{"id":"https://openalex.org/W4306645256","doi":"https://doi.org/10.1021/acs.molpharmaceut.2c00653","title":"Nucleic Acid Delivery to the Vascular Endothelium","display_name":"Nucleic Acid Delivery to the Vascular Endothelium","publication_year":2022,"publication_date":"2022-10-17","ids":{"openalex":"https://openalex.org/W4306645256","doi":"https://doi.org/10.1021/acs.molpharmaceut.2c00653","pmid":"https://pubmed.ncbi.nlm.nih.gov/36251765","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10673694"},"language":"en","primary_location":{"id":"doi:10.1021/acs.molpharmaceut.2c00653","doi":"https://doi.org/10.1021/acs.molpharmaceut.2c00653","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.molpharmaceut.2c00653","pdf_url":null,"source":{"id":"https://openalex.org/S204562082","display_name":"Molecular Pharmaceutics","issn_l":"1543-8384","issn":["1543-8384","1543-8392"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pharmaceutics","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10673694/pdf/nihms-1940666.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071749448","display_name":"Melanie Reschke","orcid":"https://orcid.org/0000-0003-1902-5876","observed_orcids":["https://orcid.org/0000-0003-1902-5876"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melanie Reschke","raw_affiliation_strings":["Department of Molecular Biophysics and Biochemistry, Yale School of Medicine, New Haven, Connecticut 06510, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biophysics and Biochemistry, Yale School of Medicine, New Haven, Connecticut 06510, United States","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058146242","display_name":"Alexandra S. Piotrowski-Daspit","orcid":"https://orcid.org/0000-0003-4555-3234","observed_orcids":["https://orcid.org/0000-0003-4555-3234"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexandra S. Piotrowski-Daspit","raw_affiliation_strings":["Department of Biomedical Engineering, Yale School of Medicine, New Haven, Connecticut 06510, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Yale School of Medicine, New Haven, Connecticut 06510, United States","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022235365","display_name":"Jordan S. Pober","orcid":"https://orcid.org/0000-0001-5990-1071","observed_orcids":["https://orcid.org/0000-0001-5990-1071"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jordan S. Pober","raw_affiliation_strings":["Department of Immunobiology, Yale School of Medicine, New Haven, Connecticut 06510, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunobiology, Yale School of Medicine, New Haven, Connecticut 06510, United States","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012106344","display_name":"W. Mark Saltzman","orcid":"https://orcid.org/0000-0002-2163-549X","observed_orcids":["https://orcid.org/0000-0002-2163-549X"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"W. Mark Saltzman","raw_affiliation_strings":["Department of Biomedical Engineering,\u00a0 Department of Chemical & Environmental Engineering,\u00a0 Department of Cellular & Molecular Physiology \u00a0and\u00a0 Department of Dermatology, Yale School of Medicine, New Haven, Connecticut 06510, United States"],"raw_orcid":"https://orcid.org/0000-0002-2163-549X","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering,\u00a0 Department of Chemical & Environmental Engineering,\u00a0 Department of Cellular & Molecular Physiology \u00a0and\u00a0 Department of Dermatology, Yale School of Medicine, New Haven, Connecticut 06510, United States","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5012106344"],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":0.2084,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.18460249,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"19","issue":"12","first_page":"4466","last_page":"4486"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nucleic-acid-delivery","display_name":"nucleic acid delivery","score":0.9869999885559082},{"id":"https://openalex.org/keywords/vascular-endothelium","display_name":"vascular endothelium","score":0.996999979019165},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.8080000281333923},{"id":"https://openalex.org/keywords/endothelial-targeting","display_name":"endothelial targeting","score":0.6610000133514404},{"id":"https://openalex.org/keywords/vascular-disease","display_name":"vascular disease","score":0.8259999752044678},{"id":"https://openalex.org/keywords/angiogenic-therapy","display_name":"angiogenic therapy","score":0.921999990940094},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.9779999852180481},{"id":"https://openalex.org/keywords/endothelial-homeostasis","display_name":"endothelial