{"id":"https://openalex.org/W4303673932","doi":"https://doi.org/10.1186/s12920-022-01370-1","title":"Identification of core genes and pathways between geriatric multimorbidity and renal insufficiency: potential therapeutic agents discovered using bioinformatics analysis","display_name":"Identification of core genes and pathways between geriatric multimorbidity and renal insufficiency: potential therapeutic agents discovered using bioinformatics analysis","publication_year":2022,"publication_date":"2022-10-08","ids":{"openalex":"https://openalex.org/W4303673932","doi":"https://doi.org/10.1186/s12920-022-01370-1","pmid":"https://pubmed.ncbi.nlm.nih.gov/36209090","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9548100"},"language":"en","primary_location":{"id":"doi:10.1186/s12920-022-01370-1","doi":"https://doi.org/10.1186/s12920-022-01370-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12920-022-01370-1","pdf_url":"https://bmcmedgenomics.biomedcentral.com/counter/pdf/10.1186/s12920-022-01370-1","source":{"id":"https://openalex.org/S119250532","display_name":"BMC Medical Genomics","issn_l":"1755-8794","issn":["1755-8794"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Genomics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcmedgenomics.biomedcentral.com/counter/pdf/10.1186/s12920-022-01370-1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100377985","display_name":"Lingyun Zhang","orcid":"https://orcid.org/0000-0001-5733-1810","observed_orcids":["https://orcid.org/0000-0001-5733-1810"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210099446","display_name":"Huadong Hospital","ror":"https://ror.org/012wm7481","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099446"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lingyun Zhang","raw_affiliation_strings":["Department of Nephrology, Huadong Hospital Affiliated to Fudan University, No. 221 West Yan'an Road, Shanghai, 200040, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Huadong Hospital Affiliated to Fudan University, No. 221 West Yan'an Road, Shanghai, 200040, People's Republic of China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210099446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101906520","display_name":"Jiasheng Cai","orcid":"https://orcid.org/0000-0001-7417-6728","observed_orcids":["https://orcid.org/0000-0001-7417-6728"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210099446","display_name":"Huadong Hospital","ror":"https://ror.org/012wm7481","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099446"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiasheng Cai","raw_affiliation_strings":["Department of Cardiology, Huadong Hospital Affiliated to Fudan University, No. 221 West Yan'an Road, Shanghai, 200040, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Huadong Hospital Affiliated to Fudan University, No. 221 West Yan'an Road, Shanghai, 200040, People's Republic of China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210099446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100640349","display_name":"Jing Xiao","orcid":"https://orcid.org/0000-0003-1357-3986","observed_orcids":["https://orcid.org/0000-0003-1357-3986"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210099446","display_name":"Huadong Hospital","ror":"https://ror.org/012wm7481","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099446"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Xiao","raw_affiliation_strings":["Department of Nephrology, Huadong Hospital Affiliated to Fudan University, No. 221 West Yan'an Road, Shanghai, 200040, People's Republic of China","Shanghai Key Laboratory of Clinical Geriatric Medicine, No. 221 West Yan'an Road, Shanghai, 200040, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Huadong Hospital Affiliated to Fudan University, No. 221 West Yan'an Road, Shanghai, 200040, People's Republic of China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210099446"]},{"raw_affiliation_string":"Shanghai Key Laboratory of Clinical Geriatric Medicine, No. 221 West Yan'an Road, Shanghai, 200040, People's Republic of China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100604430","display_name":"Zhibin Ye","orcid":"https://orcid.org/0000-0002-4057-1663","observed_orcids":["https://orcid.org/0000-0002-4057-1663"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210099446","display_name":"Huadong Hospital","ror":"https://ror.org/012wm7481","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099446"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhibin Ye","raw_affiliation_strings":["Department of Nephrology, Huadong Hospital Affiliated to Fudan University, No. 221 West Yan'an Road, Shanghai, 200040, People's Republic of China. yezhibin3@126.com","Shanghai Key Laboratory of Clinical Geriatric Medicine, No. 221 West Yan'an Road, Shanghai, 200040, People's Republic of China. yezhibin3@126.com","Shanghai Key Laboratory of Clinical Geriatric Medicine, No. 221 West Yan'an Road, Shanghai, 200040, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Huadong Hospital Affiliated to Fudan University, No. 221 West Yan'an Road, Shanghai, 200040, People's Republic of China. yezhibin3@126.com","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210099446"]},{"raw_affiliation_string":"Shanghai Key Laboratory of Clinical Geriatric Medicine, No. 221 West Yan'an Road, Shanghai, 200040, People's Republic of China. yezhibin3@126.com","institution_ids":[]},{"raw_affiliation_string":"Shanghai Key Laboratory of Clinical Geriatric Medicine, No. 221 West Yan'an Road, Shanghai, 200040, People's Republic of China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100604430"],"corresponding_institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210099446"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":0.3651,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.4348916,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"15","issue":"1","first_page":"212","last_page":"212"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.00989999994635582,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12246","display_name":"Chronic Disease Management Strategies","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kidney-failure","display_name":"renal failure","score":0.9750000238418579},{"id":"https://openalex.org/keywords/core-genes","display_name":"core genes","score":0.8889999985694885},{"id":"https://openalex.org/keywords/protein-protein-interaction-network","display_name":"protein-protein interaction network","score":0.8309999704360962},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.8489999771118164},{"id":"https://openalex.org/keywords/drug-gene-interactions","display_name":"drug-gene interactions","score":0.6890000104904175},{"id":"https://openalex.org/keywords/hif-1-signaling-pathway","display_name":"HIF-1 signaling","score":0.9210000038146973},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.9890000224113464},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.996999979019165},{"id":"https://openalex.org/keywords/rap1-signaling-pathway","display_name":"Rap1 signaling","score":0.972000002861023},{"id":"https://openalex.org/keywords/foxo-signaling-pathway","display_name":"FoxO signaling","score":0.9959999918937683},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.6690000295639038},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.41499999165534973},{"id":"https://openalex.org/keywords/gene-modules","display_name":"gene modules","score":0.41499999165534973},{"id":"https://openalex.org/keywords/literature-mining","display_name":"literature mining","score":0.4830000102519989},{"id":"https://openalex.org/keywords/kegg-pathways","display_name":"KEGG pathways","score":0.515999972820282}],"concepts":[{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.8167810440063477},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6807764172554016},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5545229911804199},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5167745351791382},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.49874067306518555},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4969971477985382},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4116394817829132},{"id":"https://openalex.org/C2987395477","wikidata":"https://www.wikidata.org/wiki/Q135085","display_name":"Gene ontology","level":4,"score":0.37245017290115356},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3273288607597351},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.32309889793395996},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.12001451849937439},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001055","descriptor_name":"Apolipoproteins B","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014841","descriptor_name":"von