{"id":"https://openalex.org/W4303457390","doi":"https://doi.org/10.1038/s41467-022-33632-y","title":"The spike gene is a major determinant for the SARS-CoV-2 Omicron-BA.1 phenotype","display_name":"The spike gene is a major determinant for the SARS-CoV-2 Omicron-BA.1 phenotype","publication_year":2022,"publication_date":"2022-10-07","ids":{"openalex":"https://openalex.org/W4303457390","doi":"https://doi.org/10.1038/s41467-022-33632-y","pmid":"https://pubmed.ncbi.nlm.nih.gov/36207334"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-022-33632-y","doi":"https://doi.org/10.1038/s41467-022-33632-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-022-33632-y","pdf_url":"https://www.nature.com/articles/s41467-022-33632-y.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-022-33632-y.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026079974","display_name":"G. Tuba Barut","orcid":"https://orcid.org/0000-0002-3863-0775","observed_orcids":["https://orcid.org/0000-0002-3863-0775"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I4405278312","display_name":"Institut f\u00fcr Virologie und Immunologie","ror":"https://ror.org/05p45f608","country_code":"CH","type":"government","lineage":["https://openalex.org/I4210105614","https://openalex.org/I4405278312"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"G. Tuba Barut","raw_affiliation_strings":["Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland","Institute of Virology and Immunology, Bern and Mittelh\u00e4usern, Bern, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-3863-0775","affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"Institute of Virology and Immunology, Bern and Mittelh\u00e4usern, Bern, Switzerland","institution_ids":["https://openalex.org/I4405278312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005187036","display_name":"Nico Jo\u00ebl Halwe","orcid":"https://orcid.org/0000-0002-7983-2808","observed_orcids":["https://orcid.org/0000-0002-7983-2808"]},"institutions":[{"id":"https://openalex.org/I1310048521","display_name":"Friedrich-Loeffler-Institut","ror":"https://ror.org/025fw7a54","country_code":"DE","type":"government","lineage":["https://openalex.org/I1310048521","https://openalex.org/I2801963157"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nico Joel Halwe","raw_affiliation_strings":["Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Greifswald, Germany"],"raw_orcid":"https://orcid.org/0000-0002-7983-2808","affiliations":[{"raw_affiliation_string":"Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Greifswald, Germany","institution_ids":["https://openalex.org/I1310048521"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055289181","display_name":"Adriano Taddeo","orcid":"https://orcid.org/0000-0003-3281-1548","observed_orcids":["https://orcid.org/0000-0003-3281-1548"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I4405278312","display_name":"Institut f\u00fcr Virologie und Immunologie","ror":"https://ror.org/05p45f608","country_code":"CH","type":"government","lineage":["https://openalex.org/I4210105614","https://openalex.org/I4405278312"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Adriano Taddeo","raw_affiliation_strings":["Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland","Institute of Virology and Immunology, Bern and Mittelh\u00e4usern, Bern, Switzerland"],"raw_orcid":"https://orcid.org/0000-0003-3281-1548","affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"Institute of Virology and Immunology, Bern and Mittelh\u00e4usern, Bern, Switzerland","institution_ids":["https://openalex.org/I4405278312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003725316","display_name":"Jenna Nicole Kelly","orcid":"https://orcid.org/0000-0001-7265-2233","observed_orcids":["https://orcid.org/0000-0001-7265-2233"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I4405278312","display_name":"Institut f\u00fcr Virologie und Immunologie","ror":"https://ror.org/05p45f608","country_code":"CH","type":"government","lineage":["https://openalex.org/I4210105614","https://openalex.org/I4405278312"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Jenna N. Kelly","raw_affiliation_strings":["Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland","European Virus Bioinformatics Center, Jena, Germany","Institute of Virology and Immunology, Bern and Mittelh\u00e4usern, Bern, Switzerland","Multidisciplinary Center for Infectious Diseases, University of Bern, Bern, Switzerland"],"raw_orcid":"https://orcid.org/0000-0001-7265-2233","affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"European Virus Bioinformatics Center, Jena, Germany","institution_ids":[]},{"raw_affiliation_string":"Institute of Virology and