{"id":"https://openalex.org/W4306936751","doi":"https://doi.org/10.3390/nano12203686","title":"SPIONs Conjugate Supported Anticancer Drug Doxorubicin\u2019s Delivery: Current Status, Challenges, and Prospects","display_name":"SPIONs Conjugate Supported Anticancer Drug Doxorubicin\u2019s Delivery: Current Status, Challenges, and Prospects","publication_year":2022,"publication_date":"2022-10-20","ids":{"openalex":"https://openalex.org/W4306936751","doi":"https://doi.org/10.3390/nano12203686","pmid":"https://pubmed.ncbi.nlm.nih.gov/36296877","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9611558"},"language":"en","primary_location":{"id":"doi:10.3390/nano12203686","doi":"https://doi.org/10.3390/nano12203686","is_oa":true,"landing_page_url":"https://doi.org/10.3390/nano12203686","pdf_url":"https://www.mdpi.com/2079-4991/12/20/3686/pdf?version=1666945396","source":{"id":"https://openalex.org/S2764646681","display_name":"Nanomaterials","issn_l":"2079-4991","issn":["2079-4991"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanomaterials","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2079-4991/12/20/3686/pdf?version=1666945396","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062095087","display_name":"Naseem Akhtar","orcid":"https://orcid.org/0000-0003-3607-3992","observed_orcids":["https://orcid.org/0000-0003-3607-3992"]},"institutions":[{"id":"https://openalex.org/I4210092650","display_name":"Buraydah Colleges","ror":"https://ror.org/00j0krs40","country_code":"SA","type":"education","lineage":["https://openalex.org/I4210092650"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Naseem Akhtar","raw_affiliation_strings":["Department of Pharmaceutics, College of Dentistry & Pharmacy, Buraydah Private Colleges, P.O. Box 31717, Buraydah 51418, Qassim, Saudi Arabia"],"raw_orcid":"https://orcid.org/0000-0003-3607-3992","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, College of Dentistry & Pharmacy, Buraydah Private Colleges, P.O. Box 31717, Buraydah 51418, Qassim, Saudi Arabia","institution_ids":["https://openalex.org/I4210092650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014073865","display_name":"Hamdoon Abdelhamid Mohammed","orcid":"https://orcid.org/0000-0003-2896-6790","observed_orcids":["https://orcid.org/0000-0003-2896-6790"]},"institutions":[{"id":"https://openalex.org/I156216236","display_name":"Qassim University","ror":"https://ror.org/01wsfe280","country_code":"SA","type":"education","lineage":["https://openalex.org/I156216236"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Hamdoon A. Mohammed","raw_affiliation_strings":["Department of Medicinal Chemistry & Pharmacognosy, College of Pharmacy, Qassim University, Buraydah 51452, Qassim, Saudi Arabia"],"raw_orcid":"https://orcid.org/0000-0003-2896-6790","affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry & Pharmacognosy, College of Pharmacy, Qassim University, Buraydah 51452, Qassim, Saudi Arabia","institution_ids":["https://openalex.org/I156216236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001687702","display_name":"Mohammad Yusuf","orcid":"https://orcid.org/0000-0003-2442-5161","observed_orcids":["https://orcid.org/0000-0003-2442-5161","https://orcid.org/0000-0003-1417-7774","https://orcid.org/0000-0002-5087-3278","https://orcid.org/0009-0008-6059-6017"]},"institutions":[{"id":"https://openalex.org/I179331831","display_name":"Taif University","ror":"https://ror.org/014g1a453","country_code":"SA","type":"education","lineage":["https://openalex.org/I179331831"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Mohammed Yusuf","raw_affiliation_strings":["Department of Clinical Pharmacy, College of Pharmacy, Taif University, P.O. Box 11099, Taif 21944, Mecca, Saudi Arabia"],"raw_orcid":"https://orcid.org/0000-0003-1417-7774","affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacy, College of Pharmacy, Taif University, P.O. Box 11099, Taif 21944, Mecca, Saudi Arabia","institution_ids":["https://openalex.org/I179331831"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052418245","display_name":"Amal Al-Subaiyel","orcid":"https://orcid.org/0000-0003-1758-4391","observed_orcids":["https://orcid.org/0000-0003-1758-4391"]},"institutions":[{"id":"https://openalex.org/I156216236","display_name":"Qassim University","ror":"https://ror.org/01wsfe280","country_code":"SA","type":"education","lineage":["https://openalex.org/I156216236"]}],"countries":["SA"],"is_corresponding":true,"raw_author_name":"Amal