{"id":"https://openalex.org/W4307091392","doi":"https://doi.org/10.1111/jnc.15713","title":"Quantitative proteomics of tau and A\u03b2 in detergent fractions from Alzheimer's disease brains","display_name":"Quantitative proteomics of tau and A\u03b2 in detergent fractions from Alzheimer's disease brains","publication_year":2022,"publication_date":"2022-10-22","ids":{"openalex":"https://openalex.org/W4307091392","doi":"https://doi.org/10.1111/jnc.15713","pmid":"https://pubmed.ncbi.nlm.nih.gov/36271678"},"language":"en","primary_location":{"id":"doi:10.1111/jnc.15713","doi":"https://doi.org/10.1111/jnc.15713","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jnc.15713","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084864678","display_name":"Soumya Mukherjee","orcid":"https://orcid.org/0000-0001-5326-4008","observed_orcids":["https://orcid.org/0000-0001-5326-4008"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I242743682","display_name":"Florey Institute of Neuroscience and Mental Health","ror":"https://ror.org/03a2tac74","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165779595","https://openalex.org/I242743682"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Soumya Mukherjee","raw_affiliation_strings":["The Florey Institute, The University of Melbourne, Parkville, Victoria, Australia"],"raw_orcid":"https://orcid.org/0000-0001-5326-4008","affiliations":[{"raw_affiliation_string":"The Florey Institute, The University of Melbourne, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I242743682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053765129","display_name":"C\u00e9line Dubois","orcid":"https://orcid.org/0000-0001-5619-7306","observed_orcids":["https://orcid.org/0000-0001-5619-7306"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I242743682","display_name":"Florey Institute of Neuroscience and Mental Health","ror":"https://ror.org/03a2tac74","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165779595","https://openalex.org/I242743682"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Celine Dubois","raw_affiliation_strings":["The Florey Institute, The University of Melbourne, Parkville, Victoria, Australia"],"raw_orcid":"https://orcid.org/0000-0001-5619-7306","affiliations":[{"raw_affiliation_string":"The Florey Institute, The University of Melbourne, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I242743682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061043399","display_name":"Keyla A. Perez","orcid":"https://orcid.org/0000-0002-8918-8294","observed_orcids":["https://orcid.org/0000-0002-8918-8294"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I242743682","display_name":"Florey Institute of Neuroscience and Mental Health","ror":"https://ror.org/03a2tac74","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165779595","https://openalex.org/I242743682"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Keyla Perez","raw_affiliation_strings":["The Florey Institute, The University of Melbourne, Parkville, Victoria, Australia"],"raw_orcid":"https://orcid.org/0000-0002-8918-8294","affiliations":[{"raw_affiliation_string":"The Florey Institute, The University of Melbourne, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I242743682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102180243","display_name":"Shiji Varghese","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I242743682","display_name":"Florey Institute of Neuroscience and Mental Health","ror":"https://ror.org/03a2tac74","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165779595","https://openalex.org/I242743682"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Shiji Varghese","raw_affiliation_strings":["The Florey Institute, The University of Melbourne, Parkville, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Florey Institute, The University of Melbourne, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I242743682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072355749","display_name":"Ian E. Birchall","orcid":"https://orcid.org/0000-0002-0124-626X","observed_orcids":["https://orcid.org/0000-0002-0124-626X"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I242743682","display_name":"Florey Institute of Neuroscience and Mental Health","ror":"https://ror.org/03a2tac74","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165779595","https://openalex.org/I242743682"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Ian E. Birchall","raw_affiliation_strings":["The Florey Institute, The University of Melbourne, Parkville, Victoria, Australia"],"raw_orcid":"https://orcid.org/0000-0002-0124-626X","affiliations":[{"raw_affiliation_string":"The Florey Institute, The University of Melbourne, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I242743682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009152525","display_name":"Miranda Leckey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I242743682","display_name":"Florey