{"id":"https://openalex.org/W4304590727","doi":null,"title":"Potential protective effect of hydroxytyrosol against glucose-induced toxicity in spermatozoa in vitro","display_name":"Potential protective effect of hydroxytyrosol against glucose-induced toxicity in spermatozoa in vitro","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W4304590727"},"language":"en","primary_location":{"id":"pmh:oai:HAL:hal-02661705v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.inrae.fr/hal-02661705","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Asia Life Sciences, 2010, 19 (2), pp.333-344","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069408712","display_name":"Khaled Hamden","orcid":"https://orcid.org/0000-0001-5651-3962","observed_orcids":["https://orcid.org/0000-0001-5651-3962"]},"institutions":[{"id":"https://openalex.org/I142899784","display_name":"University of Sfax","ror":"https://ror.org/04d4sd432","country_code":"TN","type":"education","lineage":["https://openalex.org/I142899784"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Hamden, Khaled","raw_affiliation_strings":["\u062c\u0627\u0645\u0639\u0629 \u0635\u0641\u0627\u0642\u0633 - Universit\u00e9 de Sfax - University of Sfax (Route de l'A\u00e9roport Km 0.5 - BP 1169 .3029 Sfax - Tunisie)","Universit\u00e9 de Sfax"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u062c\u0627\u0645\u0639\u0629 \u0635\u0641\u0627\u0642\u0633 - Universit\u00e9 de Sfax - University of Sfax (Route de l'A\u00e9roport Km 0.5 - BP 1169 .3029 Sfax - Tunisie)","institution_ids":["https://openalex.org/I142899784"]},{"raw_affiliation_string":"Universit\u00e9 de Sfax","institution_ids":["https://openalex.org/I142899784"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074307008","display_name":"Nourreddine Allouche","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142899784","display_name":"University of Sfax","ror":"https://ror.org/04d4sd432","country_code":"TN","type":"education","lineage":["https://openalex.org/I142899784"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Allouche, Nourreddine","raw_affiliation_strings":["\u062c\u0627\u0645\u0639\u0629 \u0635\u0641\u0627\u0642\u0633 - Universit\u00e9 de Sfax - University of Sfax (Route de l'A\u00e9roport Km 0.5 - BP 1169 .3029 Sfax - Tunisie)","Universit\u00e9 de Sfax"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u062c\u0627\u0645\u0639\u0629 \u0635\u0641\u0627\u0642\u0633 - Universit\u00e9 de Sfax - University of Sfax (Route de l'A\u00e9roport Km 0.5 - BP 1169 .3029 Sfax - Tunisie)","institution_ids":["https://openalex.org/I142899784"]},{"raw_affiliation_string":"Universit\u00e9 de Sfax","institution_ids":["https://openalex.org/I142899784"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103062831","display_name":"Mohamed Damak A","orcid":"https://orcid.org/0000-0001-6780-7296","observed_orcids":["https://orcid.org/0000-0001-6780-7296"]},"institutions":[{"id":"https://openalex.org/I142899784","display_name":"University of Sfax","ror":"https://ror.org/04d4sd432","country_code":"TN","type":"education","lineage":["https://openalex.org/I142899784"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Damak, Mohamed","raw_affiliation_strings":["\u062c\u0627\u0645\u0639\u0629 \u0635\u0641\u0627\u0642\u0633 - Universit\u00e9 de Sfax - University of Sfax (Route de l'A\u00e9roport Km 0.5 - BP 1169 .3029 Sfax - Tunisie)","Universit\u00e9 de Sfax"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u062c\u0627\u0645\u0639\u0629 \u0635\u0641\u0627\u0642\u0633 - Universit\u00e9 de Sfax - University of Sfax (Route de l'A\u00e9roport Km 0.5 - BP 1169 .3029 Sfax - Tunisie)","institution_ids":["https://openalex.org/I142899784"]},{"raw_affiliation_string":"Universit\u00e9 de Sfax","institution_ids":["https://openalex.org/I142899784"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109201928","display_name":"Serge Carreau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210132088","display_name":"D\u00e9partement Physiologie Animale et Syst\u00e8mes