{"id":"https://openalex.org/W4306247888","doi":null,"title":"Obesity influence on bladder inflammation and cancer: a cystitis model.","display_name":"Obesity influence on bladder inflammation and cancer: a cystitis model.","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4306247888","pmid":"https://pubmed.ncbi.nlm.nih.gov/36237635","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9547991"},"language":"en","primary_location":{"id":"pmid:36237635","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36237635","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental pathology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9547991/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110893414","display_name":"Cristiano Trindade de Andrade","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Cristiano Trindade de Andrade","raw_affiliation_strings":["UroScience, Urology Division, Department of Surgery, State University of Campinas (UNICAMP) Campinas, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UroScience, Urology Division, Department of Surgery, State University of Campinas (UNICAMP) Campinas, SP, Brazil","institution_ids":["https://openalex.org/I181391015"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Guilherme Zweig Rocha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Guilherme Zweig Rocha","raw_affiliation_strings":["UroScience, Urology Division, Department of Surgery, State University of Campinas (UNICAMP) Campinas, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UroScience, Urology Division, Department of Surgery, State University of Campinas (UNICAMP) Campinas, SP, Brazil","institution_ids":["https://openalex.org/I181391015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032524715","display_name":"Marina Zamuner","orcid":"https://orcid.org/0000-0003-2746-0894","observed_orcids":["https://orcid.org/0000-0003-2746-0894"]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marina Zamuner","raw_affiliation_strings":["UroScience, Urology Division, Department of Surgery, State University of Campinas (UNICAMP) Campinas, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UroScience, Urology Division, Department of Surgery, State University of Campinas (UNICAMP) Campinas, SP, Brazil","institution_ids":["https://openalex.org/I181391015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086970907","display_name":"Rodolfo Borges dos Reis","orcid":"https://orcid.org/0000-0003-0328-1840","observed_orcids":["https://orcid.org/0000-0003-0328-1840"]},"institutions":[{"id":"https://openalex.org/I1331278255","display_name":"Universidade de Ribeir\u00e3o Preto","ror":"https://ror.org/00ey54k21","country_code":"BR","type":"education","lineage":["https://openalex.org/I1331278255"]},{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Rodolfo Borges Dos Reis","raw_affiliation_strings":["Urology Division, Department of Surgery, University of Ribeir\u00e3o Preto, USP-RP SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Urology Division, Department of Surgery, University of Ribeir\u00e3o Preto, USP-RP SP, Brazil","institution_ids":["https://openalex.org/I1331278255","https://openalex.org/I17974374"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014762258","display_name":"Leonardo Oliveira Reis","orcid":"https://orcid.org/0000-0003-2092-414X","observed_orcids":["https://orcid.org/0000-0003-2092-414X"]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]},{"id":"https://openalex.org/I79767729","display_name":"Pontif\u00edcia Universidade Cat\u00f3lica de Campinas","ror":"https://ror.org/01wjxn842","country_code":"BR","type":"education","lineage":["https://openalex.org/I79767729"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Leonardo Oliveira Reis","raw_affiliation_strings":["Urology Division, Center for Life Sciences, Pontifical Catholic University of Campinas (PUC-Campinas) Campinas, SP, Brazil","UroScience, Urology Division, Department of Surgery, State University of Campinas (UNICAMP) Campinas, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Urology Division, Center for Life Sciences, Pontifical Catholic University of Campinas (PUC-Campinas) Campinas, SP, Brazil","institution_ids":["https://openalex.org/I79767729"]},{"raw_affiliation_string":"UroScience, Urology Division, Department of Surgery, State University of Campinas (UNICAMP) Campinas, SP, Brazil","institution_ids":["https://openalex.org/I181391015"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8152,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.83196676,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"15","issue":"9","first_page":"373","last_page":"379"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.49239999055862427,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.49239999055862427,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.18330000340938568,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors","score":0.1680999994277954,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":1.0},{"id":"https://openalex.org/keywords/cystitis","display_name":"cystitis","score":0.8830000162124634},{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"bladder cancer","score":0.8289999961853027},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.8309999704360962},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.7350000143051147},{"id":"https://openalex.org/keywords/jnk","display_name":"JNK","score":0.7559999823570251},{"id":"https://openalex.org/keywords/ikkbeta","display_name":"IKK\u03b2","score":0.7960000038146973},{"id":"https://openalex.org/keywords/c-jun-phosphorylation","display_name":"c-Jun phosphorylation","score":0.7979999780654907},{"id":"https://openalex.org/keywords/urothelial-dysplasia","display_name":"urothelial