{"id":"https://openalex.org/W4306947985","doi":"https://doi.org/10.3389/fendo.2022.1033208","title":"IGF1R is a mediator of sex-specific metabolism in mice: Effects of age and high-fat diet","display_name":"IGF1R is a mediator of sex-specific metabolism in mice: Effects of age and high-fat diet","publication_year":2022,"publication_date":"2022-10-20","ids":{"openalex":"https://openalex.org/W4306947985","doi":"https://doi.org/10.3389/fendo.2022.1033208","pmid":"https://pubmed.ncbi.nlm.nih.gov/36353242","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9638844"},"language":"en","primary_location":{"id":"doi:10.3389/fendo.2022.1033208","doi":"https://doi.org/10.3389/fendo.2022.1033208","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2022.1033208","pdf_url":null,"source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fendo.2022.1033208","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003202911","display_name":"Patricia P\u00e9rez\u2010Matute","orcid":"https://orcid.org/0000-0003-2232-7971","observed_orcids":["https://orcid.org/0000-0003-2232-7971"]},"institutions":[{"id":"https://openalex.org/I4210138511","display_name":"Hospital San Pedro","ror":"https://ror.org/031va0421","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210138511"]},{"id":"https://openalex.org/I4210139648","display_name":"Center for Biomedical Research of La Rioja","ror":"https://ror.org/03vfjzd38","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210139648"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Patricia P\u00e9rez-Matute","raw_affiliation_strings":["Infectious Diseases, Microbiota and Metabolism Unit, Infectious Diseases Department, Center for Biomedical Research of La Rioja (CIBIR) -Hospital Universitario San Pedro, Logro\u00f1o, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases, Microbiota and Metabolism Unit, Infectious Diseases Department, Center for Biomedical Research of La Rioja (CIBIR) -Hospital Universitario San Pedro, Logro\u00f1o, Spain","institution_ids":["https://openalex.org/I4210138511","https://openalex.org/I4210139648"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027998951","display_name":"Ic\u00edar P. L\u00f3pez","orcid":"https://orcid.org/0000-0002-5905-2978","observed_orcids":["https://orcid.org/0000-0002-5905-2978"]},"institutions":[{"id":"https://openalex.org/I4210139648","display_name":"Center for Biomedical Research of La Rioja","ror":"https://ror.org/03vfjzd38","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210139648"]},{"id":"https://openalex.org/I4405267958","display_name":"Servicio Riojano de Salud","ror":"https://ror.org/055trtj48","country_code":"ES","type":"government","lineage":["https://openalex.org/I4405267958"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ic\u00edar P. L\u00f3pez","raw_affiliation_strings":["Lung Cancer and Respiratory Diseases Unit. Fundaci\u00f3n Rioja Salud, Center for Biomedical Research of La Rioja (CIBIR), Logro\u00f1o, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lung Cancer and Respiratory Diseases Unit. Fundaci\u00f3n Rioja Salud, Center for Biomedical Research of La Rioja (CIBIR), Logro\u00f1o, Spain","institution_ids":["https://openalex.org/I4210139648","https://openalex.org/I4405267958"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064511254","display_name":"Mar\u00eda \u00cd\u00f1iguez","orcid":"https://orcid.org/0000-0002-6485-8992","observed_orcids":["https://orcid.org/0000-0002-6485-8992"]},"institutions":[{"id":"https://openalex.org/I4210138511","display_name":"Hospital San Pedro","ror":"https://ror.org/031va0421","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210138511"]},{"id":"https://openalex.org/I4210139648","display_name":"Center for Biomedical Research of La Rioja","ror":"https://ror.org/03vfjzd38","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210139648"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mar\u00eda \u00cd\u00f1iguez","raw_affiliation_strings":["Infectious Diseases, Microbiota and Metabolism Unit, Infectious Diseases Department, Center for Biomedical Research of La Rioja (CIBIR) -Hospital Universitario San Pedro, Logro\u00f1o, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases, Microbiota and Metabolism Unit, Infectious Diseases Department, Center for Biomedical Research of La Rioja (CIBIR) -Hospital Universitario San Pedro, Logro\u00f1o, Spain","institution_ids":["https://openalex.org/I4210138511","https://openalex.org/I4210139648"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082208617","display_name":"Emma Recio\u2010Fern\u00e1ndez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210138511","display_name":"Hospital San Pedro","ror":"https://ror.org/031va0421","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210138511"]},{"id":"https://openalex.org/I4210139648","display_name":"Center for Biomedical Research of La Rioja","ror":"https://ror.org/03vfjzd38","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210139648"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Emma Recio-Fern\u00e1ndez","raw_affiliation_strings":["Infectious