{"id":"https://openalex.org/W4306828696","doi":"https://doi.org/10.1101/2022.10.19.512755","title":"Prevention of thrombocytopenia and thrombosis in heparin-induced thrombocytopenia (HIT) using deglycosylated KKO: A novel therapeutic?","display_name":"Prevention of thrombocytopenia and thrombosis in heparin-induced thrombocytopenia (HIT) using deglycosylated KKO: A novel therapeutic?","publication_year":2022,"publication_date":"2022-10-19","ids":{"openalex":"https://openalex.org/W4306828696","doi":"https://doi.org/10.1101/2022.10.19.512755"},"language":"en","primary_location":{"id":"doi:10.1101/2022.10.19.512755","doi":"https://doi.org/10.1101/2022.10.19.512755","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.10.19.512755","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/10/19/2022.10.19.512755.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2022/10/19/2022.10.19.512755.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045140204","display_name":"Amrita Sarkar","orcid":"https://orcid.org/0000-0002-5828-9682","observed_orcids":["https://orcid.org/0000-0002-5828-9682"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amrita Sarkar","raw_affiliation_strings":["Department of Pediatrics, The Children\u2019s Hospital of Philadelphia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, The Children\u2019s Hospital of Philadelphia","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015567000","display_name":"Sanjay Khandelwal","orcid":"https://orcid.org/0000-0002-5661-3856","observed_orcids":["https://orcid.org/0000-0002-5661-3856"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sanjay Khandelwal","raw_affiliation_strings":["Division of Hematology, Duke University Medical Center, Durham, NC"],"raw_orcid":"https://orcid.org/0000-0002-5661-3856","affiliations":[{"raw_affiliation_string":"Division of Hematology, Duke University Medical Center, Durham, NC","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100775837","display_name":"Hyun\u2010Jun Kim","orcid":"https://orcid.org/0000-0001-9254-394X","observed_orcids":["https://orcid.org/0000-0001-9254-394X","https://orcid.org/0000-0001-7059-0040"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hyunjun Kim","raw_affiliation_strings":["Department of Pediatrics, The Children\u2019s Hospital of Philadelphia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, The Children\u2019s Hospital of Philadelphia","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018171524","display_name":"Yves Gruel","orcid":"https://orcid.org/0000-0002-1250-6063","observed_orcids":["https://orcid.org/0000-0002-1250-6063"]},"institutions":[{"id":"https://openalex.org/I110017253","display_name":"Universit\u00e9 de Tours","ror":"https://ror.org/02wwzvj46","country_code":"FR","type":"education","lineage":["https://openalex.org/I110017253"]},{"id":"https://openalex.org/I4210095477","display_name":"Centre Hospitalier Universitaire de Tours","ror":"https://ror.org/00jpq0w62","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210095477"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Yves Gruel","raw_affiliation_strings":["Department of Hemostasis, University Hospital Center of Tours, and EA4245 T2i, University of Tours, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hemostasis, University Hospital Center of Tours, and EA4245 T2i, University of Tours, France","institution_ids":["https://openalex.org/I110017253","https://openalex.org/I4210095477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083661496","display_name":"J\u00e9r\u00f4me Rollin","orcid":"https://orcid.org/0000-0001-6861-1551","observed_orcids":["https://orcid.org/0000-0001-6861-1551"]},"institutions":[{"id":"https://openalex.org/I110017253","display_name":"Universit\u00e9 de Tours","ror":"https://ror.org/02wwzvj46","country_code":"FR","type":"education","lineage":["https://openalex.org/I110017253"]},{"id":"https://openalex.org/I4210095477","display_name":"Centre Hospitalier Universitaire de Tours","ror":"https://ror.org/00jpq0w62","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210095477"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jerome Rollin","raw_affiliation_strings":["Department of Hemostasis, University Hospital Center of Tours, and EA4245 T2i, University of Tours, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hemostasis, University Hospital Center of Tours, and EA4245 T2i, University of Tours, France","institution_ids":["https://openalex.org/I110017253","https://openalex.org/I4210095477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038739204","display_name":"Geoffrey D. Wool","orcid":"https://orcid.org/0000-0002-3335-2905","observed_orcids":["https://orcid.org/0000-0002-3335-2905"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Geoffrey D. Wool","raw_affiliation_strings":["Department of Pathology, University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040851400","display_name":"Gowthami M. Arepally","orcid":"https://orcid.org/0000-0003-0496-5064","observed_orcids":["https://orcid.org/0000-0003-0496-5064"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gowthami M. Arepally","raw_affiliation_strings":["Division of Hematology, Duke University Medical Center, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Duke University Medical Center, Durham, NC","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077478635","display_name":"Douglas B. Cines","orcid":"https://orcid.org/0000-0001-5986-504X","observed_orcids":["https://orcid.org/0000-0001-5986-504X"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas B. Cines","raw_affiliation_strings":["Department of Pathology and Clinical Laboratories, The Perelman School of Medicine at the University of Pennsylvania. Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Clinical Laboratories, The Perelman School of Medicine at the University of Pennsylvania. Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075920531","display_name":"Lubica Rauova","orcid":"https://orcid.org/0000-0003-1990-3077","observed_orcids":["https://orcid.org/0000-0003-1990-3077"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lubica Rauova","raw_affiliation_strings":["Department of Pediatrics, The Children\u2019s Hospital of Philadelphia","Department of Pediatrics, The Perelman School of Medicine at the University of Pennsylvania. Philadelphia, PA"],"raw_orcid":"https://orcid.org/0000-0003-1990-3077","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, The Children\u2019s Hospital of Philadelphia","institution_ids":["https://openalex.org/I1335321130"]},{"raw_affiliation_string":"Department of Pediatrics, The Perelman School of Medicine at the University of Pennsylvania. Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030315782","display_name":"Mortimer Poncz","orcid":"https://orcid.org/0000-0001-7237-3613","observed_orcids":["https://orcid.org/0000-0001-7237-3613"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mortimer Poncz","raw_affiliation_strings":["Department of Pediatrics, The Children\u2019s Hospital of Philadelphia","Department of Pediatrics, The Perelman School of Medicine at the University of Pennsylvania. Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, The Children\u2019s Hospital of Philadelphia","institution_ids":["https://openalex.org/I1335321130"]},{"raw_affiliation_string":"Department of Pediatrics, The Perelman School of Medicine at the University of Pennsylvania. Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5030315782"],"corresponding_institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12352","display_name":"Heparin-Induced Thrombocytopenia and Thrombosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12352","display_name":"Heparin-Induced Thrombocytopenia and Thrombosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heparin-induced-thrombocytopenia","display_name":"heparin-induced thrombocytopenia","score":1.0},{"id":"https://openalex.org/keywords/platelet-factor-4","display_name":"platelet factor 4","score":0.9480000138282776},{"id":"https://openalex.org/keywords/fcgammariia","display_name":"Fc\u03b3RIIa","score":0.9200000166893005},{"id":"https://openalex.org/keywords/complement-activation","display_name":"complement activation","score":0.699999988079071},{"id":"https://openalex.org/keywords/platelet-activation","display_name":"platelet activation","score":0.6489999890327454},{"id":"https://openalex.org/keywords/anti-pf4-antibodies","display_name":"anti-PF4 antibodies","score":0.5370000004768372},{"id":"https://openalex.org/keywords/thromboprophylaxis","display_name":"thromboprophylaxis","score":0.8769999742507935},{"id":"https://openalex.org/keywords/vaccine-induced-thrombotic-thrombocytopenia","display_name":"vaccine-induced immune thrombotic thrombocytopenia","score":0.9490000009536743},{"id":"https://openalex.org/keywords/therapeutic-antibodies","display_name":"therapeutic antibodies","score":0.367000013589859}],"concepts":[{"id":"https://openalex.org/C2776472838","wikidata":"https://www.wikidata.org/wiki/Q1598365","display_name":"Heparin-induced thrombocytopenia","level":3,"score":0.9431979060173035},{"id":"https://openalex.org/C159973064","wikidata":"https://www.wikidata.org/wiki/Q3740205","display_name":"Platelet factor 4","level":3,"score":0.7777783870697021},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.7023873329162598},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6816752552986145},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.6764558553695679},{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.6334739923477173},{"id":"https://openalex.org/C3018697912","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Platelet activation","level":3,"score":0.6230156421661377},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5872414708137512},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5251083970069885},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.471342533826828},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.36516261100769043},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.132278174161911}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/2022.10.19.512755","doi":"https://doi.org/10.1101/2022.10.19.512755","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.10.19.512755","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/10/19/2022.10.19.512755.