{"id":"https://openalex.org/W4306178657","doi":"https://doi.org/10.1530/rep-22-0242","title":"Processes involved in prostaglandin F2alpha autoamplification in heifers","display_name":"Processes involved in prostaglandin F2alpha autoamplification in heifers","publication_year":2022,"publication_date":"2022-10-14","ids":{"openalex":"https://openalex.org/W4306178657","doi":"https://doi.org/10.1530/rep-22-0242","pmid":"https://pubmed.ncbi.nlm.nih.gov/36239920"},"language":"en","primary_location":{"id":"doi:10.1530/rep-22-0242","doi":"https://doi.org/10.1530/rep-22-0242","is_oa":false,"landing_page_url":"https://doi.org/10.1530/rep-22-0242","pdf_url":null,"source":{"id":"https://openalex.org/S28473761","display_name":"Reproduction","issn_l":"1470-1626","issn":["1470-1626","1741-7899"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproduction","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085847086","display_name":"Rafael Reis Domingues","orcid":"https://orcid.org/0000-0002-1407-2617","observed_orcids":["https://orcid.org/0000-0002-1407-2617"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rafael R Domingues","raw_affiliation_strings":["Department of Animal and Dairy Sciences, University of Wisconsin-Madison, USA","Endocrinology and Reproductive Physiology Program, University of Wisconsin-Madison, USA"],"raw_orcid":"https://orcid.org/0000-0002-1407-2617","affiliations":[{"raw_affiliation_string":"Department of Animal and Dairy Sciences, University of Wisconsin-Madison, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Endocrinology and Reproductive Physiology Program, University of Wisconsin-Madison, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004626928","display_name":"O.J. Ginther","orcid":"https://orcid.org/0000-0002-6872-4860","observed_orcids":["https://orcid.org/0000-0002-6872-4860","https://orcid.org/0000-0003-2853-2386"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"OJ Ginther","raw_affiliation_strings":["Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, USA","Eutheria Foundation, Cross Plains, Wisconsin, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Eutheria Foundation, Cross Plains, Wisconsin, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033728930","display_name":"Victor Gomez-Le\u00f3n","orcid":"https://orcid.org/0000-0003-1557-4157","observed_orcids":["https://orcid.org/0000-0003-1557-4157"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victor Gomez-Leon","raw_affiliation_strings":["Department of Animal and Dairy Sciences, University of Wisconsin-Madison, USA","Eutheria Foundation, Cross Plains, Wisconsin, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal and Dairy Sciences, University of Wisconsin-Madison, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Eutheria Foundation, Cross Plains, Wisconsin, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072575131","display_name":"Polyana Nunes da Silva","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Polyana Nunes da Silva","raw_affiliation_strings":["Eutheria Foundation, Cross Plains, Wisconsin, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eutheria Foundation, Cross Plains, Wisconsin, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108844816","display_name":"Thadeu Castro","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thadeu Castro","raw_affiliation_strings":["Eutheria Foundation, Cross Plains, Wisconsin, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eutheria Foundation, Cross Plains, Wisconsin, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037867372","display_name":"August Hoppmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"August Hoppmann","raw_affiliation_strings":["Department of Animal and Dairy Sciences, University of Wisconsin-Madison, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal and Dairy Sciences, University of Wisconsin-Madison, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068420345","display_name":"Milo Charles Wiltbank","orcid":"https://orcid.org/0000-0001-8188-0991","observed_orcids":["https://orcid.org/0000-0001-8188-0991"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Milo C Wiltbank","raw_affiliation_strings":["Department of Animal and Dairy Sciences, University of Wisconsin-Madison, USA","Endocrinology and Reproductive Physiology Program, University of Wisconsin-Madison, USA"],"raw_orcid":"https://orcid.org/0000-0001-8188-0991","affiliations":[{"raw_affiliation_string":"Department of Animal and Dairy Sciences, University of Wisconsin-Madison, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Endocrinology and Reproductive Physiology Program, University of