d\u2019\u00c9levage","ror":"https://ror.org/03tpcfk14","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4210132088"]},{"id":"https://openalex.org/I4387154544","display_name":"Institut National de la Recherche Agronomique","ror":"https://ror.org/01x3gbx83","country_code":"FR","type":"funder","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4387154544"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Carreau, Serge","raw_affiliation_strings":["INRA - Institut National de la Recherche Agronomique (France)","PHASE - D\u00e9partement Physiologie Animale et Syst\u00e8mes d'Elevage (France)","D\u00e9partement Physiologie Animale et Syst\u00e8mes d'Elevage","Institut National de la Recherche Agronomique"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INRA - Institut National de la Recherche Agronomique (France)","institution_ids":["https://openalex.org/I4387154544"]},{"raw_affiliation_string":"PHASE - D\u00e9partement Physiologie Animale et Syst\u00e8mes d'Elevage (France)","institution_ids":["https://openalex.org/I4210132088"]},{"raw_affiliation_string":"D\u00e9partement Physiologie Animale et Syst\u00e8mes d'Elevage","institution_ids":["https://openalex.org/I4210132088"]},{"raw_affiliation_string":"Institut National de la Recherche Agronomique","institution_ids":["https://openalex.org/I4387154544"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110468041","display_name":"Abdelfattah Elfeki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142899784","display_name":"University of Sfax","ror":"https://ror.org/04d4sd432","country_code":"TN","type":"education","lineage":["https://openalex.org/I142899784"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Elfeki, Abdelfattah","raw_affiliation_strings":["\u062c\u0627\u0645\u0639\u0629 \u0635\u0641\u0627\u0642\u0633 - Universit\u00e9 de Sfax - University of Sfax (Route de l'A\u00e9roport Km 0.5 - BP 1169 .3029 Sfax - Tunisie)","Universit\u00e9 de Sfax"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u062c\u0627\u0645\u0639\u0629 \u0635\u0641\u0627\u0642\u0633 - Universit\u00e9 de Sfax - University of Sfax (Route de l'A\u00e9roport Km 0.5 - BP 1169 .3029 Sfax - Tunisie)","institution_ids":["https://openalex.org/I142899784"]},{"raw_affiliation_string":"Universit\u00e9 de Sfax","institution_ids":["https://openalex.org/I142899784"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.54577811,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"19","issue":"2","first_page":"333","last_page":"344"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydroxytyrosol","display_name":"hydroxytyrosol","score":1.0},{"id":"https://openalex.org/keywords/glucotoxicity","display_name":"glucotoxicity","score":0.8050000071525574},{"id":"https://openalex.org/keywords/spermatozoa","display_name":"spermatozoa","score":0.9079999923706055},{"id":"https://openalex.org/keywords/epididymal-spermatozoa","display_name":"epididymal sperm","score":0.8619999885559082},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8820000290870667},{"id":"https://openalex.org/keywords/antioxidant-defense","display_name":"antioxidant defense","score":0.8489999771118164},{"id":"https://openalex.org/keywords/sperm-motility","display_name":"sperm motility","score":0.9279999732971191},{"id":"https://openalex.org/keywords/sperm-viability","display_name":"sperm viability","score":0.9990000128746033},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.9150000214576721},{"id":"https://openalex.org/keywords/glutathione-peroxidase","display_name":"glutathione peroxidase","score":0.9330000281333923},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.9980000257492065},{"id":"https://openalex.org/keywords/reduced-glutathione","display_name":"reduced glutathione","score":0.9660000205039978},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9369999766349792},{"id":"https://openalex.org/keywords/lactate-dehydrogenase","display_name":"lactate dehydrogenase","score":0.8759999871253967},{"id":"https://openalex.org/keywords/antioxidant-supplementation","display_name":"antioxidant