{"id":"https://openalex.org/W4303699233","doi":"https://doi.org/10.3390/ijms231911745","title":"Augmented CPT1A Expression Is Associated with Proliferation and Colony Formation during Barrett\u2019s Tumorigenesis","display_name":"Augmented CPT1A Expression Is Associated with Proliferation and Colony Formation during Barrett\u2019s Tumorigenesis","publication_year":2022,"publication_date":"2022-10-04","ids":{"openalex":"https://openalex.org/W4303699233","doi":"https://doi.org/10.3390/ijms231911745","pmid":"https://pubmed.ncbi.nlm.nih.gov/36233047","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9570428"},"language":"en","primary_location":{"id":"doi:10.3390/ijms231911745","doi":"https://doi.org/10.3390/ijms231911745","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms231911745","pdf_url":"https://www.mdpi.com/1422-0067/23/19/11745/pdf?version=1665223353","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/23/19/11745/pdf?version=1665223353","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054132743","display_name":"Joshua N. Bernard","orcid":"https://orcid.org/0000-0003-4940-6274","observed_orcids":["https://orcid.org/0000-0003-4940-6274"]},"institutions":[{"id":"https://openalex.org/I106165777","display_name":"University of Central Florida","ror":"https://ror.org/036nfer12","country_code":"US","type":"education","lineage":["https://openalex.org/I106165777"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua N. Bernard","raw_affiliation_strings":["Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32816, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32816, USA","institution_ids":["https://openalex.org/I106165777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031294926","display_name":"Vikram Chinnaiyan","orcid":"https://orcid.org/0000-0001-5458-5495","observed_orcids":["https://orcid.org/0000-0001-5458-5495"]},"institutions":[{"id":"https://openalex.org/I106165777","display_name":"University of Central Florida","ror":"https://ror.org/036nfer12","country_code":"US","type":"education","lineage":["https://openalex.org/I106165777"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vikram Chinnaiyan","raw_affiliation_strings":["Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32816, USA"],"raw_orcid":"https://orcid.org/0000-0001-5458-5495","affiliations":[{"raw_affiliation_string":"Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32816, USA","institution_ids":["https://openalex.org/I106165777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013343878","display_name":"Thomas Andl","orcid":"https://orcid.org/0009-0006-7163-3624","observed_orcids":["https://orcid.org/0009-0006-7163-3624","https://orcid.org/0000-0002-5555-468X"]},"institutions":[{"id":"https://openalex.org/I106165777","display_name":"University of Central Florida","ror":"https://ror.org/036nfer12","country_code":"US","type":"education","lineage":["https://openalex.org/I106165777"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Andl","raw_affiliation_strings":["Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32816, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32816, USA","institution_ids":["https://openalex.org/I106165777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086892130","display_name":"Gr\u00e9goire F. Le Bras","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I106165777","display_name":"University of Central Florida","ror":"https://ror.org/036nfer12","country_code":"US","type":"education","lineage":["https://openalex.org/I106165777"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregoire F. Le Bras","raw_affiliation_strings":["Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32816, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32816, USA","institution_ids":["https://openalex.org/I106165777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113025550","display_name":"M. Nasar Qureshi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Nasar Qureshi","raw_affiliation_strings":["QDx Pathology Services, Edison, NJ 08837, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"QDx Pathology Services, Edison, NJ 08837, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054111631","display_name":"Deborah A. Altomare","orcid":"https://orcid.org/0000-0002-7014-0397","observed_orcids":["https://orcid.org/0000-0002-7014-0397"]},"institutions":[{"id":"https://openalex.org/I106165777","display_name":"University of Central Florida","ror":"https://ror.org/036nfer12","country_code":"US","type":"education","lineage":["https://openalex.org/I106165777"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deborah A. Altomare","raw_affiliation_strings":["Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32816, USA"],"raw_orcid":"https://orcid.org/0000-0002-7014-0397","affiliations":[{"raw_affiliation_string":"Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32816, USA","institution_ids":["https://openalex.org/I106165777"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020588666","display_name":"Claudia D. Andl","orcid":"https://orcid.org/0000-0001-7358-9520","observed_orcids":["https://orcid.org/0000-0001-7358-9520"]},"institutions":[{"id":"https://openalex.org/I106165777","display_name":"University of Central Florida","ror":"https://ror.org/036nfer12","country_code":"US","type":"education","lineage":["https://openalex.org/I106165777"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Claudia