{"id":"https://openalex.org/W4306771925","doi":"https://doi.org/10.1016/j.biopha.2022.113871","title":"Pharmacological management of cancer pain: Novel therapeutics","display_name":"Pharmacological management of cancer pain: Novel therapeutics","publication_year":2022,"publication_date":"2022-10-19","ids":{"openalex":"https://openalex.org/W4306771925","doi":"https://doi.org/10.1016/j.biopha.2022.113871","pmid":"https://pubmed.ncbi.nlm.nih.gov/36272265"},"language":"en","primary_location":{"id":"doi:10.1016/j.biopha.2022.113871","doi":"https://doi.org/10.1016/j.biopha.2022.113871","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biopha.2022.113871","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0753332222012604/pdf","source":{"id":"https://openalex.org/S15111687","display_name":"Biomedicine & Pharmacotherapy","issn_l":"0753-3322","issn":["0753-3322","1950-6007"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-2","ki-jl-1","medline","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine & Pharmacotherapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S0753332222012604/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001888120","display_name":"Celina Guadalupe Virgen","orcid":"https://orcid.org/0000-0002-6393-7525","observed_orcids":["https://orcid.org/0000-0002-6393-7525"]},"institutions":[{"id":"https://openalex.org/I4405259572","display_name":"University of Arizona College of Medicine- Phoenix","ror":"https://ror.org/02drhvq25","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243","https://openalex.org/I4405259572"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Celina G. Virgen","raw_affiliation_strings":["University of Arizona College of Medicine Phoenix, USA. Electronic address: celinav@email.arizona.edu","University of Arizona College of Medicine Phoenix, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Arizona College of Medicine Phoenix, USA. Electronic address: celinav@email.arizona.edu","institution_ids":["https://openalex.org/I4405259572"]},{"raw_affiliation_string":"University of Arizona College of Medicine Phoenix, USA","institution_ids":["https://openalex.org/I4405259572"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057106393","display_name":"Neil Kelkar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405259572","display_name":"University of Arizona College of Medicine- Phoenix","ror":"https://ror.org/02drhvq25","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243","https://openalex.org/I4405259572"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neil Kelkar","raw_affiliation_strings":["University of Arizona, College of Medicine, Phoenix, Phoenix, AZ, USA. Electronic address: nkelkar@email.arizona.edu","University of Arizona, College of Medicine, Phoenix, Phoenix, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Arizona, College of Medicine, Phoenix, Phoenix, AZ, USA. Electronic address: nkelkar@email.arizona.edu","institution_ids":["https://openalex.org/I4405259572"]},{"raw_affiliation_string":"University of Arizona, College of Medicine, Phoenix, Phoenix, AZ, USA","institution_ids":["https://openalex.org/I4405259572"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Aaron Tran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405259572","display_name":"University of Arizona College of Medicine- Phoenix","ror":"https://ror.org/02drhvq25","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243","https://openalex.org/I4405259572"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron Tran","raw_affiliation_strings":["The University of Arizona College of Medicine, Phoenix, Phoenix, AZ, USA. Electronic address: atran13@email.arizona.edu","The University of Arizona College of Medicine, Phoenix, Phoenix, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Arizona College of Medicine, Phoenix, Phoenix, AZ, USA. Electronic address: atran13@email.arizona.edu","institution_ids":["https://openalex.org/I4405259572"]},{"raw_affiliation_string":"The University of Arizona College of Medicine, Phoenix, Phoenix, AZ, USA","institution_ids":["https://openalex.org/I4405259572"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005016418","display_name":"Christina M. Rosa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina M. Rosa","raw_affiliation_strings":["Psychological and Brain Sciences, University of California, Santa Barbara, USA. Electronic address: christinarosa@ucsb.edu","Psychological and Brain Sciences, University of California, Santa Barbara, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychological and Brain Sciences, University of California, Santa Barbara, USA. Electronic address: christinarosa@ucsb.edu","institution_ids":["https://openalex.org/I154570441"]},{"raw_affiliation_string":"Psychological and Brain Sciences, University of California, Santa Barbara, USA","institution_ids":["https://openalex.org/I154570441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022618012","display_name":"Diana