{"id":"https://openalex.org/W4306971019","doi":"https://doi.org/10.3389/fncir.2022.753496","title":"Reconstructing neural circuits using multiresolution correlated light and electron microscopy","display_name":"Reconstructing neural circuits using multiresolution correlated light and electron microscopy","publication_year":2022,"publication_date":"2022-10-21","ids":{"openalex":"https://openalex.org/W4306971019","doi":"https://doi.org/10.3389/fncir.2022.753496","pmid":"https://pubmed.ncbi.nlm.nih.gov/36338333","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9635852"},"language":"en","primary_location":{"id":"doi:10.3389/fncir.2022.753496","doi":"https://doi.org/10.3389/fncir.2022.753496","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fncir.2022.753496","pdf_url":"https://www.frontiersin.org/articles/10.3389/fncir.2022.753496/pdf","source":{"id":"https://openalex.org/S73252628","display_name":"Frontiers in Neural Circuits","issn_l":"1662-5110","issn":["1662-5110"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neural Circuits","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fncir.2022.753496/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002480456","display_name":"Karl A. Friedrichsen","orcid":"https://orcid.org/0000-0002-9233-1418","observed_orcids":["https://orcid.org/0000-0002-9233-1418"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karl Friedrichsen","raw_affiliation_strings":["Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, United States","Department of Neuroscience, Washington University in St. Louis, St. Louis, MO, United States","Department of Ophthalmology and Visual Sciences, Washington University in St. Louis, St. Louis, MO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, United States","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Neuroscience, Washington University in St. Louis, St. Louis, MO, United States","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Ophthalmology and Visual Sciences, Washington University in St. Louis, St. Louis, MO, United States","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Pratyush Ramakrishna","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pratyush Ramakrishna","raw_affiliation_strings":["Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, United States","Department of Neuroscience, Washington University in St. Louis, St. Louis, MO, United States","Department of Ophthalmology and Visual Sciences, Washington University in St. Louis, St. Louis, MO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, United States","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Neuroscience, Washington University in St. Louis, St. Louis, MO, United States","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Ophthalmology and Visual Sciences, Washington University in St. Louis, St. Louis, MO, United States","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039790457","display_name":"Jen-Chun Hsiang","orcid":"https://orcid.org/0000-0002-5268-9239","observed_orcids":["https://orcid.org/0000-0002-5268-9239"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jen-Chun Hsiang","raw_affiliation_strings":["Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, United States","Department of Neuroscience, Washington University in St. Louis, St. Louis, MO, United States","Department of Ophthalmology and Visual Sciences, Washington University in St. Louis, St. Louis, MO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, United States","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Neuroscience, Washington University in St. Louis, St. Louis, MO, United States","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Ophthalmology and Visual Sciences, Washington University in St. Louis, St. Louis, MO, United States","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069119656","display_name":"Katia Valkova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katia Valkova","raw_affiliation_strings":["Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, United States","Department of Neuroscience, Washington University in St. Louis, St. Louis, MO, United States","Department of Ophthalmology and Visual Sciences, Washington University in St. Louis, St. Louis, MO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, United States","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Neuroscience, Washington University in St. Louis, St. Louis, MO, United States","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Ophthalmology and Visual Sciences, Washington University in St. Louis, St. Louis, MO, United States","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062248397","display_name":"Daniel Kerschensteiner","orcid":"https://orcid.org/0000-0002-6794-9056","observed_orcids":["https://orcid.org/0000-0002-6794-9056"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Kerschensteiner","raw_affiliation_strings":["Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, United States","Department of Neuroscience, Washington University in St. Louis, St. Louis, MO, United States","Department of Ophthalmology and Visual Sciences, Washington University in St. Louis, St. Louis, MO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, United States","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Neuroscience, Washington University in St. Louis, St. Louis, MO, United States","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Ophthalmology and Visual Sciences, Washington University in St. Louis, St. Louis, MO, United States","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086695747","display_name":"Josh