Immunology, Bern and Mittelh\u00e4usern, Bern, Switzerland","institution_ids":["https://openalex.org/I4405278312"]},{"raw_affiliation_string":"Multidisciplinary Center for Infectious Diseases, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074491535","display_name":"Jacob Sch\u00f6n","orcid":"https://orcid.org/0000-0002-9801-7972","observed_orcids":["https://orcid.org/0000-0002-9801-7972"]},"institutions":[{"id":"https://openalex.org/I1310048521","display_name":"Friedrich-Loeffler-Institut","ror":"https://ror.org/025fw7a54","country_code":"DE","type":"government","lineage":["https://openalex.org/I1310048521","https://openalex.org/I2801963157"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jacob Sch\u00f6n","raw_affiliation_strings":["Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Greifswald, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Greifswald, Germany","institution_ids":["https://openalex.org/I1310048521"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069347522","display_name":"Nadine Ebert","orcid":"https://orcid.org/0000-0001-7603-1864","observed_orcids":["https://orcid.org/0000-0001-7603-1864"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I4405278312","display_name":"Institut f\u00fcr Virologie und Immunologie","ror":"https://ror.org/05p45f608","country_code":"CH","type":"government","lineage":["https://openalex.org/I4210105614","https://openalex.org/I4405278312"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Nadine Ebert","raw_affiliation_strings":["Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland","Institute of Virology and Immunology, Bern and Mittelh\u00e4usern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"Institute of Virology and Immunology, Bern and Mittelh\u00e4usern, Bern, Switzerland","institution_ids":["https://openalex.org/I4405278312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070237970","display_name":"Lorenz Ulrich","orcid":"https://orcid.org/0000-0001-5004-806X","observed_orcids":["https://orcid.org/0000-0001-5004-806X"]},"institutions":[{"id":"https://openalex.org/I1310048521","display_name":"Friedrich-Loeffler-Institut","ror":"https://ror.org/025fw7a54","country_code":"DE","type":"government","lineage":["https://openalex.org/I1310048521","https://openalex.org/I2801963157"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lorenz Ulrich","raw_affiliation_strings":["Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Greifswald, Germany"],"raw_orcid":"https://orcid.org/0000-0001-5004-806X","affiliations":[{"raw_affiliation_string":"Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Greifswald, Germany","institution_ids":["https://openalex.org/I1310048521"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086350238","display_name":"Christelle Devisme","orcid":"https://orcid.org/0000-0002-5219-1131","observed_orcids":["https://orcid.org/0000-0002-5219-1131"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I4405278312","display_name":"Institut f\u00fcr Virologie und Immunologie","ror":"https://ror.org/05p45f608","country_code":"CH","type":"government","lineage":["https://openalex.org/I4210105614","https://openalex.org/I4405278312"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Christelle Devisme","raw_affiliation_strings":["Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland","Institute of Virology and Immunology, Bern and Mittelh\u00e4usern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"Institute of Virology and Immunology, Bern and Mittelh\u00e4usern, Bern, Switzerland","institution_ids":["https://openalex.org/I4405278312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047600157","display_name":"Silvio Steiner","orcid":"https://orcid.org/0000-0003-1999-1425","observed_orcids":["https://orcid.org/0000-0003-1999-1425"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I4405278312","display_name":"Institut f\u00fcr Virologie und Immunologie","ror":"https://ror.org/05p45f608","country_code":"CH","type":"government","lineage":["https://openalex.org/I4210105614","https://openalex.org/I4405278312"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Silvio Steiner","raw_affiliation_strings":["Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland","Institute of Virology and Immunology, Bern and Mittelh\u00e4usern, Bern, Switzerland"],"raw_orcid":"https://orcid.org/0000-0003-1999-1425","affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"Institute of Virology and Immunology, Bern and Mittelh\u00e4usern, Bern, Switzerland","institution_ids":["https://openalex.org/I4405278312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072645095","display_name":"Bettina Salome