{"id":"https://openalex.org/W4304893067","doi":"https://doi.org/10.1186/s13195-022-01094-5","title":"Classification accuracy of blood-based and neurophysiological markers in the differential diagnosis of Alzheimer\u2019s disease and frontotemporal lobar degeneration","display_name":"Classification accuracy of blood-based and neurophysiological markers in the differential diagnosis of Alzheimer\u2019s disease and frontotemporal lobar degeneration","publication_year":2022,"publication_date":"2022-10-13","ids":{"openalex":"https://openalex.org/W4304893067","doi":"https://doi.org/10.1186/s13195-022-01094-5","pmid":"https://pubmed.ncbi.nlm.nih.gov/36229847","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9558959"},"language":"en","primary_location":{"id":"doi:10.1186/s13195-022-01094-5","doi":"https://doi.org/10.1186/s13195-022-01094-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13195-022-01094-5","pdf_url":"https://alzres.biomedcentral.com/counter/pdf/10.1186/s13195-022-01094-5","source":{"id":"https://openalex.org/S140755874","display_name":"Alzheimer s Research & Therapy","issn_l":"1758-9193","issn":["1758-9193"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's Research &amp; Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://alzres.biomedcentral.com/counter/pdf/10.1186/s13195-022-01094-5","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059023249","display_name":"Alberto Benussi","orcid":"https://orcid.org/0000-0002-8703-6940","observed_orcids":["https://orcid.org/0000-0002-8703-6940"]},"institutions":[{"id":"https://openalex.org/I4210103289","display_name":"Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia","ror":"https://ror.org/015rhss58","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210103289"]},{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alberto Benussi","raw_affiliation_strings":["Neurology Unit, ASST Spedali Civili Brescia, Brescia, Italy","Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, P.le Spedali Civili 1, 25123, Brescia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Unit, ASST Spedali Civili Brescia, Brescia, Italy","institution_ids":["https://openalex.org/I4210103289"]},{"raw_affiliation_string":"Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, P.le Spedali Civili 1, 25123, Brescia, Italy","institution_ids":["https://openalex.org/I79940851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073819154","display_name":"Valentina Cantoni","orcid":"https://orcid.org/0000-0002-9933-5649","observed_orcids":["https://orcid.org/0000-0002-9933-5649"]},"institutions":[{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Valentina Cantoni","raw_affiliation_strings":["Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy","institution_ids":["https://openalex.org/I79940851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054029379","display_name":"Jasmine Rivolta","orcid":"https://orcid.org/0009-0002-1614-4861","observed_orcids":["https://orcid.org/0009-0002-1614-4861"]},"institutions":[{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Jasmine Rivolta","raw_affiliation_strings":["Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, P.le Spedali Civili 1, 25123, Brescia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, P.le Spedali Civili 1, 25123, Brescia, Italy","institution_ids":["https://openalex.org/I79940851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108126783","display_name":"Silvana Archetti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Silvana Archetti","raw_affiliation_strings":["Biotechnology Laboratory and Department of Diagnostics, Civic Hospital of Brescia, Brescia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Laboratory and Department of Diagnostics, Civic Hospital of Brescia, Brescia, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102464275","display_name":"Anna Micheli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149406","display_name":"Casa di Cura Citt\u00e0 di Roma","ror":"https://ror.org/046ww9q34","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210149406"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Anna Micheli","raw_affiliation_strings":["Casa Di Cura San Francesco, Bergamo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Casa Di Cura San Francesco, Bergamo, Italy","institution_ids":["https://openalex.org/I4210149406"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010532057","display_name":"Nicholas James Ashton","orcid":"https://orcid.org/0000-0002-3579-8804","observed_orcids":["https://orcid.org/0000-0002-3579-8804","https://orcid.org/0000-0002-6353-9316"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I200323923","display_name":"South London and Maudsley NHS Foundation Trust","ror":"https://ror.org/015803449","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200323923"]},{"id":"https://openalex.org/I4405272501","display_name":"Wallenberg Centre for Molecular and Translational Medicine","ror":"https://ror.org/048rhnt15","country_code":"SE","type":"facility","lineage":["https://openalex.org/I4405272501"]},{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["GB","SE"],"is_corresponding":false,"raw_author_name":"Nicholas