{"id":"https://openalex.org/W4306158018","doi":"https://doi.org/10.3389/fphar.2022.1019312","title":"Short-chain L-3-hydroxyacyl-CoA dehydrogenase: A novel vital oncogene or tumor suppressor gene in cancers","display_name":"Short-chain L-3-hydroxyacyl-CoA dehydrogenase: A novel vital oncogene or tumor suppressor gene in cancers","publication_year":2022,"publication_date":"2022-10-14","ids":{"openalex":"https://openalex.org/W4306158018","doi":"https://doi.org/10.3389/fphar.2022.1019312","pmid":"https://pubmed.ncbi.nlm.nih.gov/36313354","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9614034"},"language":"en","primary_location":{"id":"doi:10.3389/fphar.2022.1019312","doi":"https://doi.org/10.3389/fphar.2022.1019312","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2022.1019312","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphar.2022.1019312/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4306158018"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fphar.2022.1019312/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047493514","display_name":"Fang He","orcid":"https://orcid.org/0000-0001-6912-6187","observed_orcids":["https://orcid.org/0000-0001-6912-6187"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210142484","display_name":"Second Affiliated Hospital of Jilin University","ror":"https://ror.org/03x6hbh34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142484"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"He Fang","raw_affiliation_strings":["Department of Hepatobiliary and Pancreatic Surgery, The Second Hospital of Jilin University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary and Pancreatic Surgery, The Second Hospital of Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210142484"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hanyang Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210142484","display_name":"Second Affiliated Hospital of Jilin University","ror":"https://ror.org/03x6hbh34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142484"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hanyang Li","raw_affiliation_strings":["Department of Thyroid Surgery, The Second Hospital of Jilin University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thyroid Surgery, The Second Hospital of Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210142484"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100438450","display_name":"Hang Zhang","orcid":"https://orcid.org/0000-0002-2768-492X","observed_orcids":["https://orcid.org/0000-0002-2768-492X"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210142484","display_name":"Second Affiliated Hospital of Jilin University","ror":"https://ror.org/03x6hbh34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142484"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hang Zhang","raw_affiliation_strings":["Department of Hepatobiliary and Pancreatic Surgery, The Second Hospital of Jilin University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary and Pancreatic Surgery, The Second Hospital of Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210142484"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100335442","display_name":"Shu Wang","orcid":"https://orcid.org/0000-0001-5447-0946","observed_orcids":["https://orcid.org/0000-0001-5447-0946"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210142484","display_name":"Second Affiliated Hospital of Jilin University","ror":"https://ror.org/03x6hbh34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142484"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shu Wang","raw_affiliation_strings":["Department of Radiotherapy, The Second Hospital of Jilin University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiotherapy, The Second Hospital of Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210142484"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046486032","display_name":"Shuang Xu","orcid":"https://orcid.org/0009-0005-7321-221X","observed_orcids":["https://orcid.org/0009-0005-7321-221X"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210142484","display_name":"Second Affiliated Hospital of Jilin University","ror":"https://ror.org/03x6hbh34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142484"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuang Xu","raw_affiliation_strings":["Department of Anesthesiology, The Second Hospital of Jilin University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, The Second Hospital of Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210142484"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075627617","display_name":"Chang Li","orcid":"https://orcid.org/0000-0003-4310-5286","observed_orcids":["https://orcid.org/0000-0003-4310-5286","https://orcid.org/0009-0006-9044-604X"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210142484","display_name":"Second Affiliated