Morgan","orcid":"https://orcid.org/0000-0002-2657-2416","observed_orcids":["https://orcid.org/0000-0002-2657-2416"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Josh L. Morgan","raw_affiliation_strings":["Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, United States","Department of Neuroscience, Washington University in St. Louis, St. Louis, MO, United States","Department of Ophthalmology and Visual Sciences, Washington University in St. Louis, St. Louis, MO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, United States","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Neuroscience, Washington University in St. Louis, St. Louis, MO, United States","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Ophthalmology and Visual Sciences, Washington University in St. Louis, St. Louis, MO, United States","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5086695747"],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":1.8459,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.85584958,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"16","issue":null,"first_page":"753496","last_page":"753496"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10857","display_name":"Advanced Electron Microscopy Techniques and Applications","score":0.9491999745368958,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10857","display_name":"Advanced Electron Microscopy Techniques and Applications","score":0.9491999745368958,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.01360000018030405,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.010700000450015068,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neural-circuit-reconstruction","display_name":"neural circuit reconstruction","score":0.8299999833106995},{"id":"https://openalex.org/keywords/synaptic-organization","display_name":"synaptic organization","score":0.5450000166893005},{"id":"https://openalex.org/keywords/mouse-retina","display_name":"mouse retina","score":0.703000009059906},{"id":"https://openalex.org/keywords/mouse-brain-slices","display_name":"mouse brain slices","score":0.9440000057220459}],"concepts":[{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.605228841304779},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6004112362861633},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.5704463124275208},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5214114189147949},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.46871036291122437},{"id":"https://openalex.org/C93877712","wikidata":"https://www.wikidata.org/wiki/Q132560","display_name":"Electron microscope","level":2,"score":0.4622696340084076},{"id":"https://openalex.org/C138268822","wikidata":"https://www.wikidata.org/wiki/Q1051925","display_name":"Resolution (logic)","level":2,"score":0.4307865798473358},{"id":"https://openalex.org/C205372480","wikidata":"https://www.wikidata.org/wiki/Q210521","display_name":"Image resolution","level":2,"score":0.42175859212875366},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.3382660150527954},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.33491289615631104}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008855","descriptor_name":"Microscopy, Electron, Scanning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.3389/fncir.2022.753496","doi":"https://doi.org/10.3389/fncir.2022.753496","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fncir.2022.753496","pdf_url":"https://www.frontiersin.org/articles/10.3389/fncir.2022.753496/pdf","source":{"id":"https://openalex.org/S73252628","display_name":"Frontiers in Neural Circuits","issn_l":"1662-5110","issn":["1662-5110"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neural Circuits","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9635852","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9635852","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Neural Circuits","raw_type":"Text"},{"id":"pmid:36338333","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36338333","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in neural circuits","raw_type":"Journal Article"},{"id":"pmh:oai:digitalcommons.wustl.edu:oa_4-3241","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.wustl.edu/oa_4/2245","pdf_url":null,"source":{"id":"https://openalex.org/S4306400764","display_name":"Digital Commons@Becker (Washington University School of Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I204465549","host_organization_name":"Washington University in St. Louis","host_organization_lineage":["https://openalex.org/I204465549"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"2020-Current year OA Pubs","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:154772d344b740bdbbb8bc972f3fa0fa","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/154772d344b740bdbbb8bc972f3fa0fa","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Neural Circuits, Vol 16 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fncir.2022.753496","doi":"https://doi.org/10.3389/fncir.2022.753496","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fncir.2022.753496","pdf_url":"https://www.frontiersin.org/articles/10.3389/fncir.2022.753496/pdf","source":{"id":"https://openalex.org/S73252628","display_name":"Frontiers in Neural Circuits","issn_l":"1662-5110","issn":["1662-5110"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neural Circuits","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2392128390","display_name":"Tools and approaches for functional connectomics of dense neuropils","funder_award_id":"R21EY030623","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G2670573768","display_name":"Development and function of glomerular microcircuits in the visual