Institute of Neuroscience and Mental Health","ror":"https://ror.org/03a2tac74","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165779595","https://openalex.org/I242743682"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Miranda Leckey","raw_affiliation_strings":["The Florey Institute, The University of Melbourne, Parkville, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Florey Institute, The University of Melbourne, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I242743682"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Natalia Davydova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334950195","display_name":"Australian Nuclear Science and Technology Organisation","ror":"https://ror.org/05j7fep28","country_code":"AU","type":"government","lineage":["https://openalex.org/I1334950195","https://openalex.org/I2801453606","https://openalex.org/I4387156119"]},{"id":"https://openalex.org/I4405259604","display_name":"National Deuteration Facility","ror":"https://ror.org/02f34aa13","country_code":"AU","type":"facility","lineage":["https://openalex.org/I1334950195","https://openalex.org/I2801453606","https://openalex.org/I4387156119","https://openalex.org/I4405259604"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Natalia Davydova","raw_affiliation_strings":["National Deuteration Facility, Australian Nuclear Science and Technology Organization, Lucas Heights, New South Wales, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Deuteration Facility, Australian Nuclear Science and Technology Organization, Lucas Heights, New South Wales, Australia","institution_ids":["https://openalex.org/I1334950195","https://openalex.org/I4405259604"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054461576","display_name":"Catriona McLean","orcid":"https://orcid.org/0000-0002-0302-5727","observed_orcids":["https://orcid.org/0000-0002-0302-5727"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I242743682","display_name":"Florey Institute of Neuroscience and Mental Health","ror":"https://ror.org/03a2tac74","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165779595","https://openalex.org/I242743682"]},{"id":"https://openalex.org/I2801993434","display_name":"The Alfred Hospital","ror":"https://ror.org/01wddqe20","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2801993434","https://openalex.org/I4210163178"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Catriona McLean","raw_affiliation_strings":["Department of Anatomical Pathology, Alfred Hospital, Prahran, Victoria, Australia","The Florey Institute, The University of Melbourne, Parkville, Victoria, Australia"],"raw_orcid":"https://orcid.org/0000-0002-0302-5727","affiliations":[{"raw_affiliation_string":"Department of Anatomical Pathology, Alfred Hospital, Prahran, Victoria, Australia","institution_ids":["https://openalex.org/I2801993434"]},{"raw_affiliation_string":"The Florey Institute, The University of Melbourne, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I242743682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004332610","display_name":"Rebecca M. Nisbet","orcid":"https://orcid.org/0000-0002-3751-9119","observed_orcids":["https://orcid.org/0000-0002-3751-9119"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I242743682","display_name":"Florey Institute of Neuroscience and Mental Health","ror":"https://ror.org/03a2tac74","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165779595","https://openalex.org/I242743682"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Rebecca M. Nisbet","raw_affiliation_strings":["The Florey Institute, The University of Melbourne, Parkville, Victoria, Australia"],"raw_orcid":"https://orcid.org/0000-0002-3751-9119","affiliations":[{"raw_affiliation_string":"The Florey Institute, The University of Melbourne, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I242743682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004863879","display_name":"Blaine Russell Roberts","orcid":"https://orcid.org/0000-0001-5466-0053","observed_orcids":["https://orcid.org/0000-0001-5466-0053"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I242743682","display_name":"Florey Institute of Neuroscience and Mental Health","ror":"https://ror.org/03a2tac74","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165779595","https://openalex.org/I242743682"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Blaine R. Roberts","raw_affiliation_strings":["The Florey Institute, The University of Melbourne, Parkville, Victoria, Australia"],"raw_orcid":"https://orcid.org/0000-0001-5466-0053","affiliations":[{"raw_affiliation_string":"The Florey Institute, The University of Melbourne, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I242743682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005681347","display_name":"Qiao\u2010Xin Li","orcid":"https://orcid.org/0000-0001-8438-3763","observed_orcids":["https://orcid.org/0000-0001-8438-3763"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I242743682","display_name":"Florey