Diseases, Microbiota and Metabolism Unit, Infectious Diseases Department, Center for Biomedical Research of La Rioja (CIBIR) -Hospital Universitario San Pedro, Logro\u00f1o, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases, Microbiota and Metabolism Unit, Infectious Diseases Department, Center for Biomedical Research of La Rioja (CIBIR) -Hospital Universitario San Pedro, Logro\u00f1o, Spain","institution_ids":["https://openalex.org/I4210138511","https://openalex.org/I4210139648"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082548780","display_name":"Raquel Torrens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139648","display_name":"Center for Biomedical Research of La Rioja","ror":"https://ror.org/03vfjzd38","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210139648"]},{"id":"https://openalex.org/I4405267958","display_name":"Servicio Riojano de Salud","ror":"https://ror.org/055trtj48","country_code":"ES","type":"government","lineage":["https://openalex.org/I4405267958"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Raquel Torrens","raw_affiliation_strings":["Lung Cancer and Respiratory Diseases Unit. Fundaci\u00f3n Rioja Salud, Center for Biomedical Research of La Rioja (CIBIR), Logro\u00f1o, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lung Cancer and Respiratory Diseases Unit. Fundaci\u00f3n Rioja Salud, Center for Biomedical Research of La Rioja (CIBIR), Logro\u00f1o, Spain","institution_ids":["https://openalex.org/I4210139648","https://openalex.org/I4405267958"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075866459","display_name":"Sergio Pi\u00f1eiro\u2010Hermida","orcid":"https://orcid.org/0000-0002-8915-5687","observed_orcids":["https://orcid.org/0000-0002-8915-5687"]},"institutions":[{"id":"https://openalex.org/I4210112085","display_name":"Navarre Institute of Health Research","ror":"https://ror.org/023d5h353","country_code":"ES","type":"education","lineage":["https://openalex.org/I4210112085"]},{"id":"https://openalex.org/I4210117069","display_name":"Navarrabiomed","ror":"https://ror.org/03atdda90","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210117069"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Sergio Pi\u00f1eiro-Hermida","raw_affiliation_strings":["Miguel Servet Foundation-Navarra's Health Research Institute (IDISNA), Navarrabiomed Biomedical Research Center, Oncoimmunology Group, Pamplona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Miguel Servet Foundation-Navarra's Health Research Institute (IDISNA), Navarrabiomed Biomedical Research Center, Oncoimmunology Group, Pamplona, Spain","institution_ids":["https://openalex.org/I4210112085","https://openalex.org/I4210117069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023433314","display_name":"Elvira Alfaro\u2010Arnedo","orcid":"https://orcid.org/0000-0002-5954-8201","observed_orcids":["https://orcid.org/0000-0002-5954-8201"]},"institutions":[{"id":"https://openalex.org/I4210139648","display_name":"Center for Biomedical Research of La Rioja","ror":"https://ror.org/03vfjzd38","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210139648"]},{"id":"https://openalex.org/I4405267958","display_name":"Servicio Riojano de Salud","ror":"https://ror.org/055trtj48","country_code":"ES","type":"government","lineage":["https://openalex.org/I4405267958"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Elvira Alfaro-Arnedo","raw_affiliation_strings":["Lung Cancer and Respiratory Diseases Unit. Fundaci\u00f3n Rioja Salud, Center for Biomedical Research of La Rioja (CIBIR), Logro\u00f1o, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lung Cancer and Respiratory Diseases Unit. Fundaci\u00f3n Rioja Salud, Center for Biomedical Research of La Rioja (CIBIR), Logro\u00f1o, Spain","institution_ids":["https://openalex.org/I4210139648","https://openalex.org/I4405267958"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035512108","display_name":"Luong Chau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119682","display_name":"Research Institute for Farm Animal Biology (FBN)","ror":"https://ror.org/02n5r1g44","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210119682"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Luong Chau","raw_affiliation_strings":["Institute for Genome Biology, Research Institute for Farm Animal Biology (FBN), Dummerstorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Genome Biology, Research Institute for Farm Animal Biology (FBN), Dummerstorf, Germany","institution_ids":["https://openalex.org/I4210119682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074246919","display_name":"Christina Walz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119682","display_name":"Research Institute for Farm Animal Biology (FBN)","ror":"https://ror.org/02n5r1g44","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210119682"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christina Walz","raw_affiliation_strings":["Institute for Genome Biology, Research Institute for Farm Animal Biology (FBN), Dummerstorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Genome Biology, Research Institute for Farm Animal Biology (FBN), Dummerstorf, Germany","institution_ids":["https://openalex.org/I4210119682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042742414","display_name":"Andreas Hoeflich","orcid":"https://orcid.org/0000-0003-2018-2836","observed_orcids":["https://orcid.org/0000-0003-2018-2836"]},"institutions":[{"id":"https://openalex.org/I4210119682","display_name":"Research Institute for Farm Animal Biology (FBN)","ror":"https://ror.org/02n5r1g44","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210119682"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas Hoeflich","raw_affiliation_strings":["Institute for Genome Biology, Research Institute for Farm Animal Biology (FBN), Dummerstorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Genome Biology, Research Institute for Farm Animal Biology (FBN), Dummerstorf, Germany","institution_ids":["https://openalex.org/I4210119682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075554687","display_name":"Jos\u00e9 Antonio Oteo","orcid":"https://orcid.org/0000-0001-7080-6542","observed_orcids":["https://orcid.org/0000-0001-7080-6542"]},"institutions":[{"id":"https://openalex.org/I4210138511","display_name":"Hospital San Pedro","ror":"https://ror.org/031va0421","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210138511"]},{"id":"https://openalex.org/I4210139648","display_name":"Center for Biomedical Research of La Rioja","ror":"https://ror.org/03vfjzd38","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210139648"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 A. Oteo","raw_affiliation_strings":["Infectious Diseases, Microbiota and Metabolism Unit, Infectious Diseases Department, Center for Biomedical Research of La Rioja (CIBIR) -Hospital Universitario San Pedro, Logro\u00f1o, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases, Microbiota and Metabolism Unit, Infectious Diseases Department, Center for Biomedical Research of La Rioja (CIBIR) -Hospital Universitario San Pedro, Logro\u00f1o, Spain","institution_ids":["https://openalex.org/I4210138511","https://openalex.org/I4210139648"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018396204","display_name":"Jos\u00e9 G. Pichel","orcid":"https://orcid.org/0000-0001-8580-0952","observed_orcids":["https://orcid.org/0000-0001-8580-0952"]},"institutions":[{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210139648","display_name":"Center for Biomedical Research of La Rioja","ror":"https://ror.org/03vfjzd38","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210139648"]},{"id":"https://openalex.org/I4405267958","display_name":"Servicio Riojano de Salud","ror":"https://ror.org/055trtj48","country_code":"ES","type":"government","lineage":["https://openalex.org/I4405267958"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 G. Pichel","raw_affiliation_strings":["Biomedical Research Networking Center on Respiratory Diseases (CIBERES), Instituto de Salud Carlos III (ISCIII), Madrid, Spain","Lung Cancer and Respiratory Diseases Unit. Fundaci\u00f3n Rioja Salud, Center for Biomedical Research of La Rioja (CIBIR), Logro\u00f1o, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Research Networking Center on Respiratory Diseases (CIBERES), Instituto de Salud Carlos III (ISCIII), Madrid, Spain","institution_ids":["https://openalex.org/I2801357902"]},{"raw_affiliation_string":"Lung Cancer and Respiratory Diseases Unit. Fundaci\u00f3n Rioja Salud, Center for Biomedical Research of La Rioja (CIBIR), Logro\u00f1o, Spain","institution_ids":["https://openalex.org/I4210139648","https://openalex.org/I4405267958"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5003202911"],"corresponding_institution_ids":["https://openalex.org/I4210138511","https://openalex.org/I4210139648"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":2.6154,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.8996059,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"13","issue":null,"first_page":"1033208","last_page":"1033208"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/igf-1-receptor","display_name":"IGF-1 receptor","score":0.953000009059906},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.6869999766349792},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.6340000033378601},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.996999979019165},{"id":"https://openalex.org/keywords/diet-induced-obesity","display_name":"diet-induced obesity","score":0.8029999732971191},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9739999771118164},{"id":"https://openalex.org/keywords/growth-hormone","display_name":"growth hormone","score":0.7360000014305115},{"id":"https://openalex.org/keywords/igfbp-2","display_name":"IGFBP-2","score":0.8389999866485596},{"id":"https://openalex.org/keywords/igfbp-3","display_name":"IGFBP-3","score":1.0},{"id":"https://openalex.org/keywords/hepatic-triglycerides","display_name":"hepatic