{"id":"https://openalex.org/W4306168232","doi":"https://doi.org/10.1177/20503121221128688","title":"Atogepant for the prevention of episodic migraine in adults","display_name":"Atogepant for the prevention of episodic migraine in adults","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4306168232","doi":"https://doi.org/10.1177/20503121221128688","pmid":"https://pubmed.ncbi.nlm.nih.gov/36226229","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9549103"},"language":"en","primary_location":{"id":"doi:10.1177/20503121221128688","doi":"https://doi.org/10.1177/20503121221128688","is_oa":true,"landing_page_url":"https://doi.org/10.1177/20503121221128688","pdf_url":null,"source":{"id":"https://openalex.org/S2764485085","display_name":"SAGE Open Medicine","issn_l":"2050-3121","issn":["2050-3121"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SAGE Open Medicine","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1177/20503121221128688","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075197848","display_name":"Maranda Paige Switzer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200033832","display_name":"Shenandoah University","ror":"https://ror.org/05w0p9h92","country_code":"US","type":"education","lineage":["https://openalex.org/I200033832"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maranda Paige Switzer","raw_affiliation_strings":["Bernard J. Dunn School of Pharmacy, Shenandoah University, Winchester, VA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bernard J. Dunn School of Pharmacy, Shenandoah University, Winchester, VA, USA","institution_ids":["https://openalex.org/I200033832"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Joseph Edward Robinson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200033832","display_name":"Shenandoah University","ror":"https://ror.org/05w0p9h92","country_code":"US","type":"education","lineage":["https://openalex.org/I200033832"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Edward Robinson","raw_affiliation_strings":["Bernard J. Dunn School of Pharmacy, Shenandoah University, Winchester, VA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bernard J. Dunn School of Pharmacy, Shenandoah University, Winchester, VA, USA","institution_ids":["https://openalex.org/I200033832"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048794741","display_name":"Kayla Rena Joyner","orcid":"https://orcid.org/0000-0003-2607-1459","observed_orcids":["https://orcid.org/0000-0003-2607-1459"]},"institutions":[{"id":"https://openalex.org/I200033832","display_name":"Shenandoah University","ror":"https://ror.org/05w0p9h92","country_code":"US","type":"education","lineage":["https://openalex.org/I200033832"]},{"id":"https://openalex.org/I4210139950","display_name":"Winchester Medical Center","ror":"https://ror.org/04svanq44","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210139950"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kayla Rena Joyner","raw_affiliation_strings":["Department of Pharmacy Practice, Bernard J. Dunn School of Pharmacy, Shenandoah University, Winchester, VA, USA","Valley Health Winchester Medical Center, Winchester, VA, USA"],"raw_orcid":"https://orcid.org/0000-0003-2607-1459","affiliations":[{"raw_affiliation_string":"Department of Pharmacy Practice, Bernard J. Dunn School of Pharmacy, Shenandoah University, Winchester, VA, USA","institution_ids":["https://openalex.org/I200033832"]},{"raw_affiliation_string":"Valley Health Winchester Medical Center, Winchester, VA, USA","institution_ids":["https://openalex.org/I4210139950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035197938","display_name":"Kelsey Woods Morgan","orcid":"https://orcid.org/0000-0002-2589-7454","observed_orcids":["https://orcid.org/0000-0002-2589-7454"]},"institutions":[{"id":"https://openalex.org/I200033832","display_name":"Shenandoah University","ror":"https://ror.org/05w0p9h92","country_code":"US","type":"education","lineage":["https://openalex.org/I200033832"]},{"id":"https://openalex.org/I4210139950","display_name":"Winchester Medical Center","ror":"https://ror.org/04svanq44","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210139950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelsey Woods Morgan","raw_affiliation_strings":["Department of Pharmacy Practice, Bernard J. Dunn School of Pharmacy, Shenandoah University, Winchester, VA, USA","Valley Health Winchester Medical Center, Winchester, VA, USA"],"raw_orcid":"https://orcid.org/0000-0002-2589-7454","affiliations":[{"raw_affiliation_string":"Department of Pharmacy Practice, Bernard J. Dunn School of Pharmacy, Shenandoah University, Winchester, VA, USA","institution_ids":["https://openalex.org/I200033832"]},{"raw_affiliation_string":"Valley Health Winchester Medical