{"id":"https://openalex.org/W4306762425","doi":"https://doi.org/10.1016/j.bbi.2022.10.010","title":"Socioeconomic determinants of inflammation and neuroendocrine activity: A longitudinal analysis of compositional and contextual effects","display_name":"Socioeconomic determinants of inflammation and neuroendocrine activity: A longitudinal analysis of compositional and contextual effects","publication_year":2022,"publication_date":"2022-10-18","ids":{"openalex":"https://openalex.org/W4306762425","doi":"https://doi.org/10.1016/j.bbi.2022.10.010","pmid":"https://pubmed.ncbi.nlm.nih.gov/36270438"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbi.2022.10.010","doi":"https://doi.org/10.1016/j.bbi.2022.10.010","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbi.2022.10.010","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0889159122004159/pdf","source":{"id":"https://openalex.org/S102243518","display_name":"Brain Behavior and Immunity","issn_l":"0889-1591","issn":["0889-1591","1090-2139"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain, Behavior, and Immunity","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S0889159122004159/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059934174","display_name":"Odessa S. Hamilton","orcid":"https://orcid.org/0000-0001-6296-935X","observed_orcids":["https://orcid.org/0000-0001-6296-935X"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Odessa S. Hamilton","raw_affiliation_strings":["Department of Behavioural Science and Health, University College London, 1-19 Torrington Place, London WC1E 7HB, UK. Electronic address: odessa.hamilton.19@ucl.ac.uk","Department of Behavioural Science and Health, University College London, 1-19 Torrington Place, London WC1E 7HB, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Behavioural Science and Health, University College London, 1-19 Torrington Place, London WC1E 7HB, UK. Electronic address: odessa.hamilton.19@ucl.ac.uk","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"Department of Behavioural Science and Health, University College London, 1-19 Torrington Place, London WC1E 7HB, UK","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005721369","display_name":"Andrew Steptoe","orcid":"https://orcid.org/0000-0001-7808-4943","observed_orcids":["https://orcid.org/0000-0001-7808-4943"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andrew Steptoe","raw_affiliation_strings":["Department of Behavioural Science and Health, University College London, 1-19 Torrington Place, London WC1E 7HB, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Behavioural Science and Health, University College London, 1-19 Torrington Place, London WC1E 7HB, UK","institution_ids":["https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5059934174"],"corresponding_institution_ids":["https://openalex.org/I45129253"],"apc_list":{"value":4070,"currency":"USD","value_usd":4070},"apc_paid":{"value":4070,"currency":"USD","value_usd":4070},"fwci":2.1098,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.86420384,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"107","issue":null,"first_page":"276","last_page":"285"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10235","display_name":"Health disparities and outcomes","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/3306","display_name":"Health"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10235","display_name":"Health disparities and outcomes","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/3306","display_name":"Health"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/socioeconomic-factors","display_name":"socioeconomic factors","score":0.8930000066757202},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.9110000133514404},{"id":"https://openalex.org/keywords/neuroendocrine-activity","display_name":"neuroendocrine activity","score":0.9929999709129333},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.8579999804496765},{"id":"https://openalex.org/keywords/fibrinogen","display_name":"fibrinogen","score":0.9980000257492065},{"id":"https://openalex.org/keywords/white-blood-cell-count","display_name":"white blood cell count","score":0.9779999852180481},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.9980000257492065},{"id":"https://openalex.org/keywords/neighborhood-deprivation","display_name":"neighborhood disadvantage","score":0.8949999809265137},{"id":"https://openalex.org/keywords/index-of-multiple-deprivation","display_name":"Index of Multiple Deprivation","score":0.8050000071525574},{"id":"https://openalex.org/keywords/wealth","display_name":"wealth","score":0.550000011920929},{"id":"https://openalex.org/keywords/educational-attainment","display_name":"educational attainment","score":0.7749999761581421},{"id":"https://openalex.org/keywords/occupational-class","display_name":"occupational