{"id":"https://openalex.org/W4303940684","doi":"https://doi.org/10.1016/j.isci.2022.105282","title":"NRas activity is regulated by dynamic interactions with nanoscale signaling clusters at the plasma membrane","display_name":"NRas activity is regulated by dynamic interactions with nanoscale signaling clusters at the plasma membrane","publication_year":2022,"publication_date":"2022-10-09","ids":{"openalex":"https://openalex.org/W4303940684","doi":"https://doi.org/10.1016/j.isci.2022.105282","pmid":"https://pubmed.ncbi.nlm.nih.gov/36304112","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9593252"},"language":"en","primary_location":{"id":"doi:10.1016/j.isci.2022.105282","doi":"https://doi.org/10.1016/j.isci.2022.105282","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.isci.2022.105282","pdf_url":"http://www.cell.com/article/S2589004222015541/pdf","source":{"id":"https://openalex.org/S2898358376","display_name":"iScience","issn_l":"2589-0042","issn":["2589-0042"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.cell.com/article/S2589004222015541/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073113714","display_name":"Oren Yakovian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Oren Yakovian","raw_affiliation_strings":["Racah Institute of Physics, The Hebrew University, Jerusalem 91904, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Racah Institute of Physics, The Hebrew University, Jerusalem 91904, Israel","institution_ids":["https://openalex.org/I197251160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007482121","display_name":"Julia Sajman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Julia Sajman","raw_affiliation_strings":["Racah Institute of Physics, The Hebrew University, Jerusalem 91904, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Racah Institute of Physics, The Hebrew University, Jerusalem 91904, Israel","institution_ids":["https://openalex.org/I197251160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011460999","display_name":"Michal Alon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Michal Alon","raw_affiliation_strings":["Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001 Rehovot, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001 Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088247659","display_name":"Rand Arafeh","orcid":"https://orcid.org/0000-0001-7107-2982","observed_orcids":["https://orcid.org/0000-0001-7107-2982"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL","US"],"is_corresponding":false,"raw_author_name":"Rand Arafeh","raw_affiliation_strings":["Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001 Rehovot, Israel","Department of Molecular Oncology, Dana Farber Cancer Institute, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001 Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]},{"raw_affiliation_string":"Department of Molecular Oncology, Dana Farber Cancer Institute, Boston, MA, USA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042139239","display_name":"Yardena Samuels","orcid":"https://orcid.org/0000-0002-3349-7266","observed_orcids":["https://orcid.org/0000-0002-3349-7266"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Yardena Samuels","raw_affiliation_strings":["Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001 Rehovot, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001 Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007105723","display_name":"Eilon Sherman","orcid":"https://orcid.org/0000-0002-7403-6036","observed_orcids":["https://orcid.org/0000-0002-7403-6036"]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Eilon Sherman","raw_affiliation_strings":["Racah Institute of Physics, The Hebrew University, Jerusalem 91904, Israel"],"raw_orcid":"https://orcid.org/0000-0002-7403-6036","affiliations":[{"raw_affiliation_string":"Racah Institute of Physics, The Hebrew University, Jerusalem 91904, Israel","institution_ids":["https://openalex.org/I197251160"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5007105723"],"corresponding_institution_ids":["https://openalex.org/I197251160"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":{"value":3000,"currency":"USD","value_usd":3000},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.09215154,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"11","first_page":"105282","last_page":"105282"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.01209999993443489,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nras","display_name":"NRAS","score":0.9959999918937683},{"id":"https://openalex.org/keywords/braf","display_name":"BRAF","score":0.890999972820282},{"id":"https://openalex.org/keywords/plasma-membrane","display_name":"plasma