Tr\u00fceb","orcid":"https://orcid.org/0000-0001-7256-9245","observed_orcids":["https://orcid.org/0000-0001-7256-9245"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I4405278312","display_name":"Institut f\u00fcr Virologie und Immunologie","ror":"https://ror.org/05p45f608","country_code":"CH","type":"government","lineage":["https://openalex.org/I4210105614","https://openalex.org/I4405278312"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Bettina Salome Tr\u00fceb","raw_affiliation_strings":["Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland","Institute of Virology and Immunology, Bern and Mittelh\u00e4usern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"Institute of Virology and Immunology, Bern and Mittelh\u00e4usern, Bern, Switzerland","institution_ids":["https://openalex.org/I4405278312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064611708","display_name":"Bernd Hoffmann","orcid":"https://orcid.org/0000-0001-5358-6445","observed_orcids":["https://orcid.org/0000-0001-5358-6445"]},"institutions":[{"id":"https://openalex.org/I1310048521","display_name":"Friedrich-Loeffler-Institut","ror":"https://ror.org/025fw7a54","country_code":"DE","type":"government","lineage":["https://openalex.org/I1310048521","https://openalex.org/I2801963157"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bernd Hoffmann","raw_affiliation_strings":["Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Greifswald, Germany"],"raw_orcid":"https://orcid.org/0000-0001-5358-6445","affiliations":[{"raw_affiliation_string":"Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Greifswald, Germany","institution_ids":["https://openalex.org/I1310048521"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091672823","display_name":"In\u00eas Berenguer Veiga","orcid":"https://orcid.org/0000-0001-8554-790X","observed_orcids":["https://orcid.org/0000-0001-8554-790X"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I4405278312","display_name":"Institut f\u00fcr Virologie und Immunologie","ror":"https://ror.org/05p45f608","country_code":"CH","type":"government","lineage":["https://openalex.org/I4210105614","https://openalex.org/I4405278312"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"In\u00eas Berenguer Veiga","raw_affiliation_strings":["Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland","Institute of Virology and Immunology, Bern and Mittelh\u00e4usern, Bern, Switzerland"],"raw_orcid":"https://orcid.org/0000-0001-8554-790X","affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"Institute of Virology and Immunology, Bern and Mittelh\u00e4usern, Bern, Switzerland","institution_ids":["https://openalex.org/I4405278312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078947079","display_name":"Nathan Georges Fran\u00e7ois Leborgne","orcid":"https://orcid.org/0000-0002-1405-1023","observed_orcids":["https://orcid.org/0000-0002-1405-1023"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I4405278312","display_name":"Institut f\u00fcr Virologie und Immunologie","ror":"https://ror.org/05p45f608","country_code":"CH","type":"government","lineage":["https://openalex.org/I4210105614","https://openalex.org/I4405278312"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Nathan Georges Fran\u00e7ois Leborgne","raw_affiliation_strings":["Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland","Institute of Virology and Immunology, Bern and Mittelh\u00e4usern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"Institute of Virology and Immunology, Bern and Mittelh\u00e4usern, Bern, Switzerland","institution_ids":["https://openalex.org/I4405278312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082604979","display_name":"\u00c9tori Aguiar Moreira","orcid":"https://orcid.org/0000-0003-2976-5325","observed_orcids":["https://orcid.org/0000-0003-2976-5325"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I4405278312","display_name":"Institut f\u00fcr Virologie und Immunologie","ror":"https://ror.org/05p45f608","country_code":"CH","type":"government","lineage":["https://openalex.org/I4210105614","https://openalex.org/I4405278312"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Etori Aguiar Moreira","raw_affiliation_strings":["Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland","Institute of Virology and Immunology, Bern and Mittelh\u00e4usern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"Institute of Virology and Immunology, Bern and Mittelh\u00e4usern, Bern, Switzerland","institution_ids":["https://openalex.org/I4405278312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014889492","display_name":"Angele