Al-Subaiyel","raw_affiliation_strings":["Department of Pharmaceutics, College of Pharmacy, Qassim University, Buraydah 51452, Qassim, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, College of Pharmacy, Qassim University, Buraydah 51452, Qassim, Saudi Arabia","institution_ids":["https://openalex.org/I156216236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090802291","display_name":"Ghassan Mohammad Sulaiman","orcid":"https://orcid.org/0000-0001-6388-3849","observed_orcids":["https://orcid.org/0000-0001-6388-3849"]},"institutions":[{"id":"https://openalex.org/I171256487","display_name":"University of Technology - Iraq","ror":"https://ror.org/01w1ehb86","country_code":"IQ","type":"education","lineage":["https://openalex.org/I171256487"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Ghassan M. Sulaiman","raw_affiliation_strings":["Division of Biotechnology, Department of Applied Sciences, University of Technology, Baghdad 10066, Iraq"],"raw_orcid":"https://orcid.org/0000-0001-6388-3849","affiliations":[{"raw_affiliation_string":"Division of Biotechnology, Department of Applied Sciences, University of Technology, Baghdad 10066, Iraq","institution_ids":["https://openalex.org/I171256487"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010591387","display_name":"Riaz A. Khan","orcid":"https://orcid.org/0000-0003-0185-0149","observed_orcids":["https://orcid.org/0000-0003-0185-0149"]},"institutions":[{"id":"https://openalex.org/I156216236","display_name":"Qassim University","ror":"https://ror.org/01wsfe280","country_code":"SA","type":"education","lineage":["https://openalex.org/I156216236"]}],"countries":["SA"],"is_corresponding":true,"raw_author_name":"Riaz A. Khan","raw_affiliation_strings":["Department of Medicinal Chemistry & Pharmacognosy, College of Pharmacy, Qassim University, Buraydah 51452, Qassim, Saudi Arabia"],"raw_orcid":"https://orcid.org/0000-0003-0185-0149","affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry & Pharmacognosy, College of Pharmacy, Qassim University, Buraydah 51452, Qassim, Saudi Arabia","institution_ids":["https://openalex.org/I156216236"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5010591387","https://openalex.org/A5052418245"],"corresponding_institution_ids":["https://openalex.org/I156216236"],"apc_list":{"value":2400,"currency":"CHF","value_usd":2513},"apc_paid":{"value":2400,"currency":"CHF","value_usd":2513},"fwci":0.6993,"has_fulltext":true,"cited_by_count":51,"citation_normalized_percentile":{"value":0.5473777,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"12","issue":"20","first_page":"3686","last_page":"3686"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12405","display_name":"Characterization and Applications of Magnetic Nanoparticles","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/superparamagnetic-iron-oxide-nanoparticles","display_name":"superparamagnetic iron oxide nanoparticles","score":0.9710000157356262},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.9779999852180481},{"id":"https://openalex.org/keywords/targeted-drug-delivery","display_name":"targeted drug delivery","score":0.9549999833106995},{"id":"https://openalex.org/keywords/magnetic-drug-carriers","display_name":"magnetic drug carriers","score":0.4959999918937683},{"id":"https://openalex.org/keywords/surface-functionalization","display_name":"surface functionalization","score":0.675000011920929},{"id":"https://openalex.org/keywords/theranostics","display_name":"theranostics","score":0.828000009059906},{"id":"https://openalex.org/keywords/tumor-imaging","display_name":"tumor imaging","score":0.550000011920929},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"magnetic resonance imaging","score":0.48899999260902405},{"id":"https://openalex.org/keywords/fluorescence-imaging","display_name":"fluorescence imaging","score":0.49399998784065247},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.39399999380111694},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.6079999804496765},{"id":"https://openalex.org/keywords/nanoparticle-toxicity","display_name":"nanoparticle toxicity","score":0.4480000138282776},{"id":"https://openalex.org/keywords/tumor-targeting","display_name":"tumor targeting","score":0.3930000066757202},{"id":"https://openalex.org/keywords/cross-linking","display_name":"crosslinking","score":0.3919999897480011}],"concepts":[{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.8112233877182007},{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.7299672365188599},{"id":"https://openalex.org/C3018146709","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Anticancer