D. Andl","raw_affiliation_strings":["Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32816, USA"],"raw_orcid":"https://orcid.org/0000-0001-7358-9520","affiliations":[{"raw_affiliation_string":"Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32816, USA","institution_ids":["https://openalex.org/I106165777"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5020588666"],"corresponding_institution_ids":["https://openalex.org/I106165777"],"apc_list":{"value":2300,"currency":"CHF","value_usd":2408},"apc_paid":{"value":2300,"currency":"CHF","value_usd":2408},"fwci":0.8422,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.65883492,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"23","issue":"19","first_page":"11745","last_page":"11745"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.02419999986886978,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cpt1a","display_name":"CPT1A","score":0.984000027179718},{"id":"https://openalex.org/keywords/barrett-s-esophagus","display_name":"Barrett's esophagus","score":0.9350000023841858},{"id":"https://openalex.org/keywords/esophageal-adenocarcinoma","display_name":"esophageal adenocarcinoma","score":0.9670000076293945},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.7519999742507935},{"id":"https://openalex.org/keywords/gastroesophageal-reflux-disease","display_name":"gastroesophageal reflux disease","score":0.9409999847412109},{"id":"https://openalex.org/keywords/fatty-acid-oxidation","display_name":"fatty acid oxidation","score":0.9440000057220459},{"id":"https://openalex.org/keywords/mitochondrial-fatty-acid-transport","display_name":"mitochondrial fatty acid transport","score":0.7099999785423279},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9580000042915344},{"id":"https://openalex.org/keywords/stemness","display_name":"stemness","score":0.6890000104904175},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.9369999766349792},{"id":"https://openalex.org/keywords/deoxycholic-acid","display_name":"deoxycholic acid","score":0.9819999933242798},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.48399999737739563}],"concepts":[{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6671256422996521},{"id":"https://openalex.org/C2777014526","wikidata":"https://www.wikidata.org/wiki/Q223591","display_name":"GERD","level":4,"score":0.6410967707633972},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6233972311019897},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5781374573707581},{"id":"https://openalex.org/C2778589982","wikidata":"https://www.wikidata.org/wiki/Q808892","display_name":"Barrett's esophagus","level":4,"score":0.502839982509613},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.47209519147872925},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.47141191363334656},{"id":"https://openalex.org/C2779936771","wikidata":"https://www.wikidata.org/wiki/Q209727","display_name":"Palmitic acid","level":3,"score":0.45640647411346436},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.42022499442100525},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41813135147094727},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4145956039428711},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4108462929725647},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.286632776260376},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18862900137901306},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18619170784950256},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.16721534729003906},{"id":"https://openalex.org/C43270747","wikidata":"https://www.wikidata.org/wiki/Q898610","display_name":"Reflux","level":3,"score":0.08212301135063171},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001471","descriptor_name":"Barrett Esophagus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002331","descriptor_name":"Carnitine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002334","descriptor_name":"Carnitine O-Palmitoyltransferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003840","descriptor_name":"Deoxycholic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005764","descriptor_name":"Gastroesophageal Reflux","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019308","descriptor_name":"Palmitic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3390/ijms231911745","doi":"https://doi.org/10.3390/ijms231911745","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms231911745","pdf_url":"https://www.mdpi.com/1422-0067/23/19/11745/pdf?version=1665223353","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9570428","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9570428","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:36233047","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36233047","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:38f6873825b5498389a170e938c96948","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/38f6873825b5498389a170e938c96948","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences, Vol 23, Iss 11745, p 11745 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ijms231911745","doi":"https://doi.org/10.3390/ijms231911745","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms231911745","pdf_url":"https://www.mdpi.com/1422-0067/23/19/11745/pdf?version=1665223353","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320333396","display_name":"College of Medicine, University of Central