Ashton","raw_affiliation_strings":["Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, M\u00f6lndal, Sweden","King's College London, Institute of Psychiatry, Psychology & Neuroscience, Maurice Wohl Clinical Neuroscience Institute, London, UK","NIHR Biomedical Research Centre for Mental Health & Biomedical Research Unit for Dementia at South London & Maudsley NHS Foundation, London, UK","Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, M\u00f6lndal, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, M\u00f6lndal, Sweden","institution_ids":["https://openalex.org/I881427289"]},{"raw_affiliation_string":"King's College London, Institute of Psychiatry, Psychology & Neuroscience, Maurice Wohl Clinical Neuroscience Institute, London, UK","institution_ids":["https://openalex.org/I183935753"]},{"raw_affiliation_string":"NIHR Biomedical Research Centre for Mental Health & Biomedical Research Unit for Dementia at South London & Maudsley NHS Foundation, London, UK","institution_ids":["https://openalex.org/I200323923"]},{"raw_affiliation_string":"Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, M\u00f6lndal, Sweden","institution_ids":["https://openalex.org/I4405272501","https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079766290","display_name":"Henrik Zetterberg","orcid":"https://orcid.org/0000-0003-3930-4354","observed_orcids":["https://orcid.org/0000-0003-3930-4354","https://orcid.org/0000-0002-4671-6763"]},"institutions":[{"id":"https://openalex.org/I2801112325","display_name":"Sahlgrenska University Hospital","ror":"https://ror.org/04vgqjj36","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I2801112325"]},{"id":"https://openalex.org/I4210126463","display_name":"UK Dementia Research Institute","ror":"https://ror.org/02wedp412","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210126463"]},{"id":"https://openalex.org/I4405260083","display_name":"UCL Queen Square Institute of Neurology","ror":"https://ror.org/0370htr03","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405260083","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["GB","SE"],"is_corresponding":false,"raw_author_name":"Henrik Zetterberg","raw_affiliation_strings":["Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, M\u00f6lndal, Sweden","Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK","Hong Kong Center for Neurodegenerative Diseases, Clear Water Bay, Hong Kong, China","Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, M\u00f6lndal, Sweden","UK Dementia Research Institute at UCL, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, M\u00f6lndal, Sweden","institution_ids":["https://openalex.org/I2801112325"]},{"raw_affiliation_string":"Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK","institution_ids":["https://openalex.org/I4405260083","https://openalex.org/I45129253"]},{"raw_affiliation_string":"Hong Kong Center for Neurodegenerative Diseases, Clear Water Bay, Hong Kong, China","institution_ids":[]},{"raw_affiliation_string":"Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, M\u00f6lndal, Sweden","institution_ids":["https://openalex.org/I881427289"]},{"raw_affiliation_string":"UK Dementia Research Institute at UCL, London, UK","institution_ids":["https://openalex.org/I4210126463","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025313057","display_name":"Kaj Blennow","orcid":"https://orcid.org/0000-0002-1890-4193","observed_orcids":["https://orcid.org/0000-0002-1890-4193"]},"institutions":[{"id":"https://openalex.org/I2801112325","display_name":"Sahlgrenska University Hospital","ror":"https://ror.org/04vgqjj36","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I2801112325"]},{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Kaj Blennow","raw_affiliation_strings":["Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, M\u00f6lndal, Sweden","Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, M\u00f6lndal, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, M\u00f6lndal, Sweden","institution_ids":["https://openalex.org/I2801112325"]},{"raw_affiliation_string":"Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, M\u00f6lndal, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090580473","display_name":"Barbara Borroni","orcid":"https://orcid.org/0000-0001-9340-9814","observed_orcids":["https://orcid.org/0000-0001-9340-9814"]},"institutions":[{"id":"https://openalex.org/I4210103289","display_name":"Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia","ror":"https://ror.org/015rhss58","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210103289"]},{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Barbara Borroni","raw_affiliation_strings":["Neurology Unit, ASST Spedali Civili Brescia, Brescia, Italy. bborroni@inwind.it","Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, P.le Spedali Civili 1, 25123, Brescia, Italy. bborroni@inwind.it","Neurology Unit, ASST Spedali Civili Brescia, Brescia, Italy","Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, P.le