Willebrand Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12920-022-01370-1","doi":"https://doi.org/10.1186/s12920-022-01370-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12920-022-01370-1","pdf_url":"https://bmcmedgenomics.biomedcentral.com/counter/pdf/10.1186/s12920-022-01370-1","source":{"id":"https://openalex.org/S119250532","display_name":"BMC Medical Genomics","issn_l":"1755-8794","issn":["1755-8794"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Genomics","raw_type":"journal-article"},{"id":"pmid:36209090","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36209090","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC medical genomics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9548100","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9548100/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Med Genomics","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:a607e9eeb7a54cbebce529487ed9ab4f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a607e9eeb7a54cbebce529487ed9ab4f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Medical Genomics, Vol 15, Iss 1, Pp 1-16 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12920-022-01370-1","doi":"https://doi.org/10.1186/s12920-022-01370-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12920-022-01370-1","pdf_url":"https://bmcmedgenomics.biomedcentral.com/counter/pdf/10.1186/s12920-022-01370-1","source":{"id":"https://openalex.org/S119250532","display_name":"BMC Medical Genomics","issn_l":"1755-8794","issn":["1755-8794"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Genomics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4303673932.pdf","grobid_xml":"https://content.openalex.org/works/W4303673932.grobid-xml"},"referenced_works_count":94,"referenced_works":["https://openalex.org/W1742887464","https://openalex.org/W1968216888","https://openalex.org/W1970024336","https://openalex.org/W1977645780","https://openalex.org/W1997788079","https://openalex.org/W2001905427","https://openalex.org/W2013215719","https://openalex.org/W2018263823","https://openalex.org/W2022827814","https://openalex.org/W2031934493","https://openalex.org/W2032385561","https://openalex.org/W2040649891","https://openalex.org/W2045805549","https://openalex.org/W2046913611","https://openalex.org/W2050412522","https://openalex.org/W2054774757","https://openalex.org/W2064387909","https://openalex.org/W2072075701","https://openalex.org/W2091126564","https://openalex.org/W2092576380","https://openalex.org/W2095134907","https://openalex.org/W2096041824","https://openalex.org/W2096172976","https://openalex.org/W2097795961","https://openalex.org/W2098919289","https://openalex.org/W2103912979","https://openalex.org/W2109468921","https://openalex.org/W2110065044","https://openalex.org/W2111297349","https://openalex.org/W2122231459","https://openalex.org/W2127848583","https://openalex.org/W2128043538","https://openalex.org/W2129550243","https://openalex.org/W2134382817","https://openalex.org/W2142663409","https://openalex.org/W2146152479","https://openalex.org/W2150341551","https://openalex.org/W2150392051","https://openalex.org/W2152026276","https://openalex.org/W2153827064","https://openalex.org/W2160200374","https://openalex.org/W2160478953","https://openalex.org/W2169496253","https://openalex.org/W2260288236","https://openalex.org/W2313959068","https://openalex.org/W2407612039","https://openalex.org/W2411709723","https://openalex.org/W2419606033","https://openalex.org/W2517599798","https://openalex.org/W2555135869","https://openalex.org/W2559588208","https://openalex.org/W2579804224","https://openalex.org/W2581017269","https://openalex.org/W2592236989","https://openalex.org/W2604690869","https://openalex.org/W2605440965","https://openalex.org/W2611129838","https://openalex.org/W2624957646","https://openalex.org/W2735269058","https://openalex.org/W2745171555","https://openalex.org/W2755254707","https://openalex.org/W2768325747","https://openalex.org/W2790711259","https://openalex.org/W2790847363","https://openalex.org/W2799819345","https://openalex.org/W2803769911","https://openalex.org/W2885079199","https://openalex.org/W2895377702","https://openalex.org/W2898861784","https://openalex.org/W2900569176","https://openalex.org/W2902388368","https://openalex.org/W2915535942","https://openalex.org/W2926369480","https://openalex.org/W2937282237","https://openalex.org/W2950764390","https://openalex.org/W2953874195","https://openalex.org/W2954314387","https://openalex.org/W2968135250","https://openalex.org/W2972899591","https://openalex.org/W2977045527","https://openalex.org/W2990498378","https://openalex.org/W2996969437