{"id":"https://openalex.org/W4304891900","doi":"https://doi.org/10.1038/s41598-022-21650-1","title":"Clinical impact of lymphocyte/C-reactive protein ratio on postoperative outcomes in patients with rectal cancer who underwent curative resection","display_name":"Clinical impact of lymphocyte/C-reactive protein ratio on postoperative outcomes in patients with rectal cancer who underwent curative resection","publication_year":2022,"publication_date":"2022-10-13","ids":{"openalex":"https://openalex.org/W4304891900","doi":"https://doi.org/10.1038/s41598-022-21650-1","pmid":"https://pubmed.ncbi.nlm.nih.gov/36229569","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9561722"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-022-21650-1","doi":"https://doi.org/10.1038/s41598-022-21650-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-022-21650-1","pdf_url":"https://www.nature.com/articles/s41598-022-21650-1.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-022-21650-1.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005670010","display_name":"Takehito Yamamoto","orcid":"https://orcid.org/0000-0002-2236-7124","observed_orcids":["https://orcid.org/0000-0002-2236-7124"]},"institutions":[{"id":"https://openalex.org/I4210161392","display_name":"Kitano Hospital","ror":"https://ror.org/05rsbck92","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210161392"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Takehito Yamamoto","raw_affiliation_strings":["Department of Gastroenterological Surgery and Oncology, Kitano Hospital Medical Research Institute, 2-4-20, Ogimachi, Kita-ku, Osaka, 530-8480, Japan. takehito_y@kuhp.kyoto-u.ac.jp","Department of Gastroenterological Surgery and Oncology, Kitano Hospital Medical Research Institute, 2-4-20, Ogimachi, Kita-ku, Osaka, 530-8480, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery and Oncology, Kitano Hospital Medical Research Institute, 2-4-20, Ogimachi, Kita-ku, Osaka, 530-8480, Japan. takehito_y@kuhp.kyoto-u.ac.jp","institution_ids":["https://openalex.org/I4210161392"]},{"raw_affiliation_string":"Department of Gastroenterological Surgery and Oncology, Kitano Hospital Medical Research Institute, 2-4-20, Ogimachi, Kita-ku, Osaka, 530-8480, Japan","institution_ids":["https://openalex.org/I4210161392"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102130463","display_name":"Meiki Fukuda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210161392","display_name":"Kitano Hospital","ror":"https://ror.org/05rsbck92","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210161392"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Meiki Fukuda","raw_affiliation_strings":["Department of Gastroenterological Surgery and Oncology, Kitano Hospital Medical Research Institute, 2-4-20, Ogimachi, Kita-ku, Osaka, 530-8480, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery and Oncology, Kitano Hospital Medical Research Institute, 2-4-20, Ogimachi, Kita-ku, Osaka, 530-8480, Japan","institution_ids":["https://openalex.org/I4210161392"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040120130","display_name":"Yoshihisa Okuchi","orcid":"https://orcid.org/0000-0003-3009-6990","observed_orcids":["https://orcid.org/0000-0003-3009-6990"]},"institutions":[{"id":"https://openalex.org/I4210161392","display_name":"Kitano Hospital","ror":"https://ror.org/05rsbck92","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210161392"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshihisa Okuchi","raw_affiliation_strings":["Department of Gastroenterological Surgery and Oncology, Kitano Hospital Medical Research Institute, 2-4-20, Ogimachi, Kita-ku, Osaka, 530-8480, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery and Oncology, Kitano Hospital Medical Research Institute, 2-4-20, Ogimachi, Kita-ku, Osaka, 530-8480, Japan","institution_ids":["https://openalex.org/I4210161392"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029340479","display_name":"Yoshiki Oshimo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210161392","display_name":"Kitano Hospital","ror":"https://ror.org/05rsbck92","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210161392"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshiki Oshimo","raw_affiliation_strings":["Department of Gastroenterological Surgery and Oncology, Kitano Hospital Medical Research Institute, 2-4-20, Ogimachi, Kita-ku, Osaka, 530-8480, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery and Oncology, Kitano Hospital Medical Research Institute, 2-4-20, Ogimachi, Kita-ku, Osaka, 530-8480, Japan","institution_ids":["https://openalex.org/I4210161392"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031379374","display_name":"Yuta Nishikawa","orcid":"https://orcid.org/0000-0001-6507-8958","observed_orcids":["https://orcid.org/0000-0001-6507-8958"]},"institutions":[{"id":"https://openalex.org/I4210161392","display_name":"Kitano Hospital","ror":"https://ror.org/05rsbck92","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210161392"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuta