{"id":"https://openalex.org/W4306973341","doi":"https://doi.org/10.3389/fphys.2022.1002238","title":"Determinants of ventilatory inefficiency in transthyretin cardiac amyloidosis: The role of excessive ventilatory drive","display_name":"Determinants of ventilatory inefficiency in transthyretin cardiac amyloidosis: The role of excessive ventilatory drive","publication_year":2022,"publication_date":"2022-10-21","ids":{"openalex":"https://openalex.org/W4306973341","doi":"https://doi.org/10.3389/fphys.2022.1002238","pmid":"https://pubmed.ncbi.nlm.nih.gov/36338485","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9634475"},"language":"en","primary_location":{"id":"doi:10.3389/fphys.2022.1002238","doi":"https://doi.org/10.3389/fphys.2022.1002238","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphys.2022.1002238","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphys.2022.1002238/pdf","source":{"id":"https://openalex.org/S52732750","display_name":"Frontiers in Physiology","issn_l":"1664-042X","issn":["1664-042X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fphys.2022.1002238/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039775425","display_name":"Astrid Monfort","orcid":"https://orcid.org/0000-0002-4432-5566","observed_orcids":["https://orcid.org/0000-0002-4432-5566"]},"institutions":[{"id":"https://openalex.org/I4210135110","display_name":"Centre Hospitalier Universitaire de Martinique","ror":"https://ror.org/0376kfa34","country_code":"MQ","type":"healthcare","lineage":["https://openalex.org/I4210135110"]},{"id":"https://openalex.org/I52585520","display_name":"Universit\u00e9 des Antilles","ror":"https://ror.org/02ryfmr77","country_code":"GP","type":"education","lineage":["https://openalex.org/I52585520"]}],"countries":["GP","MQ"],"is_corresponding":false,"raw_author_name":"Astrid Monfort","raw_affiliation_strings":["Cardiovascular Research Team EA7525, Universit\u00e9 des Antilles, Fort de France, France","Department of Cardiology, CHU Martinique (University Hospital of Martinique), Fort de France, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Team EA7525, Universit\u00e9 des Antilles, Fort de France, France","institution_ids":["https://openalex.org/I52585520"]},{"raw_affiliation_string":"Department of Cardiology, CHU Martinique (University Hospital of Martinique), Fort de France, France","institution_ids":["https://openalex.org/I4210135110"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049538066","display_name":"Eug\u00e9nie Thevenet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210135110","display_name":"Centre Hospitalier Universitaire de Martinique","ror":"https://ror.org/0376kfa34","country_code":"MQ","type":"healthcare","lineage":["https://openalex.org/I4210135110"]},{"id":"https://openalex.org/I52585520","display_name":"Universit\u00e9 des Antilles","ror":"https://ror.org/02ryfmr77","country_code":"GP","type":"education","lineage":["https://openalex.org/I52585520"]}],"countries":["GP","MQ"],"is_corresponding":false,"raw_author_name":"Eugenie Thevenet","raw_affiliation_strings":["Cardiovascular Research Team EA7525, Universit\u00e9 des Antilles, Fort de France, France","Department of Cardiology, CHU Martinique (University Hospital of Martinique), Fort de France, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Team EA7525, Universit\u00e9 des Antilles, Fort de France, France","institution_ids":["https://openalex.org/I52585520"]},{"raw_affiliation_string":"Department of Cardiology, CHU Martinique (University Hospital of Martinique), Fort de France, France","institution_ids":["https://openalex.org/I4210135110"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010280207","display_name":"Mickael Rejaudry Lacavalerie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210135110","display_name":"Centre Hospitalier Universitaire de Martinique","ror":"https://ror.org/0376kfa34","country_code":"MQ","type":"healthcare","lineage":["https://openalex.org/I4210135110"]}],"countries":["MQ"],"is_corresponding":false,"raw_author_name":"Mickael Rejaudry Lacavalerie","raw_affiliation_strings":["Department of Cardiology, CHU Martinique (University Hospital of Martinique), Fort de France, France","Department of Clinical Physiology, CHU Martinique (University Hospital of Martinique), Fort de France, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, CHU Martinique (University Hospital of Martinique), Fort de France, France","institution_ids":["https://openalex.org/I4210135110"]},{"raw_affiliation_string":"Department of Clinical Physiology, CHU