{"id":"https://openalex.org/W4304892916","doi":"https://doi.org/10.1016/j.isci.2022.105352","title":"Manganese enhances DNA- or RNA-mediated innate immune response by inducing phosphorylation of TANK-binding kinase 1","display_name":"Manganese enhances DNA- or RNA-mediated innate immune response by inducing phosphorylation of TANK-binding kinase 1","publication_year":2022,"publication_date":"2022-10-13","ids":{"openalex":"https://openalex.org/W4304892916","doi":"https://doi.org/10.1016/j.isci.2022.105352","pmid":"https://pubmed.ncbi.nlm.nih.gov/36325059","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9619380"},"language":"en","primary_location":{"id":"doi:10.1016/j.isci.2022.105352","doi":"https://doi.org/10.1016/j.isci.2022.105352","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.isci.2022.105352","pdf_url":null,"source":{"id":"https://openalex.org/S2898358376","display_name":"iScience","issn_l":"2589-0042","issn":["2589-0042"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.isci.2022.105352","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009595543","display_name":"Hongyan Sui","orcid":"https://orcid.org/0000-0002-4341-0929","observed_orcids":["https://orcid.org/0000-0002-4341-0929"]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hongyan Sui","raw_affiliation_strings":["Laboratory of Human Retrovirology and Immunoinformatics, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA"],"raw_orcid":"https://orcid.org/0000-0002-4341-0929","affiliations":[{"raw_affiliation_string":"Laboratory of Human Retrovirology and Immunoinformatics, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA","institution_ids":["https://openalex.org/I4210130649"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Qian Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qian Chen","raw_affiliation_strings":["Laboratory of Human Retrovirology and Immunoinformatics, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Human Retrovirology and Immunoinformatics, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA","institution_ids":["https://openalex.org/I4210130649"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101558976","display_name":"Jun Yang","orcid":"https://orcid.org/0000-0003-2775-8914","observed_orcids":["https://orcid.org/0000-0003-2775-8914"]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jun Yang","raw_affiliation_strings":["Laboratory of Human Retrovirology and Immunoinformatics, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Human Retrovirology and Immunoinformatics, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA","institution_ids":["https://openalex.org/I4210130649"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009798405","display_name":"Selena Srirattanapirom","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Selena Srirattanapirom","raw_affiliation_strings":["Laboratory of Human Retrovirology and Immunoinformatics, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Human Retrovirology and Immunoinformatics, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA","institution_ids":["https://openalex.org/I4210130649"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089434852","display_name":"Tomozumi Imamichi","orcid":"https://orcid.org/0000-0002-1474-1796","observed_orcids":["https://orcid.org/0000-0002-1474-1796","https://orcid.org/0009-0007-0910-5297"]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Tomozumi Imamichi","raw_affiliation_strings":["Laboratory of Human Retrovirology and Immunoinformatics, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA"],"raw_orcid":"https://orcid.org/0000-0002-1474-1796","affiliations":[{"raw_affiliation_string":"Laboratory of Human Retrovirology and Immunoinformatics, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA","institution_ids":["https://openalex.org/I4210130649"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5009595543","https://openalex.org/A5089434852"],"corresponding_institution_ids":["https://openalex.org/I4210130649"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":{"value":3000,"currency":"USD","value_usd":3000},"fwci":1.7266,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.8473193,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"25","issue":"11","first_page":"105352","last_page":"105352"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.009200000204145908,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/manganese","display_name":"manganese","score":1.0},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.9660000205039978},{"id":"https://openalex.org/keywords/tbk1","display_name":"TBK1","score":0.9190000295639038},{"id":"https://openalex.org/keywords/tbk1-phosphorylation","display_name":"TBK1 phosphorylation","score":0.9929999709129333},{"id":"https://openalex.org/keywords/ataxia-telangiectasia-mutated","display_name":"ATM kinase","score":0.9599999785423279},{"id":"https://openalex.org/keywords/interferon-alpha","display_name":"interferon-alpha","score":0.800000011920929},{"id":"https://openalex.org/keywords/interferon-beta","display_name":"interferon-beta","score":0.9950000047683716},{"id":"https://openalex.org/keywords/interferon-lambda","display_name":"interferon