Wisconsin-Madison, USA","institution_ids":["https://openalex.org/I135310074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5068420345"],"corresponding_institution_ids":["https://openalex.org/I135310074"],"apc_list":null,"apc_paid":null,"fwci":0.3469,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.4921399,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"165","issue":"1","first_page":"93","last_page":"101"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10584","display_name":"Reproductive Physiology in Livestock","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10584","display_name":"Reproductive Physiology in Livestock","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostaglandin-f2alpha","display_name":"prostaglandin F2alpha","score":0.9909999966621399},{"id":"https://openalex.org/keywords/luteolysis","display_name":"luteolysis","score":0.9789999723434448},{"id":"https://openalex.org/keywords/corpus-luteum","display_name":"corpus luteum","score":0.859000027179718},{"id":"https://openalex.org/keywords/heifers","display_name":"heifers","score":0.7699999809265137},{"id":"https://openalex.org/keywords/endometrium","display_name":"endometrium","score":0.6660000085830688},{"id":"https://openalex.org/keywords/flunixin-meglumine","display_name":"flunixin meglumine","score":0.8809999823570251},{"id":"https://openalex.org/keywords/progesterone","display_name":"progesterone","score":0.8080000281333923},{"id":"https://openalex.org/keywords/15-hydroxyprostaglandin-dehydrogenase","display_name":"15-hydroxyprostaglandin dehydrogenase","score":0.8579999804496765},{"id":"https://openalex.org/keywords/oxytocin-receptor","display_name":"oxytocin receptor","score":0.9359999895095825},{"id":"https://openalex.org/keywords/luteal-regression","display_name":"luteal regression","score":0.6579999923706055}],"concepts":[{"id":"https://openalex.org/C2781021844","wikidata":"https://www.wikidata.org/wiki/Q421375","display_name":"Prostaglandin F2alpha","level":3,"score":0.9738836288452148},{"id":"https://openalex.org/C2777330693","wikidata":"https://www.wikidata.org/wiki/Q1136340","display_name":"Luteolysis","level":4,"score":0.95485520362854},{"id":"https://openalex.org/C143228043","wikidata":"https://www.wikidata.org/wiki/Q2363481","display_name":"Luteal phase","level":3,"score":0.8715846538543701},{"id":"https://openalex.org/C2776608385","wikidata":"https://www.wikidata.org/wiki/Q749637","display_name":"Corpus luteum","level":3,"score":0.8387055397033691},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6316575407981873},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5972429513931274},{"id":"https://openalex.org/C2780664492","wikidata":"https://www.wikidata.org/wiki/Q209717","display_name":"Prostaglandin","level":2,"score":0.5832617878913879},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5729801654815674},{"id":"https://openalex.org/C2909370928","wikidata":"https://www.wikidata.org/wiki/Q209717","display_name":"Prostaglandins F","level":3,"score":0.43963974714279175},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.4253082275390625},{"id":"https://openalex.org/C2778324911","wikidata":"https://www.wikidata.org/wiki/Q9631","display_name":"Ovary","level":2,"score":0.20079845190048218},{"id":"https://openalex.org/C187785154","wikidata":"https://www.wikidata.org/wiki/Q5464664","display_name":"Follicular phase","level":2,"score":0.19530647993087769},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18624520301818848}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003338","descriptor_name":"Corpus Luteum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003341","descriptor_name":"Luteolysis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004717","descriptor_name":"Endometrium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011374","descriptor_name":"Progesterone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015237","descriptor_name":"Dinoprost","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1530/rep-22-0242","doi":"https://doi.org/10.1530/rep-22-0242","is_oa":false,"landing_page_url":"https://doi.org/10.1530/rep-22-0242","pdf_url":null,"source":{"id":"https://openalex.org/S28473761","display_name":"Reproduction","issn_l":"1470-1626","issn":["1470-1626","1741-7899"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproduction","raw_type":"journal-article"},{"id":"pmid:36239920","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36239920","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproduction (Cambridge, England)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4043000042438507,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W29245845","https://openalex.org/W1659749843","https://openalex.org/W1967001524","https://openalex.org/W1969022675","https://openalex.org/W1970416630","https://openalex.org/W1980363631","https://openalex.org/W1985522128","https://openalex.org/W2002413591","https://openalex.org/W2025080247","https://openalex.org/W2041786228","https://openalex.org/W2055753544","https://openalex.org/W2084711947","https://openalex.org/W2099165943","https://openalex.org/W2107277218","https://openalex.org/W2107574756","https://openalex.org/W2110526641","https://openalex.org/W2112030362","https://openalex.org/W2112862426","https://openalex.org/W2116883094","https://openalex.org/W2132000204","https://openalex.org/W2138071010","https://openalex.org/W2153621482","https://openalex.org/W2164782230","https://openalex.org/W2168650068","https://openalex.org/W2172283366","https://openalex.org/W2181983966","https://openalex.org/W2285680395","https://openalex.org/W2443514586","https://openalex.org/W2766649071","https://openalex.org/W2944609757","https://openalex.org/W2971445887","https://openalex.org/W3013433487","https://openalex.org/W3097822114","https://openalex.org/W3174408137","https://openalex.org/W3190726109","https://openalex.org/W4210495632","https://openalex.org/W4248984685","https://openalex.org/W4301772598"],"related_works":["https://openalex.org/W2766649071","https://openalex.org/W4210495632","https://openalex.org/W1996527290","https://openalex.org/W2594933661","https://openalex.org/W2285680395","https://openalex.org/W2938757443","https://openalex.org/W2597069908","https://openalex.org/W1582715545","https://openalex.org/W2012446316","https://openalex.org/W115873700"],"abstract_inverted_index":{"In":[0],"brief:":[1],"Endometrial":[2],"and":[3,12,15,51,123,145,149,160,196,202,226,246,280],"luteal":[4,19,50,215,241,251],"synthesis":[5,29,89,130,237],"of":[6,41,59,90,111,131,214,221,224,228,231,235,238,243,275,284],"prostaglandin":[7,42],"F2alpha":[8,43],"(PGF2A)":[9,44],"occurs":[10],"before":[11],"during":[13,170],"luteolysis":[14,169,183,192],"is":[16,46],"critical":[17],"for":[18],"regression.":[20],"This":[21],"study":[22],"demonstrates":[23],"that":[24,267],"PGF2A":[25,28,72,93,102,132,210,254,270,285,289],"stimulates":[26,286],"further":[27],"(autoamplification)":[30],"apparently":[31],"from":[32],"the":[33,38,116,121,126,171,176,219,273,281],"corpus":[34],"luteum.":[35],"Abstract:":[36],"Understanding":[37],"endocrine":[39],"profile":[40],"autoamplification":[45],"fundamental":[47],"to":[48,54,86,108,154,212,218,253],"comprehend":[49],"endometrial":[52,229,236],"responses":[53],"PGF2A.":[55,91],"On":[56],"day":[57],"10":[58],"postovulation":[60],"(preluteolysis),":[61],"heifers":[62,167,189,204],"(n":[63],"=":[64],"6/group)":[65],"were":[66,113,260],"treated":[67],"intrauterine":[68],"with":[69],"saline":[70],"or":[71,165],"(0.5":[73],"mg;":[74],"hour":[75,97,200],"0).":[76],"A":[77],"third":[78],"group":[79],"received":[80],"flunixin":[81],"meglumine":[82],"+":[83],"PGF":[84,117,135,148,177,244],"(FM+PGF)":[85],"prevent":[87],"endogenous":[88,129,288],"Exogenous":[92],"was":[94,265],"metabolized":[95],"at":[96],"2":[98],"as":[99],"measured":[100],"by":[101,157,194,199],"metabolite":[103],"(PGFM).":[104],"From":[105],"hours":[106,143,158],"5":[107],"48,":[109,201],"concentrations":[110,139,156],"PGFM":[112,225],"greatest":[114],"in":[115,120,125,134,147,175],"group,":[118,178],"smallest":[119],"FM+PGF,":[122],"intermediate":[124],"control":[127,164],"suggesting":[128],"only":[133],"group.":[136],"Progesterone":[137],"(P4)":[138],"decreased":[140],"transiently":[141],"between":[142],"0":[144],"1":[146,186],"FM+PGF":[150,166],"groups":[151],"but":[152],"rebounded":[153],"pretreatment":[155],"6":[159],"4,":[161],"respectively.":[162],"No":[163],"underwent":[168],"experimental":[172],"period.":[173],"Conversely,":[174],"one":[179],"heifer":[180],"had":[181,190],"complete":[182],"(P4":[184],"<":[185],"ng/mL),":[187],"two":[188],"partial":[191],"followed":[193],"P4":[195],"CL":[197],"resurgence":[198],"three":[203],"did":[205],"not":[206,261],"undergo":[207],"luteolysis.":[208],"Endogenous":[209],"appears":[211],"be":[213],"origin":[216],"due":[217],"lack":[220,227],"pulsatile":[222],"pattern":[223],"upregulation":[230],"oxytocin":[232],"receptor":[233,245],"(typical":[234],"PGF2A),":[239],"whereas":[240],"downregulation":[242],"HPGD":[247],"indicates":[248],"a":[249,268,276],"classic":[250],"response":[252],"signaling":[255],"although":[256],"other":[257],"specific":[258],"mechanisms":[259],"investigated.":[262],"The":[263],"hypothesis":[264],"supported":[266],"single":[269],"treatment":[271],"simulating":[272],"peak":[274],"natural":[277],"luteolytic":[278],"pulse":[279],"uteroovarian":[282],"transport":[283],"measurable":[287],"production.":[290]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-10-14T00:00:00"}