Spedali Civili 1, 25123, Brescia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Unit, ASST Spedali Civili Brescia, Brescia, Italy. bborroni@inwind.it","institution_ids":["https://openalex.org/I4210103289"]},{"raw_affiliation_string":"Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, P.le Spedali Civili 1, 25123, Brescia, Italy. bborroni@inwind.it","institution_ids":["https://openalex.org/I79940851"]},{"raw_affiliation_string":"Neurology Unit, ASST Spedali Civili Brescia, Brescia, Italy","institution_ids":["https://openalex.org/I4210103289"]},{"raw_affiliation_string":"Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, P.le Spedali Civili 1, 25123, Brescia, Italy","institution_ids":["https://openalex.org/I79940851"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5090580473"],"corresponding_institution_ids":["https://openalex.org/I4210103289","https://openalex.org/I79940851"],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":{"value":3590,"currency":"USD","value_usd":3590},"fwci":6.8224,"has_fulltext":true,"cited_by_count":57,"citation_normalized_percentile":{"value":0.98361693,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"14","issue":"1","first_page":"155","last_page":"155"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.019099999219179153,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10614","display_name":"Transcranial Magnetic Stimulation Studies","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/frontotemporal-lobar-degeneration","display_name":"frontotemporal lobar degeneration","score":1.0},{"id":"https://openalex.org/keywords/differential-diagnosis","display_name":"differential diagnosis","score":0.9449999928474426},{"id":"https://openalex.org/keywords/plasma-biomarkers","display_name":"plasma biomarkers","score":0.8510000109672546},{"id":"https://openalex.org/keywords/neurofilament-light-chain","display_name":"neurofilament light chain","score":0.9589999914169312},{"id":"https://openalex.org/keywords/glial-fibrillary-acidic-protein","display_name":"glial fibrillary acidic protein","score":0.9559999704360962},{"id":"https://openalex.org/keywords/p-tau181","display_name":"p-tau181","score":0.9169999957084656},{"id":"https://openalex.org/keywords/amyloid-beta-42-40-ratio","display_name":"amyloid-beta 42/40 ratio","score":0.8330000042915344},{"id":"https://openalex.org/keywords/transcranial-magnetic-stimulation","display_name":"transcranial magnetic stimulation","score":0.8999999761581421},{"id":"https://openalex.org/keywords/short-interval-intracortical-inhibition","display_name":"short-interval intracortical inhibition","score":0.8769999742507935},{"id":"https://openalex.org/keywords/short-latency-afferent-inhibition","display_name":"short-latency afferent inhibition","score":0.9860000014305115},{"id":"https://openalex.org/keywords/intracortical-facilitation","display_name":"intracortical facilitation","score":0.9290000200271606},{"id":"https://openalex.org/keywords/long-interval-intracortical-inhibition","display_name":"long-interval intracortical inhibition","score":0.9769999980926514},{"id":"https://openalex.org/keywords/simoa","display_name":"Simoa","score":0.49399998784065247},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.7609999775886536},{"id":"https://openalex.org/keywords/healthy-aging","display_name":"healthy aging","score":0.6819999814033508},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.6449999809265137},{"id":"https://openalex.org/keywords/diagnostic-accuracy","display_name":"diagnostic accuracy","score":0.5920000076293945}],"concepts":[{"id":"https://openalex.org/C2776939681","wikidata":"https://www.wikidata.org/wiki/Q18579","display_name":"Frontotemporal lobar degeneration","level":5,"score":0.7917580008506775},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.7036373615264893},{"id":"https://openalex.org/C2778581513","wikidata":"https://www.wikidata.org/wiki/Q263962","display_name":"Transcranial magnetic stimulation","level":3,"score":0.662174642086029},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5649797916412354},{"id":"https://openalex.org/C2778641062","wikidata":"https://www.wikidata.org/wiki/Q18592","display_name":"Frontotemporal dementia","level":4,"score":0.5556918978691101},{"id":"https://openalex.org/C2780801072","wikidata":"https://www.wikidata.org/wiki/Q837512","display_name":"Differential diagnosis","level":2,"score":0.49209922552108765},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.48291656374931335},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.46357280015945435},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.45230913162231445},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.45051756501197815},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4343680441379547},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.39717596769332886},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3404712975025177},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3383256196975708},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.11427310109138489},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.09231358766555786},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06692367792129517}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003937","descriptor_name":"Diagnosis, Differential","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005904","descriptor_name":"Glial