lambda","score":0.9789999723434448},{"id":"https://openalex.org/keywords/antiviral-immunity","display_name":"antiviral immunity","score":0.7990000247955322},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8289999961853027},{"id":"https://openalex.org/keywords/herpes-simplex-virus-type-1","display_name":"herpes simplex virus type 1","score":0.7940000295639038},{"id":"https://openalex.org/keywords/sendai-virus","display_name":"Sendai virus","score":1.0},{"id":"https://openalex.org/keywords/trace-metals","display_name":"trace metals","score":0.6179999709129333},{"id":"https://openalex.org/keywords/nucleic-acid-therapeutics","display_name":"nucleic acid therapeutics","score":0.6790000200271606}],"concepts":[{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.7661837935447693},{"id":"https://openalex.org/C2780127873","wikidata":"https://www.wikidata.org/wiki/Q1055751","display_name":"Sendai virus","level":3,"score":0.7070328593254089},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5752168297767639},{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.5450998544692993},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5201399922370911},{"id":"https://openalex.org/C156155473","wikidata":"https://www.wikidata.org/wiki/Q18258483","display_name":"TANK-binding kinase 1","level":5,"score":0.5099219083786011},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49484390020370483},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.4941294491291046},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.47864043712615967},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4733602702617645},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.434339702129364},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42186325788497925},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37857192754745483},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3372804820537567},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.33253347873687744},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.28065547347068787},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2536889314651489},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.25365695357322693},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.20943889021873474},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1727524697780609},{"id":"https://openalex.org/C90934575","wikidata":"https://www.wikidata.org/wiki/Q6593810","display_name":"Mitogen-activated protein kinase kinase","level":4,"score":0.09123408794403076}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1016/j.isci.2022.105352","doi":"https://doi.org/10.1016/j.isci.2022.105352","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.isci.2022.105352","pdf_url":null,"source":{"id":"https://openalex.org/S2898358376","display_name":"iScience","issn_l":"2589-0042","issn":["2589-0042"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"journal-article"},{"id":"doi:10.2139/ssrn.4063315","doi":"https://doi.org/10.2139/ssrn.4063315","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.4063315","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:9619380","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9619380","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"Text"},{"id":"pmid:36325059","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36325059","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:3651dea7653a4b2d8e4574466f60f4fe","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3651dea7653a4b2d8e4574466f60f4fe","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"iScience, Vol 25, Iss 11, Pp 105352- (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.isci.2022.105352","doi":"https://doi.org/10.1016/j.isci.2022.105352","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.isci.2022.105352","pdf_url":null,"source":{"id":"https://openalex.org/S2898358376","display_name":"iScience","issn_l":"2589-0042","issn":["2589-0042"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8199999928474426}],"study_designs":[],"awards":[{"id":"https://openalex.org/G386607036","display_name":null,"funder_award_id":"HHSN261200800001E)","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5867949827","display_name":null,"funder_award_id":"HHSN261200800001E","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5888954722","display_name":null,"funder_award_id":"HHSN261200800001C","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":97,"referenced_works":["https://openalex.org/W22142711","https://openalex.org/W1601203296","https://openalex.org/W1655860314","https://openalex.org/W1904975159","https://openalex.org/W1968559867","https://openalex.org/W1969540951","https://openalex.org/W1970436087","https://openalex.org/W1973309978","https://openalex.org/W1973646620","https://openalex.org/W1974070281","https://openalex.org/W1980923315","https://openalex.org/W1983281945","https://openalex.org/W1987322786","https://openalex.org/W1989122526","https://openalex.org/W1994252899","https://openalex.org/W1995744610","https://openalex.org/W1997069349","https://openalex.org