dysplasia","score":0.8980000019073486},{"id":"https://openalex.org/keywords/urothelial-proliferation","display_name":"urothelial proliferation","score":0.9520000219345093},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9819999933242798},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.6060000061988831},{"id":"https://openalex.org/keywords/precancerous-lesions","display_name":"precancerous lesions","score":0.734000027179718}],"concepts":[{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.7408331632614136},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6184282898902893},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5888711214065552},{"id":"https://openalex.org/C2780352672","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder cancer","level":3,"score":0.5500525236129761},{"id":"https://openalex.org/C2777540882","wikidata":"https://www.wikidata.org/wiki/Q11878994","display_name":"Urothelium","level":3,"score":0.5288499593734741},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.49235379695892334},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.480173259973526},{"id":"https://openalex.org/C544855455","wikidata":"https://www.wikidata.org/wiki/Q1070952","display_name":"Histopathology","level":2,"score":0.4512866139411926},{"id":"https://openalex.org/C2779762690","wikidata":"https://www.wikidata.org/wiki/Q9382","display_name":"Urinary bladder","level":2,"score":0.34253376722335815},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.32746896147727966},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2656463384628296},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21294960379600525},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmid:36237635","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36237635","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental pathology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9547991","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9547991/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9547991","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9547991/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1483194800","https://openalex.org/W1652153701","https://openalex.org/W1976431577","https://openalex.org/W1984061101","https://openalex.org/W2000746666","https://openalex.org/W2007456673","https://openalex.org/W2007682549","https://openalex.org/W2013743238","https://openalex.org/W2017596133","https://openalex.org/W2026381062","https://openalex.org/W2034172614","https://openalex.org/W2046056065","https://openalex.org/W2059561965","https://openalex.org/W2062334173","https://openalex.org/W2074150439","https://openalex.org/W2107398537","https://openalex.org/W2111793830","https://openalex.org/W2117692326","https://openalex.org/W2120169362","https://openalex.org/W2124076790","https://openalex.org/W2141662760","https://openalex.org/W2145028653","https://openalex.org/W2155052327","https://openalex.org/W2166311080","https://openalex.org/W2519193025","https://openalex.org/W2556968169","https://openalex.org/W2854223583","https://openalex.org/W2917338402","https://openalex.org/W4200020699","https://openalex.org/W4281683309","https://openalex.org/W4283817434"],"related_works":["https://openalex.org/W4225351690","https://openalex.org/W2891327347","https://openalex.org/W198624498","https://openalex.org/W1496730963","https://openalex.org/W2911330472","https://openalex.org/W4392381555","https://openalex.org/W2273488026","https://openalex.org/W4377892772","https://openalex.org/W2791135975","https://openalex.org/W2107925903"],"abstract_inverted_index":{"BACKGROUND:":[0],"Recently,":[1],"the":[2,80,145,176,180],"role":[3],"of":[4,79,104],"subclinical":[5],"inflammation":[6,18,123],"in":[7,22,45,59,102,144,179],"obesity":[8,15,169],"has":[9,19],"gained":[10],"prominence.":[11],"An":[12],"association":[13],"between":[14,29],"and":[16,32,50,74,87,90,118,130,137,141,156,162],"chronic":[17,121],"been":[20],"observed":[21],"several":[23],"studies":[24],"that":[25,168],"show":[26],"a":[27,60,111,172],"relationship":[28],"increased":[30,127,135,152],"morbidity":[31],"high":[33,112],"Body":[34],"Mass":[35],"Index":[36],"(BMI).":[37],"This":[38],"study":[39],"aims":[40],"to":[41,55],"compare":[42],"inflammatory":[43,81,131,177],"pathways":[44],"obese":[46],"(by":[47],"high-fat":[48,149,173],"diet)":[49],"non-obese":[51],"mice":[52,94],"after":[53],"exposure":[54],"an":[56],"intravesical":[57],"carcinogen":[58],"cystitis":[61,160],"model.":[62],"METHODS:":[63],"-methylurea":[64],"(MNU)":[65],"pro-inflammatory":[66],"bladder":[67,107,181],"instillation.":[68],"Bladder":[69],"was":[70],"analyzed":[71],"by":[72,171],"histopathology":[73],"western":[75],"blotting":[76],"for":[77],"proteins":[78],"pathway":[82,132,178],"(JNK,":[83],"NF\u03baB,":[84,136],"c-JUN,":[85],"IKK),":[86],"immunohistochemistry":[88],"(proliferation":[89],"apoptosis).":[91],"RESULTS:":[92],"While":[93],"eating":[95,110],"standard":[96],"diet":[97,114,150,174],"showed":[98,115],"minimal":[99],"histologic":[100],"alteration":[101],"4":[103],"5":[105],"(80%)":[106],"tissues,":[108],"those":[109],"fat":[113],"moderate":[116],"(60%)":[117],"intense":[119],"(40%)":[120],"active":[122],"with":[124,134,159,182],"dysplasia":[125],"foci,":[126],"proliferation,":[128,154],"apoptosis":[129],"activation":[133],"also":[138],"IKK\u03b2,":[139],"JNK,":[140],"c-JUN":[142],"phosphorylation":[143],"urothelium.":[146],"CONCLUSION:":[147],"A":[148],"causes":[151],"urothelial":[153],"apoptosis,":[155],"NF\u03baB":[157],"expression":[158],"exacerbation":[161],"dysplasia.":[163],"Together,":[164],"these":[165],"results":[166],"suggest":[167],"induced":[170],"increases":[175],"possible":[183],"pre-malignant":[184],"alterations.":[185]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-10-15T00:00:00"}