Fibrillary Acidic Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057174","descriptor_name":"Frontotemporal Lobar Degeneration","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D057180","descriptor_name":"Frontotemporal Dementia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1186/s13195-022-01094-5","doi":"https://doi.org/10.1186/s13195-022-01094-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13195-022-01094-5","pdf_url":"https://alzres.biomedcentral.com/counter/pdf/10.1186/s13195-022-01094-5","source":{"id":"https://openalex.org/S140755874","display_name":"Alzheimer s Research & Therapy","issn_l":"1758-9193","issn":["1758-9193"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's Research &amp; Therapy","raw_type":"journal-article"},{"id":"pmid:36229847","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36229847","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's research & therapy","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9558959","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9558959/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimers Res Ther","raw_type":"Text"},{"id":"pmh:oai:arts.units.it:11368/3097181","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9558959/","pdf_url":"https://arts.units.it/bitstream/11368/3097181/1/36229847.pdf","source":{"id":"https://openalex.org/S4306400480","display_name":"ArTS Archivio della ricerca di Trieste (University of Trieste https://www.units.it/)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I142444530","host_organization_name":"University of Trieste","host_organization_lineage":["https://openalex.org/I142444530"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:5806da4938df4701baa6c3871d677745","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5806da4938df4701baa6c3871d677745","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Alzheimer\u2019s Research & Therapy, Vol 14, Iss 1, Pp 1-12 (2022)","raw_type":"article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:10158006","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/10158006/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Alzheimer's Research and Therapy , 14 (1) , Article 155. (2022)","raw_type":"Article"},{"id":"pmh:oai:iris.unibs.it:11379/614574","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11379/614574","pdf_url":null,"source":{"id":"https://openalex.org/S4306400804","display_name":"Institutional Research Information System (Universit\u00e0 degli Studi di Brescia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66752286","host_organization_name":"University of Milano-Bicocca","host_organization_lineage":["https://openalex.org/I66752286"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/s13195-022-01094-5","doi":"https://doi.org/10.1186/s13195-022-01094-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13195-022-01094-5","pdf_url":"https://alzres.biomedcentral.com/counter/pdf/10.1186/s13195-022-01094-5","source":{"id":"https://openalex.org/S140755874","display_name":"Alzheimer s Research & Therapy","issn_l":"1758-9193","issn":["1758-9193"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's Research &amp; Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1057200632","display_name":null,"funder_award_id":"2016862","funder_id":"https://openalex.org/F4320307132","funder_display_name":"Alzheimer's Drug Discovery Foundation"},{"id":"https://openalex.org/G1088883541","display_name":null,"funder_award_id":"JPND 2021-00694","funder_id":"https://openalex.org/F4320314158","funder_display_name":"EU Joint Programme \u2013 Neurodegenerative Disease Research"},{"id":"https://openalex.org/G1253720191","display_name":null,"funder_award_id":"FO2017-0243","funder_id":"https://openalex.org/F4320307132","funder_display_name":"Alzheimer's Drug Discovery Foundation"},{"id":"https://openalex.org/G1343867371","display_name":null,"funder_award_id":"-71320","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G1373393710","display_name":null,"funder_award_id":"#2017-00915","funder_id":"https://openalex.org/F4320329730","funder_display_name":"UK Dementia Research Institute"},{"id":"https://openalex.org/G1407244959","display_name":null,"funder_award_id":"ZEN-21-848495","funder_id":"https://openalex.org/F4320329730","funder_display_name":"UK Dementia Research Institute"},{"id":"https://openalex.org/G1551449788","display_name":null,"funder_award_id":"201809","funder_id":"https://openalex.org/F4320307132","funder_display_name":"Alzheimer's Drug Discovery Foundation"},{"id":"https://openalex.org/G1588116593","display_name":null,"funder_award_id":"ADSF-21-831377-C","funder_id":"https://openalex.org/F4320306219","funder_display_name":"Alzheimer's