Hospital of Jilin University","ror":"https://ror.org/03x6hbh34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142484"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Chang","raw_affiliation_strings":["Department of Pathology, The Second Hospital of Jilin University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, The Second Hospital of Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210142484"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101412966","display_name":"Yongsheng Yang","orcid":"https://orcid.org/0000-0003-3503-2590","observed_orcids":["https://orcid.org/0000-0003-3503-2590"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210142484","display_name":"Second Affiliated Hospital of Jilin University","ror":"https://ror.org/03x6hbh34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142484"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yongsheng Yang","raw_affiliation_strings":["Department of Hepatobiliary and Pancreatic Surgery, The Second Hospital of Jilin University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary and Pancreatic Surgery, The Second Hospital of Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210142484"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050876876","display_name":"Ranji Cui","orcid":"https://orcid.org/0000-0002-1129-3772","observed_orcids":["https://orcid.org/0000-0002-1129-3772"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210142484","display_name":"Second Affiliated Hospital of Jilin University","ror":"https://ror.org/03x6hbh34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142484"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ranji Cui","raw_affiliation_strings":["Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210142484"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5050876876","https://openalex.org/A5101412966"],"corresponding_institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210142484"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":0.2892,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.29156293,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"13","issue":null,"first_page":"1019312","last_page":"1019312"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydroxyacyl-coa-dehydrogenase","display_name":"hydroxyacyl-CoA dehydrogenase","score":0.890999972820282},{"id":"https://openalex.org/keywords/fatty-acid-oxidation","display_name":"fatty acid oxidation","score":0.824999988079071},{"id":"https://openalex.org/keywords/mitochondrial-metabolism","display_name":"mitochondrial metabolism","score":0.6919999718666077},{"id":"https://openalex.org/keywords/tumor-metabolism","display_name":"cancer metabolism","score":0.5720000267028809},{"id":"https://openalex.org/keywords/oncogenes","display_name":"oncogenes","score":0.8379999995231628},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.9819999933242798},{"id":"https://openalex.org/keywords/tumor-markers","display_name":"tumor markers","score":0.621999979019165},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.7020000219345093},{"id":"https://openalex.org/keywords/metabolic-reprogramming","display_name":"metabolic reprogramming","score":0.6019999980926514}],"concepts":[{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6653028726577759},{"id":"https://openalex.org/C82714985","wikidata":"https://www.wikidata.org/wiki/Q306213","display_name":"Beta oxidation","level":3,"score":0.5743884444236755},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5694745779037476},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.568644106388092},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.557446300983429},{"id":"https://openalex.org/C2776317432","wikidata":"https://www.wikidata.org/wiki/Q412547","display_name":"Dehydrogenase","level":3,"score":0.5332863926887512},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.5219628214836121},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.48345598578453064},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.47548118233680725},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4389136731624603},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.4230071008205414},{"id":"https://openalex.org/C2776991927","wikidata":"https://www.wikidata.org/wiki/Q14860867","display_name":"Fatty acid metabolism","level":3,"score":0.41777732968330383},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4028279185295105},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17435327172279358},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.09991723299026489}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fphar.2022.1019312","doi":"https://doi.org/10.3389/fphar.2022.1019312","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2022.1019312","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphar.2022.1019312/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},{"id":"pmid:36313354","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36313354","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9614034","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9614034/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Pharmacol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:a15f820ee5b34bfc99ff043b69c6ba2b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a15f820ee5b34bfc99ff043b69c6ba2b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pharmacology, Vol 