{"id":"https://openalex.org/W4306938136","doi":"https://doi.org/10.3390/jfb13040196","title":"Overview of Physicochemical Properties of Nanoparticles as Drug Carriers for Targeted Cancer Therapy","display_name":"Overview of Physicochemical Properties of Nanoparticles as Drug Carriers for Targeted Cancer Therapy","publication_year":2022,"publication_date":"2022-10-20","ids":{"openalex":"https://openalex.org/W4306938136","doi":"https://doi.org/10.3390/jfb13040196","pmid":"https://pubmed.ncbi.nlm.nih.gov/36278665","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9590029"},"language":"en","primary_location":{"id":"doi:10.3390/jfb13040196","doi":"https://doi.org/10.3390/jfb13040196","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jfb13040196","pdf_url":"https://www.mdpi.com/2079-4983/13/4/196/pdf?version=1666246906","source":{"id":"https://openalex.org/S86392829","display_name":"Journal of Functional Biomaterials","issn_l":"2079-4983","issn":["2079-4983"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Functional Biomaterials","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2079-4983/13/4/196/pdf?version=1666246906","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071004844","display_name":"Vugar Yagublu","orcid":"https://orcid.org/0000-0003-3078-9543","observed_orcids":["https://orcid.org/0000-0003-3078-9543"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4387153978","display_name":"Medizinische Fakult\u00e4t Mannheim","ror":"https://ror.org/02m1z0a87","country_code":"DE","type":"education","lineage":["https://openalex.org/I4387153978"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Vugar Yagublu","raw_affiliation_strings":["Department of Surgery, Medical Faculty Mannheim, University of Heidelberg, 68167 Mannheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Medical Faculty Mannheim, University of Heidelberg, 68167 Mannheim, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I4387153978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036243833","display_name":"Aynura Karimova","orcid":"https://orcid.org/0000-0002-5706-2566","observed_orcids":["https://orcid.org/0000-0002-5706-2566"]},"institutions":[{"id":"https://openalex.org/I194342707","display_name":"Baku State University","ror":"https://ror.org/054gw3b40","country_code":"AZ","type":"education","lineage":["https://openalex.org/I194342707"]}],"countries":["AZ"],"is_corresponding":true,"raw_author_name":"Aynura Karimova","raw_affiliation_strings":["Nanoresearch Laboratory, Baku State University, AZ 1148 Baku, Azerbaijan"],"raw_orcid":"https://orcid.org/0000-0002-5706-2566","affiliations":[{"raw_affiliation_string":"Nanoresearch Laboratory, Baku State University, AZ 1148 Baku, Azerbaijan","institution_ids":["https://openalex.org/I194342707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093086180","display_name":"Javahir Hajibabazade","orcid":"https://orcid.org/0000-0002-3565-0439","observed_orcids":["https://orcid.org/0000-0002-3565-0439"]},"institutions":[{"id":"https://openalex.org/I194342707","display_name":"Baku State University","ror":"https://ror.org/054gw3b40","country_code":"AZ","type":"education","lineage":["https://openalex.org/I194342707"]}],"countries":["AZ"],"is_corresponding":false,"raw_author_name":"Javahir Hajibabazadeh","raw_affiliation_strings":["Nanoresearch Laboratory, Baku State University, AZ 1148 Baku, Azerbaijan"],"raw_orcid":"https://orcid.org/0000-0002-3565-0439","affiliations":[{"raw_affiliation_string":"Nanoresearch Laboratory, Baku State University, AZ 1148 Baku, Azerbaijan","institution_ids":["https://openalex.org/I194342707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035586224","display_name":"Christoph Rei\u00dffelder","orcid":"https://orcid.org/0000-0003-4591-1046","observed_orcids":["https://orcid.org/0000-0003-4591-1046"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4387153978","display_name":"Medizinische Fakult\u00e4t Mannheim","ror":"https://ror.org/02m1z0a87","country_code":"DE","type":"education","lineage":["https://openalex.org/I4387153978"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christoph Reissfelder","raw_affiliation_strings":["Department of Surgery, Medical Faculty Mannheim, University of Heidelberg, 68167 Mannheim, Germany"],"raw_orcid":"https://orcid.org/0000-0003-4591-1046","affiliations":[{"raw_affiliation_string":"Department