Association"},{"id":"https://openalex.org/G1802301745","display_name":null,"funder_award_id":"#101053962","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G180825096","display_name":null,"funder_award_id":"#FO2017-0243","funder_id":"https://openalex.org/F4320309793","funder_display_name":"Familjen Erling-Perssons Stiftelse"},{"id":"https://openalex.org/G184585344","display_name":"Understanding Alzheimer Blood Biomarkers for Tau Pathology","funder_award_id":"ZEN-21-848495","funder_id":"https://openalex.org/F4320306219","funder_display_name":"Alzheimer's Association"},{"id":"https://openalex.org/G1928552717","display_name":null,"funder_award_id":"21-831376 -C","funder_id":"https://openalex.org/F4320306219","funder_display_name":"Alzheimer's Association"},{"id":"https://openalex.org/G1938858119","display_name":null,"funder_award_id":"860197","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G201353144","display_name":null,"funder_award_id":"ADSF\u201021\u2010831376\u2010C","funder_id":"https://openalex.org/F4320306219","funder_display_name":"Alzheimer's Association"},{"id":"https://openalex.org/G2057385626","display_name":null,"funder_award_id":"ADSF-21-831381-C","funder_id":"https://openalex.org/F4320307132","funder_display_name":"Alzheimer's Drug Discovery Foundation"},{"id":"https://openalex.org/G2076520454","display_name":null,"funder_award_id":"2018-","funder_id":"https://openalex.org/F4320321781","funder_display_name":"Ministero della Salute"},{"id":"https://openalex.org/G2108271864","display_name":null,"funder_award_id":"2017-00915","funder_id":"https://openalex.org/F4320307132","funder_display_name":"Alzheimer's Drug Discovery Foundation"},{"id":"https://openalex.org/G237833635","display_name":null,"funder_award_id":"#ADSF-21-831381-C","funder_id":"https://openalex.org/F4320306219","funder_display_name":"Alzheimer's Association"},{"id":"https://openalex.org/G2384069237","display_name":null,"funder_award_id":"FO2019-0228","funder_id":"https://openalex.org/F4320309793","funder_display_name":"Familjen Erling-Perssons Stiftelse"},{"id":"https://openalex.org/G2385484910","display_name":null,"funder_award_id":"FO2017\u20110243","funder_id":"https://openalex.org/F4320322168","funder_display_name":"Hj\u00e4rnfonden"},{"id":"https://openalex.org/G2521197280","display_name":null,"funder_award_id":"ALFGBG-715986","funder_id":"https://openalex.org/F4320329730","funder_display_name":"UK Dementia Research Institute"},{"id":"https://openalex.org/G2543812357","display_name":null,"funder_award_id":"UKDRI\u2010 1003","funder_id":"https://openalex.org/F4320329730","funder_display_name":"UK Dementia Research Institute"},{"id":"https://openalex.org/G2567931567","display_name":null,"funder_award_id":"#FO2019-0228","funder_id":"https://openalex.org/F4320331442","funder_display_name":"Olav Thon Stiftelsen"},{"id":"https://openalex.org/G2799940023","display_name":null,"funder_award_id":"UKDRI-1003","funder_id":"https://openalex.org/F4320307132","funder_display_name":"Alzheimer's Drug Discovery Foundation"},{"id":"https://openalex.org/G2813665880","display_name":"The Alzheimer biomarker toolbox \u2013 use in pathogenic studies, diagnostics and theragnostics","funder_award_id":"2017-00915","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G2841269746","display_name":null,"funder_award_id":"#ALFGBG-715986","funder_id":"https://openalex.org/F4320307132","funder_display_name":"Alzheimer's Drug Discovery Foundation"},{"id":"https://openalex.org/G2879339865","display_name":null,"funder_award_id":"ZEN-21-848495","funder_id":"https://openalex.org/F4320307132","funder_display_name":"Alzheimer's Drug Discovery Foundation"},{"id":"https://openalex.org/G292763017","display_name":null,"funder_award_id":"201809\u20132016862","funder_id":"https://openalex.org/F4320307132","funder_display_name":"Alzheimer's Drug Discovery Foundation"},{"id":"https://openalex.org/G299123355","display_name":null,"funder_award_id":"2021-1516","funder_id":"https://openalex.org/F4320321499","funder_display_name":"Fondazione Cariplo"},{"id":"https://openalex.org/G3027168043","display_name":null,"funder_award_id":"FO2017","funder_id":"https://openalex.org/F4320322168","funder_display_name":"Hj\u00e4rnfonden"},{"id":"https://openalex.org/G308275008","display_name":null,"funder_award_id":"ALFGBG-715986","funder_id":"https://openalex.org/F4320322168","funder_display_name":"Hj\u00e4rnfonden"},{"id":"https://openalex.org/G3126964432","display_name":null,"funder_award_id":"2021 Zenith Award","funder_id":"https://openalex.org/F4320306219","funder_display_name":"Alzheimer's Association"},{"id":"https://openalex.org/G313301595","display_name":null,"funder_award_id":"(#ALFGBG-715986","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G3210292989","display_name":null,"funder_award_id":"Airalzh-AGYR2020","funder_id":"https://openalex.org/F4320330057","funder_display_name":"Associazione Italiana Ricerca Alzheimer"},{"id":"https://openalex.org/G3239081004","display_name":null,"funder_award_id":"AGYR2020","funder_id":"https://openalex.org/F4320330057","funder_display_name":"Associazione