13 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fphar.2022.1019312","doi":"https://doi.org/10.3389/fphar.2022.1019312","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2022.1019312","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphar.2022.1019312/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2808004117","display_name":null,"funder_award_id":"2018GDYYZ001","funder_id":"https://openalex.org/F4320323171","funder_display_name":"Jilin Department of Health"}],"funders":[{"id":"https://openalex.org/F4320322174","display_name":"People's Government of Jilin Province","ror":"https://ror.org/02fzqav45"},{"id":"https://openalex.org/F4320323171","display_name":"Jilin Department of Health","ror":"https://ror.org/01a67y017"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4306158018.pdf","grobid_xml":"https://content.openalex.org/works/W4306158018.grobid-xml"},"referenced_works_count":185,"referenced_works":["https://openalex.org/W163773482","https://openalex.org/W859568217","https://openalex.org/W1485838909","https://openalex.org/W1486228890","https://openalex.org/W1487234933","https://openalex.org/W1509669696","https://openalex.org/W1528547033","https://openalex.org/W1534849470","https://openalex.org/W1553510815","https://openalex.org/W1562623840","https://openalex.org/W1581623713","https://openalex.org/W1598629558","https://openalex.org/W1605149237","https://openalex.org/W1617532721","https://openalex.org/W1685927984","https://openalex.org/W1729812787","https://openalex.org/W1963449298","https://openalex.org/W1963912235","https://openalex.org/W1964837364","https://openalex.org/W1966133006","https://openalex.org/W1967137553","https://openalex.org/W1972825083","https://openalex.org/W1977118413","https://openalex.org/W1977462853","https://openalex.org/W1980568044","https://openalex.org/W1984621921","https://openalex.org/W1984951395","https://openalex.org/W1988835053","https://openalex.org/W1989116783","https://openalex.org/W1994917415","https://openalex.org/W1994928797","https://openalex.org/W1998038367","https://openalex.org/W1998265194","https://openalex.org/W1999202782","https://openalex.org/W1999447199","https://openalex.org/W2000093333","https://openalex.org/W2002490399","https://openalex.org/W2006148253","https://openalex.org/W2006419043","https://openalex.org/W2018023891","https://openalex.org/W2022488821","https://openalex.org/W2031469256","https://openalex.org/W2035008060","https://openalex.org/W2036292540","https://openalex.org/W2036464404","https://openalex.org/W2036691369","https://openalex.org/W2041237929","https://openalex.org/W2043054174","https://openalex.org/W2044182846","https://openalex.org/W2046404915","https://openalex.org/W2047580791","https://openalex.org/W2048742751","https://openalex.org/W2049439127","https://openalex.org/W2052543023","https://openalex.org/W2053363358","https://openalex.org/W2054917860","https://openalex.org/W2055557491","https://openalex.org/W2059221693","https://openalex.org/W2059502948","https://openalex.org/W2061791832","https://openalex.org/W2063247572","https://openalex.org/W2063632665","https://openalex.org/W2066457776","https://openalex.org/W2067674453","https://openalex.org/W2068912983","https://openalex.org/W2073694032","https://openalex.org/W2074873270","https://openalex.org/W2077173862","https://openalex.org/W2077478539","https://openalex.org/W2078019686","https://openalex.org/W2080719056","https://openalex.org/W2081940606","https://openalex.org/W2090551359","https://openalex.org/W2093295316","https://openalex.org/W2093617151","https://openalex.org/W2097733751","https://openalex.org/W2099000660","https://openalex.org/W2099409085","https://openalex.org/W2100039832","https://openalex.org/W2103304405","https://openalex.org/W2110015442","https://openalex.org/W2111101616","https://openalex.org/W2113280225","https://openalex.org/W2117692326","https://openalex.org/W2118278569","https://openalex.org/W2122355930","https://openalex.org/W2123105952","https://openalex.org/W2129172946","https://openalex.org/W2129755293","https://openalex.org/W2130924845","https://openalex.org/W2147114673","https://openalex.org/W2147457396","https://openalex.org/W2147656718","https://openalex.org/W2149441684","https://openalex.org/W2162206731","https://openalex.org/W2168631000","https://openalex.org/W2171398898","https://openalex.org/W2209805859","https://openalex.org/W2214530781","https://