class","score":0.9739999771118164},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.7649999856948853},{"id":"https://openalex.org/keywords/lifestyle-factors","display_name":"lifestyle factors","score":0.5730000138282776},{"id":"https://openalex.org/keywords/compositional-effects","display_name":"composition effects","score":0.6110000014305115},{"id":"https://openalex.org/keywords/contextual-effects","display_name":"contextual effects","score":0.6520000100135803},{"id":"https://openalex.org/keywords/english-longitudinal-study-of-ageing","display_name":"English Longitudinal Study of Ageing","score":0.8539999723434448}],"concepts":[{"id":"https://openalex.org/C147077947","wikidata":"https://www.wikidata.org/wiki/Q1515895","display_name":"Socioeconomic status","level":3,"score":0.7622781991958618},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.6027212738990784},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5119184255599976},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.4903102219104767},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.4684980511665344},{"id":"https://openalex.org/C2777895361","wikidata":"https://www.wikidata.org/wiki/Q1758614","display_name":"Longitudinal study","level":2,"score":0.44553497433662415},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4319548010826111},{"id":"https://openalex.org/C2781195455","wikidata":"https://www.wikidata.org/wiki/Q422766","display_name":"C-reactive protein","level":3,"score":0.42185208201408386},{"id":"https://openalex.org/C161677786","wikidata":"https://www.wikidata.org/wiki/Q2478475","display_name":"Neighbourhood (mathematics)","level":2,"score":0.4158562421798706},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.38959550857543945},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3692457973957062},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1714843213558197},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.16931423544883728},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.13605087995529175},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.09712392091751099},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004739","descriptor_name":"England","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009490","descriptor_name":"Neurosecretory Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012959","descriptor_name":"Socioeconomic Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064890","descriptor_name":"Social Determinants of Health","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bbi.2022.10.010","doi":"https://doi.org/10.1016/j.bbi.2022.10.010","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbi.2022.10.010","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0889159122004159/pdf","source":{"id":"https://openalex.org/S102243518","display_name":"Brain Behavior and Immunity","issn_l":"0889-1591","issn":["0889-1591","1090-2139"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain, Behavior, and Immunity","raw_type":"journal-article"},{"id":"pmid:36270438","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36270438","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain, behavior, and immunity","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.bbi.2022.10.010","doi":"https://doi.org/10.1016/j.bbi.2022.10.010","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbi.2022.10.010","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0889159122004159/pdf","source":{"id":"https://openalex.org/S102243518","display_name":"Brain Behavior and Immunity","issn_l":"0889-1591","issn":["0889-1591","1090-2139"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain, Behavior, and Immunity","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"},{"score":0.5676000118255615,"display_name":"Reduced inequalities","id":"https://metadata.un.org/sdg/10"}],"sustainable_development_goals_aurora":[{"score":0.5,"display_name":"No poverty","id":"https://metadata.un.org/sdg/1"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000859600","display_name":"English Longitudinal Study of Ageing - Renewal 2024","funder_award_id":"R01AG017644","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4306762425.pdf","grobid_xml":"https://content.openalex.org/works/W4306762425.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W126711707","https://openalex.org/W174814305","https://openalex.org/W1812416290","https://openalex.org/W1904593995","https://openalex.org/W1966537913","https://openalex.org/W1968607580","https://openalex.org/W1971676592","https://openalex.org/W1979615936","https://openalex.org/W1980481118","https://openalex.org/W1986049860","https://openalex.org/W1987752024","https://openalex.org/W2006585084","https://openalex.org/W2010027177","https://openalex.org/W2014597408","https://openalex.org/W2021411595","https://openalex.org/W2022204696","https://openalex.org/W2064186732","https://openalex.org/W2065974896","https://openalex.org/W2070009842","https://openalex.org/W2078473706","https://openalex.org/W2084349484