Italiana Ricerca Alzheimer"},{"id":"https://openalex.org/G3241251457","display_name":null,"funder_award_id":"ADSF-21-831377-C","funder_id":"https://openalex.org/F4320307132","funder_display_name":"Alzheimer's Drug Discovery Foundation"},{"id":"https://openalex.org/G3375203780","display_name":null,"funder_award_id":"RF-2018-12366665","funder_id":"https://openalex.org/F4320321781","funder_display_name":"Ministero della Salute"},{"id":"https://openalex.org/G3609843232","display_name":null,"funder_award_id":"RDAPB-201809-2016615","funder_id":"https://openalex.org/F4320329730","funder_display_name":"UK Dementia Research Institute"},{"id":"https://openalex.org/G366952799","display_name":null,"funder_award_id":"JPND2019-466-236","funder_id":"https://openalex.org/F4320306219","funder_display_name":"Alzheimer's Association"},{"id":"https://openalex.org/G3686084576","display_name":"The effects of iron on oxidative stress and Alzheimer's biomarkers in amyloid-positive and negative elderly normal","funder_award_id":"R01AG068398","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3842727039","display_name":null,"funder_award_id":"-21-831381-C","funder_id":"https://openalex.org/F4320306219","funder_display_name":"Alzheimer's Association"},{"id":"https://openalex.org/G3903502641","display_name":null,"funder_award_id":"860197","funder_id":"https://openalex.org/F4320307132","funder_display_name":"Alzheimer's Drug Discovery Foundation"},{"id":"https://openalex.org/G3914690605","display_name":null,"funder_award_id":"ALFGBG\u201071320","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G4181470480","display_name":null,"funder_award_id":"JPND2019-466-236","funder_id":"https://openalex.org/F4320307132","funder_display_name":"Alzheimer's Drug Discovery Foundation"},{"id":"https://openalex.org/G4234328627","display_name":null,"funder_award_id":"JPND2021-00694","funder_id":"https://openalex.org/F4320307132","funder_display_name":"Alzheimer's Drug Discovery Foundation"},{"id":"https://openalex.org/G4260843567","display_name":null,"funder_award_id":"101,053,962","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G432431387","display_name":null,"funder_award_id":"JPND2021\u201000694","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G434337789","display_name":null,"funder_award_id":"HORIZON2020","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G4404751248","display_name":null,"funder_award_id":"JPND2019-466-236","funder_id":"https://openalex.org/F4320314158","funder_display_name":"EU Joint Programme \u2013 Neurodegenerative Disease Research"},{"id":"https://openalex.org/G4457840320","display_name":null,"funder_award_id":"RF-2018","funder_id":"https://openalex.org/F4320321781","funder_display_name":"Ministero della Salute"},{"id":"https://openalex.org/G4495868458","display_name":null,"funder_award_id":"ZEN-21-848495","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G4896876283","display_name":null,"funder_award_id":"FO2019\u20100228","funder_id":"https://openalex.org/F4320322168","funder_display_name":"Hj\u00e4rnfonden"},{"id":"https://openalex.org/G4962764320","display_name":null,"funder_award_id":"FO2017-0243","funder_id":"https://openalex.org/F4320329730","funder_display_name":"UK Dementia Research Institute"},{"id":"https://openalex.org/G5040492720","display_name":null,"funder_award_id":"ALFGBG-71320","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G506008078","display_name":null,"funder_award_id":"860197","funder_id":"https://openalex.org/F4320309793","funder_display_name":"Familjen Erling-Perssons Stiftelse"},{"id":"https://openalex.org/G5063629206","display_name":null,"funder_award_id":"ZEN-21-848495","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G5111822078","display_name":null,"funder_award_id":"681712","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G516766298","display_name":null,"funder_award_id":"860197","funder_id":"https://openalex.org/F4320312359","funder_display_name":"Stiftelsen f\u00f6r Gamla Tj\u00e4narinnor"},{"id":"https://openalex.org/G5332654608","display_name":null,"funder_award_id":"ADSF-21-831376-C, #ADSF-21-831381","funder_id":"https://openalex.org/F4320306219","funder_display_name":"Alzheimer's Association"},{"id":"https://openalex.org/G56684467","display_name":null,"funder_award_id":"201809-2016615","funder_id":"https://openalex.org/F4320307132","funder_display_name":"Alzheimer's Drug Discovery Foundation"},{"id":"https://openalex.org/G5749088205","display_name":null,"funder_award_id":"ZEN-21- 848495","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6020134442","display_name":null,"funder_award_id":"FO2019\u20100228","funder_id":"https://openalex.org/F4320312359","funder_display_name":"Stiftelsen f\u00f6r Gamla Tj\u00e4narinnor"},{"id":"https://openalex.org/G6142763750","display_name":null,"funder_award_id":"JPND2019-466-236","funder_id":"https://openalex.org/F4320322168","funder_display_name":"Hj\u00e4rnfonden"},{"id":"https://openalex.org/G6168044258","display_name":null,"funder_award_id":"JPND2019\u2010466\u2010236","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G6289970089","display_name":null,"funder_award_id":"#ADSF-21-831376-C","funder_id":"https://openalex.org/F4320307132","funder_display_name":"Alzheimer's