Martinique (University Hospital of Martinique), Fort de France, France","institution_ids":["https://openalex.org/I4210135110"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006797660","display_name":"Rishika Banydeen","orcid":"https://orcid.org/0000-0002-8237-190X","observed_orcids":["https://orcid.org/0000-0002-8237-190X"]},"institutions":[{"id":"https://openalex.org/I4210135110","display_name":"Centre Hospitalier Universitaire de Martinique","ror":"https://ror.org/0376kfa34","country_code":"MQ","type":"healthcare","lineage":["https://openalex.org/I4210135110"]},{"id":"https://openalex.org/I52585520","display_name":"Universit\u00e9 des Antilles","ror":"https://ror.org/02ryfmr77","country_code":"GP","type":"education","lineage":["https://openalex.org/I52585520"]}],"countries":["GP","MQ"],"is_corresponding":false,"raw_author_name":"Rishika Banydeen","raw_affiliation_strings":["Cardiovascular Research Team EA7525, Universit\u00e9 des Antilles, Fort de France, France","Department of Clinical Research, CHU Martinique (University Hospital of Martinique), Fort de France, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Team EA7525, Universit\u00e9 des Antilles, Fort de France, France","institution_ids":["https://openalex.org/I52585520"]},{"raw_affiliation_string":"Department of Clinical Research, CHU Martinique (University Hospital of Martinique), Fort de France, France","institution_ids":["https://openalex.org/I4210135110"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002852113","display_name":"Jocelyn Inamo","orcid":"https://orcid.org/0000-0002-1057-9699","observed_orcids":["https://orcid.org/0000-0002-1057-9699"]},"institutions":[{"id":"https://openalex.org/I4210135110","display_name":"Centre Hospitalier Universitaire de Martinique","ror":"https://ror.org/0376kfa34","country_code":"MQ","type":"healthcare","lineage":["https://openalex.org/I4210135110"]},{"id":"https://openalex.org/I52585520","display_name":"Universit\u00e9 des Antilles","ror":"https://ror.org/02ryfmr77","country_code":"GP","type":"education","lineage":["https://openalex.org/I52585520"]}],"countries":["GP","MQ"],"is_corresponding":false,"raw_author_name":"Jocelyn Inamo","raw_affiliation_strings":["Cardiovascular Research Team EA7525, Universit\u00e9 des Antilles, Fort de France, France","Department of Cardiology, CHU Martinique (University Hospital of Martinique), Fort de France, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Team EA7525, Universit\u00e9 des Antilles, Fort de France, France","institution_ids":["https://openalex.org/I52585520"]},{"raw_affiliation_string":"Department of Cardiology, CHU Martinique (University Hospital of Martinique), Fort de France, France","institution_ids":["https://openalex.org/I4210135110"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001217840","display_name":"R\u00e9mi Nevi\u00e8re","orcid":"https://orcid.org/0000-0002-7966-0110","observed_orcids":["https://orcid.org/0000-0002-7966-0110"]},"institutions":[{"id":"https://openalex.org/I4210135110","display_name":"Centre Hospitalier Universitaire de Martinique","ror":"https://ror.org/0376kfa34","country_code":"MQ","type":"healthcare","lineage":["https://openalex.org/I4210135110"]},{"id":"https://openalex.org/I52585520","display_name":"Universit\u00e9 des Antilles","ror":"https://ror.org/02ryfmr77","country_code":"GP","type":"education","lineage":["https://openalex.org/I52585520"]}],"countries":["GP","MQ"],"is_corresponding":true,"raw_author_name":"Remi Neviere","raw_affiliation_strings":["Cardiovascular Research Team EA7525, Universit\u00e9 des Antilles, Fort de France, France","Department of Cardiology, CHU Martinique (University Hospital of Martinique), Fort de France, France","Department of Clinical Physiology, CHU Martinique (University Hospital of Martinique), Fort de France, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Team EA7525, Universit\u00e9 des Antilles, Fort de France, France","institution_ids":["https://openalex.org/I52585520"]},{"raw_affiliation_string":"Department of Cardiology, CHU Martinique (University Hospital of Martinique), Fort de France, France","institution_ids":["https://openalex.org/I4210135110"]},{"raw_affiliation_string":"Department of Clinical Physiology, CHU Martinique (University Hospital of Martinique), Fort de