homeostasis","score":0.8980000019073486}],"concepts":[{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.7559981346130371},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.7018815279006958},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.47826826572418213},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.44330573081970215},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42047086358070374},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.357389897108078},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3245112895965576},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2519845962524414},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14274263381958008},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13955479860305786},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13110819458961487}],"mesh":[{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009696","descriptor_name":"Nucleic Acids","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/acs.molpharmaceut.2c00653","doi":"https://doi.org/10.1021/acs.molpharmaceut.2c00653","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.molpharmaceut.2c00653","pdf_url":null,"source":{"id":"https://openalex.org/S204562082","display_name":"Molecular Pharmaceutics","issn_l":"1543-8384","issn":["1543-8384","1543-8392"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pharmaceutics","raw_type":"journal-article"},{"id":"pmid:36251765","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36251765","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular pharmaceutics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10673694","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10673694","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10673694/pdf/nihms-1940666.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Mol Pharm","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10673694","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10673694","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10673694/pdf/nihms-1940666.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Mol Pharm","raw_type":"Text"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1687430429","display_name":null,"funder_award_id":"UH3 HL147352","funder_id":"https://openalex.org/F4320306080","funder_display_name":"Foundation for the National Institutes of Health"},{"id":"https://openalex.org/G2118509040","display_name":"Poly(amine-co-ester)s for Targeted Delivery In Vivo of Gene Editing Agents to Bone Marrow and Lung","funder_award_id":"UH3HL147352","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2295902442","display_name":null,"funder_award_id":"UG3 HL147352","funder_id":"https://openalex.org/F4320306080","funder_display_name":"Foundation for the National Institutes of Health"},{"id":"https://openalex.org/G2620004248","display_name":"Optimizing Therapeutic Revascularization by Endothelial Cell Transplantation","funder_award_id":"R01HL085416","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3392975650","display_name":"Ex Vivo Nanoparticle Drug Delivery Targeted to Human Renal Allograft Endothelium","funder_award_id":"U01AI132895","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G371940023","display_name":null,"funder_award_id":"U01 AI32895","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3981458918","display_name":null,"funder_award_id":"K99 HL151806","funder_id":"https://openalex.org/F4320306080","funder_display_name":"Foundation for the National Institutes of Health"},{"id":"https://openalex.org/G4404358305","display_name":null,"funder_award_id":"R01 HL085416","funder_id":"https://openalex.org/F4320306080","funder_display_name":"Foundation for the National Institutes of Health"},{"id":"https://openalex.org/G4765979323","display_name":null,"funder_award_id":"U01 AI32895","funder_id":"https://openalex.org/F4320306080","funder_display_name":"Foundation for the National Institutes of Health"},{"id":"https://openalex.org/G4998615386","display_name":null,"funder_award_id":"PIOTRO21F5","funder_id":"https://openalex.org/F4320306168","funder_display_name":"Cystic Fibrosis Foundation"},{"id":"https://openalex.org/G5980670185","display_name":"Developing Gene Editing Therapeutics, Biodegradable Polymeric Delivery Vehicles, and High-throughput Platforms for the Treatment of Cystic Fibrosis","funder_award_id":"K99HL151806","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G738160294","display_name":null,"funder_award_id":"K99-R00","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000915631","display_name":"Developing Gene Editing Therapeutics, Biodegradable Polymeric Delivery Vehicles, and High-throughput Platforms for the Treatment of Cystic Fibrosis","funder_award_id":"R00HL151806","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G953866727","display_name":"Poly(amine-co-ester)s for Targeted Delivery In Vivo of Gene Editing Agents to Bone Marrow and Lung","funder_award_id":"UG3HL147352","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306080","display_name":"Foundation for the National Institutes of Health","ror":"https://ror.org/00k86s890"},{"id":"https://openalex.org/F4320306168","display_name":"Cystic Fibrosis