Nishikawa","raw_affiliation_strings":["Department of Gastroenterological Surgery and Oncology, Kitano Hospital Medical Research Institute, 2-4-20, Ogimachi, Kita-ku, Osaka, 530-8480, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery and Oncology, Kitano Hospital Medical Research Institute, 2-4-20, Ogimachi, Kita-ku, Osaka, 530-8480, Japan","institution_ids":["https://openalex.org/I4210161392"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076572526","display_name":"Koji Hisano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210161392","display_name":"Kitano Hospital","ror":"https://ror.org/05rsbck92","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210161392"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koji Hisano","raw_affiliation_strings":["Department of Gastroenterological Surgery and Oncology, Kitano Hospital Medical Research Institute, 2-4-20, Ogimachi, Kita-ku, Osaka, 530-8480, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery and Oncology, Kitano Hospital Medical Research Institute, 2-4-20, Ogimachi, Kita-ku, Osaka, 530-8480, Japan","institution_ids":["https://openalex.org/I4210161392"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000104554","display_name":"Takayuki Kawai","orcid":"https://orcid.org/0000-0001-7520-6861","observed_orcids":["https://orcid.org/0000-0001-7520-6861"]},"institutions":[{"id":"https://openalex.org/I4210161392","display_name":"Kitano Hospital","ror":"https://ror.org/05rsbck92","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210161392"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takayuki Kawai","raw_affiliation_strings":["Department of Gastroenterological Surgery and Oncology, Kitano Hospital Medical Research Institute, 2-4-20, Ogimachi, Kita-ku, Osaka, 530-8480, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery and Oncology, Kitano Hospital Medical Research Institute, 2-4-20, Ogimachi, Kita-ku, Osaka, 530-8480, Japan","institution_ids":["https://openalex.org/I4210161392"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057533461","display_name":"Kohta Iguchi","orcid":"https://orcid.org/0009-0000-0910-4955","observed_orcids":["https://orcid.org/0009-0000-0910-4955"]},"institutions":[{"id":"https://openalex.org/I4210161392","display_name":"Kitano Hospital","ror":"https://ror.org/05rsbck92","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210161392"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kohta Iguchi","raw_affiliation_strings":["Department of Gastroenterological Surgery and Oncology, Kitano Hospital Medical Research Institute, 2-4-20, Ogimachi, Kita-ku, Osaka, 530-8480, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery and Oncology, Kitano Hospital Medical Research Institute, 2-4-20, Ogimachi, Kita-ku, Osaka, 530-8480, Japan","institution_ids":["https://openalex.org/I4210161392"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043499683","display_name":"Yukihiro Okuda","orcid":"https://orcid.org/0000-0002-8897-236X","observed_orcids":["https://orcid.org/0000-0002-8897-236X"]},"institutions":[{"id":"https://openalex.org/I4210161392","display_name":"Kitano Hospital","ror":"https://ror.org/05rsbck92","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210161392"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yukihiro Okuda","raw_affiliation_strings":["Department of Gastroenterological Surgery and Oncology, Kitano Hospital Medical Research Institute, 2-4-20, Ogimachi, Kita-ku, Osaka, 530-8480, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery and Oncology, Kitano Hospital Medical Research Institute, 2-4-20, Ogimachi, Kita-ku, Osaka, 530-8480, Japan","institution_ids":["https://openalex.org/I4210161392"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114033876","display_name":"Ryo Kamimura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210161392","display_name":"Kitano Hospital","ror":"https://ror.org/05rsbck92","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210161392"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryo Kamimura","raw_affiliation_strings":["Department of Gastroenterological Surgery and Oncology, Kitano Hospital Medical Research Institute, 2-4-20, Ogimachi, Kita-ku, Osaka, 530-8480, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery and Oncology, Kitano Hospital Medical Research Institute, 2-4-20, Ogimachi, Kita-ku, Osaka, 530-8480, Japan","institution_ids":["https://openalex.org/I4210161392"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062390379","display_name":"Eiji I. Tanaka","orcid":"https://orcid.org/0000-0002-2707-1613","observed_orcids":["https://orcid.org/0000-0002-2707-1613"]},"institutions":[{"id":"https://openalex.org/I4210161392","display_name":"Kitano Hospital","ror":"https://ror.org/05rsbck92","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210161392"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Eiji Tanaka","raw_affiliation_strings":["Department of Gastroenterological Surgery and Oncology, Kitano Hospital Medical Research Institute, 2-4-20, Ogimachi, Kita-ku, Osaka, 