triglycerides","score":0.8090000152587891},{"id":"https://openalex.org/keywords/adiposity","display_name":"adiposity","score":0.8479999899864197},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.8920000195503235},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.9919999837875366}],"concepts":[{"id":"https://openalex.org/C144174609","wikidata":"https://www.wikidata.org/wiki/Q14901457","display_name":"Insulin-like growth factor 1 receptor","level":4,"score":0.9263395071029663},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7520822286605835},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7459566593170166},{"id":"https://openalex.org/C2778279177","wikidata":"https://www.wikidata.org/wiki/Q18027678","display_name":"IGFBP3","level":4,"score":0.6247803568840027},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5473312735557556},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5091235041618347},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3640449047088623},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2978360056877136},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.20979946851730347}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050154","descriptor_name":"Adiposity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.3389/fendo.2022.1033208","doi":"https://doi.org/10.3389/fendo.2022.1033208","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2022.1033208","pdf_url":null,"source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9638844","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9638844/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9638844/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Endocrinol (Lausanne)","raw_type":"Text"},{"id":"pmid:36353242","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36353242","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in endocrinology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:d487c97cd50643339ffa6225129c7e2c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d487c97cd50643339ffa6225129c7e2c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Endocrinology, Vol 13 (2022)","raw_type":"article"},{"id":"pmh:oai:portal.dialnet.es:doc/6379521b0b78045a77808b8a","doi":null,"is_oa":true,"landing_page_url":"https://investigacion.unirioja.es/documentos/6379521b0b78045a77808b8a","pdf_url":null,"source":{"id":"https://openalex.org/S4306402551","display_name":"RIUR (Universidad de La Rioja)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I168974976","host_organization_name":"Universidad de La Rioja","host_organization_lineage":["https://openalex.org/I168974976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3389/fendo.2022.1033208","doi":"https://doi.org/10.3389/fendo.2022.1033208","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2022.1033208","pdf_url":null,"source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1175115578","display_name":null,"funder_award_id":"AEI//10.13039/501100011033/","funder_id":"https://openalex.org/F4320335598","funder_display_name":"Agencia Estatal de Investigaci\u00f3n"},{"id":"https://openalex.org/G2262748287","display_name":null,"funder_award_id":"501100011033","funder_id":"https://openalex.org/F4320335598","funder_display_name":"Agencia Estatal de Investigaci\u00f3n"},{"id":"https://openalex.org/G300979063","display_name":null,"funder_award_id":"10.13039/501100011033","funder_id":"https://openalex.org/F4320335598","funder_display_name":"Agencia Estatal de Investigaci\u00f3n"},{"id":"https://openalex.org/G3480869486","display_name":null,"funder_award_id":"13039","funder_id":"https://openalex.org/F4320335598","funder_display_name":"Agencia Estatal de Investigaci\u00f3n"},{"id":"https://openalex.org/G410571670","display_name":null,"funder_award_id":"10.13039/501100011033","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G425668148","display_name":null,"funder_award_id":".13039/501100011033","funder_id":"https://openalex.org/F4320335598","funder_display_name":"Agencia Estatal de Investigaci\u00f3n"},{"id":"https://openalex.org/G451917667","display_name":null,"funder_award_id":"13039/501100011033","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G5080475149","display_name":null,"funder_award_id":"10.13039","funder_id":"https://openalex.org/F4320335598","funder_display_name":"Agencia Estatal de Investigaci\u00f3n"},{"id":"https://openalex.org/G5967599077","display_name":null,"funder_award_id":"501100011033","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G6218905885","display_name":null,"funder_award_id":"501100011033","funder_id":"https://openalex.org/F4320338080","funder_display_name":"European Social Fund"},{"id":"https://openalex.org/G6731467812","display_name":null,"funder_award_id":"PGC2018","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G7843794407","display_name":null,"funder_award_id":"PGC2018-097397-B-I00","funder_id":"https://openalex.org/F4320335598","funder_display_name":"Agencia Estatal de Investigaci\u00f3n"},{"id":"https://openalex.org/G8178315791","display_name":null,"funder_award_id":"PGC2018","funder_id":"https://openalex.org/F4320335598","funder_display_name":"Agencia