Foundation","ror":"https://ror.org/00ax59295"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4306645256.pdf","grobid_xml":"https://content.openalex.org/works/W4306645256.grobid-xml"},"referenced_works_count":242,"referenced_works":["https://openalex.org/W56623326","https://openalex.org/W193616686","https://openalex.org/W262451031","https://openalex.org/W1026816495","https://openalex.org/W1584452806","https://openalex.org/W1611419331","https://openalex.org/W1647075334","https://openalex.org/W1656696280","https://openalex.org/W1663004000","https://openalex.org/W1862237309","https://openalex.org/W1963525654","https://openalex.org/W1963706689","https://openalex.org/W1967503156","https://openalex.org/W1968514069","https://openalex.org/W1971290197","https://openalex.org/W1975528602","https://openalex.org/W1976307024","https://openalex.org/W1980052502","https://openalex.org/W1981417606","https://openalex.org/W1982228392","https://openalex.org/W1996810856","https://openalex.org/W2002050544","https://openalex.org/W2002914110","https://openalex.org/W2003311493","https://openalex.org/W2003470252","https://openalex.org/W2003884504","https://openalex.org/W2004180909","https://openalex.org/W2006558987","https://openalex.org/W2006807357","https://openalex.org/W2006846934","https://openalex.org/W2007114633","https://openalex.org/W2008365765","https://openalex.org/W2011001489","https://openalex.org/W2011502202","https://openalex.org/W2017611825","https://openalex.org/W2018616490","https://openalex.org/W2019613864","https://openalex.org/W2021367421","https://openalex.org/W2024102779","https://openalex.org/W2024341039","https://openalex.org/W2033048770","https://openalex.org/W2034974949","https://openalex.org/W2036132667","https://openalex.org/W2037378426","https://openalex.org/W2039551908","https://openalex.org/W2041665769","https://openalex.org/W2049340874","https://openalex.org/W2051091654","https://openalex.org/W2051984245","https://openalex.org/W2052045396","https://openalex.org/W2053704719","https://openalex.org/W2058313023","https://openalex.org/W2058435567","https://openalex.org/W2060216304","https://openalex.org/W2060221489","https://openalex.org/W2061207811","https://openalex.org/W2061235037","https://openalex.org/W2061316598","https://openalex.org/W2065284939","https://openalex.org/W2067302150","https://openalex.org/W2075902865","https://openalex.org/W2079852426","https://openalex.org/W2081042870","https://openalex.org/W2082143317","https://openalex.org/W2082243712","https://openalex.org/W2082959764","https://openalex.org/W2083249633","https://openalex.org/W2084121938","https://openalex.org/W2084671441","https://openalex.org/W2086919915","https://openalex.org/W2090569473","https://openalex.org/W2091268360","https://openalex.org/W2091448236","https://openalex.org/W2092201159","https://openalex.org/W2095317094","https://openalex.org/W2105074740","https://openalex.org/W2106885643","https://openalex.org/W2116424844","https://openalex.org/W2124904564","https://openalex.org/W2132759642","https://openalex.org/W2137017984","https://openalex.org/W2138733854","https://openalex.org/W2143463421","https://openalex.org/W2145790583","https://openalex.org/W2155777849","https://openalex.org/W2156357692","https://openalex.org/W2163611331","https://openalex.org/W2165446052","https://openalex.org/W2170222308","https://openalex.org/W2170255011","https://openalex.org/W2171783221","https://openalex.org/W2171802467","https://openalex.org/W2200197276","https://openalex.org/W2209402024","https://openalex.org/W2212530691","https://openalex.org/W2284745064","https://openalex.org/W2300272821","https://openalex.org/W2311441150","https://openalex.org/W2312775972","https://openalex.org/W2317891189","https://openalex.org/W2317982666","https://openalex.org/W2363878512","https://openalex.org/W2364450308","https://openalex.org/W2395032546","https://openalex.org/W2410598374","https://openalex.org/W2413302280","https://openalex.org/W2518408723","https://openalex.org/W2545689480","https://openalex.org/W2548568005","https://openalex.org/W2549628327","https://openalex.org/W2557261433","https://openalex.org/W2573033399","https://openalex.org/W2574405809","https://openalex.org/W2575012967","https://openalex.org/W2588025094","https://openalex.org/W2588383997","https://openalex.org/W2593815839","https://openalex.org/W2598913488","https://openalex.org/W2612152740","https://openalex.org/W2618307797","https://openalex.org/W2618419720","https://openalex.org/W2621009688","https://openalex.org/W2731227355","https://openalex.org/W2735017428","https://openalex.org/W2739174192","https://openalex.org/W2740959302","https://openalex.org/W2741561366","https://openalex.org/W2743742472","https://openalex.org/W2748490245","https://openalex.org/W2752990404","https://openalex.org/W2759188738","https://openalex.org/W2765953043","https://openalex.org/W2775312572","https://openalex.org/W2780075441","https://openalex.org/W2782917400","https://openalex.org/W2784122804","https://openalex.org/W2785550518","https://openalex.org/W2791854174","https://openalex.org/W2806030766","https://openalex.org/W2809709644","https://openalex.org/W2809713403","https://openalex.org/W2885485598","https://openalex.org/W2886819502","https://openalex.org/W2888209830","https://openalex.org/W2888758890","https://openalex.org/W2888908334","https://