530-8480, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery and Oncology, Kitano Hospital Medical Research Institute, 2-4-20, Ogimachi, Kita-ku, Osaka, 530-8480, Japan","institution_ids":["https://openalex.org/I4210161392"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003733073","display_name":"Hiroaki Terajima","orcid":"https://orcid.org/0000-0001-7938-6345","observed_orcids":["https://orcid.org/0000-0001-7938-6345"]},"institutions":[{"id":"https://openalex.org/I4210161392","display_name":"Kitano Hospital","ror":"https://ror.org/05rsbck92","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210161392"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroaki Terajima","raw_affiliation_strings":["Department of Gastroenterological Surgery and Oncology, Kitano Hospital Medical Research Institute, 2-4-20, Ogimachi, Kita-ku, Osaka, 530-8480, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery and Oncology, Kitano Hospital Medical Research Institute, 2-4-20, Ogimachi, Kita-ku, Osaka, 530-8480, Japan","institution_ids":["https://openalex.org/I4210161392"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5005670010"],"corresponding_institution_ids":["https://openalex.org/I4210161392"],"apc_list":{"value":2190,"currency":"USD","value_usd":2190},"apc_paid":{"value":2190,"currency":"USD","value_usd":2190},"fwci":0.6643,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.65462398,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"12","issue":"1","first_page":"17136","last_page":"17136"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rectal-cancer","display_name":"rectal cancer","score":0.9929999709129333},{"id":"https://openalex.org/keywords/postoperative-complications","display_name":"postoperative complications","score":0.800000011920929},{"id":"https://openalex.org/keywords/curative-resection","display_name":"curative resection","score":0.7519999742507935},{"id":"https://openalex.org/keywords/systemic-inflammation","display_name":"systemic inflammation","score":0.75},{"id":"https://openalex.org/keywords/inflammatory-markers","display_name":"inflammatory markers","score":0.6549999713897705},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.8679999709129333},{"id":"https://openalex.org/keywords/recurrence-free-survival","display_name":"recurrence-free survival","score":0.9990000128746033},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7149999737739563},{"id":"https://openalex.org/keywords/tumor-location","display_name":"tumor location","score":0.7590000033378601}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8480350971221924},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.8270658254623413},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7419039607048035},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.712557315826416},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.6827509999275208},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6533308029174805},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.588961124420166},{"id":"https://openalex.org/C2778963024","wikidata":"https://www.wikidata.org/wiki/Q17132454","display_name":"Neutrophil to lymphocyte ratio","level":3,"score":0.5758242011070251},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5685645937919617},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.5558395385742188},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5288981795310974},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.5251483917236328},{"id":"https://openalex.org/C2781195455","wikidata":"https://www.wikidata.org/wiki/Q422766","display_name":"C-reactive protein","level":3,"score":0.4944803714752197},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4028054475784302},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3987111747264862},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.3928494453430176}],"mesh":[{"descriptor_ui":"D002097","descriptor_name":"C-Reactive Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011183","descriptor_name":"Postoperative Complications","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012004","descriptor_name":"Rectal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/s41598-022-21650-1","doi":"https://doi.org/10.1038/s41598-022-21650-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-022-21650-1","pdf_url":"https://www.nature.com/articles/s41598-022-21650-1.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmid:36229569","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36229569","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9561722","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9561722/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:3950bce2e7a14ded8fe7564ecf424ffb","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3950bce2e7a14ded8fe7564ecf424ffb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-022-21650-1","doi":"https://doi.org/10.1038/s41598-022-21650-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-022-21650-1","pdf_url":"https://www.nature.com/articles/s41598-022-21650-1.