thalamus","funder_award_id":"R01EY029313","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G2994460957","display_name":"Neuronal plasticity in retinal circuit development and disease","funder_award_id":"R01EY023341","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G9000859242","display_name":"Visual pathway cooperation to align viewing strategies and processing specializations for predation","funder_award_id":"R01EY034001","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G9000893103","display_name":"Synapse rescue and neuroprotection in the retina","funder_award_id":"R01EY027411","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G9000917587","display_name":"Synaptic Organization and Function of Retinal Interneurons and Downstream Visual Pathways","funder_award_id":"R01EY026978","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320306811","display_name":"Research to Prevent Blindness","ror":"https://ror.org/04drjs621"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333635","display_name":"Center for Cellular Imaging, Washington University","ror":null},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4306971019.pdf","grobid_xml":"https://content.openalex.org/works/W4306971019.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1505560697","https://openalex.org/W1513082520","https://openalex.org/W1517319742","https://openalex.org/W1585273445","https://openalex.org/W1627384048","https://openalex.org/W1975593040","https://openalex.org/W1977691361","https://openalex.org/W1981731007","https://openalex.org/W1982396943","https://openalex.org/W1985838949","https://openalex.org/W1991875744","https://openalex.org/W2006499654","https://openalex.org/W2012469563","https://openalex.org/W2013878893","https://openalex.org/W2019516397","https://openalex.org/W2022235653","https://openalex.org/W2023949937","https://openalex.org/W2025224767","https://openalex.org/W2026140461","https://openalex.org/W2026981426","https://openalex.org/W2031886209","https://openalex.org/W2036100004","https://openalex.org/W2048450239","https://openalex.org/W2049059765","https://openalex.org/W2093361997","https://openalex.org/W2109343416","https://openalex.org/W2121071682","https://openalex.org/W2121289914","https://openalex.org/W2157151515","https://openalex.org/W2160737695","https://openalex.org/W2160938187","https://openalex.org/W2162407586","https://openalex.org/W2169805405","https://openalex.org/W2254436645","https://openalex.org/W2307899896","https://openalex.org/W2612078078","https://openalex.org/W2735195016","https://openalex.org/W2760861884","https://openalex.org/W2761972343","https://openalex.org/W2766316896","https://openalex.org/W2789207897","https://openalex.org/W2805770110","https://openalex.org/W2893497986","https://openalex.org/W2894268969","https://openalex.org/W2894822713","https://openalex.org/W2922311875","https://openalex.org/W2947838372","https://openalex.org/W2949905780","https://openalex.org/W2959132662","https://openalex.org/W3086057402","https://openalex.org/W3090744416","https://openalex.org/W3091095424","https://openalex.org/W3160415498","https://openalex.org/W3206088544","https://openalex.org/W4232736820"],"related_works":["https://openalex.org/W4310369088","https://openalex.org/W2946124308","https://openalex.org/W2509306306","https://openalex.org/W2901935592","https://openalex.org/W7112278862","https://openalex.org/W1543222687","https://openalex.org/W2623155182","https://openalex.org/W4408993007","https://openalex.org/W4293717806","https://openalex.org/W7204627568"],"abstract_inverted_index":{"Correlated":[0],"light":[1,168],"and":[2,12,122,137,147],"electron":[3,37,79],"microscopy":[4,38],"(CLEM)":[5],"can":[6,70,127],"be":[7,71,129],"used":[8,130,151],"to":[9,31,41,103,131,139,152,157,169],"combine":[10],"functional":[11],"molecular":[13],"characterizations":[14],"of":[15,21,63,91,111,141,149,164],"neurons":[16],"with":[17,60,87,118,124],"detailed":[18],"anatomical":[19,120],"maps":[20,110],"their":[22],"synaptic":[23],"organization.":[24],"Here":[25],"we":[26,160],"describe":[27],"a":[28,67,162,165],"multiresolution":[29,84,88],"approach":[30,55],"CLEM":[32],"(mrCLEM)":[33],"that":[34],"efficiently":[35],"targets":[36],"(EM)":[39],"imaging":[40,86,156],"optically":[42],"characterized":[43],"cells":[44,140],"while":[45],"maintaining":[46],"optimal":[47],"tissue":[48],"preparation":[49],"for":[50],"high-throughput":[51],"EM":[52,85,100,134,158,170],"reconstruction.":[53],"This":[54],"hinges":[56],"on":[57,66],"the":[58,92],"ease":[59],"which":[61],"arrays":[62],"sections":[64],"collected":[65],"solid":[68],"substrate":[69],"repeatedly":[72],"imaged":[73],"at":[74],"different":[75],"scales":[76],"using":[77],"scanning":[78],"microscopy.":[80],"We":[81],"match":[82],"this":[83,145],"confocal":[89],"mapping":[90],"aldehyde-fixed":[93],"tissue.":[94,113],"Features":[95],"visible":[96,105],"in":[97,106],"lower":[98],"resolution":[99],"correspond":[101],"well":[102,173],"features":[104],"densely":[107],"labeled":[108],"optical":[109,155],"fixed":[112],"Iterative":[114],"feature":[115],"matching,":[116],"starting":[117],"gross":[119],"correspondences":[121],"ending":[123],"subcellular":[125],"structure,":[126],"then":[128],"target":[132],"high-resolution":[133],"image":[135],"acquisition":[136],"annotation":[138],"interest.":[142],"To":[143],"demonstrate":[144],"technique":[146],"range":[148],"images":[150],"link":[153],"live":[154],"reconstructions,":[159],"provide":[161],"walkthrough":[163],"mouse":[166,178],"retinal":[167],"experiment":[171],"as":[172,174],"some":[175],"examples":[176],"from":[177],"brain":[179],"slices.":[180]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-10-22T00:00:00"}