Florida","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4303699233.pdf","grobid_xml":"https://content.openalex.org/works/W4303699233.grobid-xml"},"referenced_works_count":89,"referenced_works":["https://openalex.org/W1512492520","https://openalex.org/W1818700566","https://openalex.org/W1904009550","https://openalex.org/W1963766953","https://openalex.org/W1968520358","https://openalex.org/W1969133453","https://openalex.org/W1969432813","https://openalex.org/W1995448901","https://openalex.org/W1999231913","https://openalex.org/W1999318918","https://openalex.org/W2000860858","https://openalex.org/W2007788183","https://openalex.org/W2013975797","https://openalex.org/W2015012139","https://openalex.org/W2021408555","https://openalex.org/W2022936535","https://openalex.org/W2031568088","https://openalex.org/W2036681478","https://openalex.org/W2038489646","https://openalex.org/W2048679759","https://openalex.org/W2051590898","https://openalex.org/W2051665354","https://openalex.org/W2053183259","https://openalex.org/W2056633943","https://openalex.org/W2060066452","https://openalex.org/W2063307907","https://openalex.org/W2071509138","https://openalex.org/W2075890816","https://openalex.org/W2077391666","https://openalex.org/W2079894548","https://openalex.org/W2080864928","https://openalex.org/W2083425688","https://openalex.org/W2089507123","https://openalex.org/W2090279335","https://openalex.org/W2101751456","https://openalex.org/W2104364363","https://openalex.org/W2107700622","https://openalex.org/W2112375566","https://openalex.org/W2128758643","https://openalex.org/W2130699826","https://openalex.org/W2153178365","https://openalex.org/W2169850732","https://openalex.org/W2182828813","https://openalex.org/W2233158352","https://openalex.org/W2273316674","https://openalex.org/W2290001148","https://openalex.org/W2399064224","https://openalex.org/W2483248188","https://openalex.org/W2519004842","https://openalex.org/W2728214347","https://openalex.org/W2767614677","https://openalex.org/W2774287749","https://openalex.org/W2792250876","https://openalex.org/W2800440086","https://openalex.org/W2802187571","https://openalex.org/W2809813847","https://openalex.org/W2862616176","https://openalex.org/W2884139219","https://openalex.org/W2911525025","https://openalex.org/W2921621013","https://openalex.org/W2936849550","https://openalex.org/W2963491244","https://openalex.org/W2964925642","https://openalex.org/W2982646774","https://openalex.org/W2986281617","https://openalex.org/W2992324722","https://openalex.org/W2994872141","https://openalex.org/W2997840987","https://openalex.org/W3003346578","https://openalex.org/W3005065004","https://openalex.org/W3005679092","https://openalex.org/W3011143029","https://openalex.org/W3024480685","https://openalex.org/W3026889798","https://openalex.org/W3083115189","https://openalex.org/W3115877346","https://openalex.org/W3119162394","https://openalex.org/W3133167620","https://openalex.org/W3170592680","https://openalex.org/W3201291089","https://openalex.org/W4223590989","https://openalex.org/W4281773617","https://openalex.org/W4284969991","https://openalex.org/W6630630037","https://openalex.org/W6650279918","https://openalex.org/W6670981992","https://openalex.org/W6685749277","https://openalex.org/W6740668303","https://openalex.org/W6773794958"],"related_works":["https://openalex.org/W1990695160","https://openalex.org/W4410426077","https://openalex.org/W7113581588","https://openalex.org/W3024480685","https://openalex.org/W3120109335","https://openalex.org/W2936849550","https://openalex.org/W3119162394","https://openalex.org/W3049056237","https://openalex.org/W2037031629","https://openalex.org/W2588717820"],"abstract_inverted_index":{"Obesity":[0],"is":[1,200,210],"a":[2,50,70,163,179],"known":[3],"risk":[4],"factor":[5],"for":[6],"the":[7,18,47,73,86,89,106,120,174,192],"development":[8],"of":[9,49,88,117,137,149,166,178],"gastroesophageal":[10],"reflux":[11,190],"disease":[12,74],"(GERD),":[13],"Barrett's":[14,144,167,203],"Esophagus":[15],"(BE)":[16],"and":[17,32,59,99,151,176,183,205,214,220],"progression":[19,34,75],"to":[20,29,57,63,78,112,143,186,212],"esophageal":[21,79],"adenocarcinoma.":[22,80],"The":[23],"mechanisms":[24],"by":[25],"which":[26],"obesity":[27],"contributes":[28],"GERD,":[30],"BE":[31,60],"its":[33],"are":[35],"currently":[36],"not":[37],"well":[38,133],"understood.":[39],"Recently,":[40],"changes":[41],"in":[42,46,72,96,105,125,173,191,202],"lipid":[43],"metabolism":[44],"especially":[45],"context":[48],"high":[51,180],"fat":[52,181],"diet":[53,182],"have":[54],"been":[55],"linked":[56],"GERD":[58,77],"leading":[61],"us":[62],"explore":[64],"whether":[65],"fatty":[66,123],"acid":[67,124,141,185,209],"oxidation":[68],"plays":[69],"role":[71],"from":[76,108],"To":[81],"that":[82,198,206],"end,":[83],"we":[84],"analyzed":[85],"expression":[87],"rate-limiting":[90],"enzyme,":[91],"carnitine":[92],"palmytoyltransferase":[93],"1A":[94],"(CPT1A),":[95],"human":[97,126],"tissues":[98],"cell":[100,218,222],"lines":[101],"representing":[102],"different":[103,159],"stages":[104],"sequence":[107],"normal":[109],"squamous":[110],"esophagus":[111,168],"cancer.":[113],"We":[114,156],"determined":[115],"uptake":[116],"palmitic":[118,140,208],"acid,":[119],"most":[121],"abundant":[122],"serum,":[127],"with":[128,139,216],"fluorescent":[129],"dye-labeled":[130],"lipids":[131],"as":[132,134],"functional":[135],"consequences":[136],"stimulation":[138],"relevant":[142],"tumorigenesis,":[145],"e.g.,":[146],"proliferation,":[147],"characteristics":[148],"stemness":[150],"IL8":[152],"mediated":[153],"inflammatory":[154],"signaling.":[155],"further":[157],"employed":[158],"mouse":[160],"models":[161],"including":[162],"genetic":[164],"model":[165],"based":[169],"on":[170],"IL1\u03b2":[171],"overexpression":[172],"presence":[175],"absence":[177],"deoxycholic":[184],"physiologically":[187],"mimic":[188],"gastrointestinal":[189],"mice.":[193],"Together,":[194],"our":[195],"data":[196],"demonstrate":[197],"CPT1A":[199],"upregulated":[201],"tumorigenesis":[204],"experimental":[207],"delivered":[211],"mitochondria":[213],"associated":[215],"increased":[217],"proliferation":[219],"stem":[221],"marker":[223],"expression.":[224]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-10-09T00:00:00"}