drug","level":3,"score":0.5888080596923828},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5409271717071533},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.5402476787567139},{"id":"https://openalex.org/C148043351","wikidata":"https://www.wikidata.org/wiki/Q4456944","display_name":"Current (fluid)","level":2,"score":0.4919297695159912},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.48498961329460144},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3974141776561737},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3118382692337036},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2259947955608368},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18762600421905518},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.1536647081375122},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.13780802488327026},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.07763803005218506},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/nano12203686","doi":"https://doi.org/10.3390/nano12203686","is_oa":true,"landing_page_url":"https://doi.org/10.3390/nano12203686","pdf_url":"https://www.mdpi.com/2079-4991/12/20/3686/pdf?version=1666945396","source":{"id":"https://openalex.org/S2764646681","display_name":"Nanomaterials","issn_l":"2079-4991","issn":["2079-4991"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanomaterials","raw_type":"journal-article"},{"id":"pmid:36296877","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36296877","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanomaterials (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9611558","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9611558/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanomaterials (Basel)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:f1bc2ad3e20a4af5a74ac0bfcf78add3","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f1bc2ad3e20a4af5a74ac0bfcf78add3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nanomaterials, Vol 12, Iss 20, p 3686 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/nano12203686","doi":"https://doi.org/10.3390/nano12203686","is_oa":true,"landing_page_url":"https://doi.org/10.3390/nano12203686","pdf_url":"https://www.mdpi.com/2079-4991/12/20/3686/pdf?version=1666945396","source":{"id":"https://openalex.org/S2764646681","display_name":"Nanomaterials","issn_l":"2079-4991","issn":["2079-4991"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanomaterials","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320324403","display_name":"Qassim University","ror":"https://ror.org/01wsfe280"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4306936751.pdf","grobid_xml":"https://content.openalex.org/works/W4306936751.grobid-xml"},"referenced_works_count":156,"referenced_works":["https://openalex.org/W62834043","https://openalex.org/W1548440309","https://openalex.org/W1832414989","https://openalex.org/W1843302206","https://openalex.org/W1976675331","https://openalex.org/W1995616460","https://openalex.org/W1995680846","https://openalex.org/W1999635578","https://openalex.org/W1999775494","https://openalex.org/W2000883471","https://openalex.org/W2002721997","https://openalex.org/W2002864119","https://openalex.org/W2004809872","https://openalex.org/W2006432226","https://openalex.org/W2008411330","https://openalex.org/W2010177878","https://openalex.org/W2011640816","https://openalex.org/W2014729248","https://openalex.org/W2017363422","https://openalex.org/W2022637591","https://openalex.org/W2022984381","https://openalex.org/W2027048152","https://openalex.org/W2036352738","https://openalex.org/W2037760261","https://openalex.org/W2045570929","https://openalex.org/W2046065045","https://openalex.org/W2047090226","https://openalex.org/W2053824559","https://openalex.org/W2058104225","https://openalex.org/W2068154745","https://openalex.org/W2069016591","https://openalex.org/W2069956310","https://openalex.org/W2071385362","https://openalex.org/W2073126015","https://openalex.org/W2075343248","https://openalex.org/W2077188806","https://openalex.org/W2078058143","https://openalex.org/W2078233764","https://openalex.org/W2078585943","https://openalex.org/W2086171977","https://openalex.org/W2087895309","https://openalex.org/W2088014532","https://openalex.org/W2088