Cruz\u2010Topete","orcid":"https://orcid.org/0000-0001-6315-6027","observed_orcids":["https://orcid.org/0000-0001-6315-6027"]},"institutions":[{"id":"https://openalex.org/I81020160","display_name":"Louisiana State University Health Sciences Center Shreveport","ror":"https://ror.org/03151rh82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I81020160"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diana Cruz-Topete","raw_affiliation_strings":["Department of Molecular and Cellular Physiology, LSU Health Shreveport, 1501 Kings Highway, Shreveport, LA 71103, USA. Electronic address: diana.cruz@lsuhs.edu","Department of Molecular and Cellular Physiology, LSU Health Shreveport, 1501 Kings Highway, Shreveport, LA 71103, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Physiology, LSU Health Shreveport, 1501 Kings Highway, Shreveport, LA 71103, USA. Electronic address: diana.cruz@lsuhs.edu","institution_ids":["https://openalex.org/I81020160"]},{"raw_affiliation_string":"Department of Molecular and Cellular Physiology, LSU Health Shreveport, 1501 Kings Highway, Shreveport, LA 71103, USA","institution_ids":["https://openalex.org/I81020160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009386318","display_name":"Shripa Amatya","orcid":"https://orcid.org/0009-0003-8190-7164","observed_orcids":["https://orcid.org/0009-0003-8190-7164"]},"institutions":[{"id":"https://openalex.org/I81020160","display_name":"Louisiana State University Health Sciences Center Shreveport","ror":"https://ror.org/03151rh82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I81020160"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shripa Amatya","raw_affiliation_strings":["Department of Molecular and Cellular Physiology, LSU Health Shreveport, 1501 Kings Highway, Shreveport, LA 71103, USA. Electronic address: shripa.amatya@lsuhs.edu","Department of Molecular and Cellular Physiology, LSU Health Shreveport, 1501 Kings Highway, Shreveport, LA 71103, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Physiology, LSU Health Shreveport, 1501 Kings Highway, Shreveport, LA 71103, USA. Electronic address: shripa.amatya@lsuhs.edu","institution_ids":["https://openalex.org/I81020160"]},{"raw_affiliation_string":"Department of Molecular and Cellular Physiology, LSU Health Shreveport, 1501 Kings Highway, Shreveport, LA 71103, USA","institution_ids":["https://openalex.org/I81020160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007412928","display_name":"Elyse M. Cornett","orcid":"https://orcid.org/0000-0001-7961-3931","observed_orcids":["https://orcid.org/0000-0001-7961-3931"]},"institutions":[{"id":"https://openalex.org/I26489229","display_name":"Louisiana State University in Shreveport","ror":"https://ror.org/02c4cbt39","country_code":"US","type":"education","lineage":["https://openalex.org/I26489229"]},{"id":"https://openalex.org/I81020160","display_name":"Louisiana State University Health Sciences Center Shreveport","ror":"https://ror.org/03151rh82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I81020160"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Elyse M. Cornett","raw_affiliation_strings":["Department of Anesthesiology, LSU Health Shreveport, 1501 Kings Highway, Shreveport LA 71103, USA. Electronic address: elyse.bradley@lsuhs.edu","Department of Anesthesiology, LSU Health Shreveport, 1501 Kings Highway, Shreveport LA 71103, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, LSU Health Shreveport, 1501 Kings Highway, Shreveport LA 71103, USA. Electronic address: elyse.bradley@lsuhs.edu","institution_ids":["https://openalex.org/I26489229","https://openalex.org/I81020160"]},{"raw_affiliation_string":"Department of Anesthesiology, LSU Health Shreveport, 1501 Kings Highway, Shreveport LA 71103, USA","institution_ids":["https://openalex.org/I81020160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078251206","display_name":"Ivan Urits","orcid":"https://orcid.org/0000-0002-3652-6085","observed_orcids":["https://orcid.org/0000-0002-3652-6085"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ivan Urits","raw_affiliation_strings":["Beth Israel Deaconess Medical Center, Department of Anesthesia, Critical Care, and Pain Medicine, 330 Brookline Ave, Boston, MA 02215, USA. Electronic address: ivanurits@gmail.com","Beth Israel Deaconess Medical Center, Department of Anesthesia, Critical Care, and Pain Medicine, 330 Brookline Ave, Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beth Israel Deaconess Medical Center, Department of Anesthesia, Critical Care, and Pain Medicine, 330 Brookline Ave, Boston, MA 02215, USA. Electronic address: ivanurits@gmail.com","institution_ids":["https://openalex.org/I1316535847"]},{"raw_affiliation_string":"Beth Israel Deaconess Medical Center, Department of Anesthesia, Critical Care, and Pain Medicine, 330 Brookline Ave, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014876140","display_name":"Omar