of Surgery, Medical Faculty Mannheim, University of Heidelberg, 68167 Mannheim, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I4387153978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110082197","display_name":"Mustafa Muradov","orcid":"https://orcid.org/0000-0003-0528-2361","observed_orcids":["https://orcid.org/0000-0003-0528-2361"]},"institutions":[{"id":"https://openalex.org/I194342707","display_name":"Baku State University","ror":"https://ror.org/054gw3b40","country_code":"AZ","type":"education","lineage":["https://openalex.org/I194342707"]}],"countries":["AZ"],"is_corresponding":false,"raw_author_name":"Mustafa Muradov","raw_affiliation_strings":["Nanoresearch Laboratory, Baku State University, AZ 1148 Baku, Azerbaijan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nanoresearch Laboratory, Baku State University, AZ 1148 Baku, Azerbaijan","institution_ids":["https://openalex.org/I194342707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055595437","display_name":"Stefano Bellucci A","orcid":"https://orcid.org/0000-0003-0326-6368","observed_orcids":["https://orcid.org/0000-0003-0326-6368","https://orcid.org/0000-0001-6736-4659"]},"institutions":[{"id":"https://openalex.org/I4210142660","display_name":"Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Frascati","ror":"https://ror.org/049jf1a25","country_code":"IT","type":"facility","lineage":["https://openalex.org/I160013858","https://openalex.org/I4210142660"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stefano Bellucci","raw_affiliation_strings":["Istituto Nazionale di Fisica Nucleare\u2014Laboratori Nazionali di Frascati, Via E. Fermi 54, 00044 Frascati, Italy"],"raw_orcid":"https://orcid.org/0000-0003-0326-6368","affiliations":[{"raw_affiliation_string":"Istituto Nazionale di Fisica Nucleare\u2014Laboratori Nazionali di Frascati, Via E. Fermi 54, 00044 Frascati, Italy","institution_ids":["https://openalex.org/I4210142660"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090063999","display_name":"Adil Allahverdiyev","orcid":"https://orcid.org/0000-0002-7031-5986","observed_orcids":["https://orcid.org/0000-0002-7031-5986"]},"institutions":[{"id":"https://openalex.org/I4405283047","display_name":"V. Y. Axundov ad\u0131na Elmi-T\u0259dqiqat Tibbi Profilaktika \u0130nstitutu","ror":"https://ror.org/00xhw8p71","country_code":"AZ","type":"healthcare","lineage":["https://openalex.org/I4210144247","https://openalex.org/I4405283047"]}],"countries":["AZ"],"is_corresponding":false,"raw_author_name":"Adil Allahverdiyev","raw_affiliation_strings":["Vali Akhundov National Scientific Research Medical Prophylactic Institute, AZ 1065 Baku, Azerbaijan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vali Akhundov National Scientific Research Medical Prophylactic Institute, AZ 1065 Baku, Azerbaijan","institution_ids":["https://openalex.org/I4405283047"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5036243833"],"corresponding_institution_ids":["https://openalex.org/I194342707"],"apc_list":{"value":1800,"currency":"CHF","value_usd":1885},"apc_paid":{"value":1800,"currency":"CHF","value_usd":1885},"fwci":1.3039,"has_fulltext":true,"cited_by_count":100,"citation_normalized_percentile":{"value":0.78038003,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"13","issue":"4","first_page":"196","last_page":"196"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11686","display_name":"Dendrimers and Hyperbranched Polymers","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2507","display_name":"Polymers and Plastics"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nanoparticles","display_name":"nanoparticles","score":0.9539999961853027},{"id":"https://openalex.org/keywords/drug-carriers","display_name":"drug carriers","score":0.8529999852180481},{"id":"https://openalex.org/keywords/targeted-cancer-therapy","display_name":"targeted cancer therapy","score":0.9800000190734863},{"id":"https://openalex.org/keywords/physicochemical-properties","display_name":"physicochemical properties","score":0.9160000085830688},{"id":"https://openalex.org/keywords/tumor-targeting","display_name":"tumor targeting","score":0.6729999780654907},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.746999979019165},{"id":"https://openalex.org/keywords/tumor-penetration","display_name":"tumor