France, France","institution_ids":["https://openalex.org/I4210135110"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5001217840"],"corresponding_institution_ids":["https://openalex.org/I4210135110","https://openalex.org/I52585520"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":1.2332,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.77535896,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"13","issue":null,"first_page":"1002238","last_page":"1002238"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11922","display_name":"Cardiovascular Effects of Exercise","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transthyretin-amyloid-cardiomyopathy","display_name":"transthyretin amyloid cardiomyopathy","score":0.9639999866485596},{"id":"https://openalex.org/keywords/ventilatory-inefficiency","display_name":"ventilatory inefficiency","score":0.9120000004768372},{"id":"https://openalex.org/keywords/ve-vco2-slope","display_name":"VE/VCO2 slope","score":0.984000027179718},{"id":"https://openalex.org/keywords/respiratory-drive","display_name":"respiratory drive","score":0.7609999775886536},{"id":"https://openalex.org/keywords/hyperventilation","display_name":"hyperventilation","score":0.9539999961853027},{"id":"https://openalex.org/keywords/exercise-intolerance","display_name":"exercise intolerance","score":0.8330000042915344},{"id":"https://openalex.org/keywords/familial-amyloid-polyneuropathy","display_name":"hereditary transthyretin amyloidosis","score":0.8059999942779541},{"id":"https://openalex.org/keywords/anaerobic-threshold","display_name":"anaerobic threshold","score":0.7639999985694885},{"id":"https://openalex.org/keywords/pulmonary-blood-flow","display_name":"pulmonary blood flow","score":0.5609999895095825},{"id":"https://openalex.org/keywords/sympathetic-stimulation","display_name":"sympathetic stimulation","score":0.7170000076293945},{"id":"https://openalex.org/keywords/heart-rate-recovery","display_name":"heart rate recovery","score":0.7689999938011169},{"id":"https://openalex.org/keywords/interventricular-septal-thickness","display_name":"interventricular septum thickness","score":0.7519999742507935}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7174248099327087},{"id":"https://openalex.org/C2777449187","wikidata":"https://www.wikidata.org/wiki/Q575168","display_name":"Hyperventilation","level":2,"score":0.6890506744384766},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6877041459083557},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6272491216659546},{"id":"https://openalex.org/C2777607188","wikidata":"https://www.wikidata.org/wiki/Q5038315","display_name":"Cardiac amyloidosis","level":3,"score":0.552688717842102},{"id":"https://openalex.org/C200457457","wikidata":"https://www.wikidata.org/wiki/Q584049","display_name":"Ventilation (architecture)","level":2,"score":0.47077107429504395},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.4326286315917969},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fphys.2022.1002238","doi":"https://doi.org/10.3389/fphys.2022.1002238","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphys.2022.1002238","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphys.2022.1002238/pdf","source":{"id":"https://openalex.org/S52732750","display_name":"Frontiers in Physiology","issn_l":"1664-042X","issn":["1664-042X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Physiology","raw_type":"journal-article"},{"id":"pmid:36338485","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36338485","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in physiology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9634475","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9634475/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Physiol","raw_type":"Text"},{"id":"pmh:oai:HAL:hal-04683137v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-04683137","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Physiology, 2022, 13, &#x27E8;10.3389/fphys.2022.1002238&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:04fc514e8f6d46df9e7603695a1121dc","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/04fc514e8f6d46df9e7603695a1121dc","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Physiology, Vol 13 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fphys.2022.1002238","doi":"https://doi.org/10.3389/fphys.2022.1002238","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphys.2022.1002238","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphys.2022.1002238/pdf","source":{"id":"https://openalex.org/S52732750","display_name":"Frontiers in Physiology","issn_l":"1664-042X","issn":["1664-042X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Physiology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4306973341.pdf","grobid_xml":"https://content.openalex.org/works/W4306973341.