Viswanath","orcid":"https://orcid.org/0000-0002-6124-7037","observed_orcids":["https://orcid.org/0000-0002-6124-7037"]},"institutions":[{"id":"https://openalex.org/I114493937","display_name":"Creighton University","ror":"https://ror.org/05wf30g94","country_code":"US","type":"education","lineage":["https://openalex.org/I114493937"]},{"id":"https://openalex.org/I4405259572","display_name":"University of Arizona College of Medicine- Phoenix","ror":"https://ror.org/02drhvq25","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243","https://openalex.org/I4405259572"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Omar Viswanath","raw_affiliation_strings":["Innovative Pain and Wellness, Scottsdale, AZ, University of Arizona College of Medicine - Phoenix, Department of Anesthesiology, Phoenix, AZ, Creighton University School of Medicine, Department of Anesthesiology, Omaha, NE, USA. Electronic address: viswanoy@gmail.com","Innovative Pain and Wellness, Scottsdale, AZ, University of Arizona College of Medicine - Phoenix, Department of Anesthesiology, Phoenix, AZ, Creighton University School of Medicine, Department of Anesthesiology, Omaha, NE, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Innovative Pain and Wellness, Scottsdale, AZ, University of Arizona College of Medicine - Phoenix, Department of Anesthesiology, Phoenix, AZ, Creighton University School of Medicine, Department of Anesthesiology, Omaha, NE, USA. Electronic address: viswanoy@gmail.com","institution_ids":["https://openalex.org/I114493937","https://openalex.org/I4405259572"]},{"raw_affiliation_string":"Innovative Pain and Wellness, Scottsdale, AZ, University of Arizona College of Medicine - Phoenix, Department of Anesthesiology, Phoenix, AZ, Creighton University School of Medicine, Department of Anesthesiology, Omaha, NE, USA","institution_ids":["https://openalex.org/I114493937","https://openalex.org/I4405259572"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018558604","display_name":"Alan D. Kaye","orcid":"https://orcid.org/0000-0003-2464-0187","observed_orcids":["https://orcid.org/0000-0003-2464-0187"]},"institutions":[{"id":"https://openalex.org/I26489229","display_name":"Louisiana State University in Shreveport","ror":"https://ror.org/02c4cbt39","country_code":"US","type":"education","lineage":["https://openalex.org/I26489229"]},{"id":"https://openalex.org/I81020160","display_name":"Louisiana State University Health Sciences Center Shreveport","ror":"https://ror.org/03151rh82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I81020160"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan David Kaye","raw_affiliation_strings":["Vice Chancellor of Academic Affairs, Professor, Departments of Anesthesiology and Pharmacology, Toxicology, and Neurosciences, Pain Fellowship Director, LSU Health Shreveport, 1501 Kings Highway, Shreveport, LA 71103, USA. Electronic address: alan.kaye@lsuhs.edu","Vice Chancellor of Academic Affairs, Professor, Departments of Anesthesiology and Pharmacology, Toxicology, and Neurosciences, Pain Fellowship Director, LSU Health Shreveport, 1501 Kings Highway, Shreveport, LA 71103, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vice Chancellor of Academic Affairs, Professor, Departments of Anesthesiology and Pharmacology, Toxicology, and Neurosciences, Pain Fellowship Director, LSU Health Shreveport, 1501 Kings Highway, Shreveport, LA 71103, USA. Electronic address: alan.kaye@lsuhs.edu","institution_ids":["https://openalex.org/I26489229","https://openalex.org/I81020160"]},{"raw_affiliation_string":"Vice Chancellor of Academic Affairs, Professor, Departments of Anesthesiology and Pharmacology, Toxicology, and Neurosciences, Pain Fellowship Director, LSU Health Shreveport, 1501 Kings Highway, Shreveport, LA 71103, USA","institution_ids":["https://openalex.org/I26489229","https://openalex.org/I81020160"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5007412928"],"corresponding_institution_ids":["https://openalex.org/I26489229","https://openalex.org/I81020160"],"apc_list":{"value":2740,"currency":"USD","value_usd":2740},"apc_paid":{"value":2740,"currency":"USD","value_usd":2740},"fwci":12.0769,"has_fulltext":true,"cited_by_count":60,"citation_normalized_percentile":{"value":0.99167902,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"156","issue":null,"first_page":"113871","last_page":"113871"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cancer-pain","display_name":"cancer pain","score":0.996999979019165},{"id":"https://openalex.org/keywords/non-opioid-analgesics","display_name":"non-opioid analgesics","score":0.8799999952316284},{"id":"https://openalex.org/keywords/opioid-side-effects","display_name":"opioid side effects","score":0.7110000252723694},{"id":"https://openalex.org/keywords/opioid-use-disorder","display_name":"opioid use disorder","score":0.609000027179718},{"id":"https://openalex.org/keywords/breakthrough-pain","display_name":"breakthrough