penetration","score":0.6449999809265137},{"id":"https://openalex.org/keywords/controlled-drug-delivery","display_name":"controlled drug delivery","score":0.6840000152587891},{"id":"https://openalex.org/keywords/nanocarriers","display_name":"nanocarriers","score":0.746999979019165},{"id":"https://openalex.org/keywords/nanoparticle-design","display_name":"nanoparticle design","score":0.4230000078678131}],"concepts":[{"id":"https://openalex.org/C18150654","wikidata":"https://www.wikidata.org/wiki/Q17153796","display_name":"Nanocarriers","level":3,"score":0.8633013963699341},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.7134667038917542},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.6871057152748108},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.614313542842865},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.6114846467971802},{"id":"https://openalex.org/C2983331546","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer therapy","level":3,"score":0.5903643369674683},{"id":"https://openalex.org/C3019816032","wikidata":"https://www.wikidata.org/wiki/Q2575340","display_name":"Cancer treatment","level":3,"score":0.48603492975234985},{"id":"https://openalex.org/C15083742","wikidata":"https://www.wikidata.org/wiki/Q261659","display_name":"Nanomedicine","level":3,"score":0.4756338596343994},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.359150767326355},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1690468192100525},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/jfb13040196","doi":"https://doi.org/10.3390/jfb13040196","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jfb13040196","pdf_url":"https://www.mdpi.com/2079-4983/13/4/196/pdf?version=1666246906","source":{"id":"https://openalex.org/S86392829","display_name":"Journal of Functional Biomaterials","issn_l":"2079-4983","issn":["2079-4983"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Functional Biomaterials","raw_type":"journal-article"},{"id":"pmid:36278665","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36278665","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of functional biomaterials","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9590029","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9590029/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Funct Biomater","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:10337c5f0c72430da660b694e9e2a034","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/10337c5f0c72430da660b694e9e2a034","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Functional Biomaterials, Vol 13, Iss 4, p 196 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/jfb13040196","doi":"https://doi.org/10.3390/jfb13040196","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jfb13040196","pdf_url":"https://www.mdpi.com/2079-4983/13/4/196/pdf?version=1666246906","source":{"id":"https://openalex.org/S86392829","display_name":"Journal of Functional Biomaterials","issn_l":"2079-4983","issn":["2079-4983"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Functional Biomaterials","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4306938136.pdf","grobid_xml":"https://content.openalex.org/works/W4306938136.grobid-xml"},"referenced_works_count":80,"referenced_works":["https://openalex.org/W167281892","https://openalex.org/W1498585337","https://openalex.org/W1553195580","https://openalex.org/W1754660988","https://openalex.org/W1866674918","https://openalex.org/W1963565300","https://openalex.org/W1965097716","https://openalex.org/W1970954421","https://openalex.org/W1973681903","https://openalex.org/W1973831032","https://openalex.org/W1974892535","https://openalex.org/W1982494232","https://openalex.org/W1985868513","https://openalex.org/W1987888610","https://openalex.org/W1990295693","https://openalex.org/W1995094849","https://openalex.org/W1995704440","https://openalex.org/W1996139192","https://openalex.org/W2003262359","https://openalex.org/W2004296046","https://openalex.org/W2006672261","https://openalex.org/W2010047685","https://openalex.org/W2013262011","https://openalex.org/W2014777534","https://openalex.org/W2025540635","https://openalex.org/W2036050007","https://openalex.org/W2038246612","https://openalex.org/W2039689914","https://openalex.org/W2040170408","https://openalex.org/W2050886209