","https://openalex.org/W3005148546","https://openalex.org/W3005796640","https://openalex.org/W3009494702","https://openalex.org/W3035166162","https://openalex.org/W3085873852","https://openalex.org/W3088672756","https://openalex.org/W3094338795","https://openalex.org/W3107626709","https://openalex.org/W3118702489","https://openalex.org/W3202248585","https://openalex.org/W4211053686","https://openalex.org/W4239791813"],"related_works":["https://openalex.org/W4205424097","https://openalex.org/W7160432042","https://openalex.org/W4308722202","https://openalex.org/W4291008891","https://openalex.org/W4283590187","https://openalex.org/W7168765471","https://openalex.org/W4410051755","https://openalex.org/W7221508812","https://openalex.org/W4313539361","https://openalex.org/W4399830676"],"abstract_inverted_index":{"BACKGROUND:":[0],"Geriatric":[1],"people":[2],"are":[3],"prone":[4],"to":[5,25,55,73,166,174,217],"suffer":[6],"from":[7],"multiple":[8],"chronic":[9],"diseases,":[10],"which":[11],"can":[12],"directly":[13],"or":[14],"indirectly":[15],"affect":[16],"renal":[17,33,45,179,244,316,338],"function.":[18],"Through":[19,187],"bioinformatics":[20],"analysis,":[21],"this":[22],"study":[23,280],"aimed":[24],"identify":[26,175],"key":[27,311],"genes":[28,57,152,173,191,231,240,270,312],"and":[29,40,65,81,86,98,108,115,129,148,157,196,208,213,256,308,335],"pathways":[30,149,259],"associated":[31,58,192,242],"with":[32,37,59,183,193,243,248,315,320],"insufficiency":[34,180,245,317],"in":[35,100,137,181,233,246,318],"patients":[36,182,247,319],"geriatric":[38,184,249,321],"multimorbidity":[39],"explore":[41,167],"potential":[42,330],"drugs":[43,326],"against":[44],"insufficiency.":[46,339],"METHODS:":[47],"The":[48,68,229,251],"text":[49,188],"mining":[50],"tool":[51],"Pubmed2Ensembl":[52],"was":[53,71,104,121,164,211,215],"used":[54,72,165,216],"detect":[56],"the":[60,124,146,160,171,219,267,333],"keywords":[61],"including":[62],"\"Geriatric\",":[63,194],"\"Multimorbidity\"":[64,195],"\"Renal":[66,197],"insufficiency\".":[67],"GeneCodis":[69],"program":[70],"specify":[74],"Gene":[75],"Ontology":[76],"(GO)":[77],"biological":[78],"process":[79],"terms":[80],"Kyoto":[82],"Encyclopedia":[83],"of":[84,118,150,170,205,266,337],"Genes":[85,135],"Genomes":[87],"(KEGG)":[88],"pathways.":[89],"Protein-protein":[90],"interaction":[91,162],"(PPI)":[92],"networks":[93],"were":[94,140,153,199,224,235,260,310,327],"constructed":[95,212],"using":[96,106,123,155],"STRING":[97],"visualized":[99,154],"Cytoscape.":[101],"Module":[102],"analysis":[103,117],"performed":[105,122],"CytoHubba":[107,214],"Molecular":[109],"Complex":[110],"Detection":[111],"(MCODE)":[112],"plugins.":[113],"GO":[114],"KEGG":[116],"gene":[119,222],"modules":[120,139,223],"Database":[125],"for":[126,178,332],"Annotation,":[127],"Visualization":[128],"Integrated":[130],"Discover":[131],"(DAVID)":[132],"platform":[133],"database.":[134],"clustered":[136,232],"salient":[138],"selected":[141,236,269],"as":[142,237,329],"core":[143,151,172,238],"genes.":[144,220],"Then,":[145],"functions":[147],"ClueGO":[156],"CluePedia.":[158],"Finally,":[159],"drug-gene":[161,168],"database":[163],"interactions":[169],"drug":[176],"candidates":[177],"multimorbidity.":[185,250,322],"RESULTS:":[186],"mining,":[189],"351":[190],"insufficiency\"":[198],"identified.":[200],"A":[201],"PPI":[202],"network":[203],"consisting":[204],"216":[206],"nodes":[207],"1087":[209],"edges":[210],"sequence":[218],"Five":[221],"obtained":[225],"by":[226,274],"MCODE":[227],"analysis.":[228],"26":[230,268],"module1":[234],"candidate":[239],"primarily":[241],"HIF-1,":[252],"PI3K-Akt,":[253],"MAPK,":[254],"Rap1,":[255],"FoxO":[257],"signaling":[258],"enriched.":[261],"We":[262],"found":[263],"that":[264,282],"21":[265],"could":[271],"be":[272],"targeted":[273],"34":[275,325],"existing":[276],"drugs.":[277],"CONCLUSION:":[278],"This":[279],"indicated":[281],"CST3,":[283],"SERPINA1,":[284],"FN1,":[285],"PF4,":[286],"IGF1,":[287],"KNG1,":[288],"IL6,":[289],"VEGFA,":[290],"ALB,":[291],"TIMP1,":[292],"TGFB1,":[293],"HGF,":[294],"SERPINE1,":[295],"APOA1,":[296],"APOB,":[297],"FGF23,":[298],"EGF,":[299],"APOE,":[300],"VWF,":[301],"TF,":[302],"CP,":[303],"GAS6,":[304],"APP,":[305],"IGFBP3,":[306],"P4HB,":[307],"SPP1":[309],"potentially":[313],"involved":[314],"In":[323],"addition,":[324],"identified":[328],"agents":[331],"treatment":[334],"management":[336]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-10-08T00:00:00"}