Estatal de Investigaci\u00f3n"}],"funders":[{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320335598","display_name":"Agencia Estatal de Investigaci\u00f3n","ror":"https://ror.org/003x0zc53"},{"id":"https://openalex.org/F4320338080","display_name":"European Social Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4306947985.pdf","grobid_xml":"https://content.openalex.org/works/W4306947985.grobid-xml"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W1888696252","https://openalex.org/W1973842058","https://openalex.org/W1985425785","https://openalex.org/W1994251361","https://openalex.org/W1995856801","https://openalex.org/W2001227905","https://openalex.org/W2006200480","https://openalex.org/W2014166552","https://openalex.org/W2019685965","https://openalex.org/W2020936520","https://openalex.org/W2038036073","https://openalex.org/W2044379830","https://openalex.org/W2055084670","https://openalex.org/W2057451497","https://openalex.org/W2057913302","https://openalex.org/W2063114187","https://openalex.org/W2068373267","https://openalex.org/W2070089423","https://openalex.org/W2076585242","https://openalex.org/W2080908190","https://openalex.org/W2082995876","https://openalex.org/W2083807723","https://openalex.org/W2096452837","https://openalex.org/W2100260875","https://openalex.org/W2119302231","https://openalex.org/W2125231550","https://openalex.org/W2136831860","https://openalex.org/W2140701702","https://openalex.org/W2146795787","https://openalex.org/W2150364650","https://openalex.org/W2153312037","https://openalex.org/W2156831368","https://openalex.org/W2158208709","https://openalex.org/W2158925425","https://openalex.org/W2158995386","https://openalex.org/W2163822546","https://openalex.org/W2166524464","https://openalex.org/W2201571627","https://openalex.org/W2208324711","https://openalex.org/W2232504117","https://openalex.org/W2255032699","https://openalex.org/W2277072337","https://openalex.org/W2438673089","https://openalex.org/W2530980908","https://openalex.org/W2588930650","https://openalex.org/W2603416940","https://openalex.org/W2613956670","https://openalex.org/W2659277361","https://openalex.org/W2705612663","https://openalex.org/W2713283324","https://openalex.org/W2748953534","https://openalex.org/W2764089454","https://openalex.org/W2780905848","https://openalex.org/W2802111045","https://openalex.org/W2807914406","https://openalex.org/W2808968956","https://openalex.org/W2917564974","https://openalex.org/W3014965580","https://openalex.org/W3022573253","https://openalex.org/W3034040497","https://openalex.org/W3046797623","https://openalex.org/W3118531871","https://openalex.org/W3183589699","https://openalex.org/W3184038912","https://openalex.org/W4281887537"],"related_works":["https://openalex.org/W2082949573","https://openalex.org/W2603416940","https://openalex.org/W1970742074","https://openalex.org/W2029206414","https://openalex.org/W2809409155","https://openalex.org/W2020546873","https://openalex.org/W1981574344","https://openalex.org/W2101959969","https://openalex.org/W2092430835","https://openalex.org/W2055084670"],"abstract_inverted_index":{"Objective:":[0],"We":[1],"aimed":[2],"to":[3,89,153],"investigate":[4],"the":[5,26,91],"short":[6],"and":[7,51,97,102,135],"long-term":[8],"metabolic":[9,106,127,155],"consequences":[10],"of":[11,28,76],"IGF1R":[12,111,123,143,161],"systemic":[13],"gene":[14,162],"deficiency":[15,144],"in":[16,36,65,99,115,126,137,145,158],"mice.":[17,23,38,117],"Methods:":[18],")":[19],"12-months":[20],"old":[21],"middle-aged":[22,37,69,116],"In":[24,67],"addition,":[25],"effects":[27,93,130],"10":[29],"weeks-long":[30],"high-fat":[31],"diet":[32],"(HFD)":[33],"were":[34,43,87],"investigated":[35],"Results:":[39],"Young":[40],"IGF1R-deficient":[41,84],"mice":[42,70,86,146],"insulin-resistant,":[44],"with":[45,129,160],"high":[46],"IGF1,":[47],"growth":[48],"hormone":[49],"(GH)":[50],"IGFBP3,":[52],"as":[53,55,149],"well":[54],"low":[56],"IGFBP2":[57],"circulating":[58],"levels.":[59],"Males":[60],"also":[61],"presented":[62],"increased":[63],"triglycerides":[64],"liver.":[66],"contrast,":[68],"did":[71],"not":[72],"clearly":[73],"show":[74],"all":[75],"these":[77],"alterations,":[78],"suggesting":[79],"possible":[80],"compensatory":[81],"effects.":[82],"Middle-aged":[83],"male":[85],"able":[88],"counteract":[90],"negative":[92],"induced":[94],"by":[95,132],"aging":[96,136],"HFD":[98],"adiposity,":[100],"inflammation":[101],"glucose":[103],"metabolism.":[104],"A":[105],"sexual":[107],"dimorphism":[108],"dependent":[109,140],"on":[110],"was":[112],"observed,":[113],"especially":[114],"Conclusions:":[118],"These":[119],"results":[120],"demonstrate":[121],"that":[122],"is":[124,147],"involved":[125],"homeostasis,":[128],"modulated":[131],"diet-induced":[133],"obesity":[134],"a":[138,150],"sex":[139],"manner.":[141],"Thus,":[142],"proposed":[148],"useful":[151],"tool":[152],"understand":[154],"alterations":[156],"observed":[157],"patients":[159],"deletions.":[163]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2022-10-21T00:00:00"}