/W1998332163","https://openalex.org/W2009662394","https://openalex.org/W2009708031","https://openalex.org/W2015129508","https://openalex.org/W2020247323","https://openalex.org/W2021848296","https://openalex.org/W2022811243","https://openalex.org/W2027446232","https://openalex.org/W2028792773","https://openalex.org/W2031182394","https://openalex.org/W2031718525","https://openalex.org/W2036693151","https://openalex.org/W2037434347","https://openalex.org/W2040527513","https://openalex.org/W2042433863","https://openalex.org/W2050934894","https://openalex.org/W2052498582","https://openalex.org/W2060004514","https://openalex.org/W2067409659","https://openalex.org/W2077291760","https://openalex.org/W2079674166","https://openalex.org/W2079716935","https://openalex.org/W2085192138","https://openalex.org/W2089077517","https://openalex.org/W2092943609","https://openalex.org/W2095401221","https://openalex.org/W2099610218","https://openalex.org/W2107830237","https://openalex.org/W2108849429","https://openalex.org/W2110809498","https://openalex.org/W2114085082","https://openalex.org/W2114860838","https://openalex.org/W2117821054","https://openalex.org/W2119864130","https://openalex.org/W2126842426","https://openalex.org/W2131617804","https://openalex.org/W2134457209","https://openalex.org/W2143074435","https://openalex.org/W2147431408","https://openalex.org/W2152502508","https://openalex.org/W2155664411","https://openalex.org/W2158542519","https://openalex.org/W2163671315","https://openalex.org/W2165748936","https://openalex.org/W2166250722","https://openalex.org/W2169267616","https://openalex.org/W2208762294","https://openalex.org/W2237990100","https://openalex.org/W2399418957","https://openalex.org/W2406911194","https://openalex.org/W2467200611","https://openalex.org/W2524429440","https://openalex.org/W2557330147","https://openalex.org/W2593038077","https://openalex.org/W2611442369","https://openalex.org/W2737001742","https://openalex.org/W2746393408","https://openalex.org/W2794127862","https://openalex.org/W2796962120","https://openalex.org/W2901282399","https://openalex.org/W2902968854","https://openalex.org/W2928665623","https://openalex.org/W2959449984","https://openalex.org/W2975482409","https://openalex.org/W2994795770","https://openalex.org/W3002186863","https://openalex.org/W3011498764","https://openalex.org/W3017215961","https://openalex.org/W3032346199","https://openalex.org/W3049659362","https://openalex.org/W3077216535","https://openalex.org/W3080399909","https://openalex.org/W3084445415","https://openalex.org/W3108522903","https://openalex.org/W3126388236","https://openalex.org/W3202775622","https://openalex.org/W3204512228","https://openalex.org/W3206475789","https://openalex.org/W4213200965","https://openalex.org/W6768748765"],"related_works":["https://openalex.org/W4416403093","https://openalex.org/W4309768897","https://openalex.org/W2803246082","https://openalex.org/W2159510917","https://openalex.org/W2800358891","https://openalex.org/W4389966622","https://openalex.org/W4417260852","https://openalex.org/W3189897138","https://openalex.org/W6922244415","https://openalex.org/W3176219076"],"abstract_inverted_index":{"Trace":[0],"metals":[1],"are":[2],"essential":[3,102],"for":[4],"various":[5],"physiological":[6],"processes,":[7],"but":[8],"their":[9],"roles":[10],"in":[11,44,92,104,142],"innate":[12,50],"immunity":[13],"have":[14],"not":[15],"been":[16],"fully":[17],"explored.":[18],"Here,":[19],"we":[20,54,110],"found":[21,55],"that":[22,56,89,98,113],"manganese":[23],"(Mn)":[24],"significantly":[25],"enhanced":[26],"DNA-mediated":[27,80],"IFN-\u03b1,":[28],"IFN-\u03b2,":[29],"and":[30],"IFN-\u03bb1":[31],"production.":[32],"Microarray":[33],"analysis":[34],"demonstrated":[35,112],"Mn":[36,57,114,141],"highly":[37],"upregulated":[38],"351":[39],"genes,":[40],"which":[41],"were":[42],"involved":[43],"multiple":[45],"biological":[46],"functions":[47],"related":[48],"to":[49],"immune":[51,81],"response.":[52],"Moreover,":[53],"2+":[58,115],"alone":[59],"activates":[60],"phosphorylation":[61,85,94],"of":[62,86,95,118,140],"TANK-binding":[63],"kinase":[64,72],"1":[65],"(TBK1).":[66],"Inhibiting":[67],"ataxia":[68],"telangiectasia":[69],"mutated":[70],"(ATM)":[71],"using":[73],"ATM":[74,90],"inhibitor":[75],"or":[76,106,122,145],"siRNA":[77],"suppressed":[78,116],"Mn-enhanced":[79],"response":[82],"with":[83],"decreasing":[84],"TBK-1,":[87],"suggesting":[88],"involves":[91],"Mn-dependent":[93],"TBK1.":[96],"Given":[97],"TBK1":[99],"is":[100],"an":[101],"mediator":[103],"DNA-":[105],"RNA-mediated":[107],"signaling":[108],"pathways,":[109],"further":[111],"infection":[117],"HSV-1":[119],"(DNA":[120],"virus)":[121,126],"Sendai":[123],"virus":[124],"(RNA":[125],"into":[127],"human":[128],"macrophages":[129],"by":[130],"enhancing":[131],"antiviral":[132],"immunity.":[133],"Our":[134],"finding":[135],"highlights":[136],"a":[137],"beneficial":[138],"role":[139],"nucleic-acid-based":[143],"preventive":[144],"therapeutic":[146],"reagents":[147],"against":[148],"infectious":[149],"diseases.":[150]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-10-13T00:00:00"}