{"id":"https://openalex.org/W4306793044","doi":"https://doi.org/10.6002/ect.2022.0269","title":"A Lipotoxic Medium Decreases the Number of Lipid Droplets in \u03b2 Cells: One Possible Explanation of the \u03b2-Cell Failure in Patients With Hyperlipidemia Receiving Tacrolimus.","display_name":"A Lipotoxic Medium Decreases the Number of Lipid Droplets in \u03b2 Cells: One Possible Explanation of the \u03b2-Cell Failure in Patients With Hyperlipidemia Receiving Tacrolimus.","publication_year":2022,"publication_date":"2022-10-19","ids":{"openalex":"https://openalex.org/W4306793044","doi":"https://doi.org/10.6002/ect.2022.0269","pmid":"https://pubmed.ncbi.nlm.nih.gov/36259627"},"language":"en","primary_location":{"id":"doi:10.6002/ect.2022.0269","doi":"https://doi.org/10.6002/ect.2022.0269","is_oa":false,"landing_page_url":"https://doi.org/10.6002/ect.2022.0269","pdf_url":null,"source":{"id":"https://openalex.org/S2756478974","display_name":"Experimental and Clinical Transplantation","issn_l":"1304-0855","issn":["1304-0855","2146-8427"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310318367","host_organization_name":"Ba\u015fkent University","host_organization_lineage":["https://openalex.org/P4310318367"],"host_organization_lineage_names":["Ba\u015fkent University"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Clinical Transplantation","raw_type":"journal-issue"},"volume":null,"type":"paratext","is_traditional":false,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036761952","display_name":"Yaprak Yal\u00e7\u0131n","orcid":"https://orcid.org/0000-0002-9337-9106","observed_orcids":["https://orcid.org/0000-0002-9337-9106"]},"institutions":[{"id":"https://openalex.org/I188740104","display_name":"Ba\u015fkent University","ror":"https://ror.org/02v9bqx10","country_code":"TR","type":"education","lineage":["https://openalex.org/I188740104"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Yaprak Y\u0131lmaz Yalcin","raw_affiliation_strings":[">From the School of Medicine Department of Medical Biology,Baskent University, Ankara","From the School of Medicine Department of Medical Biology, Baskent University, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":">From the School of Medicine Department of Medical Biology,Baskent University, Ankara","institution_ids":["https://openalex.org/I188740104"]},{"raw_affiliation_string":"From the School of Medicine Department of Medical Biology, Baskent University, Ankara, Turkey","institution_ids":["https://openalex.org/I188740104"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046031399","display_name":"Neslihan Ba\u015f\u00e7\u0131l T\u00fct\u00fcnc\u00fc","orcid":"https://orcid.org/0000-0002-1816-3903","observed_orcids":["https://orcid.org/0000-0002-1816-3903"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Neslihan Bascil Tutuncu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068004525","display_name":"Hatice P\u0131nar Baysan \u00c7ebi","orcid":"https://orcid.org/0000-0002-9141-9987","observed_orcids":["https://orcid.org/0000-0002-9141-9987"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hatice P\u0131nar Baysan Cebi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001941479","display_name":"Hasibe Verdi","orcid":"https://orcid.org/0000-0003-0591-009X","observed_orcids":["https://orcid.org/0000-0003-0591-009X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hasibe Verdi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042955058","display_name":"S\u00fcleyman Erol","orcid":"https://orcid.org/0000-0002-4542-8225","observed_orcids":["https://orcid.org/0000-0002-4542-8225"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Suleyman Erol","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006813552","display_name":"Figen Fevziye Kaymaz","orcid":"https://orcid.org/0000-0001-8896-2471","observed_orcids":["https://orcid.org/0000-0001-8896-2471"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fevziye Figen Kaymaz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5073217377","display_name":"Fatma Belgin Ata\u00e7","orcid":"https://orcid.org/0000-0001-6868-2165","observed_orcids":["https://orcid.org/0000-0001-6868-2165"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fatma Belgin