pain","score":0.9300000071525574},{"id":"https://openalex.org/keywords/pain-management-guidelines","display_name":"pain management guidelines","score":0.5509999990463257}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8133597373962402},{"id":"https://openalex.org/C2778904085","wikidata":"https://www.wikidata.org/wiki/Q3712728","display_name":"Cancer pain","level":3,"score":0.7531043291091919},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6204596757888794},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5528450012207031},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.5476648807525635},{"id":"https://openalex.org/C2777107010","wikidata":"https://www.wikidata.org/wiki/Q2798704","display_name":"Neuropathic pain","level":2,"score":0.4407922327518463},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.43885892629623413},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4179009795188904},{"id":"https://openalex.org/C2781118164","wikidata":"https://www.wikidata.org/wiki/Q1088113","display_name":"Chronic pain","level":2,"score":0.4177156090736389},{"id":"https://openalex.org/C2991975920","wikidata":"https://www.wikidata.org/wiki/Q621261","display_name":"Pain medicine","level":3,"score":0.414757639169693},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.29905539751052856},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20542243123054504},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.1860082447528839},{"id":"https://openalex.org/C2779526319","wikidata":"https://www.wikidata.org/wiki/Q615057","display_name":"Anesthesiology","level":2,"score":0.09345406293869019},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000072716","descriptor_name":"Cancer Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000072716","descriptor_name":"Cancer Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000072716","descriptor_name":"Cancer Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000203","descriptor_name":"Activities of Daily Living","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000203","descriptor_name":"Activities of Daily Living","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000203","descriptor_name":"Activities of Daily Living","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.biopha.2022.113871","doi":"https://doi.org/10.1016/j.biopha.2022.113871","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biopha.2022.113871","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0753332222012604/pdf","source":{"id":"https://openalex.org/S15111687","display_name":"Biomedicine & Pharmacotherapy","issn_l":"0753-3322","issn":["0753-3322","1950-6007"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-2","ki-jl-1","medline","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine & Pharmacotherapy","raw_type":"journal-article"},{"id":"pmid:36272265","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36272265","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:b3bf794357bf4e2a960be4fea6f70fc2","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b3bf794357bf4e2a960be4fea6f70fc2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomedicine & Pharmacotherapy, Vol 156, Iss , Pp 113871- (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.biopha.2022.113871","doi":"https://doi.org/10.1016/j.biopha.2022.113871","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biopha.2022.113871","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0753332222012604/pdf","source":{"id":"https://openalex.org/S15111687","display_name":"Biomedicine & Pharmacotherapy","issn_l":"0753-3322","issn":["0753-3322","1950-6007"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-2","ki-jl-1","medline","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine & Pharmacotherapy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8100000023841858,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4306771925.pdf","grobid_xml":"https://content.openalex.org/works/W4306771925.grobid-xml"},"referenced_works_count":98,"referenced_works":["https://openalex.org/W74490440","https://openalex.org/W142954314","https://openalex.org/W179318752","https://openalex.org/W1753139437","https://openalex.org/W1837483630","https://openalex.org/W1873305365","https://openalex.org/W1914955254","https://openalex.org/W1963407696","https://openalex.org/W1968984411","https://openalex.org/W1972988091","https://openalex.org/W1997268860","https://openalex.org/W2008870611","https://openalex.org/W2022288627","https://openalex.org/W2023338676","https://openalex.org/W2024177131","https://openalex.org/W2030336964","https://openalex.org/W2042741271","https://openalex.org/W2046167624","https://openalex.org/W2060772141","https://openalex.org/W2084080149","https://openalex.org/W2088224276","https://openalex.org/W2101795926","https://openalex.org/W2108050502","https://openalex.org/W2113377346","https://