Breithaupt","orcid":"https://orcid.org/0000-0002-6373-5923","observed_orcids":["https://orcid.org/0000-0002-6373-5923"]},"institutions":[{"id":"https://openalex.org/I1310048521","display_name":"Friedrich-Loeffler-Institut","ror":"https://ror.org/025fw7a54","country_code":"DE","type":"government","lineage":["https://openalex.org/I1310048521","https://openalex.org/I2801963157"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Angele Breithaupt","raw_affiliation_strings":["Department of Experimental Animal Facilities and Biorisk Management, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Greifswald, Germany"],"raw_orcid":"https://orcid.org/0000-0002-6373-5923","affiliations":[{"raw_affiliation_string":"Department of Experimental Animal Facilities and Biorisk Management, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Greifswald, Germany","institution_ids":["https://openalex.org/I1310048521"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065565260","display_name":"Claudia Wylezich","orcid":"https://orcid.org/0000-0002-0436-4480","observed_orcids":["https://orcid.org/0000-0002-0436-4480"]},"institutions":[{"id":"https://openalex.org/I1310048521","display_name":"Friedrich-Loeffler-Institut","ror":"https://ror.org/025fw7a54","country_code":"DE","type":"government","lineage":["https://openalex.org/I1310048521","https://openalex.org/I2801963157"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Claudia Wylezich","raw_affiliation_strings":["Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Greifswald, Germany"],"raw_orcid":"https://orcid.org/0000-0002-0436-4480","affiliations":[{"raw_affiliation_string":"Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Greifswald, Germany","institution_ids":["https://openalex.org/I1310048521"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056334251","display_name":"Dirk W. H\u00f6per","orcid":"https://orcid.org/0000-0001-8408-2274","observed_orcids":["https://orcid.org/0000-0001-8408-2274"]},"institutions":[{"id":"https://openalex.org/I1310048521","display_name":"Friedrich-Loeffler-Institut","ror":"https://ror.org/025fw7a54","country_code":"DE","type":"government","lineage":["https://openalex.org/I1310048521","https://openalex.org/I2801963157"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dirk H\u00f6per","raw_affiliation_strings":["Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Greifswald, Germany"],"raw_orcid":"https://orcid.org/0000-0001-8408-2274","affiliations":[{"raw_affiliation_string":"Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Greifswald, Germany","institution_ids":["https://openalex.org/I1310048521"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040790794","display_name":"Kerstin Wernike","orcid":"https://orcid.org/0000-0001-8071-0827","observed_orcids":["https://orcid.org/0000-0001-8071-0827"]},"institutions":[{"id":"https://openalex.org/I1310048521","display_name":"Friedrich-Loeffler-Institut","ror":"https://ror.org/025fw7a54","country_code":"DE","type":"government","lineage":["https://openalex.org/I1310048521","https://openalex.org/I2801963157"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kerstin Wernike","raw_affiliation_strings":["Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Greifswald, Germany"],"raw_orcid":"https://orcid.org/0000-0001-8071-0827","affiliations":[{"raw_affiliation_string":"Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Greifswald, Germany","institution_ids":["https://openalex.org/I1310048521"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021484789","display_name":"Aur\u00e9lie Godel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I4405278312","display_name":"Institut f\u00fcr Virologie und Immunologie","ror":"https://ror.org/05p45f608","country_code":"CH","type":"government","lineage":["https://openalex.org/I4210105614","https://openalex.org/I4405278312"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Aur\u00e9lie Godel","raw_affiliation_strings":["Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland","Institute of Virology and Immunology, Bern and Mittelh\u00e4usern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"Institute of Virology and Immunology, Bern and Mittelh\u00e4usern, Bern, Switzerland","institution_ids":["https://openalex.org/I4405278312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013962805","display_name":"Lisa Thomann","orcid":"https://orcid.org/0000-0003-3530-0524","observed_orcids":["https://orcid.org/0000-0003-3530-0524"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I4405278312","display_name":"Institut f\u00fcr Virologie und Immunologie","ror":"https://ror.org/05p45f608","country_code":"CH","type":"government","lineage":["https://openalex.org/I4210105614","https://openalex.org/I4405278312"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Lisa