openalex.org/W2265313182","https://openalex.org/W2273895520","https://openalex.org/W2286695724","https://openalex.org/W2292016096","https://openalex.org/W2318391521","https://openalex.org/W2332116295","https://openalex.org/W2388163742","https://openalex.org/W2397963384","https://openalex.org/W2414792635","https://openalex.org/W2414920160","https://openalex.org/W2427868980","https://openalex.org/W2516006356","https://openalex.org/W2520632143","https://openalex.org/W2532343326","https://openalex.org/W2566861409","https://openalex.org/W2567661897","https://openalex.org/W2606513998","https://openalex.org/W2607103422","https://openalex.org/W2609085309","https://openalex.org/W2609408781","https://openalex.org/W2611694282","https://openalex.org/W2613084028","https://openalex.org/W2617255104","https://openalex.org/W2621902941","https://openalex.org/W2626932481","https://openalex.org/W2727828415","https://openalex.org/W2738886992","https://openalex.org/W2747485667","https://openalex.org/W2760375764","https://openalex.org/W2767055857","https://openalex.org/W2778137650","https://openalex.org/W2783087461","https://openalex.org/W2786152874","https://openalex.org/W2793616572","https://openalex.org/W2803358834","https://openalex.org/W2803901658","https://openalex.org/W2804201638","https://openalex.org/W2808347790","https://openalex.org/W2811408032","https://openalex.org/W2883333275","https://openalex.org/W2884204113","https://openalex.org/W2886253007","https://openalex.org/W2889481010","https://openalex.org/W2894321487","https://openalex.org/W2910546933","https://openalex.org/W2915469462","https://openalex.org/W2915478882","https://openalex.org/W2927027947","https://openalex.org/W2938884772","https://openalex.org/W2943947791","https://openalex.org/W2948438687","https://openalex.org/W2956024695","https://openalex.org/W2956627195","https://openalex.org/W2967658879","https://openalex.org/W2975182090","https://openalex.org/W2982275842","https://openalex.org/W2982505906","https://openalex.org/W2984617082","https://openalex.org/W2990791923","https://openalex.org/W2995989004","https://openalex.org/W3015933390","https://openalex.org/W3025420172","https://openalex.org/W3026790418","https://openalex.org/W3029628311","https://openalex.org/W3043304339","https://openalex.org/W3044255220","https://openalex.org/W3047922102","https://openalex.org/W3068772833","https://openalex.org/W3082907405","https://openalex.org/W3090406951","https://openalex.org/W3091887725","https://openalex.org/W3109051366","https://openalex.org/W3153802431","https://openalex.org/W3170448176","https://openalex.org/W3175706857","https://openalex.org/W3194470668","https://openalex.org/W3216158976","https://openalex.org/W4206841660","https://openalex.org/W4210446089","https://openalex.org/W4211158689","https://openalex.org/W4213197580","https://openalex.org/W4213382484","https://openalex.org/W4238112438","https://openalex.org/W4251110191","https://openalex.org/W6717780503","https://openalex.org/W6777721346"],"related_works":["https://openalex.org/W6962244668","https://openalex.org/W4304891459","https://openalex.org/W3088348674","https://openalex.org/W2519842257","https://openalex.org/W2900166571","https://openalex.org/W4309706585","https://openalex.org/W2972717591","https://openalex.org/W2729786544","https://openalex.org/W1485838909","https://openalex.org/W4407907945"],"abstract_inverted_index":{"The":[0,28,77,103],"reprogramming":[1],"of":[2,50,67,79,88,95,106,118],"cellular":[3],"metabolism":[4],"is":[5,61,70,121],"frequently":[6],"linked":[7,71],"to":[8,72],"tumorigenesis.":[9],"Glucose,":[10],"fatty":[11,42,51],"acids,":[12],"and":[13,69,75,84,93,116],"amino":[14],"acids":[15],"are":[16,98],"the":[17,33,47,91,114],"specific":[18],"substrates":[19],"involved":[20],"in":[21,41,54,64,82,90,100],"how":[22],"an":[23],"organism":[24],"maintains":[25],"metabolic":[26],"equilibrium.":[27],"HADH":[29,60,80,107],"gene":[30],"codes":[31],"for":[32,113],"short-chain":[34],"L-3-hydroxyacyl-CoA":[35],"dehydrogenase":[36],"(HADH),":[37],"a":[38,109],"crucial":[39],"enzyme":[40],"acid":[43,52],"oxidation":[44,53],"that":[45,59],"catalyzes":[46],"third":[48],"phase":[49],"mitochondria.":[55],"Increasing":[56],"data":[57],"suggest":[58],"differentially":[62],"expressed":[63],"various":[65,119],"types":[66],"malignancies":[68,120],"cancer":[73],"development":[74],"progression.":[76],"significance":[78],"expression":[81],"tumors":[83],"its":[85],"potential":[86],"mechanisms":[87],"action":[89],"onset":[92],"progression":[94],"certain":[96],"cancers":[97],"summarized":[99],"this":[101],"article.":[102],"possible":[104],"roles":[105],"as":[108],"target":[110],"and/or":[111],"biomarker":[112],"detection":[115],"treatment":[117],"also":[122],"described":[123],"here.":[124]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":6}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-10-14T00:00:00"}