_by_count":58,"citation_normalized_percentile":{"value":0.99236492,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"78","issue":"4","first_page":"1047","last_page":"1059"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alopecia-areata","display_name":"alopecia areata","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dupilumab","display_name":"dupilumab","score":1.0},{"id":"https://openalex.org/keywords/th2-pathway","display_name":"Th2 pathway","score":0.8989999890327454},{"id":"https://openalex.org/keywords/hair-keratin","display_name":"hair keratin","score":0.8460000157356262},{"id":"https://openalex.org/keywords/th1-cytokines","display_name":"Th1 cytokines","score":0.7269999980926514},{"id":"https://openalex.org/keywords/atopy","display_name":"atopy","score":0.7730000019073486},{"id":"https://openalex.org/keywords/hair-regrowth","display_name":"hair regrowth","score":0.9670000076293945},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.6380000114440918},{"id":"https://openalex.org/keywords/early-treatment-response","display_name":"early treatment response","score":0.3970000147819519}],"concepts":[{"id":"https://openalex.org/C2779824493","wikidata":"https://www.wikidata.org/wiki/Q5315925","display_name":"Dupilumab","level":3,"score":0.9759427309036255},{"id":"https://openalex.org/C2777524370","wikidata":"https://www.wikidata.org/wiki/Q5075435","display_name":"Alopecia areata","level":2,"score":0.9714082479476929},{"id":"https://openalex.org/C2778515351","wikidata":"https://www.wikidata.org/wiki/Q9622","display_name":"Scalp","level":2,"score":0.6642547249794006},{"id":"https://openalex.org/C2778329239","wikidata":"https://www.wikidata.org/wiki/Q268667","display_name":"Atopic dermatitis","level":2,"score":0.5580793619155884},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5404428243637085},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5341419577598572},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.5060839056968689},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.502192497253418}],"mesh":[{"descriptor_ui":"D000506","descriptor_name":"Alopecia Areata","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000506","descriptor_name":"Alopecia Areata","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000506","descriptor_name":"Alopecia Areata","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000506","descriptor_name":"Alopecia Areata","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012535","descriptor_name":"Scalp","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012535","descriptor_name":"Scalp","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012535","descriptor_name":"Scalp","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012535","descriptor_name":"Scalp","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014774","descriptor_name":"Virulence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014774","descriptor_name":"Virulence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014774","descriptor_name":"Virulence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014774","descriptor_name":"Virulence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053564","descriptor_name":"Keratins, Hair-Specific","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D053564","descriptor_name":"Keratins, Hair-Specific","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D053564","descriptor_name":"Keratins, Hair-Specific","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D053564","descriptor_name":"Keratins, Hair-Specific","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/all.15561","doi":"https://doi.org/10.1111/all.15561","is_oa":false,"landing_page_url":"https://doi.org/10.1111/all.15561","pdf_url":null,"source":{"id":"https://openalex.org/S68090385","display_name":"Allergy","issn_l":"0105-4538","issn":["0105-4538","1398-9995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergy","raw_type":"journal-article"},{"id":"pmid:36271804","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36271804","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergy","raw_type":"Randomized Controlled Trial"},{"id":"pmh:oai:pubmedcentral.nih.gov:11344221","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11344221","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Allergy","raw_type":"Text"},{"id":"pmh:oai:iris.uniroma1.it:11573/1712007","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11573/1712007","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:11344221","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11344221","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Allergy","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.800000011920929}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G9000909024","display_name":"Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success","funder_award_id":"UL1TR001866","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320311600","display_name":"Regeneron