Institute of Neuroscience and Mental Health","ror":"https://ror.org/03a2tac74","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165779595","https://openalex.org/I242743682"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Qiao\u2010Xin Li","raw_affiliation_strings":["The Florey Institute, The University of Melbourne, Parkville, Victoria, Australia"],"raw_orcid":"https://orcid.org/0000-0001-8438-3763","affiliations":[{"raw_affiliation_string":"The Florey Institute, The University of Melbourne, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I242743682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047385288","display_name":"Colin Louis Masters","orcid":"https://orcid.org/0000-0003-3072-7940","observed_orcids":["https://orcid.org/0000-0003-3072-7940"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I242743682","display_name":"Florey Institute of Neuroscience and Mental Health","ror":"https://ror.org/03a2tac74","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165779595","https://openalex.org/I242743682"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Colin L. Masters","raw_affiliation_strings":["The Florey Institute, The University of Melbourne, Parkville, Victoria, Australia"],"raw_orcid":"https://orcid.org/0000-0003-3072-7940","affiliations":[{"raw_affiliation_string":"The Florey Institute, The University of Melbourne, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I242743682"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083111142","display_name":"Victor A. Streltsov","orcid":"https://orcid.org/0000-0002-7846-4396","observed_orcids":["https://orcid.org/0000-0002-7846-4396"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I242743682","display_name":"Florey Institute of Neuroscience and Mental Health","ror":"https://ror.org/03a2tac74","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165779595","https://openalex.org/I242743682"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Victor A. Streltsov","raw_affiliation_strings":["The Florey Institute, The University of Melbourne, Parkville, Victoria, Australia"],"raw_orcid":"https://orcid.org/0000-0002-7846-4396","affiliations":[{"raw_affiliation_string":"The Florey Institute, The University of Melbourne, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I242743682"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5083111142","https://openalex.org/A5084864678"],"corresponding_institution_ids":["https://openalex.org/I165779595","https://openalex.org/I242743682"],"apc_list":{"value":4700,"currency":"USD","value_usd":4700},"apc_paid":null,"fwci":2.5654,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.90545813,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"164","issue":"4","first_page":"529","last_page":"552"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9950000047683716},{"id":"https://openalex.org/keywords/tau-protein","display_name":"tau protein","score":0.6869999766349792},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.9359999895095825},{"id":"https://openalex.org/keywords/tau-aggregation","display_name":"tau aggregation","score":0.4320000112056732},{"id":"https://openalex.org/keywords/proline-rich-region","display_name":"proline-rich region","score":0.718999981880188},{"id":"https://openalex.org/keywords/tau-phosphorylation","display_name":"tau phosphorylation","score":0.7120000123977661},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.8240000009536743},{"id":"https://openalex.org/keywords/amyloid-beta-1-42","display_name":"amyloid-beta 42","score":0.7070000171661377},{"id":"https://openalex.org/keywords/tau-filaments","display_name":"tau filaments","score":0.6039999723434448},{"id":"https://openalex.org/keywords/immunogold-labeling","display_name":"immunogold labeling","score":0.6700000166893005},{"id":"https://openalex.org/keywords/postmortem-brain","display_name":"postmortem brain","score":0.6129999756813049}],"concepts":[{"id":"https://openalex.org/C2778670691","wikidata":"https://www.wikidata.org/wiki/Q419507","display_name":"Tau protein","level":4,"score":0.7288080453872681},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.705924391746521},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5864067077636719},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5054225921630859},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.49787330627441406},{"id":"https://openalex.org/C2777739294","wikidata":"https://www.wikidata.org/wiki/Q2397106","display_name":"Tauopathy","level":4,"score":0.4705303907394409},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.46885284781455994},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.45401233434677124},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.444561243057251},{"id":"https://openalex.org/C2776156579","wikidata":"https://www.wikidata.org/wiki/Q417667","display_name":"Amyloid