Atac","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"3","first_page":"237","last_page":"242"},"is_retracted":false,"is_paratext":true,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipotoxicity","display_name":"lipotoxicity","score":0.9139999747276306},{"id":"https://openalex.org/keywords/lipid-droplets","display_name":"lipid droplets","score":0.9279999732971191},{"id":"https://openalex.org/keywords/beta-cell-failure","display_name":"beta-cell failure","score":0.7059999704360962},{"id":"https://openalex.org/keywords/glucolipotoxicity","display_name":"glucolipotoxicity","score":0.8569999933242798},{"id":"https://openalex.org/keywords/glucotoxicity","display_name":"glucotoxicity","score":0.7429999709129333},{"id":"https://openalex.org/keywords/dyslipidemia","display_name":"dyslipidemia","score":0.8050000071525574},{"id":"https://openalex.org/keywords/tacrolimus","display_name":"tacrolimus","score":0.9559999704360962},{"id":"https://openalex.org/keywords/post-transplant-diabetes-mellitus","display_name":"post-transplant diabetes mellitus","score":0.9800000190734863},{"id":"https://openalex.org/keywords/palmitic-acid","display_name":"palmitic acid","score":0.9240000247955322},{"id":"https://openalex.org/keywords/insulinoma-cells","display_name":"insulinoma cells","score":0.6269999742507935},{"id":"https://openalex.org/keywords/beta-cell-morphology","display_name":"beta cell morphology","score":0.6240000128746033},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.4560000002384186}],"concepts":[{"id":"https://openalex.org/C44353895","wikidata":"https://www.wikidata.org/wiki/Q6556772","display_name":"Lipotoxicity","level":4,"score":0.9737977981567383},{"id":"https://openalex.org/C25095133","wikidata":"https://www.wikidata.org/wiki/Q573950","display_name":"Lipid droplet","level":2,"score":0.8605753183364868},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.6567795276641846},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5179542303085327},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5111353993415833},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5038344264030457},{"id":"https://openalex.org/C2778096610","wikidata":"https://www.wikidata.org/wiki/Q1476525","display_name":"Dyslipidemia","level":3,"score":0.4504486322402954},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.44776731729507446},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35770511627197266},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30580949783325195},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.258314311504364},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.2543606460094452},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.23908782005310059},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22984957695007324},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006949","descriptor_name":"Hyperlipidemias","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006949","descriptor_name":"Hyperlipidemias","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006949","descriptor_name":"Hyperlipidemias","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006949","descriptor_name":"Hyperlipidemias","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016559","descriptor_name":"Tacrolimus","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D019308","descriptor_name":"Palmitic Acid","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066292","descriptor_name":"Lipid Droplets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D066292","descriptor_name":"Lipid Droplets","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.6002/ect.2022.0269","doi":"https://doi.org/10.6002/ect.2022.0269","is_oa":false,"landing_page_url":"https://doi.org/10.6002/ect.2022.0269","pdf_url":null,"source":{"id":"https://openalex.org/S2756478974","display_name":"Experimental and Clinical Transplantation","issn_l":"1304-0855","issn":["1304-0855","2146-8427"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310318367","host_organization_name":"Ba\u015fkent University","host_organization_lineage":["https://openalex.org/P4310318367"],"host_organization_lineage_names":["Ba\u015fkent University"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Clinical