Thomann","raw_affiliation_strings":["Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland","Institute of Virology and Immunology, Bern and Mittelh\u00e4usern, Bern, Switzerland"],"raw_orcid":"https://orcid.org/0000-0003-3530-0524","affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"Institute of Virology and Immunology, Bern and Mittelh\u00e4usern, Bern, Switzerland","institution_ids":["https://openalex.org/I4405278312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040359490","display_name":"Vera Fl\u00fcck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I4405278312","display_name":"Institut f\u00fcr Virologie und Immunologie","ror":"https://ror.org/05p45f608","country_code":"CH","type":"government","lineage":["https://openalex.org/I4210105614","https://openalex.org/I4405278312"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Vera Fl\u00fcck","raw_affiliation_strings":["Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland","Institute of Virology and Immunology, Bern and Mittelh\u00e4usern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"Institute of Virology and Immunology, Bern and Mittelh\u00e4usern, Bern, Switzerland","institution_ids":["https://openalex.org/I4405278312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058142962","display_name":"Hanspeter Stalder","orcid":"https://orcid.org/0000-0003-0763-6469","observed_orcids":["https://orcid.org/0000-0003-0763-6469"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I4405278312","display_name":"Institut f\u00fcr Virologie und Immunologie","ror":"https://ror.org/05p45f608","country_code":"CH","type":"government","lineage":["https://openalex.org/I4210105614","https://openalex.org/I4405278312"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Hanspeter Stalder","raw_affiliation_strings":["Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland","Institute of Virology and Immunology, Bern and Mittelh\u00e4usern, Bern, Switzerland"],"raw_orcid":"https://orcid.org/0000-0003-0763-6469","affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"Institute of Virology and Immunology, Bern and Mittelh\u00e4usern, Bern, Switzerland","institution_ids":["https://openalex.org/I4405278312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066849540","display_name":"Melanie Br\u00fcgger","orcid":"https://orcid.org/0000-0003-3810-7682","observed_orcids":["https://orcid.org/0000-0003-3810-7682"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I4405278312","display_name":"Institut f\u00fcr Virologie und Immunologie","ror":"https://ror.org/05p45f608","country_code":"CH","type":"government","lineage":["https://openalex.org/I4210105614","https://openalex.org/I4405278312"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Melanie Br\u00fcgger","raw_affiliation_strings":["Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland","Institute of Virology and Immunology, Bern and Mittelh\u00e4usern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"Institute of Virology and Immunology, Bern and Mittelh\u00e4usern, Bern, Switzerland","institution_ids":["https://openalex.org/I4405278312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062759441","display_name":"Blandina I. Oliveira Esteves","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I4405278312","display_name":"Institut f\u00fcr Virologie und Immunologie","ror":"https://ror.org/05p45f608","country_code":"CH","type":"government","lineage":["https://openalex.org/I4210105614","https://openalex.org/I4405278312"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Blandina I. Oliveira Esteves","raw_affiliation_strings":["Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland","Institute of Virology and Immunology, Bern and Mittelh\u00e4usern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"Institute of Virology and Immunology, Bern and Mittelh\u00e4usern, Bern, Switzerland","institution_ids":["https://openalex.org/I4405278312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007169418","display_name":"B\u00e9atrice Zumkehr","orcid":"https://orcid.org/0000-0002-4696-3019","observed_orcids":["https://orcid.org/0000-0002-4696-3019"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I4405278312","display_name":"Institut f\u00fcr Virologie und Immunologie","ror":"https://ror.org/05p45f608","country_code":"CH","type":"government","lineage":["https://openalex.org/I4210105614","https://openalex.org/I4405278312"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Beatrice Zumkehr","raw_affiliation_strings":["Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland","Institute of Virology and Immunology, Bern and Mittelh\u00e4usern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"Institute of Virology and Immunology, Bern and