{"id":"https://openalex.org/W4306249092","doi":"https://doi.org/10.1210/endocr/bqac169","title":"Inhibition of Glycogen Metabolism Induces Reactive Oxygen Species-Dependent Cytotoxicity in Anaplastic Thyroid Cancer in Female Mice","display_name":"Inhibition of Glycogen Metabolism Induces Reactive Oxygen Species-Dependent Cytotoxicity in Anaplastic Thyroid Cancer in Female Mice","publication_year":2022,"publication_date":"2022-10-14","ids":{"openalex":"https://openalex.org/W4306249092","doi":"https://doi.org/10.1210/endocr/bqac169","pmid":"https://pubmed.ncbi.nlm.nih.gov/36240295","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10233255"},"language":"en","primary_location":{"id":"doi:10.1210/endocr/bqac169","doi":"https://doi.org/10.1210/endocr/bqac169","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endocr/bqac169","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2022/02/21/2022.02.16.480663.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087107030","display_name":"Cole D. Davidson","orcid":"https://orcid.org/0000-0001-7324-2041","observed_orcids":["https://orcid.org/0000-0001-7324-2041"]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]},{"id":"https://openalex.org/I2801980284","display_name":"University of Vermont Medical Center","ror":"https://ror.org/04cewr321","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801980284"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cole D. Davidson","raw_affiliation_strings":["Department of Pharmacology, Larner College of Medicine, Burlington, VT","University of Vermont Cancer Center, Larner College of Medicine, Burlington, VT","Department of Pharmacology, Larner College of Medicine, University of Vermont , Burlington, VT 05405 , USA","University of Vermont Cancer Center, University of Vermont , Burlington, VT 05405 , USA"],"raw_orcid":"https://orcid.org/0000-0002-3582-2691","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Larner College of Medicine, Burlington, VT","institution_ids":[]},{"raw_affiliation_string":"University of Vermont Cancer Center, Larner College of Medicine, Burlington, VT","institution_ids":["https://openalex.org/I111236770","https://openalex.org/I2801980284"]},{"raw_affiliation_string":"Department of Pharmacology, Larner College of Medicine, University of Vermont , Burlington, VT 05405 , USA","institution_ids":["https://openalex.org/I111236770"]},{"raw_affiliation_string":"University of Vermont Cancer Center, University of Vermont , Burlington, VT 05405 , USA","institution_ids":["https://openalex.org/I111236770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112719687","display_name":"Jennifer A. Tomczak","orcid":"https://orcid.org/0009-0009-0002-5295","observed_orcids":["https://orcid.org/0009-0009-0002-5295"]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer A. Tomczak","raw_affiliation_strings":["Department of Pharmacology, Larner College of Medicine, Burlington, VT","Department of Pharmacology, Larner College of Medicine, University of Vermont , Burlington, VT 05405 , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Larner College of Medicine, Burlington, VT","institution_ids":[]},{"raw_affiliation_string":"Department of Pharmacology, Larner College of Medicine, University of Vermont , Burlington, VT 05405 , USA","institution_ids":["https://openalex.org/I111236770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042866760","display_name":"Eyal Amiel","orcid":"https://orcid.org/0000-0002-1578-8705","observed_orcids":["https://orcid.org/0000-0002-1578-8705"]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]},{"id":"https://openalex.org/I2801980284","display_name":"University of Vermont Medical Center","ror":"https://ror.org/04cewr321","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801980284"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Eyal Amiel","raw_affiliation_strings":["Department of Biomedical and Health Sciences, Larner College of Medicine, Burlington, VT","University of Vermont Cancer Center, Larner College of Medicine, Burlington, VT","Department of Biomedical and Health Sciences, College of Nursing and Health Sciences, University of Vermont , Burlington, VT 05405 , USA","University of Vermont Cancer Center, University of Vermont , Burlington, VT 05405 , USA"],"raw_orcid":"https://orcid.org/0000-0002-1578-8705","affiliations":[{"raw_affiliation_string":"Department of Biomedical and Health Sciences, Larner College of Medicine, Burlington, VT","institution_ids":[]},{"raw_affiliation_string":"University of Vermont Cancer Center, Larner College of Medicine, Burlington, VT","institution_ids":["https://openalex.org/I111236770","https://openalex.org/I2801980284"]},{"raw_affiliation_string":"Department of Biomedical and Health Sciences, College of Nursing and Health Sciences, University of Vermont , Burlington, VT 05405 , USA","institution_ids":["https://openalex.org/I111236770"]},{"raw_affiliation_string":"University of Vermont Cancer Center, University of Vermont , Burlington, VT 05405 , USA","institution_ids":["https://openalex.org/I111236770"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087721092","display_name":"Frances E. Carr","orcid":"https://orcid.org/0000-0001-7266-8788","observed_orcids":["https://orcid.org/0000-0001-7266-8788"]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]},{"id":"https://openalex.org/I2801980284","display_name":"University of Vermont Medical Center","ror":"https://ror.org/04cewr321","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801980284"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Frances