656686","https://openalex.org/W2115072986","https://openalex.org/W2119692843","https://openalex.org/W2120766304","https://openalex.org/W2122330840","https://openalex.org/W2133045820","https://openalex.org/W2137374477","https://openalex.org/W2145468594","https://openalex.org/W2145706118","https://openalex.org/W2150433337","https://openalex.org/W2150741268","https://openalex.org/W2151562965","https://openalex.org/W2171384411","https://openalex.org/W2318831902","https://openalex.org/W2330741866","https://openalex.org/W2343332765","https://openalex.org/W2397320986","https://openalex.org/W2399890704","https://openalex.org/W2405530013","https://openalex.org/W2464586678","https://openalex.org/W2471391453","https://openalex.org/W2480705264","https://openalex.org/W2518043380","https://openalex.org/W2524153263","https://openalex.org/W2530419937","https://openalex.org/W2542924420","https://openalex.org/W2555039079","https://openalex.org/W2564551688","https://openalex.org/W2592280201","https://openalex.org/W2670389637","https://openalex.org/W2739460013","https://openalex.org/W2744989157","https://openalex.org/W2753619093","https://openalex.org/W2754923195","https://openalex.org/W2766261199","https://openalex.org/W2770081907","https://openalex.org/W2789545916","https://openalex.org/W2797902184","https://openalex.org/W2802838619","https://openalex.org/W2807258826","https://openalex.org/W2811001673","https://openalex.org/W2883536304","https://openalex.org/W2889082005","https://openalex.org/W2896276429","https://openalex.org/W2899913556","https://openalex.org/W2901910938","https://openalex.org/W2903591395","https://openalex.org/W2904046471","https://openalex.org/W2904432268","https://openalex.org/W2912217268","https://openalex.org/W2913935491","https://openalex.org/W2940002985","https://openalex.org/W2945939089","https://openalex.org/W2947197516","https://openalex.org/W2951587394","https://openalex.org/W2955089298","https://openalex.org/W2961282364","https://openalex.org/W2962116204","https://openalex.org/W2962281447","https://openalex.org/W2965489340","https://openalex.org/W2966278337","https://openalex.org/W2972067683","https://openalex.org/W2980448995","https://openalex.org/W2980767702","https://openalex.org/W2982103792","https://openalex.org/W2985840625","https://openalex.org/W2987904517","https://openalex.org/W2991409747","https://openalex.org/W2992408432","https://openalex.org/W2995681728","https://openalex.org/W3004779767","https://openalex.org/W3005192601","https://openalex.org/W3005904186","https://openalex.org/W3006761252","https://openalex.org/W3013813924","https://openalex.org/W3014311823","https://openalex.org/W3014644009","https://openalex.org/W3015464161","https://openalex.org/W3016690131","https://openalex.org/W3016987950","https://openalex.org/W3021554248","https://openalex.org/W3024304341","https://openalex.org/W3030306928","https://openalex.org/W3034087263","https://openalex.org/W3037304095","https://openalex.org/W3041373504","https://openalex.org/W3048265323","https://openalex.org/W3049148691","https://openalex.org/W3095447794","https://openalex.org/W3095501460","https://openalex.org/W3108109351","https://openalex.org/W3128209920","https://openalex.org/W3133876553","https://openalex.org/W3137728161","https://openalex.org/W3154254177","https://openalex.org/W3155048381","https://openalex.org/W3162733120","https://openalex.org/W3170214253","https://openalex.org/W3180655972","https://openalex.org/W3183618333","https://openalex.org/W3185469738","https://openalex.org/W3200768928","https://openalex.org/W3203939532","https://openalex.org/W3206470164","https://openalex.org/W3211323755","https://openalex.org/W3217410708","https://openalex.org/W4205255597","https://openalex.org/W4206177276","https://openalex.org/W4212813053","https://openalex.org/W4213225002","https://openalex.org/W4224987113","https://openalex.org/W4283578478","https://openalex.org/W4290716331","https://openalex.org/W4297989761"],"related_works":["https://openalex.org/W2990574737","https://openalex.org/W2541686853","https://openalex.org/W2524153263","https://openalex.org/W1897953391","https://openalex.org/W4293474929","https://openalex.org/W2884843292","https://openalex.org/W2801976403","https://openalex.org/W7171467182","https://openalex.org/W3176513594","https://openalex.org/W2944043806"],"abstract_inverted_index":{"Considerable":[0],"efforts":[1],"have":[2,47,94,168,230,271,310,333,353],"been":[3,95,311],"directed":[4],"towards":[5],"development":[6,51,260,287],"of":[7,14,44,52,64,84,104,110,123,131,134,142,161,165,253,261,288,327],"nano-structured":[8,308],"carriers":[9],"to":[10,19,27,49,90,114,155,199,201,225,240,266,296],"overcome":[11],"the":[12,45,50,65,70,85,92,115,139,143,156,177,193,221,251,274,286,328,355,362],"limitations":[13],"anticancer":[15],"drug,":[16,66],"doxorubicin's,":[17],"delivery":[18,59,255,262,295],"various":[20,289],"cancer":[21,214,227,244,298],"sites.":[22],"The":[23,282,324],"drug's":[24],"severe":[25],"toxicity":[26],"cardio":[28],"and":[29,38,102,106,118,152,171,179,197,206,220,234,236,280,304,314,320,341,350,365],"hepatic":[30],"systems,":[31],"low":[32],"therapeutic":[33],"outcomes,":[34],"inappropriate":[35],"dose-demands,":[36],"metastatic":[37],"general":[39],"resistance,":[40],"together":[41,137,183],"with":[42,68,75,138,184,192,347],"non-selectivity":[43],"drug":[46,58,235,269,344],"led":[48],"superparamagnetic":[53],"iron":[54],"oxide":[55],"nanoparticles":[56],"(SPIONs)-based":[57],"modules.":[60],"Nano-scale":[61],"polymeric":[62],"co-encapsulation":[63],"doxorubicin,":[67,93],"SPIONs,":[69],"SPIONs":[71,111,157,194],"surface":[72],"end-groups'":[73],"cappings":[74],"small":[76],"molecular":[77],"entities,":[78,117,136],"as":[79,81,125,127,210,212,257,368,370],"well":[80,126,211,369],"structural":[82],"modifications":[83],"SPIONs'":[86,222,275],"surface-located":[87],"functional":[88,172],"end-groups,":[89],"attach":[91],"achieved":[96],"through":[97,121,300],"chemical":[98,135],"bonding":[99],"by":[100,360],"conjugation":[101],"cross-linking":[103],"natural":[105],"synthetic":[107],"polymers,":[108],"attachments":[109,119,130],"made":[112,120,231],"directly":[113],"non-polymeric":[116],"mediation":[122],"molecular-spacer":[124],"non-spacer":[128],"mediated":[129],"several":[132],"types":[133],"physico-chemical":[140],"bondings":[141],"moieties,":[144],"e.g.,":[145],"peptides,":[146],"proteins,":[147],"antibodies,":[148],"antigens,":[149],"aptamers,":[150],"glycoproteins,":[151],"enzymes,":[153],"etc.":[154],"which":[158],"are":[159],"capable":[160],"targeting":[162],"multiple":[163,301],"kinds":[164],"cancerous":[166,241],"sites,":[167],"provided":[169,334],"stable":[170],"SPIONs-based":[173,254,290],"nano-carriers":[174,291],"suitable":[175,186],"for":[176,187,243,277,292,357,374],"systemic,":[178],"in":[180,250,318,321,330],"vitro":[181,322],"deliveries,":[182],"being":[185],"other":[188,237],"biomedical/biotechnical":[189],"applications.":[190],"Together":[191],"inherent":[195],"properties,":[196],"ability":[198],"respond":[200],"magnetic":[202],"resonance,":[203],"fluorescence-directed,":[204],"dual-module,":[205],"molecular-level":[207],"tumor":[208],"imaging;":[209],"multi-modular":[213],"cell":[215],"targeting;":[216],"magnetic-field-inducible":[217],"drug-elution":[218],"capacity,":[219],"magnetometry-led":[223],"feasibility":[224],"reach":[226],"action":[228],"sites":[229,242,299],"sensing,":[232],"imaging,":[233],"payloads":[238],"deliveries":[239],"treatment":[245],"a":[246],"viable":[247],"option.":[248],"Innovations":[249],"preparation":[252],"modules,":[256],"biocompatible":[258],"carriers;":[259],"route":[263],"modalities;":[264],"approaches":[265],"enhancing":[267],"their":[268],"delivery-cum-bioavailability":[270],"explicitly":[272],"established":[273],"versatility":[276],"oncological":[278],"theranostics":[279],"imaging.":[281],"current":[283,325],"review":[284],"outlines":[285],"targeted":[293],"doxorubicin":[294],"different":[297],"methods,":[302],"modalities,":[303],"materials,":[305],"wherein":[306],"high-potential":[307],"platforms":[309],"conceptualized,":[312],"developed,":[313],"tested":[315],"for,":[316],"both,":[317],"vivo":[319],"conditions.":[323],"state":[326],"knowledge":[329],"this":[331],"arena":[332],"definite":[335],"dose-control,":[336],"site-specificity,":[337],"stability,":[338],"transport":[339],"feasibility,":[340],"effective":[342],"onsite":[343],"de-loading,":[345],"however,":[346],"certain":[348],"limitations,":[349],"these":[351],"shortcomings":[352],"opened":[354],"field":[356],"further":[358],"advancements":[359],"identifying":[361],"bottlenecks,":[363],"suggestive":[364],"plausible":[366],"remediation,":[367],"more":[371],"clear":[372],"directions":[373],"future":[375],"development.":[376]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":22},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-10-21T00:00:00"}