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/2022.10.19.512755","doi":"https://doi.org/10.1101/2022.10.19.512755","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.10.19.512755","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/10/19/2022.10.19.512755.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4306828696.pdf","grobid_xml":"https://content.openalex.org/works/W4306828696.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W5602845","https://openalex.org/W25152566","https://openalex.org/W915184378","https://openalex.org/W1513585711","https://openalex.org/W1593968135","https://openalex.org/W1873218418","https://openalex.org/W1969633857","https://openalex.org/W1990546866","https://openalex.org/W2024305286","https://openalex.org/W2027718106","https://openalex.org/W2057508226","https://openalex.org/W2062957366","https://openalex.org/W2079222079","https://openalex.org/W2087881750","https://openalex.org/W2089267656","https://openalex.org/W2105079657","https://openalex.org/W2128775077","https://openalex.org/W2156871984","https://openalex.org/W2466116900","https://openalex.org/W2558514376","https://openalex.org/W2588399936","https://openalex.org/W2594382840","https://openalex.org/W2604966034","https://openalex.org/W2605638326","https://openalex.org/W2691764704","https://openalex.org/W2744474093","https://openalex.org/W2753807115","https://openalex.org/W2926008380","https://openalex.org/W2964909673","https://openalex.org/W2971202060","https://openalex.org/W2983391355","https://openalex.org/W3007614442","https://openalex.org/W3167662617","https://openalex.org/W3173443401","https://openalex.org/W3180418018","https://openalex.org/W3186656284","https://openalex.org/W4225616587","https://openalex.org/W4292833841"],"related_works":["https://openalex.org/W4376866962","https://openalex.org/W3213428040","https://openalex.org/W1593968135","https://openalex.org/W4385687692","https://openalex.org/W2550159359","https://openalex.org/W4408558635","https://openalex.org/W2587814161","https://openalex.org/W4388596698","https://openalex.org/W7203840883","https://openalex.org/W1546557507"],"abstract_inverted_index":{"Abstract":[0],"Heparin-induced":[1],"thrombocytopenia":[2,8,176,244],"(HIT)":[3],"is":[4],"characterized":[5],"by":[6,134,208],"mild":[7],"associated":[9],"with":[10,31,213,235],"a":[11,59,104,189,211,225,246,258],"highly":[12],"prothrombotic":[13],"state":[14],"due":[15],"to":[16,75,107,123],"the":[17,42,66,76,113,214],"development":[18],"of":[19,44,51,69,130,154,159,228,233],"pathogenic":[20,70],"antibodies":[21],"that":[22,64],"recognize":[23],"human":[24],"(h)":[25],"platelet":[26],"factor":[27],"4":[28],"(PF4)":[29],"complexed":[30],"various":[32],"polyanions.":[33],"While":[34],"non-heparin":[35],"anticoagulants":[36],"and":[37,49,90,126,141,152,171,174,256],"intravenous":[38],"immunoglobulin":[39],"(IVIG)":[40],"are":[41],"mainstay":[43],"care,":[45],"bleeding":[46],"may":[47,223],"develop,":[48],"risk":[50],"new":[52,226],"thromboembolic":[53],"events":[54],"remain.":[55],"We":[56,94],"had":[57],"described":[58],"mouse":[60,165],"IgG\u03ba2b":[61],"antibody":[62],"KKO":[63,99,119,241],"mimics":[65],"sentinel":[67],"features":[68],"HIT":[71,84,145,185,198,247,259],"antibodies,":[72],"including":[73],"binding":[74],"same":[77],"neoepitope":[78],"on":[79,156],"hPF4:polyanion":[80],"complexes.":[81],"KKO,":[82,135,182],"like":[83],"IgGs,":[85],"activates":[86],"platelets":[87,133],"through":[88],"Fc\u03b3RIIA":[89],"induces":[91],"complement":[92,150],"activation.":[93],"now":[95],"asked":[96],"whether":[97],"Fc-modified":[98],"can":[100,242,251],"be":[101],"used":[102],"as":[103],"novel":[105],"therapeutic":[106],"prevent":[108],"or":[109,180,184],"treat":[110],"HIT.":[111,236],"Using":[112],"endoglycosidase":[114],"EndoS,":[115],"we":[116],"created":[117],"deglycosylated":[118],"(DGKKO).":[120],"DGKKO":[121,147,160,192,202,222,250],"bound":[122],"PF4-polyanion":[124],"complexes,":[125],"blocked":[127],"Fc\u03b3RIIA-dependent":[128],"activation":[129,151],"PF4":[131],"treated":[132],"5B9":[136,183],"(another":[137],"HIT-like":[138],"monoclonal":[139],"antibody),":[140],"isolated":[142],"IgGs":[143],"from":[144,210],"patients.":[146],"also":[148],"decreased":[149],"deposition":[153],"C3c":[155],"platelets.":[157],"Injection":[158],"into":[161],"\u201cHIT":[162],"mice\u201d":[163],"lacking":[164],"PF4,":[166],"but":[167],"transgenic":[168],"for":[169,230],"hPF4":[170],"Fc\u03b3RIIA,":[172],"prevented":[173],"reversed":[175,193],"when":[177],"injected":[178],"before":[179],"after":[181],"IgG,":[186],"respectively,":[187],"in":[188,197,205,245,254,257],"microfluidic":[190],"system.":[191],"antibody-induced":[194],"thrombus":[195],"growth":[196],"mice.":[199],"In":[200],"contrast,":[201],"was":[203],"ineffective":[204],"preventing":[206],"thrombosis":[207,253],"IgG":[209],"patient":[212],"HIT-related":[215],"disorder,":[216],"vaccine-induced":[217],"immune":[218],"thrombotic":[219],"thrombocytopenia.":[220],"Thus,":[221],"represent":[224],"class":[227],"therapeutics":[229],"targeted":[231],"treatment":[232],"patients":[234],"Key":[237],"Points":[238],"Deglycosylated":[239],"(DG)":[240],"reverse":[243],"murine":[248,260],"model.":[249,261],"prevent/reverse":[252],"vitro":[255]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2022-10-20T00:00:00"}