Pharmaceuticals","ror":"https://ror.org/02f51rf24"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W1948399611","https://openalex.org/W1966059955","https://openalex.org/W1996278388","https://openalex.org/W2000922493","https://openalex.org/W2031487819","https://openalex.org/W2049804077","https://openalex.org/W2064089850","https://openalex.org/W2068259827","https://openalex.org/W2069364241","https://openalex.org/W2076896224","https://openalex.org/W2103825953","https://openalex.org/W2127196816","https://openalex.org/W2137526110","https://openalex.org/W2138207763","https://openalex.org/W2139730563","https://openalex.org/W2152812950","https://openalex.org/W2153422316","https://openalex.org/W2163968757","https://openalex.org/W2169456326","https://openalex.org/W2199733448","https://openalex.org/W2230599036","https://openalex.org/W2279527004","https://openalex.org/W2360881202","https://openalex.org/W2432815617","https://openalex.org/W2766619563","https://openalex.org/W2804830550","https://openalex.org/W2859717791","https://openalex.org/W2892288216","https://openalex.org/W2896189628","https://openalex.org/W2912961096","https://openalex.org/W2914096765","https://openalex.org/W2923748325","https://openalex.org/W2940378003","https://openalex.org/W2953477425","https://openalex.org/W2970954519","https://openalex.org/W3004436169","https://openalex.org/W3010126302","https://openalex.org/W3013147675","https://openalex.org/W3034958681","https://openalex.org/W3043372169","https://openalex.org/W3085268199","https://openalex.org/W3091222502","https://openalex.org/W3124513630","https://openalex.org/W3135199447","https://openalex.org/W3139214381","https://openalex.org/W3139259218","https://openalex.org/W3196343717","https://openalex.org/W3217308671","https://openalex.org/W4281952996"],"related_works":["https://openalex.org/W3167826726","https://openalex.org/W3180031743","https://openalex.org/W2408550297","https://openalex.org/W3177720512","https://openalex.org/W4237621822","https://openalex.org/W4225834195","https://openalex.org/W3043783927","https://openalex.org/W3041364120","https://openalex.org/W2111183337","https://openalex.org/W4323567762"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1],"mechanisms":[2],"driving":[3],"alopecia":[4],"areata":[5],"(AA)":[6],"are":[7],"still":[8],"unclear,":[9],"hindering":[10],"development":[11],"of":[12,34,103,210,227],"targeted":[13],"therapeutics.":[14],"Specific":[15],"Th2":[16,35,228,244],"targeting":[17],"with":[18,84,115,184,200,221],"dupilumab":[19,55,64,211],"in":[20,41,44,69,118,139,149,166,179,193,202,213],"AA":[21,45,141,152,247],"provides":[22],"a":[23,240],"unique":[24],"opportunity":[25],"to":[26,53,218],"dissect":[27],"its":[28],"pathogenesis":[29],"and":[30,48,78,80,106,146,158,230],"explore":[31],"the":[32,119,150,167],"role":[33,242],"pathway.":[36],"METHODS:":[37],"We":[38],"evaluated":[39],"changes":[40],"scalp":[42,153],"biomarkers":[43,207],"patients":[46,99,131,175],"(with":[47],"without":[49],"concomitant":[50],"atopy)":[51],"randomized":[52],"weekly":[54],"or":[56],"placebo":[57,168],"for":[58,65,243],"24":[59,66,157],"weeks,":[60],"followed":[61],"by":[62],"open-label":[63,133],"weeks.":[67],"Changes":[68],"biomarker":[70],"levels":[71],"were":[72,81,136],"measured":[73],"at":[74,155,170,186],"weeks":[75,156],"12,":[76],"24,":[77,91,191],"48":[79],"also":[82],"correlated":[83],"clinical":[85,93,219],"hair":[86,94,120,180,194,232],"regrowth.":[87],"RESULTS:":[88],"At":[89,189],"week":[90,171,187,190],"preceding":[92],"regrowth":[95],"outcomes,":[96],"only":[97,199],"dupilumab-treated":[98],"presented":[100,176],"significant":[101,116,197],"suppression":[102,123,226],"cellular":[104],"infiltrates,":[105],"multiple":[107],"Th2-related,":[108],"markers":[109,229],"(CCL13/MCP-4,":[110],"CCL18/PARC,":[111],"CCL26/eotaxin-3,":[112],"CCL24/Eotaxin-2),":[113],"coupled":[114],"upregulation":[117],"keratins.":[121,233],"Th1-related":[122],"was":[124,164],"evident":[125],"later":[126],"(week":[127],"48)":[128],"when":[129,182],"all":[130],"received":[132],"dupilumab.":[134],"Results":[135],"more":[137],"pronounced":[138],"atopic":[140],"patients,":[142],"that":[143],"showed":[144,196],"48%":[145],"97%":[147],"improvements":[148],"lesional":[151],"profile":[154],"48,":[159],"respectively,":[160],"while":[161],"2%":[162],"worsening":[163,178],"seen":[165],"arm":[169],"24.":[172,188],"Moreover,":[173],"placebo-treated":[174],"54%":[177],"keratins":[181,195],"compared":[183],"baseline":[185],"increases":[192],"correlations":[198,223],"decreases":[201],"Th2-related":[203],"markers.":[204],"CONCLUSIONS:":[205],"Scalp":[206],"provide":[208],"evidence":[209],"efficacy":[212],"AA,":[214],"detected":[215],"even":[216],"prior":[217],"response,":[220],"exclusive":[222],"between":[224],"early":[225],"increased":[231],"These":[234],"findings":[235],"strengthen":[236],"previous":[237],"reports":[238],"suggesting":[239],"possible":[241],"cytokines":[245],"as":[246],"drivers.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":17},{"year":2024,"cited_by_count":22},{"year":2023,"cited_by_count":10}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}