{"id":"https://openalex.org/W4306155103","doi":"https://doi.org/10.1016/j.molimm.2022.05.077","title":"Acute Pharmacologic Degradation of a Stable Antigen enhances its Direct Presentation on MHC class I Molecules","display_name":"Acute Pharmacologic Degradation of a Stable Antigen enhances its Direct Presentation on MHC class I Molecules","publication_year":2022,"publication_date":"2022-10-01","ids":{"openalex":"https://openalex.org/W4306155103","doi":"https://doi.org/10.1016/j.molimm.2022.05.077"},"language":"en","primary_location":{"id":"doi:10.1016/j.molimm.2022.05.077","doi":"https://doi.org/10.1016/j.molimm.2022.05.077","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.molimm.2022.05.077","pdf_url":null,"source":{"id":"https://openalex.org/S92126311","display_name":"Molecular Immunology","issn_l":"0161-5890","issn":["0161-5890","1872-9142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069439662","display_name":"Sarah C. Moser","orcid":"https://orcid.org/0000-0002-1678-4079","observed_orcids":["https://orcid.org/0000-0002-1678-4079"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]},{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]},{"id":"https://openalex.org/I4210149908","display_name":"Erasmus MC Cancer Institute","ror":"https://ror.org/03r4m3349","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686","https://openalex.org/I4210149908"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Sarah C. Moser","raw_affiliation_strings":["Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands","Present affiliation: Netherlands Cancer Institute, Amsterdam, Netherlands","Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands; Present affiliation: Netherlands Cancer Institute, Amsterdam, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands","institution_ids":["https://openalex.org/I2801952686"]},{"raw_affiliation_string":"Present affiliation: Netherlands Cancer Institute, Amsterdam, Netherlands","institution_ids":["https://openalex.org/I2898336195"]},{"raw_affiliation_string":"Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands; Present affiliation: Netherlands Cancer Institute, Amsterdam, Netherlands","institution_ids":["https://openalex.org/I2801952686","https://openalex.org/I2898336195","https://openalex.org/I4210149908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110467985","display_name":"Jane S.A. Voerman","orcid":"https://orcid.org/0009-0000-6516-4098","observed_orcids":["https://orcid.org/0009-0000-6516-4098"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jane S.A. Voerman","raw_affiliation_strings":["Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075891845","display_name":"Dennis L. Buckley","orcid":"https://orcid.org/0000-0003-1916-7807","observed_orcids":["https://orcid.org/0000-0003-1916-7807"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dennis L. Buckley","raw_affiliation_strings":["Department for Medical Oncology, Dana-Farber Cancer Institute, Boston, United States","Present affiliation: Novartis Institutes for Biomedical Research, Cambridge, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for Medical Oncology, Dana-Farber Cancer Institute, Boston, United States","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Present affiliation: Novartis Institutes for Biomedical Research, Cambridge, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002922655","display_name":"Georg E. Winter","orcid":"https://orcid.org/0000-0001-6606-1437","observed_orcids":["https://orcid.org/0000-0001-6606-1437"]},"institutions":[{"id":"https://openalex.org/I138211613","display_name":"Austrian Academy of Sciences","ror":"https://ror.org/03anc3s24","country_code":"AT","type":"government","lineage":["https://openalex.org/I138211613"]},{"id":"https://openalex.org/I4210127611","display_name":"CeMM Research Center for Molecular Medicine","ror":"https://ror.org/02z2dfb58","country_code":"AT","type":"facility","lineage":["https://openalex.org/I138211613","https://openalex.org/I4210127611"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Georg E. Winter","raw_affiliation_strings":["CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria","institution_ids":["https://openalex.org/I138211613","https://openalex.org/I4210127611"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083561712","display_name":"Christopher Schliehe","orcid":"https://orcid.org/0000-0002-1923-8620","observed_orcids":["https://orcid.org/0000-0002-1923-8620"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Christopher Schliehe","raw_affiliation_strings":["Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2880,"currency":"USD","value_usd":2880},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.12191655,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"150","issue":null,"first_page":"22","last_page":"22"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.8848000168800354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.8848000168800354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.07590000331401825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.025499999523162842,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protacs","display_name":"PROTACs","score":0.8259999752044678},{"id":"https://openalex.org/keywords/bifunctional-degraders","display_name":"bifunctional degraders","score":0.9729999899864197},{"id":"https://openalex.org/keywords/mhc-class-i-antigen-presentation","display_name":"MHC class I antigen presentation","score":0.8700000047683716},{"id":"https://openalex.org/keywords/direct-antigen-presentation","display_name":"direct antigen presentation","score":0.7789999842643738},{"id":"https://openalex.org/keywords/defective-ribosomal-products","display_name":"defective ribosomal products","score":0.8299999833106995},{"id":"https://openalex.org/keywords/proteasomal-degradation","display_name":"proteasomal degradation","score":0.8379999995231628},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.6510000228881836}],"concepts":[{"id":"https://openalex.org/C170627219","wikidata":"https://www.wikidata.org/wiki/Q13218497","display_name":"MHC class I","level":4,"score":0.8315359354019165},{"id":"https://openalex.org/C108249834","wikidata":"https://www.wikidata.org/wiki/Q3922363","display_name":"Antigen processing","level":5,"score":0.7474333047866821},{"id":"https://openalex.org/C83464605","wikidata":"https://www.wikidata.org/wiki/Q575296","display_name":"Antigen presentation","level":4,"score":0.711032509803772},{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.6841611862182617},{"id":"https://openalex.org/C22845430","wikidata":"https://www.wikidata.org/wiki/Q224879","display_name":"Transporter associated with antigen processing","level":5,"score":0.6612605452537537},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6015951633453369},{"id":"https://openalex.org/C2992195973","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Protein degradation","level":2,"score":0.5653228759765625},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4869552552700043},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4732910990715027},{"id":"https://openalex.org/C2781307694","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Proteolysis","level":3,"score":0.47089603543281555},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4699440598487854},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.461816668510437},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3548309803009033},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34571078419685364},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.298917293548584},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.29086893796920776},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19037941098213196},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.13019120693206787},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.molimm.2022.05.077","doi":"https://doi.org/10.1016/j.molimm.2022.05.077","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.molimm.2022.05.077","pdf_url":null,"source":{"id":"https://openalex.org/S92126311","display_name":"Molecular Immunology","issn_l":"0161-5890","issn":["0161-5890","1872-9142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1608231811","https://openalex.org/W4313348187","https://openalex.org/W2239047161","https://openalex.org/W2776230051","https://openalex.org/W1965266522","https://openalex.org/W4313369185","https://openalex.org/W1527289043","https://openalex.org/W1989125189","https://openalex.org/W2080105559","https://openalex.org/W4313383619"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2022-10-14T00:00:00"}