Mittelh\u00e4usern, Bern, Switzerland","institution_ids":["https://openalex.org/I4405278312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083144920","display_name":"Guillaume Beilleau","orcid":"https://orcid.org/0000-0002-5528-7227","observed_orcids":["https://orcid.org/0000-0002-5528-7227"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I4405278312","display_name":"Institut f\u00fcr Virologie und Immunologie","ror":"https://ror.org/05p45f608","country_code":"CH","type":"government","lineage":["https://openalex.org/I4210105614","https://openalex.org/I4405278312"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Guillaume Beilleau","raw_affiliation_strings":["Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland","Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland","Institute of Virology and Immunology, Bern and Mittelh\u00e4usern, Bern, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-5528-7227","affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"Institute of Virology and Immunology, Bern and Mittelh\u00e4usern, Bern, Switzerland","institution_ids":["https://openalex.org/I4405278312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059029831","display_name":"Annika Kratzel","orcid":"https://orcid.org/0000-0001-8468-4742","observed_orcids":["https://orcid.org/0000-0001-8468-4742"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I4405278312","display_name":"Institut f\u00fcr Virologie und Immunologie","ror":"https://ror.org/05p45f608","country_code":"CH","type":"government","lineage":["https://openalex.org/I4210105614","https://openalex.org/I4405278312"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Annika Kratzel","raw_affiliation_strings":["Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland","Institute of Virology and Immunology, Bern and Mittelh\u00e4usern, Bern, Switzerland"],"raw_orcid":"https://orcid.org/0000-0001-8468-4742","affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"Institute of Virology and Immunology, Bern and Mittelh\u00e4usern, Bern, Switzerland","institution_ids":["https://openalex.org/I4405278312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035586417","display_name":"Kimberly Schmied","orcid":"https://orcid.org/0000-0002-6158-7074","observed_orcids":["https://orcid.org/0000-0002-6158-7074"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I4405278312","display_name":"Institut f\u00fcr Virologie und Immunologie","ror":"https://ror.org/05p45f608","country_code":"CH","type":"government","lineage":["https://openalex.org/I4210105614","https://openalex.org/I4405278312"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Kimberly Schmied","raw_affiliation_strings":["Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland","Institute of Virology and Immunology, Bern and Mittelh\u00e4usern, Bern, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-6158-7074","affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"Institute of Virology and Immunology, Bern and Mittelh\u00e4usern, Bern, Switzerland","institution_ids":["https://openalex.org/I4405278312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022492897","display_name":"Sarah Ochsenbein","orcid":"https://orcid.org/0009-0005-1796-4505","observed_orcids":["https://orcid.org/0009-0005-1796-4505"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I4405278312","display_name":"Institut f\u00fcr Virologie und Immunologie","ror":"https://ror.org/05p45f608","country_code":"CH","type":"government","lineage":["https://openalex.org/I4210105614","https://openalex.org/I4405278312"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Sarah Ochsenbein","raw_affiliation_strings":["Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland","Institute of Virology and Immunology, Bern and Mittelh\u00e4usern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"Institute of Virology and Immunology, Bern and Mittelh\u00e4usern, Bern, Switzerland","institution_ids":["https://openalex.org/I4405278312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085582983","display_name":"Reto M. Lang","orcid":"https://orcid.org/0009-0005-9028-0863","observed_orcids":["https://orcid.org/0009-0005-9028-0863"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I4405278312","display_name":"Institut f\u00fcr Virologie und Immunologie","ror":"https://ror.org/05p45f608","country_code":"CH","type":"government","lineage":["https://openalex.org/I4210105614","https://openalex.org/I4405278312"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Reto M. Lang","raw_affiliation_strings":["Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland","Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland","Institute of Virology and Immunology, Bern and