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1966375856","https://openalex.org/W1981671170","https://openalex.org/W2001659263","https://openalex.org/W2013653398","https://openalex.org/W2044353077","https://openalex.org/W2049316457","https://openalex.org/W2066781238","https://openalex.org/W2075000956","https://openalex.org/W2076720381","https://openalex.org/W2127318804","https://openalex.org/W2150352328","https://openalex.org/W2154473109","https://openalex.org/W2549198059","https://openalex.org/W2610637780","https://openalex.org/W2735021378","https://openalex.org/W2748391199","https://openalex.org/W2789597086","https://openalex.org/W2792017974","https://openalex.org/W2890932667","https://openalex.org/W2937755845","https://openalex.org/W2951943711","https://openalex.org/W2971160408","https://openalex.org/W2971824914","https://openalex.org/W2981067716","https://openalex.org/W3005060659","https://openalex.org/W3037243220","https://openalex.org/W3085675504","https://openalex.org/W3116375614","https://openalex.org/W3157815381","https://openalex.org/W3182766297","https://openalex.org/W3186668188","https://openalex.org/W4206353703","https://openalex.org/W4210975502","https://openalex.org/W4211210278","https://openalex.org/W4214577047","https://openalex.org/W4281655933"],"related_works":["https://openalex.org/W4378781894","https://openalex.org/W3085675504","https://openalex.org/W4409997085","https://openalex.org/W4404425956","https://openalex.org/W2937755845","https://openalex.org/W3005060659","https://openalex.org/W2625885144","https://openalex.org/W4405697687","https://openalex.org/W4414747962","https://openalex.org/W4400682254"],"abstract_inverted_index":{"Background":[0],"and":[1,16,86,155,235],"objective:":[2],"Along":[3],"with":[4,30,110,118,126,137,153],"impaired":[5],"aerobic":[6],"capacity,":[7],"increased":[8,145],"slope":[9,23,96,133,141],"of":[10,52,77,94,166,181,201,219],"the":[11,58,62,198,217],"relationship":[12],"between":[13],"ventilation":[14],"(VE)":[15],"pulmonary":[17,78,237],"CO2":[18],"output":[19],"(VCO2),":[20],"i.e.,":[21],"VE-VCO2":[22,95],"is":[24,39,197],"a":[25],"common":[26],"finding":[27,212],"in":[28,47,66,204,222],"patients":[29,106,128,136,224],"cardiac":[31,120,207],"amyloidosis":[32,114,208],"(CA),":[33],"which":[34,90],"suggests":[35],"ventilatory":[36,45,64,74,130,138,182,190,202],"inefficiency.":[37,183],"Little":[38],"known":[40,92,111],"about":[41],"mechanisms":[42,93],"leading":[43,194],"to":[44,56,81,195,214,231],"inefficiency":[46,131,139,203],"CA":[48,69,127],"patients.":[49,209],"The":[50],"purpose":[51],"this":[53,100],"investigation":[54],"was":[55],"examine":[57],"factors":[59],"that":[60,188],"underlie":[61],"abnormal":[63,236],"efficiency":[65],"transthyretin":[67,113,206],"hereditary":[68,205],"patients,":[70],"such":[71],"as":[72],"excessive":[73,87],"drive,":[75],"inability":[76],"blood":[79],"flow":[80],"increase":[82],"adequately":[83],"during":[84,192],"exercise":[85,193,220],"sympathetic":[88],"stimulation,":[89],"are":[91],"increase.":[97],"Methods:":[98],"In":[99],"single-center":[101],"retrospective":[102],"observational":[103],"study,":[104],"consecutive":[105],"(n":[107],"=":[108,172,175],"41)":[109],"familial":[112],"p.Val142Ile":[115],"mutation":[116],"carriers":[117],"confirmed":[119],"phenotype":[121],"were":[122],"included.":[123],"Results:":[124],"Compared":[125],"without":[129],"(VE-VCO2":[132,140],"<":[134],"36),":[135],"\u2265":[142],"36)":[143],"had":[144],"inter-ventricular":[146],"septum":[147],"thickness,":[148],"lower":[149],"VO2":[150],"peak":[151],"along":[152],"hyperventilation,":[154],"prolonged":[156],"post-exercise":[157],"heart":[158,233],"rate":[159],"recovery.":[160],"By":[161],"multivariate":[162],"analysis,":[163],"only":[164],"excess":[165],"minute-ventilation":[167],"at":[168],"anaerobic":[169],"threshold":[170],"(\u03b2":[171],"0.127;":[173],"p":[174],"0.011)":[176],"remained":[177],"an":[178],"independent":[179],"predictor":[180],"Conclusion:":[184],"Our":[185],"data":[186],"suggest":[187],"high":[189],"stimulation":[191],"hyperventilation":[196],"main":[199],"determinant":[200],"This":[210],"novel":[211],"helps":[213],"better":[215],"understand":[216],"mechanism":[218],"intolerance":[221],"these":[223],"where":[225],"physiological":[226],"limitation":[227],"may":[228],"be":[229],"related":[230],"both":[232],"dysfunction":[234],"response.":[238]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-10-22T00:00:00"}