E. Carr","raw_affiliation_strings":["Department of Pharmacology, Larner College of Medicine, Burlington, VT","University of Vermont Cancer Center, Larner College of Medicine, Burlington, VT","Department of Pharmacology, Larner College of Medicine, University of Vermont , Burlington, VT 05405 , USA","University of Vermont Cancer Center, University of Vermont , Burlington, VT 05405 , USA"],"raw_orcid":"https://orcid.org/0000-0001-7266-8788","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Larner College of Medicine, Burlington, VT","institution_ids":[]},{"raw_affiliation_string":"University of Vermont Cancer Center, Larner College of Medicine, Burlington, VT","institution_ids":["https://openalex.org/I111236770","https://openalex.org/I2801980284"]},{"raw_affiliation_string":"Department of Pharmacology, Larner College of Medicine, University of Vermont , Burlington, VT 05405 , USA","institution_ids":["https://openalex.org/I111236770"]},{"raw_affiliation_string":"University of Vermont Cancer Center, University of Vermont , Burlington, VT 05405 , USA","institution_ids":["https://openalex.org/I111236770"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5042866760","https://openalex.org/A5087721092"],"corresponding_institution_ids":["https://openalex.org/I111236770","https://openalex.org/I2801980284"],"apc_list":{"value":3400,"currency":"USD","value_usd":3400},"apc_paid":null,"fwci":1.0503,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.72217899,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":97},"biblio":{"volume":"163","issue":"12","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.4309000074863434,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.4309000074863434,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.2362000048160553,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.16459999978542328,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anaplastic-thyroid-carcinoma","display_name":"anaplastic thyroid carcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/glycogen-metabolism","display_name":"glycogen metabolism","score":0.9980000257492065},{"id":"https://openalex.org/keywords/glycogen-phosphorylase","display_name":"glycogen phosphorylase","score":0.8899999856948853},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8090000152587891},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7160000205039978},{"id":"https://openalex.org/keywords/nadph-depletion","display_name":"NADPH depletion","score":0.8820000290870667},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.6420000195503235},{"id":"https://openalex.org/keywords/tumor-metabolism","display_name":"cancer metabolism","score":0.550000011920929}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.79087895154953},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7719119787216187},{"id":"https://openalex.org/C2780256643","wikidata":"https://www.wikidata.org/wiki/Q3658382","display_name":"Anaplastic thyroid cancer","level":4,"score":0.632487416267395},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.6125260591506958},{"id":"https://openalex.org/C2777499176","wikidata":"https://www.wikidata.org/wiki/Q174936","display_name":"Glycogen","level":2,"score":0.6110256910324097},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.6109436750411987},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.5209494829177856},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.43454214930534363},{"id":"https://openalex.org/C2779761222","wikidata":"https://www.wikidata.org/wiki/Q826522","display_name":"Thyroid cancer","level":3,"score":0.3910559415817261},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38923928141593933},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3807634711265564},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3476831018924713},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1410595178604126},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.09690254926681519}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006003","descriptor_name":"Glycogen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065646","descriptor_name":"Thyroid Carcinoma, Anaplastic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1210/endocr/bqac169","doi":"https://doi.org/10.1210/endocr/bqac169","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endocr/bqac169","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"doi:10.1101/2022.02.16.480663","doi":"https://doi.org/10.1101/2022.02.16.480663","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.02.16.480663","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/02/21/2022.02.16.480663.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:10233255","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10233255","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Text"},{"id":"pmid:36240295","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36240295","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"},{"id":"doi:10.6084/m9.figshare.21266577.v1","doi":"https://doi.org/10.6084/m9.figshare.21266577.v1","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.21266577.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Image"}],"best_oa_location":{"id":"doi:10.1101/2022.02.16.480663","doi":"https://doi.org/10.1101/2022.02.16.480663","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.02.16.480663","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/02/21/2022.02.16.480663.