beta","level":3,"score":0.41964447498321533},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3595738708972931},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.317654013633728},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31221866607666016},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.1931692361831665},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.1822274625301361},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.153973788022995},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003902","descriptor_name":"Detergents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003902","descriptor_name":"Detergents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/jnc.15713","doi":"https://doi.org/10.1111/jnc.15713","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jnc.15713","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},{"id":"pmid:36271678","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36271678","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurochemistry","raw_type":"Journal Article"},{"id":"pmh:oai:jupiter.its.unimelb.edu.au:11343/333421","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11343/333421","pdf_url":null,"source":{"id":"https://openalex.org/S4377196259","display_name":"Minerva Access (University of Melbourne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I165779595","host_organization_name":"The University of Melbourne","host_organization_lineage":["https://openalex.org/I165779595"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7887738850","display_name":"Diseases of the aging brain","funder_award_id":"628946","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G8139338663","display_name":"Do Extracellular Vesicles Mediate Progression of Alzheimer's Disease?","funder_award_id":"AARF-18-566256","funder_id":"https://openalex.org/F4320306219","funder_display_name":"Alzheimer's Association"}],"funders":[{"id":"https://openalex.org/F4320306219","display_name":"Alzheimer's Association","ror":"https://ror.org/0375f4d26"},{"id":"https://openalex.org/F4320320974","display_name":"University of Melbourne","ror":"https://ror.org/01ej9dk98"},{"id":"https://openalex.org/F4320322704","display_name":"Tokyo Institute of Technology","ror":"https://ror.org/0112mx960"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":98,"referenced_works":["https://openalex.org/W205316367","https://openalex.org/W1603448131","https://openalex.org/W1618236677","https://openalex.org/W1893669995","https://openalex.org/W1973855353","https://openalex.org/W2005755021","https://openalex.org/W2017377045","https://openalex.org/W2033672635","https://openalex.org/W2036321220","https://openalex.org/W2043661712","https://openalex.org/W2046847750","https://openalex.org/W2057682957","https://openalex.org/W2059809766","https://openalex.org/W2075426349","https://openalex.org/W2083054399","https://openalex.org/W2089331767","https://openalex.org/W2090228228","https://openalex.org/W2091617831","https://openalex.org/W2092704615","https://openalex.org/W2093852116","https://openalex.org/W2109355761","https://openalex.org/W2118012105","https://openalex.org/W2122110838","https://openalex.org/W2132537459","https://openalex.org/W2132629607","https://openalex.org/W2135857094","https://openalex.org/W2141839336","https://openalex.org/W2143216632","https://openalex.org/W2153323361","https://openalex.org/W2170087857","https://openalex.org/W2170776626","https://openalex.org/W2203125727","https://openalex.org/W2253163222","https://openalex.org/W2273923068","https://openalex.org/W2279268939","https://openalex.org/W2319150273","https://openalex.org/W2469515394","https://openalex.org/W2529144260","https://openalex.org/W2568577628","https://openalex.org/W2604285326","https://openalex.org/W2727929522","https://openalex.org/W2765391605","https://openalex.org/W2768374354","https://openalex.org/W2774278644","https://openalex.org/W2791354025","https://openalex.org/W2794390181","https://openalex.org/W2796637563","https://openalex.org/W2802724927","https://openalex.org/W2889082939","https://openalex.org/W2891796239","https://openalex.org/W2900691417","https://openalex.org/W2982620303","https://openalex.org/W3003974826","https://openalex.org/W3005492459","https://openalex.org/W3011927235","https://openalex.org/W3012272172","https://openalex.org/W3031912651","https://openalex.org/W3045987239","https://openalex.org/W3082754683","https://openalex.org/W3102160053","https://openalex.org/W3111942360","https://openalex.org/W3112532663","https://openalex.org/W3119598339","https://openalex.org/W3133020172","https://openalex.org/W3133558561","https://openalex.org/W3134816712","https://openalex.org/W3138745875","https://openalex.org/W3139413239","https://openalex.org/W3157170278","https://openalex.org/W3161140821","https://openalex.org/W3161342469","https://openalex.org/W3178611625","https://openalex.org/W3182665139","https://openalex.org/W3193864919","https://openalex.org/W3198052269","https://openalex.org/W3200284920","https://openalex.org/W3201122724","https://openalex.org/W3202815206","https://openalex.org/W3208691473","https://openalex.org/W4200169681","https://openalex.org/W4200415658","https://openalex.org/W4205765478","https://openalex.org/W4206179494","https://openalex.org/W4210544859","https://openalex.org/W4214871091","https://openalex.org/W4220776729","https://openalex.org/W4220864844","https://openalex.org/W4220960364","https://openalex.org/W4220991397","https://openalex.org/W4224252863","https://openalex.org/W4225741213","https://openalex.org/W4232534952","https://openalex.org/W4281476900","https://openalex.org/W4281624589","https://openalex.org/W4288074063","https://openalex.org/W6769598780","https://openalex.org/W6804948204","https://openalex.org/W7073722236"],"related_works":["https://openalex.org/W4210389940","https://openalex.org/W2529144260","https://openalex.org/W2886794835","https://openalex.org/W3133020172","https://openalex.org/W3082754683","https://openalex.org/W2539044678","https://openalex.org/W2980695902","https://openalex.org/W3102160053","https://openalex.org/W4205331799","https://openalex.org/W4400799529"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"two":[2],"hallmarks":[3],"of":[4,47,56,61,70,88,143,179,191,208,218,233,293],"Alzheimer's":[5],"disease":[6],"(AD)":[7],"are":[8],"amyloid\u2010\u03b2":[9],"(A\u03b2)":[10],"plaques":[11],"and":[12,64,103,109,120,153,187,195,206,213,227,273,283],"neurofibrillary":[13],"tangles":[14],"marked":[15],"by":[16,112],"phosphorylated":[17],"tau.":[18,237],"Increasing":[19],"evidence":[20],"suggests":[21],"that":[22,30,43,175,241,271],"aggregating":[23],"A\u03b2":[24,48,110,254,272,284],"drives":[25],"tau":[26,108,144,155,171,182,197,242,261,274,282],"accumulation,":[27],"a":[28,41,75,165,230,269],"process":[29],"involves":[31],"synaptic":[32],"degeneration":[33],"leading":[34],"to":[35,85,106,136,297],"cognitive":[36],"impairment.":[37],"Conversely,":[38],"there":[39],"is":[40],"realization":[42],"non\u2010fibrillar":[44],"(oligomeric)":[45],"forms":[46],"mediate":[49],"toxicity":[50],"in":[51,91,160,224,235,245,255],"AD.":[52],"Fibrillar":[53],"(filamentous)":[54],"aggregates":[55],"proteins":[57,90],"across":[58],"the":[59,62,68,92,161,176,180,184,225,256,291],"spectrum":[60],"primary":[63],"secondary":[65],"tauopathies":[66],"were":[67,127,157],"focus":[69],"recent":[71],"structural":[72],"studies":[73],"with":[74,130,145,164,198,221,253,260],"filament":[76],"structure\u2010based":[77],"nosologic":[78],"classification,":[79],"but":[80],"less":[81],"emphasis":[82],"was":[83,183],"given":[84],"non\u2010filamentous":[86,247],"co\u2010aggregates":[87],"insoluble":[89],"fractions":[93],"derived":[94],"from":[95,279],"post\u2010mortem":[96],"human":[97],"brains.":[98],"Here,":[99],"we":[100],"revisited":[101],"sarkosyl\u2010soluble":[102],"\u2010insoluble":[104],"extracts":[105],"characterize":[107],"species":[111],"quantitative":[113],"targeted":[114],"mass":[115],"spectrometric":[116],"proteomics,":[117],"biochemical":[118],"assays,":[119],"electron":[121],"microscopy.":[122],"AD":[123,299],"brain":[124],"sarkosyl\u2010insoluble":[125,162,257],"pellets":[126,258],"greatly":[128],"enriched":[129,181],"A\u03b242":[131],"at":[132],"almost":[133],"equimolar":[134],"levels":[135],"N\u2010terminal":[137,170,186],"truncated":[138,192],"microtubule\u2010binding":[139],"region":[140,189],"(MTBR)":[141],"isoforms":[142],"multiple":[146],"site\u2010specific":[147,209],"post\u2010translational":[148],"modifications":[149],"(PTMs).":[150],"MTBR":[151,228,264],"R3":[152],"R4":[154],"peptides":[156],"most":[158],"abundant":[159],"materials":[163],"10\u2010fold":[166],"higher":[167],"concentration":[168,205],"than":[169,201],"peptides.":[172],"This":[173],"indicates":[174],"major":[177],"proportion":[178],"aggregation\u2010prone":[185],"proline\u2010rich":[188],"(PRR)":[190],"mixed":[193],"4R":[194,200],"3R":[196,202],"more":[199],"isoforms.":[203],"High":[204],"occupancies":[207],"phosphorylation":[210],"pT181":[211],"(~22%)":[212],"pT217":[214],"(~16%)":[215],"(key":[216],"biomarkers":[217],"AD)":[219],"along":[220,259],"other":[222],"PTMs":[223,234],"PRR":[226],"indicated":[229],"regional":[231],"susceptibility":[232],"aggregated":[236],"Immunogold":[238],"labelling":[239],"revealed":[240],"may":[243],"exist":[244],"globular":[246,277],"form":[248],"(N\u2010terminal":[249],"intact":[250],"tau)":[251],"co\u2010localized":[252],"filaments":[262],"(N\u2010truncated":[263],"tau).":[265],"Our":[266],"results":[267],"suggest":[268],"model":[270],"interact":[275],"forming":[276],"aggregates,":[278],"which":[280,295],"filamentous":[281],"emerge.":[285],"These":[286],"characterizations":[287],"contribute":[288],"towards":[289],"unravelling":[290],"sequence":[292],"events":[294],"lead":[296],"end\u2010stage":[298],"changes.":[300],"image":[301]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-10-25T00:00:00"}