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G5588303946","display_name":"Development of a novel colorectal cancer preventing drug by controlling gene expression changes that contribute to tumorigenesis","funder_award_id":"21K16487","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7801379377","display_name":"Establishment of the novel therapeutic strategies targeting cancer stem cells in hepatocellular carcinoma","funder_award_id":"21K16461","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4304891900.pdf","grobid_xml":"https://content.openalex.org/works/W4304891900.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W58571634","https://openalex.org/W1841968883","https://openalex.org/W1963697247","https://openalex.org/W1987773883","https://openalex.org/W1990185848","https://openalex.org/W1990423062","https://openalex.org/W2028186534","https://openalex.org/W2078065548","https://openalex.org/W2081238838","https://openalex.org/W2084222857","https://openalex.org/W2116554142","https://openalex.org/W2117393082","https://openalex.org/W2141092170","https://openalex.org/W2144173184","https://openalex.org/W2163761041","https://openalex.org/W2337736379","https://openalex.org/W2562243252","https://openalex.org/W2588648630","https://openalex.org/W2607031422","https://openalex.org/W2735635753","https://openalex.org/W2743199111","https://openalex.org/W2772092431","https://openalex.org/W2804886465","https://openalex.org/W2808590765","https://openalex.org/W2883446711","https://openalex.org/W2903526531","https://openalex.org/W2919457236","https://openalex.org/W2954399561","https://openalex.org/W2967784018","https://openalex.org/W2981000021","https://openalex.org/W2988331199","https://openalex.org/W3015900834","https://openalex.org/W3088232962","https://openalex.org/W3093813703","https://openalex.org/W3109656868","https://openalex.org/W3158048438","https://openalex.org/W3160449385","https://openalex.org/W3183775578","https://openalex.org/W4211133582"],"related_works":["https://openalex.org/W3180184799","https://openalex.org/W3006410398","https://openalex.org/W2919457236","https://openalex.org/W3185430590","https://openalex.org/W3158048438","https://openalex.org/W3167557949","https://openalex.org/W7154570155","https://openalex.org/W2770116227","https://openalex.org/W2894575840","https://openalex.org/W7160522316"],"abstract_inverted_index":{"Cancer-related":[0],"systemic":[1],"inflammation":[2],"influences":[3],"postoperative":[4,16,94,119,170,233],"outcomes":[5,17,52,234],"in":[6,21,31,47,74,92,235],"cancer":[7,33,55,60,237],"patients.":[8,34],"Although":[9],"the":[10,38,80,107,111,116,122,167,183],"relationship":[11],"between":[12,68],"inflammation-related":[13,84],"markers":[14],"and":[15,44,50,70,88,96,150,163,211,231],"have":[18],"been":[19],"investigated":[20],"many":[22],"studies,":[23],"their":[24],"clinical":[25],"significance":[26],"remains":[27],"to":[28],"be":[29],"elucidated":[30],"rectal":[32,54,59,236],"We":[35,77],"focused":[36],"on":[37],"lymphocyte":[39],"count/C-reactive":[40],"protein":[41],"ratio":[42,128,202],"(LCR)":[43],"its":[45],"usefulness":[46],"predicting":[48,93,115,228],"short-":[49,230],"long-term":[51,232],"after":[53],"surgery.":[56,242],"Patients":[57],"with":[58,166,196],"who":[61,239],"underwent":[62,240],"curative":[63,241],"resection":[64],"at":[65],"our":[66],"institution":[67],"2010":[69],"2018":[71],"were":[72,161],"enrolled":[73],"this":[75],"study.":[76],"comprehensively":[78],"compared":[79],"effectiveness":[81],"of":[82,118,169,185],"11":[83],"markers,":[85],"including":[86],"LCR":[87,105,152,190,222],"other":[89],"clinicopathological":[90],"characteristics,":[91],"complications":[95],"survival.":[97],"Receiver":[98],"operating":[99],"characteristic":[100],"curve":[101,112],"analysis":[102,175],"indicated":[103],"that":[104,188],"had":[106],"highest":[108],"area":[109],"under":[110],"value":[113],"for":[114,182,227],"occurrence":[117,168],"complications.":[120,171],"In":[121,172],"multivariate":[123,174],"analysis,":[124],"male":[125],"sex":[126],"(odds":[127],"[OR]:":[129],"2.21,":[130,215],"95%":[131,144,155,205,216],"confidence":[132],"interval":[133],"[CI]":[134],"1.07-4.57,":[135],"P":[136,147,158,208,219],"=":[137,148,159,209,220],"0.031),":[138],"low":[139,151,189],"tumor":[140],"location":[141],"(OR:":[142,153],"2.44,":[143],"CI":[145,156,206,217],"1.23-4.88,":[146],"0.011),":[149],"3.51,":[154],"1.63-7.58,":[157],"0.001)":[160],"significantly":[162,194],"independently":[164],"associated":[165,195],"addition,":[173],"using":[176],"Cox's":[177],"proportional":[178],"hazard":[179],"regression":[180],"model":[181],"prediction":[184],"survival":[186,200,213],"showed":[187],"(\u2264":[191],"12,600)":[192],"was":[193],"both":[197,229],"poor":[198],"overall":[199],"(hazard":[201],"[HR]:":[203],"2.07,":[204],"1.03-4.15,":[207],"0.041)":[210],"recurrence-free":[212],"(HR:":[214],"1.22-4.01,":[218],"0.009).":[221],"is":[223],"a":[224],"useful":[225],"marker":[226],"patients":[238]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-10-13T00:00:00"}