Transplantation","raw_type":"journal-issue"},{"id":"pmid:36259627","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36259627","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W829483284","https://openalex.org/W1545442421","https://openalex.org/W1600183974","https://openalex.org/W1917835527","https://openalex.org/W1942089699","https://openalex.org/W1968909833","https://openalex.org/W1974313161","https://openalex.org/W2006405957","https://openalex.org/W2035310767","https://openalex.org/W2043234667","https://openalex.org/W2058866009","https://openalex.org/W2076710842","https://openalex.org/W2084997793","https://openalex.org/W2101369715","https://openalex.org/W2163947659","https://openalex.org/W2165569721","https://openalex.org/W2291510111","https://openalex.org/W2560888990","https://openalex.org/W2607067380","https://openalex.org/W2793435470","https://openalex.org/W2837512072","https://openalex.org/W2885582506","https://openalex.org/W3202679698","https://openalex.org/W3211672313","https://openalex.org/W4213464763","https://openalex.org/W4284890877"],"related_works":["https://openalex.org/W4283834359","https://openalex.org/W3010198068","https://openalex.org/W2088125653","https://openalex.org/W6992533632","https://openalex.org/W9560361","https://openalex.org/W3016791728","https://openalex.org/W2008188747","https://openalex.org/W3177285124","https://openalex.org/W2992975671","https://openalex.org/W2086113191"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Dyslipidemia":[1],"is":[2,33,43,261,296],"a":[3,34,46,203],"risk":[4,274],"factor":[5],"for":[6,118,299],"post-transplant":[7],"diabetes":[8,277,292],"mellitus,":[9,278],"especially":[10,298],"in":[11,36,52,59,74,96,137,144,156,164,221,237,254,269,285,293],"patients":[12,271,295],"who":[13],"are":[14],"taking":[15,301],"tacrolimus.":[16,302],"Although":[17],"lipotoxicity":[18,244,260],"of":[19,28,49,91,140,194,206,224,251,263,275,282,291],"dyslipidemia":[20,258],"leads":[21],"to":[22,63],"\u03b2":[23,31,60,75,101,142,200,225,233,255,286],"-cell":[24,226],"failure,":[25],"the":[26,71,138,145,157,160,222,249,264,280,289],"handling":[27],"lipids":[29],"by":[30],"cells":[32,53,61,76,143,201,234,287],"mystery":[35,281],"molecular":[37],"endocrinology.":[38],"Likewise,":[39],"lipid":[40,50,81,133,181,207,238,252,283],"droplet":[41,217],"homeostasis":[42,223],"appreciated":[44],"as":[45],"key":[47],"component":[48],"metabolism":[51],"like":[54],"hepatocytes,":[55],"but":[56],"its":[57],"role":[58],"remains":[62],"be":[64],"elucidated.":[65],"MATERIALS":[66],"AND":[67],"METHODS:":[68],"To":[69],"evaluate":[70],"morphologic":[72,123,192],"changes":[73,124],"with":[77,106,127,176,190,213],"special":[78],"focus":[79],"on":[80],"droplets,":[82],"we":[83],"evaluated":[84],"electron":[85,129],"micrographs":[86],"under":[87,169,240],"metabolic":[88,267],"stress":[89],"conditions":[90],"glucotoxicity,":[92],"lipotoxicity,":[93],"and":[94,159,166,209,246,272,288],"glucolipotoxicity":[95,247],"isolated":[97],"rat":[98],"insulinoma":[99],"INS-1E":[100],"cells.":[102,256],"Cells":[103],"were":[104,125,135,153,183,187],"treated":[105],"palmitic":[107,177],"acid":[108],"(0.5":[109],"mM":[110,114],"),":[111,115],"glucose":[112,171],"(33":[113],"or":[116],"both":[117],"16":[119],"hours,":[120],"after":[121,174],"which":[122],"observed":[126,136],"an":[128],"microscope.":[130],"RESULTS:":[131],"Many":[132],"droplets":[134,152,182,208,239,253,284],"cytoplasm":[139,161],"healthy":[141,232],"control":[146],"group":[147],"(no":[148],"treatment":[149,175],").":[150],"Lipid":[151,216],"also":[154,188],"visible":[155],"cytosol,":[158],"was":[162],"rich":[163,236],"organelles":[165],"insulin":[167,210],"vesicles":[168,186,211],"high":[170],"stimulation.":[172],"However,":[173,243],"acid,":[178],"almost":[179],"no":[180],"observed.":[184],"Endocrine":[185],"depleted,":[189],"severe":[191],"disruption":[193],"other":[195],"organelles.":[196],"Under":[197],"glucolipotoxic":[198],"conditions,":[199],"showed":[202],"decreased":[204,248],"number":[205,250],"compared":[212],"controls.":[214],"CONCLUSIONS:":[215],"dynamics":[218],"seemed":[219],"important":[220],"metabolism.":[227],"In":[228],"this":[229],"preliminary":[230],"study,":[231],"appeared":[235],"normal":[241],"conditions.":[242],"depleted":[245],"Because":[257],"causing":[259],"one":[262],"most":[265],"frequent":[266],"problems":[268],"transplant":[270,294],"increases":[273],"posttransplant":[276],"understanding":[279],"pathophysiology":[290],"important,":[297],"those":[300]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-11T09:32:39.932853","created_date":"2022-10-20T00:00:00"}