Center, Winchester, VA, USA","institution_ids":["https://openalex.org/I4210139950"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5048794741"],"corresponding_institution_ids":["https://openalex.org/I200033832","https://openalex.org/I4210139950"],"apc_list":{"value":1125,"currency":"USD","value_usd":1125},"apc_paid":{"value":1125,"currency":"USD","value_usd":1125},"fwci":0.3019,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.28576132,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"10","issue":null,"first_page":"20503121221128688","last_page":"20503121221128688"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10420","display_name":"Intracranial Aneurysms: Treatment and Complications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10852","display_name":"Temporomandibular Joint Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atogepant","display_name":"atogepant","score":1.0},{"id":"https://openalex.org/keywords/episodic-migraine","display_name":"episodic migraine","score":0.9380000233650208},{"id":"https://openalex.org/keywords/migraine-prevention","display_name":"migraine prophylaxis","score":0.9779999852180481},{"id":"https://openalex.org/keywords/cgrp-receptor-antagonists","display_name":"CGRP receptor antagonists","score":0.9620000123977661},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.7210000157356262},{"id":"https://openalex.org/keywords/treatment-costs","display_name":"treatment costs","score":0.609000027179718},{"id":"https://openalex.org/keywords/chronic-migraine","display_name":"chronic migraine","score":0.5},{"id":"https://openalex.org/keywords/monoclonal-antibody-alternatives","display_name":"monoclonal antibody alternatives","score":0.7639999985694885}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9100439548492432},{"id":"https://openalex.org/C2778541695","wikidata":"https://www.wikidata.org/wiki/Q133823","display_name":"Migraine","level":2,"score":0.8441179394721985},{"id":"https://openalex.org/C2776478404","wikidata":"https://www.wikidata.org/wiki/Q1105187","display_name":"Cochrane Library","level":3,"score":0.5972328782081604},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5759727954864502},{"id":"https://openalex.org/C2780580376","wikidata":"https://www.wikidata.org/wiki/Q186889","display_name":"Nausea","level":2,"score":0.5618295073509216},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5597467422485352},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.555896520614624},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5328617095947266},{"id":"https://openalex.org/C2910587157","wikidata":"https://www.wikidata.org/wiki/Q133823","display_name":"Chronic Migraine","level":3,"score":0.49133673310279846},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.4496701657772064},{"id":"https://openalex.org/C2778871607","wikidata":"https://www.wikidata.org/wiki/Q416978","display_name":"Sumatriptan","level":4,"score":0.42506909370422363},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.3851720690727234},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28893202543258667},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07545292377471924},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1177/20503121221128688","doi":"https://doi.org/10.1177/20503121221128688","is_oa":true,"landing_page_url":"https://doi.org/10.1177/20503121221128688","pdf_url":null,"source":{"id":"https://openalex.org/S2764485085","display_name":"SAGE Open Medicine","issn_l":"2050-3121","issn":["2050-3121"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SAGE Open Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9549103","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9549103/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9549103/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SAGE Open Med","raw_type":"Text"},{"id":"pmid:36226229","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36226229","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SAGE open medicine","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:0cb415f0e6654f28a3c843d64c0459f9","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/0cb415f0e6654f28a3c843d64c0459f9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"SAGE Open Medicine, Vol 10 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1177/20503121221128688","doi":"https://doi.org/10.1177/20503121221128688","is_oa":true,"landing_page_url":"https://doi.org/10.1177/20503121221128688","pdf_url":null,"source":{"id":"https://openalex.org/S2764485085","display_name":"SAGE Open Medicine","issn_l":"2050-3121","issn":["2050-3121"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SAGE Open Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4306168232.pdf","grobid_xml":"https://content.openalex.org/works/W4306168232.