{"id":"https://openalex.org/W4304136229","doi":"https://doi.org/10.3390/medicina58101423","title":"Systemic Endothelial Function, Plasma Xanthine Oxidoreductase Activity, and Blood Pressure Variability in Patients with Stable Coronary Artery Disease","display_name":"Systemic Endothelial Function, Plasma Xanthine Oxidoreductase Activity, and Blood Pressure Variability in Patients with Stable Coronary Artery Disease","publication_year":2022,"publication_date":"2022-10-10","ids":{"openalex":"https://openalex.org/W4304136229","doi":"https://doi.org/10.3390/medicina58101423","pmid":"https://pubmed.ncbi.nlm.nih.gov/36295583","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9611040"},"language":"en","primary_location":{"id":"doi:10.3390/medicina58101423","doi":"https://doi.org/10.3390/medicina58101423","is_oa":true,"landing_page_url":"https://doi.org/10.3390/medicina58101423","pdf_url":"https://www.mdpi.com/1648-9144/58/10/1423/pdf?version=1665395920","source":{"id":"https://openalex.org/S1008817457","display_name":"Medicina","issn_l":"1010-660X","issn":["1010-660X","1648-9144"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1648-9144/58/10/1423/pdf?version=1665395920","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Takashi Hiraga","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Hiraga","raw_affiliation_strings":["Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, Chiba 260-0856, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, Chiba 260-0856, Japan","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006441304","display_name":"Yuichi Saito","orcid":"https://orcid.org/0000-0003-3574-0685","observed_orcids":["https://orcid.org/0000-0003-3574-0685"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yuichi Saito","raw_affiliation_strings":["Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, Chiba 260-0856, Japan"],"raw_orcid":"https://orcid.org/0000-0003-3574-0685","affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, Chiba 260-0856, Japan","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035933204","display_name":"Kazuya Tateishi","orcid":"https://orcid.org/0000-0002-7655-7628","observed_orcids":["https://orcid.org/0000-0002-7655-7628"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuya Tateishi","raw_affiliation_strings":["Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, Chiba 260-0856, Japan"],"raw_orcid":"https://orcid.org/0000-0002-7655-7628","affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, Chiba 260-0856, Japan","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088138890","display_name":"Naoto Mori","orcid":"https://orcid.org/0000-0001-9522-9518","observed_orcids":["https://orcid.org/0000-0001-9522-9518"]},"institutions":[{"id":"https://openalex.org/I4210136332","display_name":"Chiba Aoba Municipal Hospital","ror":"https://ror.org/02y2arb86","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210136332"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoto Mori","raw_affiliation_strings":["Department of Internal Medicine, Chiba Aoba Municipal Hospital, Chiba 260-0852, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Chiba Aoba Municipal Hospital, Chiba 260-0852, Japan","institution_ids":["https://openalex.org/I4210136332"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085926407","display_name":"Takayo Murase","orcid":"https://orcid.org/0000-0002-4515-9504","observed_orcids":["https://orcid.org/0000-0002-4515-9504"]},"institutions":[{"id":"https://openalex.org/I4405270935","display_name":"Sanwa Kagaku Kenkyusho Co., Ltd. (Japan)","ror":"https://ror.org/01jrk5n74","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405270935"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takayo Murase","raw_affiliation_strings":["Sanwa Kagaku Kenkyusho Co., Ltd., Nagoya 511-0406, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sanwa Kagaku Kenkyusho Co., Ltd., Nagoya 511-0406, Japan","institution_ids":["https://openalex.org/I4405270935"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006041066","display_name":"Takashi Nakamura","orcid":"https://orcid.org/0000-0003-2324-3569","observed_orcids":["https://orcid.org/0000-0003-2324-3569"]},"institutions":[{"id":"https://openalex.org/I4405270935","display_name":"Sanwa Kagaku Kenkyusho Co., Ltd. (Japan)","ror":"https://ror.org/01jrk5n74","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405270935"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Nakamura","raw_affiliation_strings":["Sanwa Kagaku Kenkyusho Co., Ltd., Nagoya 511-0406, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sanwa Kagaku Kenkyusho Co., Ltd., Nagoya 511-0406, Japan","institution_ids":["https://openalex.org/I4405270935"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039283556","display_name":"Seigo Akari","orcid":"https://orcid.org/0000-0001-6641-1062","observed_orcids":["https://orcid.org/0000-0001-6641-1062"]},"institutions":[{"id":"https://openalex.org/I4405270935","display_name":"Sanwa Kagaku Kenkyusho Co., Ltd. (Japan)","ror":"https://ror.org/01jrk5n74","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405270935"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Seigo