Drug Discovery Foundation"},{"id":"https://openalex.org/G6301189673","display_name":null,"funder_award_id":"2018-02532","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6559127122","display_name":null,"funder_award_id":"2017-00915","funder_id":"https://openalex.org/F4320312359","funder_display_name":"Stiftelsen f\u00f6r Gamla Tj\u00e4narinnor"},{"id":"https://openalex.org/G664749828","display_name":"Multi-omics Interdisciplinary Research Integration to Address DEmentia diagnosis","funder_award_id":"860197","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G691317373","display_name":null,"funder_award_id":"-21- 831377-C","funder_id":"https://openalex.org/F4320306219","funder_display_name":"Alzheimer's Association"},{"id":"https://openalex.org/G6958338825","display_name":"Pathways to Alzheimer's disease","funder_award_id":"681712","funder_id":"https://openalex.org/F4320338335","funder_display_name":"H2020 European Research Council"},{"id":"https://openalex.org/G712881263","display_name":null,"funder_award_id":"2018-","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G7143958211","display_name":null,"funder_award_id":"JPND2019-466-236","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G791739130","display_name":null,"funder_award_id":"FO2017-0243","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G7956815115","display_name":null,"funder_award_id":"-201809-2016615","funder_id":"https://openalex.org/F4320329730","funder_display_name":"UK Dementia Research Institute"},{"id":"https://openalex.org/G8653344385","display_name":"What determines amyloid beta aggregation and toxicity in Alzheimer\u2019s disease?","funder_award_id":"2018-02532","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G8711430475","display_name":null,"funder_award_id":"-715986","funder_id":"https://openalex.org/F4320329730","funder_display_name":"UK Dementia Research Institute"},{"id":"https://openalex.org/G8782684654","display_name":null,"funder_award_id":"JPND2021-00694","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G958583170","display_name":null,"funder_award_id":"#RDAPB\u2010201809\u20102016615","funder_id":"https://openalex.org/F4320307132","funder_display_name":"Alzheimer's Drug Discovery Foundation"},{"id":"https://openalex.org/G96521508","display_name":null,"funder_award_id":"AF-742881","funder_id":"https://openalex.org/F4320307132","funder_display_name":"Alzheimer's Drug Discovery Foundation"}],"funders":[{"id":"https://openalex.org/F4320306219","display_name":"Alzheimer's Association","ror":"https://ror.org/0375f4d26"},{"id":"https://openalex.org/F4320307132","display_name":"Alzheimer's Drug Discovery Foundation","ror":"https://ror.org/0185drb55"},{"id":"https://openalex.org/F4320309793","display_name":"Familjen Erling-Perssons Stiftelse","ror":"https://ror.org/04sfsy924"},{"id":"https://openalex.org/F4320312359","display_name":"Stiftelsen f\u00f6r Gamla Tj\u00e4narinnor","ror":"https://ror.org/04fx88130"},{"id":"https://openalex.org/F4320314158","display_name":"EU Joint Programme \u2013 Neurodegenerative Disease Research","ror":null},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321499","display_name":"Fondazione Cariplo","ror":"https://ror.org/01gb56c55"},{"id":"https://openalex.org/F4320321781","display_name":"Ministero della Salute","ror":"https://ror.org/00789fa95"},{"id":"https://openalex.org/F4320322168","display_name":"Hj\u00e4rnfonden","ror":"https://ror.org/014btj409"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320329730","display_name":"UK Dementia Research Institute","ror":"https://ror.org/02wedp412"},{"id":"https://openalex.org/F4320330057","display_name":"Associazione Italiana Ricerca Alzheimer","ror":"https://ror.org/02erjrm45"},{"id":"https://openalex.org/F4320331442","display_name":"Olav Thon Stiftelsen","ror":"https://ror.org/014am8n90"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320338335","display_name":"H2020 European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4304893067.pdf","grobid_xml":"https://content.openalex.org/works/W4304893067.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W1958842451","https://openalex.org/W1964472291","https://openalex.org/W1968429176","https://openalex.org/W2006214194","https://openalex.org/W2028069634","https://openalex.org/W2037784693","https://openalex.org/W2048370916","https://openalex.org/W2098483589","https://openalex.org/W2115017507","https://openalex.org/W2128030851","https://openalex.org/W2132946280","https://openalex.org/W2138190873","https://openalex.org/W2144707045","https://openalex.org/W2146051854","https://openalex.org/W2158196600","https://openalex.org/W2511246053","https://openalex.org/W2619097621","https://openalex.org/W2623663856","https://openalex.org/W2625796101","https://openalex.org/W2736213625","https://openalex.org/W2770164379","https://openalex.org/W2773276313","https://openalex.org