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W73775937","https://openalex.org/W1802284765","https://openalex.org/W1991627994","https://openalex.org/W2001650386","https://openalex.org/W2086228377","https://openalex.org/W2152848856","https://openalex.org/W2157733244","https://openalex.org/W2268603990","https://openalex.org/W2534944171","https://openalex.org/W2770965214","https://openalex.org/W2771927282","https://openalex.org/W2780526171","https://openalex.org/W2791018156","https://openalex.org/W2792811290","https://openalex.org/W2803715733","https://openalex.org/W2805181790","https://openalex.org/W2805937849","https://openalex.org/W2895070640","https://openalex.org/W2896011253","https://openalex.org/W2898072840","https://openalex.org/W2959015323","https://openalex.org/W2968435022","https://openalex.org/W2985571327","https://openalex.org/W2986364716","https://openalex.org/W2987178463","https://openalex.org/W3007053288","https://openalex.org/W3007834801","https://openalex.org/W3012091141","https://openalex.org/W3016322114","https://openalex.org/W3050017463","https://openalex.org/W3086189755","https://openalex.org/W3099375191","https://openalex.org/W3107747907","https://openalex.org/W3111685616","https://openalex.org/W3113984977","https://openalex.org/W3120635632","https://openalex.org/W3124565589","https://openalex.org/W3157910822","https://openalex.org/W3173551259","https://openalex.org/W3176461052","https://openalex.org/W3176839476","https://openalex.org/W3185467542","https://openalex.org/W3193766373","https://openalex.org/W3198972203","https://openalex.org/W4200098322","https://openalex.org/W4205200610","https://openalex.org/W4214697113","https://openalex.org/W4310989061"],"related_works":["https://openalex.org/W4214611176","https://openalex.org/W7108227238","https://openalex.org/W4282914756","https://openalex.org/W7162233804","https://openalex.org/W4210800132","https://openalex.org/W4400827677","https://openalex.org/W4317209460","https://openalex.org/W4407608161","https://openalex.org/W4391770845","https://openalex.org/W4413929962"],"abstract_inverted_index":{"Objective:":[0],"Atogepant":[1,204,233],"is":[2,144],"a":[3,31,136,145,274],"newly":[4],"approved":[5],"medication":[6],"for":[7,34,104,117,149,211,227,273],"the":[8,17,45,61,89,100,212],"prevention":[9,213,229],"of":[10,25,48,53,111,198,207,214,221,277],"migraine.":[11,170,215],"This":[12],"review":[13],"aims":[14],"to":[15,82,239,250,261],"discuss":[16],"efficacy,":[18],"safety,":[19],"cost,":[20],"and":[21,39,60,71,96,133,177,182,188,246,265],"place":[22],"in":[23,88,106,119,166,190],"therapy":[24,238],"atogepant.":[26],"Methods:":[27],"The":[28],"authors":[29],"performed":[30],"systematic":[32],"search":[33,101],"sources,":[35],"including":[36],"articles,":[37],"abstracts,":[38,95],"poster":[40],"presentations.":[41],"Queried":[42],"databases":[43],"were":[44,86,102,115,130],"National":[46,51],"Institute":[47],"Health,":[49],"US":[50],"Library":[52],"Medicine":[54],"Clinical":[55],"Trials,":[56],"PubMed,":[57],"European":[58],"PMC,":[59],"Cochrane":[62],"Library.":[63],"Search":[64],"terms":[65],"included":[66,87],"atogepant,":[67],"QULIPTA\u2122,":[68],"AGN-241689,":[69],"MK-803,":[70],"N02CD07.":[72],"Full-text,":[73],"English":[74],"language,":[75],"randomized-controlled":[76],"trials":[77,129],"from":[78],"1":[79,83],"February":[80,84],"2012":[81],"2022":[85],"review.":[90,108,122],"Additional":[91],"relevant":[92],"prescribing":[93],"information,":[94],"articles":[97,124],"identified":[98],"through":[99],"considered":[103],"inclusion":[105,118],"this":[107,120],"A":[109],"total":[110],"193":[112],"database":[113],"entries":[114],"evaluated":[116],"narrative":[121],"Three":[123],"representing":[125],"two":[126,196],"randomized":[127],"controlled":[128],"reviewed.":[131],"Results":[132],"conclusions:":[134],"Atogepant,":[135],"small-molecule":[137],"calcitonin":[138],"gene-related":[139],"peptide":[140],"(CGRP)":[141],"receptor":[142],"antagonist,":[143],"daily":[146],"oral":[147,281],"treatment":[148],"migraine":[150,160,186,228,252],"prevention.":[151],"In":[152],"placebo-controlled":[153,180],"clinical":[154],"trials,":[155],"atogepant":[156,222,269],"decreased":[157],"mean":[158],"monthly":[159],"days":[161],"(MMD)":[162],"over":[163],"12":[164],"weeks":[165],"patients":[167,191,235],"with":[168,257],"episodic":[169],"Major":[171],"treatment-related":[172],"adverse":[173],"effects":[174],"include":[175],"nausea":[176],"constipation.":[178],"Long-term":[179],"efficacy":[181],"safety":[183],"studies,":[184,187],"chronic":[185],"studies":[189],"that":[192,254],"failed":[193],"more":[194],"than":[195],"classes":[197],"preventive":[199],"therapies":[200,210],"are":[201,255],"still":[202],"pending.":[203],"represents":[205],"one":[206],"many":[208],"novel":[209],"To":[216],"date,":[217],"no":[218],"head-to-head":[219],"comparisons":[220],"versus":[223],"other":[224],"agents":[225],"indicated":[226],"have":[230],"been":[231],"published.":[232],"offers":[234,247],"an":[236,248],"alternative":[237,249],"injectable":[240],"or":[241],"infusion":[242],"monoclonal":[243],"antibody":[244],"treatments":[245],"non-specific":[251],"medications":[253],"associated":[256],"poor":[258],"tolerability.":[259],"Due":[260],"its":[262],"high":[263],"cost":[264],"narrower":[266],"therapeutic":[267],"indications,":[268],"may":[270],"be":[271],"reserved":[272],"small":[275],"subset":[276],"migraineurs":[278],"who":[279],"prefer":[280],"therapy.":[282]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2022-10-14T00:00:00"}