Akari","raw_affiliation_strings":["Sanwa Kagaku Kenkyusho Co., Ltd., Nagoya 511-0406, Japan"],"raw_orcid":"https://orcid.org/0000-0001-6641-1062","affiliations":[{"raw_affiliation_string":"Sanwa Kagaku Kenkyusho Co., Ltd., Nagoya 511-0406, Japan","institution_ids":["https://openalex.org/I4405270935"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010588865","display_name":"Kan Saito","orcid":"https://orcid.org/0000-0002-3834-8665","observed_orcids":["https://orcid.org/0000-0002-3834-8665"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kan Saito","raw_affiliation_strings":["Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, Chiba 260-0856, Japan"],"raw_orcid":"https://orcid.org/0000-0002-3834-8665","affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, Chiba 260-0856, Japan","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023092029","display_name":"Hideki Kitahara","orcid":"https://orcid.org/0000-0002-2888-6160","observed_orcids":["https://orcid.org/0000-0002-2888-6160"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideki Kitahara","raw_affiliation_strings":["Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, Chiba 260-0856, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, Chiba 260-0856, Japan","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108551006","display_name":"Yoshio Kobayashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshio Kobayashi","raw_affiliation_strings":["Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, Chiba 260-0856, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, Chiba 260-0856, Japan","institution_ids":["https://openalex.org/I159385669"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5006441304"],"corresponding_institution_ids":["https://openalex.org/I159385669"],"apc_list":{"value":1800,"currency":"CHF","value_usd":1885},"apc_paid":{"value":1800,"currency":"CHF","value_usd":1885},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"58","issue":"10","first_page":"1423","last_page":"1423"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":0.9312000274658203,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":0.9312000274658203,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.03150000050663948,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.024800000712275505,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/xanthine-oxidoreductase","display_name":"xanthine oxidoreductase","score":0.8640000224113464},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.9210000038146973},{"id":"https://openalex.org/keywords/blood-pressure-variability","display_name":"blood pressure variability","score":0.953000009059906},{"id":"https://openalex.org/keywords/stable-coronary-artery-disease","display_name":"stable coronary artery disease","score":0.9750000238418579},{"id":"https://openalex.org/keywords/reactive-hyperemia-index","display_name":"reactive hyperemia index","score":0.9539999961853027},{"id":"https://openalex.org/keywords/purine-metabolism","display_name":"purine metabolism","score":0.9580000042915344},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.7929999828338623},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.9210000038146973},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.9120000004768372},{"id":"https://openalex.org/keywords/percutaneous-coronary-intervention","display_name":"percutaneous coronary intervention","score":0.8690000176429749}],"concepts":[{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.8381451368331909},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7117172479629517},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6738578677177429},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.6530106663703918},{"id":"https://openalex.org/C2779881121","wikidata":"https://www.wikidata.org/wiki/Q105522","display_name":"Uric acid","level":2,"score":0.6314287185668945},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.6303627490997314},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6081316471099854},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.5860602259635925},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.43285757303237915},{"id":"https://openalex.org/C2776246508","wikidata":"https://www.wikidata.org/wiki/Q5376428","display_name":"Endothelial activation","level":3,"score":0.42906510829925537},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.362338125705719}],"mesh":[{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003324","descriptor_name":"Coronary Artery Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014527","descriptor_name":"Uric Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014968","descriptor_name":"Xanthine Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3390/medicina58101423","doi":"https://doi.org/10.3390/medicina58101423","is_oa":true,"landing_page_url":"https://doi.org/10.3390/medicina58101423","pdf_url":"https://www.mdpi.com/1648-9144/58/10/1423/pdf?version=1665395920","source":{"id":"https://openalex.org/S1008817457","display_name":"Medicina","issn_l":"1010-660X","issn":["1010-660X","1648-9144"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina","raw_type":"journal-article"},{"id":"pmid:36295583","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36295583","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina (Kaunas, Lithuania)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9611040","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9611040/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina (Kaunas)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:7f935d9c8388415c9370f14cd3b5b39e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7f935d9c8388415c9370f14cd3b5b39e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Medicina, Vol 58, Iss 10, p 1423 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/medicina58101423","doi":"https://doi.org/10.3390/medicina58101423","is_oa":true,"landing_page_url":"https://doi.org/10.3390/medicina58101423","pdf_url":"https://www.mdpi.com/1648-9144/58/10/1423/pdf?version=1665395920","source":{"id":"https://openalex.org/S1008817457","display_name":"Medicina","issn_l":"1010-660X","issn":["1010-660X","1648-9144"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4304136229.pdf","grobid_xml":"https://content.openalex.org/works/W4304136229.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W65283676","https://openalex.org/W157576739","https://openalex.org/W1837090173","https://openalex.org/W1900037312","https://openalex.org/W2000376328","https://openalex.org/W2133298737","https://openalex.org/W2136429263","https://openalex.org/W2173257315","https://openalex.org/W2306517023","https://openalex.org/W2306820912","https://openalex.org/W2337420921","https://openalex.org/W2544610207","https://openalex.org/W2566130574","https://openalex.org/W2741016628","https://openalex.org/W2756089258","https://openalex.org/W2891776958","https://openalex.org/W3000698553","https://openalex.org/W3005595762","https://openalex.org/W3012183387","https://openalex.org/W3091820726","https://openalex.org/W3116221844","https://openalex.org/W3120594975","https://openalex.org/W3155091134","https://openalex.org/W3198740020","https://openalex.org/W3204522434","https://openalex.org/W3215617492"],"related_works":["https://openalex.org/W2889390733","https://openalex.org/W2811123000","https://openalex.org/W2922388035","https://openalex.org/W4391567353","https://openalex.org/W2083659732","https://openalex.org/W4322769087","https://openalex.org/W3108587503","https://openalex.org/W3010723811","https://openalex.org/W3000698553","https://openalex.org/W3024439196"],"abstract_inverted_index":{"Background":[0],"and":[1,44,64,68,102,119,165,198,248],"Objectives:":[2],"Although":[3],"previous":[4],"studies":[5],"showed":[6],"that":[7],"an":[8,171,181,235],"activity":[9,105],"of":[10,31,78,125],"xanthine":[11],"oxidoreductase":[12],"(XOR),":[13],"a":[14,45,53,72,81,129,133,146,157,219,230],"rate-limiting":[15],"enzyme":[16],"in":[17,88,185],"purine":[18],"metabolism,":[19],"beyond":[20],"the":[21,29,36,57,60,90,97,103,117,140,196,202,210,244],"serum":[22],"uric":[23],"acid":[24],"level,":[25],"was":[26,71,94,106,111,177,193,206],"associated":[27,169,207,228],"with":[28,80,96,128,170,208,218,229],"development":[30],"coronary":[32,135],"artery":[33],"disease":[34],"(CAD),":[35],"underlying":[37],"mechanisms":[38],"are":[39],"unclear.":[40],"Because":[41],"endothelial":[42,61,92,148,172,211,232,245],"dysfunction":[43,149,233],"greater":[46],"blood":[47],"pressure":[48],"(BP)":[49],"variability":[50,110,205,250],"may":[51],"play":[52],"role,":[54],"we":[55],"investigated":[56],"relations":[58,242],"among":[59],"function,":[62,246],"XOR,":[63,247],"BP":[65,109,114,204,249],"variability.":[66],"Materials":[67],"Methods:":[69],"This":[70],"post-hoc":[73],"study":[74],"using":[75,113],"pooled":[76],"data":[77],"patients":[79,127,217],"stable":[82,130,220],"CAD":[83,131],"from":[84],"two":[85],"prospective":[86],"investigations,":[87],"which":[89],"systemic":[91,147,231],"function":[93,212],"assessed":[95],"reactive":[98],"hyperemia":[99],"index":[100,161],"(RHI)":[101],"XOR":[104,183,199,237],"measured.":[107],"The":[108,153],"evaluated":[112],"measurements":[115],"during":[116],"three-":[118],"four-day":[120],"hospitalization.":[121],"Results:":[122],"A":[123,174],"total":[124],"106":[126,141],"undergoing":[132],"percutaneous":[134],"intervention":[136],"were":[137,224,251],"included.":[138],"Of":[139],"patients,":[142],"46":[143],"(43.4%)":[144],"had":[145],"(RHI":[150],"<":[151],"1.67).":[152],"multivariable":[154],"analysis":[155],"identified":[156,225],"higher":[158,175],"body":[159],"mass":[160],"(BMI),":[162],"female":[163],"gender,":[164],"diabetes":[166],"as":[167,226],"factors":[168,223],"dysfunction.":[173],"BMI":[176],"also":[178],"related":[179],"to":[180,187],"elevated":[182,236],"activity,":[184],"addition":[186],"current":[188],"smoking.":[189],"No":[190],"significant":[191],"correlation":[192],"observed":[194],"between":[195,243],"RHI":[197],"activity.":[200,238],"Similarly,":[201],"in-hospital":[203],"neither":[209],"nor":[213],"XOR.":[214],"Conclusions:":[215],"Among":[216],"CAD,":[221],"several":[222],"being":[227],"or":[234],"However,":[239],"no":[240],"direct":[241],"found.":[252]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-10-11T00:00:00"}