/W2889223700","https://openalex.org/W2890619993","https://openalex.org/W2917353757","https://openalex.org/W2928352487","https://openalex.org/W2989670899","https://openalex.org/W2995682845","https://openalex.org/W2998543239","https://openalex.org/W3000064280","https://openalex.org/W3009441391","https://openalex.org/W3009833354","https://openalex.org/W3018431352","https://openalex.org/W3035735968","https://openalex.org/W3038972655","https://openalex.org/W3046275966","https://openalex.org/W3092232253","https://openalex.org/W3119240988","https://openalex.org/W3119309452","https://openalex.org/W3185313788","https://openalex.org/W3194334734","https://openalex.org/W3206830763","https://openalex.org/W3212642754","https://openalex.org/W3215066238","https://openalex.org/W4200169681","https://openalex.org/W4200429384","https://openalex.org/W4207083026","https://openalex.org/W4210357094"],"related_works":["https://openalex.org/W4406172704","https://openalex.org/W4313895196","https://openalex.org/W4285304595","https://openalex.org/W7164170836","https://openalex.org/W4406985760","https://openalex.org/W7150931577","https://openalex.org/W4411615275","https://openalex.org/W4304588918","https://openalex.org/W7221677419","https://openalex.org/W7213279914"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"In":[2,65,199],"the":[3,16,24,42,52,104,138,150,172,177,181,193,200,203,221,224,258,277,284,288,319],"last":[4],"decade,":[5],"non-invasive":[6],"blood-based":[7],"and":[8,59,84,110,131,146,157,168,265,296,313,324],"neurophysiological":[9,111,147,314],"biomarkers":[10,148,244],"have":[11],"shown":[12],"great":[13],"potential":[14,44],"for":[15,176,252],"discrimination":[17],"of":[18,27,55,141,143,183,242,271,290,302,311,322],"several":[19],"neurodegenerative":[20],"disorders.":[21],"However,":[22],"in":[23,149,164,220,268,299],"clinical":[25,194,197],"workup":[26],"patients":[28],"with":[29],"cognitive":[30],"impairment,":[31],"it":[32],"will":[33,40],"be":[34],"highly":[35],"unlikely":[36],"that":[37],"any":[38],"biomarker":[39,206,227],"achieve":[41],"highest":[43],"predictive":[45],"accuracy":[46,140],"on":[47,70,196],"its":[48],"own,":[49],"owing":[50],"to":[51,98,207,228],"multifactorial":[53],"nature":[54],"Alzheimer\u2019s":[56],"disease":[57],"(AD)":[58],"frontotemporal":[60],"lobar":[61],"degeneration":[62],"(FTLD).":[63],"Methods":[64],"this":[66],"retrospective":[67],"study,":[68],"performed":[69],"202":[71],"participants,":[72],"we":[73,186],"analysed":[74],"plasma":[75,145,165,312],"neurofilament":[76],"light":[77],"(NfL),":[78],"glial":[79],"fibrillary":[80],"acidic":[81],"protein":[82],"(GFAP),":[83],"tau":[85],"phosphorylated":[86],"at":[87],"amino":[88],"acid":[89],"181":[90],"(p-Tau181)":[91],"concentrations,":[92],"as":[93,95],"well":[94],"amyloid":[96],"\u03b242":[97],"40":[99],"ratio":[100],"(A\u03b21\u201342/1\u201340)":[101],"ratio,":[102,292],"using":[103],"ultrasensitive":[105],"single-molecule":[106],"array":[107],"(Simoa)":[108],"technique,":[109],"measures":[112,315],"obtained":[113],"by":[114],"transcranial":[115],"magnetic":[116],"stimulation":[117],"(TMS),":[118],"including":[119],"short-interval":[120],"intracortical":[121,124,128],"inhibition":[122,129,134],"(SICI),":[123],"facilitation":[125],"(ICF),":[126],"long-interval":[127],"(LICI),":[130],"short-latency":[132],"afferent":[133],"(SAI).":[135],"We":[136,160],"assessed":[137],"diagnostic":[139,184,247],"combinations":[142],"both":[144],"differential":[151,320],"diagnosis":[152,321],"between":[153,171],"healthy":[154],"ageing,":[155],"AD,":[156],"FTLD.":[158,325],"Results":[159],"observed":[161],"significant":[162],"differences":[163],"NfL,":[166,262],"GFAP,":[167,261],"p-Tau181":[169],"levels":[170],"groups,":[173],"but":[174],"not":[175],"A\u03b21\u201342/A\u03b21\u201340":[178,291],"ratio.":[179],"For":[180,276],"evaluation":[182],"accuracy,":[185],"adopted":[187],"a":[188],"two-step":[189],"process":[190],"which":[191],"reflects":[192],"judgement":[195],"grounds.":[198],"first":[201],"step,":[202,223,279],"best":[204,225,250,285],"single":[205,226],"classify":[208,229],"\u201ccases\u201d":[209,254],"vs":[210,231,255],"\u201ccontrols\u201d":[211,256],"was":[212,233],"NfL":[213],"(AUC":[214,235],"0.94,":[215],"p":[216,237],"<":[217,238,274,305],"0.001),":[218],"whilst":[219],"second":[222,278],"AD":[230,281,323],"FTLD":[232],"SAI":[234],"0.96,":[236],"0.001).":[239,275,306],"The":[240,249,308],"combination":[241,289],"multiple":[243],"significantly":[245],"increased":[246],"accuracy.":[248],"model":[251,286],"classifying":[253,280],"included":[257,287],"predictors":[259],"p-Tau181,":[260,293],"SICI,":[263,294],"ICF,":[264,295],"SAI,":[266,297],"resulting":[267,298],"an":[269,300],"AUC":[270,301],"0.99":[272],"(p":[273,304],"from":[282],"FTD,":[283],"0.98":[303],"Conclusions":[307],"combined":[309],"assessment":[310],"may":[316],"greatly":[317],"improve":[318]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":22},{"year":2023,"cited_by_count":15}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-10-13T00:00:00"}