openalex.org/W2113737911","https://openalex.org/W2119739355","https://openalex.org/W2129950400","https://openalex.org/W2135849985","https://openalex.org/W2143783928","https://openalex.org/W2150311669","https://openalex.org/W2152211563","https://openalex.org/W2174687664","https://openalex.org/W2296364176","https://openalex.org/W2337699335","https://openalex.org/W2395312381","https://openalex.org/W2398521189","https://openalex.org/W2468992771","https://openalex.org/W2488099980","https://openalex.org/W2491579167","https://openalex.org/W2497268117","https://openalex.org/W2532651727","https://openalex.org/W2543985504","https://openalex.org/W2588889435","https://openalex.org/W2593043086","https://openalex.org/W2609342591","https://openalex.org/W2610210672","https://openalex.org/W2614607398","https://openalex.org/W2616059838","https://openalex.org/W2619557568","https://openalex.org/W2734807593","https://openalex.org/W2743717700","https://openalex.org/W2751631865","https://openalex.org/W2752069735","https://openalex.org/W2755428210","https://openalex.org/W2790198706","https://openalex.org/W2794534803","https://openalex.org/W2809390815","https://openalex.org/W2839561797","https://openalex.org/W2887174016","https://openalex.org/W2888796235","https://openalex.org/W2889646458","https://openalex.org/W2890185787","https://openalex.org/W2898207866","https://openalex.org/W2905856542","https://openalex.org/W2919501482","https://openalex.org/W2943831806","https://openalex.org/W2944250160","https://openalex.org/W2944468452","https://openalex.org/W2946165115","https://openalex.org/W2955941728","https://openalex.org/W2969530695","https://openalex.org/W2969638044","https://openalex.org/W2990369851","https://openalex.org/W2994017974","https://openalex.org/W3000989368","https://openalex.org/W3004137954","https://openalex.org/W3011499824","https://openalex.org/W3012764595","https://openalex.org/W3048243918","https://openalex.org/W3048818058","https://openalex.org/W3084384393","https://openalex.org/W3092067338","https://openalex.org/W3125639318","https://openalex.org/W3160630885","https://openalex.org/W3178227008","https://openalex.org/W3202118418","https://openalex.org/W4210554607","https://openalex.org/W4213340539","https://openalex.org/W4221002669","https://openalex.org/W4224138878","https://openalex.org/W4234134992","https://openalex.org/W4237588022","https://openalex.org/W4238280429","https://openalex.org/W4247607344","https://openalex.org/W4252166743","https://openalex.org/W4285405222","https://openalex.org/W4293217060","https://openalex.org/W6839771354"],"related_works":["https://openalex.org/W2070149391","https://openalex.org/W2093716795","https://openalex.org/W2072216912","https://openalex.org/W2007157545","https://openalex.org/W2119739355","https://openalex.org/W1957870570","https://openalex.org/W2093026550","https://openalex.org/W4296795193","https://openalex.org/W2924040652","https://openalex.org/W2112157093"],"abstract_inverted_index":{"Patients":[0],"diagnosed":[1],"with":[2,20],"cancer":[3,27,106,113,122,132,136,145,152],"often":[4,66],"experience":[5],"pain":[6,34,62,107,114,137,146,153],"during":[7],"their":[8,21,41,73],"treatment":[9,130,147,154],"course,":[10],"making":[11],"it":[12],"difficult":[13],"to":[14,56,89],"care":[15],"for":[16,60,69,78,103,128],"themselves":[17],"and":[18,38,45,49,76,149],"continue":[19],"activities":[22],"of":[23,43,72,92,131,135],"daily":[24],"living.":[25],"When":[26],"is":[28,100],"found":[29],"at":[30],"later":[31],"stages,":[32],"the":[33,67,129],"can":[35],"become":[36],"severe":[37],"constant;":[39],"reducing":[40],"quality":[42],"life":[44],"significantly":[46],"affecting":[47],"mental":[48],"physical":[50],"well-being.":[51],"Despite":[52],"opioids":[53,90],"being":[54],"known":[55],"provide":[57],"adequate":[58],"analgesia":[59],"higher":[61],"levels,":[63],"they":[64],"are":[65,81,110,117],"reason":[68],"under-dosing":[70],"because":[71,91],"adverse":[74],"effects":[75],"concern":[77],"addiction.":[79],"There":[80,109],"also":[82],"patients":[83],"who":[84],"do":[85],"not":[86],"respond":[87],"well":[88],"genetic":[93],"anomalies":[94],"or":[95],"personal":[96],"preference.":[97],"Therefore,":[98],"there":[99],"a":[101],"need":[102],"novel":[104,150],"non-opioid":[105],"treatments.":[108],"many":[111],"new":[112],"treatments":[115],"that":[116],"emerging.":[118],"This":[119],"manuscript":[120],"discusses":[121],"pain,":[123,133,140],"risk":[124],"factors,":[125],"epidemiology,":[126],"guidelines":[127],"personalization":[134],"therapy,":[138],"breakthrough":[139],"cancer-induced":[141],"peripheral":[142],"neuropathy,":[143],"established":[144],"options,":[148],"emerging":[151],"options.":[155]},"counts_by_year":[{"year":2026,"cited_by_count":13},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":24},{"year":2023,"cited_by_count":14}],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2025-10-10T00:00:00"}