openalex.org/W2891144852","https://openalex.org/W2893918473","https://openalex.org/W2897295193","https://openalex.org/W2897789147","https://openalex.org/W2899363605","https://openalex.org/W2900555394","https://openalex.org/W2912349604","https://openalex.org/W2912572612","https://openalex.org/W2914900293","https://openalex.org/W2941157893","https://openalex.org/W2943598144","https://openalex.org/W2944970981","https://openalex.org/W2947404060","https://openalex.org/W2962237301","https://openalex.org/W2963065854","https://openalex.org/W2963114940","https://openalex.org/W2973160898","https://openalex.org/W2974110939","https://openalex.org/W2976305105","https://openalex.org/W2980184938","https://openalex.org/W2980262350","https://openalex.org/W2981137429","https://openalex.org/W2982734724","https://openalex.org/W2995605908","https://openalex.org/W2999193811","https://openalex.org/W3003353139","https://openalex.org/W3004131145","https://openalex.org/W3007156965","https://openalex.org/W3007353392","https://openalex.org/W3007361734","https://openalex.org/W3011106978","https://openalex.org/W3013352650","https://openalex.org/W3015140168","https://openalex.org/W3017125154","https://openalex.org/W3021822282","https://openalex.org/W3025200871","https://openalex.org/W3027918021","https://openalex.org/W3036759077","https://openalex.org/W3037243268","https://openalex.org/W3038372263","https://openalex.org/W3038464575","https://openalex.org/W3040254875","https://openalex.org/W3043490206","https://openalex.org/W3046221565","https://openalex.org/W3046559315","https://openalex.org/W3046997297","https://openalex.org/W3049480757","https://openalex.org/W3084748409","https://openalex.org/W3093991109","https://openalex.org/W3095884448","https://openalex.org/W3102247579","https://openalex.org/W3102899245","https://openalex.org/W3108231643","https://openalex.org/W3108790522","https://openalex.org/W3115301924","https://openalex.org/W3119387738","https://openalex.org/W3120672343","https://openalex.org/W3121271818","https://openalex.org/W3121560287","https://openalex.org/W3125630250","https://openalex.org/W3127249681","https://openalex.org/W3128600120","https://openalex.org/W3131091394","https://openalex.org/W3131142477","https://openalex.org/W3134802906","https://openalex.org/W3134961986","https://openalex.org/W3137008460","https://openalex.org/W3137153690","https://openalex.org/W3140895223","https://openalex.org/W3140967360","https://openalex.org/W3150842678","https://openalex.org/W3157841475","https://openalex.org/W3160282231","https://openalex.org/W3160491056","https://openalex.org/W3164069457","https://openalex.org/W3164967630","https://openalex.org/W3165670466","https://openalex.org/W3172739738","https://openalex.org/W3173222845","https://openalex.org/W3182913217","https://openalex.org/W3183982924","https://openalex.org/W3188940990","https://openalex.org/W3200244304","https://openalex.org/W3205058520","https://openalex.org/W3208878211","https://openalex.org/W3212789570","https://openalex.org/W4200311265","https://openalex.org/W4200464329","https://openalex.org/W4205108559","https://openalex.org/W4205407809","https://openalex.org/W4205824800","https://openalex.org/W4206598427","https://openalex.org/W4211218985","https://openalex.org/W4221052766","https://openalex.org/W4228999954","https://openalex.org/W4289637123"],"related_works":["https://openalex.org/W2058435567","https://openalex.org/W2085535234","https://openalex.org/W2143740226","https://openalex.org/W2547076160","https://openalex.org/W2139364348","https://openalex.org/W1987130455","https://openalex.org/W2313486430","https://openalex.org/W2046008242","https://openalex.org/W1965083498","https://openalex.org/W2401866006"],"abstract_inverted_index":{"This":[0],"Review":[1],"examines":[2],"the":[3,6,16,22,30,35,53,57,64,71,79,89,107,115],"state-of-the-art":[4],"in":[5,118],"delivery":[7],"of":[8,29,73,114],"nucleic":[9,36,47],"acid":[10,37,48],"therapies":[11],"that":[12,39,67,85],"are":[13,40,86],"directed":[14],"to":[15,69,81],"vascular":[17,31,90,93],"endothelium.":[18],"First,":[19],"we":[20,51,77],"review":[21,78],"most":[23],"important":[24],"homeostatic":[25],"functions":[26],"and":[27,33,46,63,105],"properties":[28],"endothelium":[32,58],"summarize":[34],"tools":[38],"currently":[41],"available":[42,55],"for":[43,92,95,98,101,106],"gene":[44],"therapy":[45],"delivery.":[49],"Second,":[50],"consider":[52],"opportunities":[54],"with":[56,111],"as":[59],"a":[60,112],"therapeutic":[61],"target":[62],"experimental":[65],"models":[66],"exist":[68],"evaluate":[70],"potential":[72],"those":[74],"opportunities.":[75],"Finally,":[76],"progress":[80],"date":[82],"from":[83],"investigations":[84],"directly":[87],"targeting":[88],"endothelium:":[91],"disease,":[94,104],"peri-transplant":[96],"therapy,":[97],"angiogenic":[99],"therapies,":[100],"pulmonary":[102],"endothelial":[103],"blood-brain":[108],"barrier,":[109],"ending":[110],"summary":[113],"future":[116],"outlook":[117],"this":[119],"field.":[120]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2022-10-18T00:00:00"}