membrane","score":0.7860000133514404},{"id":"https://openalex.org/keywords/melanoma-cells","display_name":"melanoma cells","score":0.6610000133514404},{"id":"https://openalex.org/keywords/egf-signaling","display_name":"EGF signaling","score":0.781000018119812},{"id":"https://openalex.org/keywords/grb2","display_name":"Grb2","score":0.656000018119812},{"id":"https://openalex.org/keywords/neurofibromatosis-type-1","display_name":"neurofibromatosis type 1","score":0.8930000066757202},{"id":"https://openalex.org/keywords/lonafarnib","display_name":"lonafarnib","score":0.8109999895095825},{"id":"https://openalex.org/keywords/vemurafenib","display_name":"vemurafenib","score":1.0},{"id":"https://openalex.org/keywords/protein-farnesylation","display_name":"farnesylation","score":0.7739999890327454},{"id":"https://openalex.org/keywords/protein-clustering","display_name":"protein clustering","score":0.4440000057220459},{"id":"https://openalex.org/keywords/mitogenic-signaling","display_name":"mitogenic signaling","score":0.5299999713897705}],"concepts":[{"id":"https://openalex.org/C21790070","wikidata":"https://www.wikidata.org/wiki/Q18030215","display_name":"Neuroblastoma RAS viral oncogene homolog","level":5,"score":0.9599587917327881},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5370728969573975},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.517386794090271},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5121662616729736},{"id":"https://openalex.org/C2779684405","wikidata":"https://www.wikidata.org/wiki/Q17928815","display_name":"FLNA","level":5,"score":0.44720733165740967},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.4169120788574219},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34556907415390015},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.24223974347114563},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.22093448042869568},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.17627033591270447},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16503161191940308},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.12759941816329956},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1049814224243164},{"id":"https://openalex.org/C20563397","wikidata":"https://www.wikidata.org/wiki/Q410803","display_name":"Filamin","level":4,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.isci.2022.105282","doi":"https://doi.org/10.1016/j.isci.2022.105282","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.isci.2022.105282","pdf_url":"http://www.cell.com/article/S2589004222015541/pdf","source":{"id":"https://openalex.org/S2898358376","display_name":"iScience","issn_l":"2589-0042","issn":["2589-0042"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9593252","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9593252","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"Text"},{"id":"pmid:36304112","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36304112","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:bee7726ca2f3415bb0694501caa074a0","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/bee7726ca2f3415bb0694501caa074a0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"iScience, Vol 25, Iss 11, Pp 105282- (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.isci.2022.105282","doi":"https://doi.org/10.1016/j.isci.2022.105282","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.isci.2022.105282","pdf_url":"http://www.cell.com/article/S2589004222015541/pdf","source":{"id":"https://openalex.org/S2898358376","display_name":"iScience","issn_l":"2589-0042","issn":["2589-0042"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3337207098","display_name":null,"funder_award_id":"754282","funder_id":"https://openalex.org/F4320335254","funder_display_name":"Horizon 2020"},{"id":"https://openalex.org/G4306196694","display_name":null,"funder_award_id":"CoG- 770854","funder_id":"https://openalex.org/F4320335254","funder_display_name":"Horizon 2020"},{"id":"https://openalex.org/G7226150580","display_name":"Studying the effects of intra-tumor heterogeneity on  anti-tumor immunity","funder_award_id":"622106","funder_id":"https://openalex.org/F4320308296","funder_display_name":"Melanoma Research Alliance"},{"id":"https://openalex.org/G964253558","display_name":null,"funder_award_id":"696/17","funder_id":"https://openalex.org/F4320322252","funder_display_name":"Israel Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320308296","display_name":"Melanoma Research Alliance","ror":"https://ror.org/025ck6r46"},{"id":"https://openalex.org/F4320320946","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306"},{"id":"https://openalex.org/F4320321950","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017"},{"id":"https://openalex.org/F4320322252","display_name":"Israel