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G849984538","display_name":"Inverted Laser-Scanning Confocal Microscope","funder_award_id":"S10RR019246","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G9000859308","display_name":"Northern New England Clinical and Translational Research Network","funder_award_id":"U54GM115516","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000891461","display_name":"University of Colorado Cancer Center Support Grant","funder_award_id":"P30CA046934","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320312462","display_name":"University of Vermont","ror":"https://ror.org/0155zta11"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334300","display_name":"Larner College of Medicine, University of Vermont","ror":null},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4306249092.pdf","grobid_xml":"https://content.openalex.org/works/W4306249092.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W918899933","https://openalex.org/W1518834306","https://openalex.org/W1764384644","https://openalex.org/W1969436325","https://openalex.org/W1971441415","https://openalex.org/W1978422731","https://openalex.org/W1999259602","https://openalex.org/W2001123985","https://openalex.org/W2004320883","https://openalex.org/W2009930854","https://openalex.org/W2026757346","https://openalex.org/W2028112070","https://openalex.org/W2029862112","https://openalex.org/W2037406465","https://openalex.org/W2039220817","https://openalex.org/W2042918869","https://openalex.org/W2044864291","https://openalex.org/W2063159238","https://openalex.org/W2064162418","https://openalex.org/W2070708921","https://openalex.org/W2072742323","https://openalex.org/W2077479824","https://openalex.org/W2085126858","https://openalex.org/W2101044166","https://openalex.org/W2106637565","https://openalex.org/W2114743575","https://openalex.org/W2120258546","https://openalex.org/W2129312301","https://openalex.org/W2147793627","https://openalex.org/W2148755064","https://openalex.org/W2158720649","https://openalex.org/W2167895853","https://openalex.org/W2168045996","https://openalex.org/W2180091152","https://openalex.org/W2537551256","https://openalex.org/W2541975385","https://openalex.org/W2595204361","https://openalex.org/W2697759619","https://openalex.org/W2752316495","https://openalex.org/W2788935695","https://openalex.org/W2790354851","https://openalex.org/W2826646794","https://openalex.org/W2885598772","https://openalex.org/W2888052802","https://openalex.org/W2889947338","https://openalex.org/W2913765486","https://openalex.org/W2925684974","https://openalex.org/W2944495935","https://openalex.org/W2944960205","https://openalex.org/W2947105115","https://openalex.org/W2953781602","https://openalex.org/W2974520132","https://openalex.org/W2974753668","https://openalex.org/W2979813691","https://openalex.org/W2983785948","https://openalex.org/W3009739339","https://openalex.org/W3010157064","https://openalex.org/W3012759635","https://openalex.org/W3048757085","https://openalex.org/W3082509061","https://openalex.org/W3087005858","https://openalex.org/W3172022826","https://openalex.org/W3178534851","https://openalex.org/W3193432270","https://openalex.org/W3196212792","https://openalex.org/W4206242866","https://openalex.org/W6684731330"],"related_works":["https://openalex.org/W4213138501","https://openalex.org/W2021331603","https://openalex.org/W3159861031","https://openalex.org/W4200278957","https://openalex.org/W2129312301","https://openalex.org/W4393088818","https://openalex.org/W4415483028","https://openalex.org/W7015731346","https://openalex.org/W2013969272","https://openalex.org/W7062548906"],"abstract_inverted_index":{"Abstract":[0],"Anaplastic":[1],"thyroid":[2,81,83,104,135],"cancer":[3,39,84],"(ATC)":[4],"is":[5],"one":[6],"of":[7,27,35,92],"the":[8,28],"most":[9],"lethal":[10],"solid":[11],"tumors,":[12,24],"yet":[13],"there":[14],"are":[15],"no":[16],"effective,":[17],"long-lasting":[18],"treatments":[19],"for":[20,68],"ATC":[21,58,99,119],"patients.":[22],"Most":[23],"including":[25],"tumors":[26],"endocrine":[29],"system,":[30],"exhibit":[31],"an":[32,146],"increased":[33],"consumption":[34],"glucose":[36,47],"to":[37,55],"fuel":[38],"progression,":[40],"and":[41,62,74,82,87,110],"some":[42],"cancers":[43],"meet":[44],"this":[45,64],"high":[46],"requirement":[48],"by":[49],"metabolizing":[50],"glycogen.":[51],"Our":[52,124],"goal":[53],"was":[54],"determine":[56],"whether":[57],"cells":[59,100],"metabolize":[60],"glycogen":[61,72,75,127],"if":[63],"could":[65,144],"be":[66],"exploited":[67],"treatment.":[69],"We":[70],"detected":[71],"synthase":[73],"phosphorylase":[76],"(PYG)":[77],"isoforms":[78],"in":[79,98,122,134],"normal":[80,103],"cell":[85],"lines":[86],"patient-derived":[88],"biopsy":[89],"samples.":[90],"Inhibition":[91],"PYG":[93],"using":[94],"CP-91,149":[95,106,116],"induced":[96,111],"apoptosis":[97],"but":[101],"not":[102],"cells.":[105],"decreased":[107],"NADPH":[108],"levels":[109],"reactive":[112],"oxygen":[113],"species":[114],"accumulation.":[115],"severely":[117],"blunted":[118],"tumor":[120],"growth":[121],"vivo.":[123],"work":[125],"establishes":[126],"metabolism":[128],"as":[129],"a":[130,139],"novel":[131],"metabolic":[132],"process":[133],"cells,":[136],"which":[137],"presents":[138],"unique,":[140],"oncogenic":[141],"target":[142],"that":[143],"offer":[145],"improved":[147],"clinical":[148],"outcome.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-10-15T00:00:00"}