","https://openalex.org/W2057069992","https://openalex.org/W2057910069","https://openalex.org/W2067302150","https://openalex.org/W2068735324","https://openalex.org/W2078057254","https://openalex.org/W2078635064","https://openalex.org/W2081560570","https://openalex.org/W2102005106","https://openalex.org/W2106654936","https://openalex.org/W2121239285","https://openalex.org/W2137374477","https://openalex.org/W2137634849","https://openalex.org/W2140518088","https://openalex.org/W2143463421","https://openalex.org/W2150146274","https://openalex.org/W2153677421","https://openalex.org/W2158558808","https://openalex.org/W2161946971","https://openalex.org/W2162838846","https://openalex.org/W2317971173","https://openalex.org/W2340662778","https://openalex.org/W2517249974","https://openalex.org/W2524394696","https://openalex.org/W2550788816","https://openalex.org/W2605007694","https://openalex.org/W2606193202","https://openalex.org/W2613204076","https://openalex.org/W2701973945","https://openalex.org/W2753425539","https://openalex.org/W2753679985","https://openalex.org/W2766753913","https://openalex.org/W2771377377","https://openalex.org/W2780371959","https://openalex.org/W2787117586","https://openalex.org/W2795821736","https://openalex.org/W2806432392","https://openalex.org/W2841604157","https://openalex.org/W2892268520","https://openalex.org/W2897653560","https://openalex.org/W2898415565","https://openalex.org/W2902174428","https://openalex.org/W2903163886","https://openalex.org/W2949036789","https://openalex.org/W2971038071","https://openalex.org/W2981066188","https://openalex.org/W2995475735","https://openalex.org/W3029981488","https://openalex.org/W3042163371","https://openalex.org/W3043899691","https://openalex.org/W4211252796"],"related_works":["https://openalex.org/W2689400097","https://openalex.org/W2769069333","https://openalex.org/W3042163371","https://openalex.org/W3152851186","https://openalex.org/W2128654928","https://openalex.org/W2305594096","https://openalex.org/W2182281181","https://openalex.org/W4385877953","https://openalex.org/W2502124983","https://openalex.org/W4281751420"],"abstract_inverted_index":{"The":[0,132],"advent":[1],"of":[2,53,88,94,135,149],"nanotechnology":[3],"has":[4],"brought":[5],"about":[6],"revolutionary":[7],"innovations":[8],"in":[9,34,59,66,81,103,116,129,138],"biological":[10],"research":[11],"techniques":[12],"and":[13,43,47,79,96,113,156],"medical":[14],"practice.":[15],"In":[16],"recent":[17],"years,":[18],"various":[19],"\"smart\"":[20],"nanocarriers":[21],"have":[22,55],"been":[23],"introduced":[24],"to":[25,30,72,75,123,144],"deliver":[26],"therapeutic":[27,64],"agents":[28],"specifically":[29],"the":[31,67,76,89,100,104,136,145,154],"tumor":[32,77,82,117],"tissue":[33],"a":[35,85],"controlled":[36],"manner,":[37],"thereby":[38],"minimizing":[39],"their":[40,97,157],"side":[41],"effects":[42],"reducing":[44],"both":[45],"dosage":[46,48],"frequency.":[49],"A":[50],"large":[51],"number":[52],"nanoparticles":[54,95,150],"demonstrated":[56],"initial":[57],"success":[58],"preclinical":[60],"evaluation":[61],"but":[62],"modest":[63],"benefits":[65],"clinical":[68],"setting,":[69],"partly":[70],"due":[71],"insufficient":[73],"delivery":[74],"site":[78],"penetration":[80],"tissue.":[83],"Therefore,":[84],"precise":[86],"understanding":[87],"relationships":[90],"betweenthe":[91],"physicochemical":[92,147],"properties":[93,148],"interaction":[98],"with":[99],"surrounding":[101],"microenvironment":[102],"body":[105,155],"is":[106],"extremely":[107],"important":[108],"for":[109,160],"achieving":[110],"higher":[111],"concentrations":[112],"better":[114],"functionality":[115],"tissues.":[118],"This":[119],"knowledge":[120],"would":[121],"help":[122],"effectively":[124],"combine":[125],"multiple":[126],"advantageous":[127],"functions":[128],"one":[130],"nanoparticle.":[131],"main":[133,146],"focus":[134],"discussion":[137],"this":[139],"review,":[140],"therefore,":[141],"will":[142],"relate":[143],"while":[151],"interacting":[152],"within":[153],"tuning":[158],"potential":[159],"increased":[161],"performance.":[162]},"counts_by_year":[{"year":2026,"cited_by_count":20},{"year":2025,"cited_by_count":41},{"year":2024,"cited_by_count":26},{"year":2023,"cited_by_count":13}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-10-21T00:00:00"}