Mittelh\u00e4usern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"Institute of Virology and Immunology, Bern and Mittelh\u00e4usern, Bern, Switzerland","institution_ids":["https://openalex.org/I4405278312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023083064","display_name":"Manon Wider","orcid":"https://orcid.org/0000-0002-9795-1472","observed_orcids":["https://orcid.org/0000-0002-9795-1472"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Manon Wider","raw_affiliation_strings":["Institute for Infectious Diseases, University of Bern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Infectious Diseases, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023931782","display_name":"Carlos Machahua","orcid":"https://orcid.org/0000-0003-4964-7393","observed_orcids":["https://orcid.org/0000-0003-4964-7393"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Carlos Machahua","raw_affiliation_strings":["Department for Pulmonary Medicine, BioMedical Research, University of Bern, Bern, Switzerland","Department of Pulmonary Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for Pulmonary Medicine, BioMedical Research, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"Department of Pulmonary Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535","https://openalex.org/I2801112126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062025470","display_name":"Patrick Dorn","orcid":"https://orcid.org/0000-0002-7203-3122","observed_orcids":["https://orcid.org/0000-0002-7203-3122"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Patrick Dorn","raw_affiliation_strings":["Department for BioMedical Research, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland","Division of General Thoracic Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for BioMedical Research, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535","https://openalex.org/I2801112126"]},{"raw_affiliation_string":"Division of General Thoracic Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535","https://openalex.org/I2801112126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080089616","display_name":"Thomas M. Marti","orcid":"https://orcid.org/0000-0003-3005-220X","observed_orcids":["https://orcid.org/0000-0003-3005-220X"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Thomas M. Marti","raw_affiliation_strings":["Department for BioMedical Research, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland","Division of General Thoracic Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland"],"raw_orcid":"https://orcid.org/0000-0003-3005-220X","affiliations":[{"raw_affiliation_string":"Department for BioMedical Research, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535","https://openalex.org/I2801112126"]},{"raw_affiliation_string":"Division of General Thoracic Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535","https://openalex.org/I2801112126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034045334","display_name":"Manuela Funke-Chambour","orcid":"https://orcid.org/0000-0003-3417-5872","observed_orcids":["https://orcid.org/0000-0003-3417-5872"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Manuela Funke-Chambour","raw_affiliation_strings":["Department for Pulmonary Medicine, BioMedical Research, University of Bern, Bern, Switzerland","Department of Pulmonary Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for Pulmonary Medicine, BioMedical Research, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"Department of Pulmonary Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535","https://openalex.org/I2801112126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088630101","display_name":"Andri Rauch","orcid":"https://orcid.org/0000-0001-5297-6062","observed_orcids":["https://orcid.org/0000-0001-5297-6062"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Andri Rauch","raw_affiliation_strings":["Department of Infectious Diseases, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland","Multidisciplinary Center for Infectious Diseases, University of Bern, Bern, Switzerland"],"raw_orcid":"https://orcid.org/0000-0001-5297-6062","affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535","https://openalex.org/I2801112126"]},{"raw_affiliation_string":"Multidisciplinary Center for Infectious Diseases, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024349567","display_name":"Marek Widera","orcid":"https://orcid.org/0000-0001-5417-9307","observed_orcids":["https://orcid.org/0000-0001-5417-9307"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I4210132578","display_name":"University Hospital Frankfurt","ror":"https://ror.org/03f6n9m15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210132578"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marek