supplementation","score":0.48100000619888306}],"concepts":[{"id":"https://openalex.org/C2775881703","wikidata":"https://www.wikidata.org/wiki/Q744577","display_name":"Hydroxytyrosol","level":4,"score":0.8368399143218994},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.7304496765136719},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.6492161750793457},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5086344480514526},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5010519027709961},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33092907071113586},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.3230186104774475},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2124958634376526},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.14312392473220825},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C70899900","wikidata":"https://www.wikidata.org/wiki/Q290439","display_name":"Polyphenol","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:HAL:hal-02661705v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.inrae.fr/hal-02661705","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Asia Life Sciences, 2010, 19 (2), pp.333-344","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2346211705","https://openalex.org/W4389805113","https://openalex.org/W7163129695","https://openalex.org/W4399264643","https://openalex.org/W4396506939","https://openalex.org/W4399701572","https://openalex.org/W2149651463","https://openalex.org/W4403899418","https://openalex.org/W2791601654","https://openalex.org/W2588046631"],"abstract_inverted_index":{"Antioxidant":[0],"supplements":[1],"have":[2],"long":[3],"been":[4],"known":[5],"to":[6,24,129,197,230],"reduce":[7],"the":[8,14,26,75,78,100,112,147,150,175],"free":[9],"radical-induced":[10],"oxidative":[11,232],"damage.":[12],"Considering":[13],"antioxidant":[15,33,193,214],"properties":[16],"of":[17,28,35,77,102,114,168,219],"hydroxytyrosol":[18,29,227],"(Ht),":[19],"this":[20],"study":[21],"was":[22,228],"aimed":[23],"evaluate":[25],"effect":[27],"and":[30,50,66,68,94,111,125,157,164,172,192,222,234],"glucose":[31,84,135,178,210],"on":[32],"system":[34,216],"rat":[36],"epididymal":[37],"sperm":[38,92,130,142,169,235],"in":[39,45,91,97,140,149,188,209],"vitro.":[40],"Sperm":[41,64],"samples":[42],"were":[43,72,118,200],"dispersed":[44],"RPS":[46],"medium":[47],"(pH":[48],"6.9)":[49],"incubated":[51,81,131],"with":[52,82,170,217,226],"Ht":[53,173],"at":[54,61,74,132],"concentration":[55,85,136,208],"50":[56,124],"\u03bcg/ml":[57],"for":[58],"1":[59],"h":[60],"32":[62],"\u00b0C.":[63],"viability":[65,191,221],"motility":[67,93],"various":[69],"biochemical":[70],"parameters":[71],"assessed":[73],"end":[76],"incubation.":[79],"Spermatozoa":[80],"higher":[83,141,207],"(HG)":[86],"(3g/l)":[87],"showed":[88],"a":[89,133,182],"decrease":[90],"viability.":[95],"Moreover,":[96],"HG-incubated":[98],"sperm,":[99],"activities":[101],"superoxide":[103],"dismutase":[104],"(SOD),":[105],"glutathione":[106,116],"peroxidase":[107],"(GPX),":[108],"catalase":[109],"(CAT)":[110],"level":[113],"reduced":[115],"(GSH)":[117],"decreased":[119],"significantly":[120],"by":[121,146,162,238],"76,":[122],"62,":[123],"57%,":[126],"respectively":[127],"compared":[128,196],"lower":[134],"(1g/l).":[137],"HG":[138,171],"resulted":[139],"toxicity":[143,236],"as":[144,195],"observed":[145],"increase":[148,184],"thiobarbituric":[151],"acid":[152],"reactive":[153],"substances":[154],"(TBARS)":[155],"levels":[156],"lactate":[158],"dehydrogenase":[159],"(LDH)":[160],"activity":[161],"24":[163],"97%,":[165],"respectively.":[166],"Co-incubation":[167],"protect":[174],"cells":[176],"from":[177],"toxicity.":[179],"In":[180],"fact":[181],"significant":[183],"(p":[185],"<":[186],"0.05)":[187],"spermatic":[189],"motility,":[190],"indices":[194],"untreated":[198],"controls":[199],"clearly":[201],"shown.":[202],"The":[203],"results":[204],"suggest":[205],"that":[206],"elicited":[211],"depletion":[212],"ofspermatozoa":[213],"defence":[215],"alteration":[218],"their":[220],"motility.":[223],"However,":[224],"treatment":[225],"found":[229],"inhibit":[231],"stress":[233],"caused":[237],"glucose.":[239]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2022-10-12T00:00:00"}