","https://openalex.org/W2087461241","https://openalex.org/W2096931219","https://openalex.org/W2102393256","https://openalex.org/W2104923005","https://openalex.org/W2106139867","https://openalex.org/W2113782945","https://openalex.org/W2126795224","https://openalex.org/W2134843796","https://openalex.org/W2142060871","https://openalex.org/W2152023516","https://openalex.org/W2152266097","https://openalex.org/W2154442536","https://openalex.org/W2162556463","https://openalex.org/W2163992156","https://openalex.org/W2166349035","https://openalex.org/W2169061346","https://openalex.org/W2263920784","https://openalex.org/W2287293938","https://openalex.org/W2480923699","https://openalex.org/W2803341725","https://openalex.org/W2808442135","https://openalex.org/W2884081989","https://openalex.org/W2895635406","https://openalex.org/W2897097583","https://openalex.org/W2900642152","https://openalex.org/W2912292980","https://openalex.org/W2921495327","https://openalex.org/W2993908729","https://openalex.org/W3003503080","https://openalex.org/W3006053565","https://openalex.org/W3008881689","https://openalex.org/W3025874466","https://openalex.org/W3034339940","https://openalex.org/W3048638052","https://openalex.org/W3179247682","https://openalex.org/W4200188913","https://openalex.org/W4220658488","https://openalex.org/W6774149469"],"related_works":["https://openalex.org/W4280508526","https://openalex.org/W4385188770","https://openalex.org/W4416116147","https://openalex.org/W2530315149","https://openalex.org/W2180479912","https://openalex.org/W2078473706","https://openalex.org/W3094359382","https://openalex.org/W4408044302","https://openalex.org/W2081974370","https://openalex.org/W2572714154"],"abstract_inverted_index":{"Socioeconomic":[0],"determinants":[1],"are":[2,18,35],"well-established":[3],"modulators":[4],"of":[5,57,62,217,244],"inflammation":[6,137,201],"and":[7,32,37,46,66,81,115,127,138,145,165,170,172,176,200,237],"neuroendocrine":[8,33,82,140,209,238],"activity.":[9],"Less":[10],"clear":[11],"is":[12],"whether":[13],"neighbourhood-contextual":[14],"or":[15],"individual-compositional":[16,222],"factors":[17,72,213,223],"more":[19,206],"closely":[20],"associated":[21,134,161],"with":[22,135,162,168,174],"gradients":[23],"in":[24,40,195,224,248],"these":[25],"biomarkers.":[26],"Here,":[27],"we":[28],"examine":[29],"how":[30],"immune":[31,236],"activity":[34,141,210,220],"cross-sectionally":[36,144],"longitudinally":[38],"nested":[39],"meso-level":[41],"socioeconomic":[42,131,198],"characteristics.":[43],"Participants,":[44],"male":[45],"female,":[47],"aged":[48],"\u226550,":[49],"were":[50,73,111,180,205,214,228],"recruited":[51],"from":[52,75],"the":[53,192,242,245,253],"English":[54],"Longitudinal":[55],"Study":[56],"Ageing":[58],"(ELSA).":[59],"Neighbourhood":[60],"(Index":[61],"Multiple":[63],"Deprivation":[64],"[IMD])":[65],"individual":[67],"(Wealth/Education/Occupational":[68],"Social":[69],"Class":[70],"[Occupation])":[71],"drawn":[74],"wave":[76],"4":[77],"(baseline;":[78],"2008).":[79],"Immune":[80],"biomarkers":[83],"(indexed":[84],"by":[85,231],"C-reactive":[86],"protein":[87],"[CRP;":[88],"n":[89,101,108],"=":[90,94,102,109],"3,968];":[91],"fibrinogen":[92,175],"[n":[93],"3,932];":[95],"white":[96],"blood":[97],"cell":[98],"counts":[99],"[WBCC;":[100],"4,022];":[103],"insulin-like":[104],"growth":[105],"factor-1":[106],"[IGF-1;":[107],"4,056])":[110],"measured":[112],"at":[113,122],"baseline":[114,123],"4-years":[116],"later":[117],"(wave":[118],"6;":[119],"2012).":[120],"Covariates":[121],"included":[124],"demographic,":[125],"clinical,":[126],"lifestyle":[128],"variables.":[129],"Lower":[130],"status":[132],"was":[133,184],"heighted":[136],"lower":[139],"unadjusted":[142],"both":[143],"longitudinally.":[146],"With":[147],"few":[148],"exceptions,":[149],"cross-sectional":[150,225],"associations":[151,179,196],"remained":[152,160],"significant":[153],"after":[154],"full":[155],"adjustment.":[156],"Prospectively,":[157],"low":[158],"IMD":[159],"higher":[163],"CRP":[164],"WBCC;":[166,169],"wealth":[167,183,232],"education":[171],"occupation":[173],"WBCC.":[177],"IMD-biomarker":[178],"reduced":[181],"when":[182],"simultaneously":[185],"taken":[186],"into":[187],"account.":[188],"Lifestyle":[189],"accounted":[190],"for":[191],"greatest":[193],"variance":[194],"between":[197],"indicators":[199,216],"(\u226442.11%),":[202],"but":[203,227],"demographics":[204],"salient":[207],"to":[208],"(\u226488.46%).":[211],"Neighbourhood-contextual":[212],"stronger":[215],"aberrant":[218],"biomarker":[219],"than":[221,252],"analyses":[226],"largely":[229],"explained":[230],"differences":[233],"prospectively.":[234],"Therefore,":[235],"changes":[239],"depended":[240],"on":[241],"composition":[243],"population":[246],"living":[247],"an":[249],"area,":[250],"rather":[251],"area":[254],"itself.":[255]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-10-19T00:00:00"}