Science Foundation","ror":"https://ror.org/04sazxf24"},{"id":"https://openalex.org/F4320329600","display_name":"Rising Tide Foundation","ror":"https://ror.org/00vc9b171"},{"id":"https://openalex.org/F4320332999","display_name":"Horizon 2020 Framework Programme","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320334678","display_name":"European Research Council","ror":"https://ror.org/0472cxd90"},{"id":"https://openalex.org/F4320335254","display_name":"Horizon 2020","ror":null}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4303940684.pdf"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W1492513673","https://openalex.org/W1525183361","https://openalex.org/W1774371590","https://openalex.org/W1994926193","https://openalex.org/W2000638372","https://openalex.org/W2004295816","https://openalex.org/W2004774286","https://openalex.org/W2010558905","https://openalex.org/W2017960640","https://openalex.org/W2019556450","https://openalex.org/W2033185023","https://openalex.org/W2039440578","https://openalex.org/W2050573392","https://openalex.org/W2051165598","https://openalex.org/W2051907667","https://openalex.org/W2054455698","https://openalex.org/W2058142370","https://openalex.org/W2059986841","https://openalex.org/W2060187044","https://openalex.org/W2073998405","https://openalex.org/W2074039305","https://openalex.org/W2076092328","https://openalex.org/W2088293068","https://openalex.org/W2092296126","https://openalex.org/W2096799430","https://openalex.org/W2098802118","https://openalex.org/W2099540110","https://openalex.org/W2103217745","https://openalex.org/W2107495112","https://openalex.org/W2114108194","https://openalex.org/W2120504118","https://openalex.org/W2121936687","https://openalex.org/W2126751256","https://openalex.org/W2129769231","https://openalex.org/W2135371328","https://openalex.org/W2135630804","https://openalex.org/W2163232525","https://openalex.org/W2181106088","https://openalex.org/W2298480233","https://openalex.org/W2404013489","https://openalex.org/W2561607790","https://openalex.org/W2612503082","https://openalex.org/W2731939996","https://openalex.org/W2767044353","https://openalex.org/W2778512169","https://openalex.org/W2785254688","https://openalex.org/W2809088670","https://openalex.org/W2884641847","https://openalex.org/W2983221291","https://openalex.org/W2985910195","https://openalex.org/W3040145735","https://openalex.org/W3115424583","https://openalex.org/W3161763717","https://openalex.org/W3204513074","https://openalex.org/W4205661141","https://openalex.org/W4246498996"],"related_works":["https://openalex.org/W3115424583","https://openalex.org/W4416901886","https://openalex.org/W2008793456","https://openalex.org/W2042298486","https://openalex.org/W2040723945","https://openalex.org/W2096799430","https://openalex.org/W2002869210","https://openalex.org/W2152821435","https://openalex.org/W3134220384","https://openalex.org/W3093206133"],"abstract_inverted_index":{"NRas":[0,42,63,73,89,100,113],"is":[1,130,136],"a":[2,60],"key":[3],"mediator":[4],"of":[5,40,62,119,121,144],"the":[6,22,38,69,99,107,117,151],"mitogenic":[7],"pathway":[8],"in":[9,13,47,71,93,132],"normal":[10],"cells":[11],"and":[12,18,43,64,74,90,134],"cancer":[14],"cells.":[15],"Its":[16],"dynamics":[17],"nanoscale":[19],"organization":[20,39],"at":[21,68,150],"plasma":[23],"membrane":[24],"(PM)":[25],"facilitate":[26],"its":[27],"signaling.":[28],"Here,":[29],"we":[30],"used":[31],"two-color":[32],"photoactivated":[33],"localization":[34],"microscopy":[35],"to":[36,54],"resolve":[37],"individual":[41],"associated":[44,77,115],"signaling":[45],"proteins":[46,149],"live":[48],"melanoma":[49],"cells,":[50],"with":[51,78,116,141],"resolution":[52],"down":[53],"\u223c20":[55],"nm.":[56],"Upon":[57],"EGF":[58],"activation,":[59],"fraction":[61],"BRAF":[65,75,91,108,145],"(dis)assembled":[66],"synchronously":[67],"PM":[70],"co-clusters.":[72],"clusters":[76,95,143],"GPI-enriched":[79],"domains,":[80],"serving":[81],"as":[82],"possible":[83],"nucleation":[84],"sites":[85],"for":[86],"these":[87],"clusters.":[88],"association":[92],"mutual":[94],"was":[96],"reduced":[97],"by":[98,106,138],"farnesylation":[101],"inhibitor":[102,109],"lonafarnib,":[103],"yet":[104],"enhanced":[105],"vemurafenib.":[110],"Surprisingly,":[111],"dispersed":[112],"molecules":[114],"periphery":[118],"self-clusters":[120],"either":[122],"Grb2":[123],"or":[124,146],"NF1.":[125],"Thus,":[126],"NRas-mediated":[127],"signaling,":[128],"which":[129],"critical":[131],"health":[133],"disease,":[135],"regulated":[137],"dynamic":[139],"interactions":[140],"functional":[142],"other":[147],"related":[148],"PM.":[152]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2022-10-10T00:00:00"}