Widera","raw_affiliation_strings":["Institute of Medical Virology, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany"],"raw_orcid":"https://orcid.org/0000-0001-5417-9307","affiliations":[{"raw_affiliation_string":"Institute of Medical Virology, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I114090438","https://openalex.org/I4210132578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048918542","display_name":"Sandra Ciesek","orcid":"https://orcid.org/0000-0002-1802-7565","observed_orcids":["https://orcid.org/0000-0002-1802-7565","https://orcid.org/0000-0002-7813-7598"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I4210132578","display_name":"University Hospital Frankfurt","ror":"https://ror.org/03f6n9m15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210132578"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sandra Ciesek","raw_affiliation_strings":["Institute of Medical Virology, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany"],"raw_orcid":"https://orcid.org/0000-0002-1802-7565","affiliations":[{"raw_affiliation_string":"Institute of Medical Virology, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I114090438","https://openalex.org/I4210132578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026764176","display_name":"Ronald Dijkman","orcid":"https://orcid.org/0000-0003-0320-2743","observed_orcids":["https://orcid.org/0000-0003-0320-2743"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Ronald Dijkman","raw_affiliation_strings":["European Virus Bioinformatics Center, Jena, Germany","Institute for Infectious Diseases, University of Bern, Bern, Switzerland","Multidisciplinary Center for Infectious Diseases, University of Bern, Bern, Switzerland"],"raw_orcid":"https://orcid.org/0000-0003-0320-2743","affiliations":[{"raw_affiliation_string":"European Virus Bioinformatics Center, Jena, Germany","institution_ids":[]},{"raw_affiliation_string":"Institute for Infectious Diseases, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"Multidisciplinary Center for Infectious Diseases, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001905405","display_name":"Donata Hoffmann","orcid":"https://orcid.org/0000-0003-4552-031X","observed_orcids":["https://orcid.org/0000-0003-4552-031X"]},"institutions":[{"id":"https://openalex.org/I1310048521","display_name":"Friedrich-Loeffler-Institut","ror":"https://ror.org/025fw7a54","country_code":"DE","type":"government","lineage":["https://openalex.org/I1310048521","https://openalex.org/I2801963157"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Donata Hoffmann","raw_affiliation_strings":["Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Greifswald, Germany"],"raw_orcid":"https://orcid.org/0000-0003-4552-031X","affiliations":[{"raw_affiliation_string":"Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Greifswald, Germany","institution_ids":["https://openalex.org/I1310048521"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009899510","display_name":"Marco P. Alves","orcid":"https://orcid.org/0000-0002-8495-6098","observed_orcids":["https://orcid.org/0000-0002-8495-6098"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I4405278312","display_name":"Institut f\u00fcr Virologie und Immunologie","ror":"https://ror.org/05p45f608","country_code":"CH","type":"government","lineage":["https://openalex.org/I4210105614","https://openalex.org/I4405278312"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Marco P. Alves","raw_affiliation_strings":["Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland. marco.alves@vetsuisse.unibe.ch","Institute of Virology and Immunology, Bern and Mittelh\u00e4usern, Bern, Switzerland. marco.alves@vetsuisse.unibe.ch","Multidisciplinary Center for Infectious Diseases, University of Bern, Bern, Switzerland. marco.alves@vetsuisse.unibe.ch"],"raw_orcid":"https://orcid.org/0000-0002-8495-6098","affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland. marco.alves@vetsuisse.unibe.ch","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"Institute of Virology and Immunology, Bern and Mittelh\u00e4usern, Bern, Switzerland. marco.alves@vetsuisse.unibe.ch","institution_ids":["https://openalex.org/I4405278312"]},{"raw_affiliation_string":"Multidisciplinary Center for Infectious Diseases, University of Bern, Bern, Switzerland. marco.alves@vetsuisse.unibe.ch","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039135113","display_name":"Charaf Benarafa","orcid":"https://orcid.org/0000-0002-2049-7769","observed_orcids":["https://orcid.org/0000-0002-2049-7769"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I4405278312","display_name":"Institut f\u00fcr Virologie und Immunologie","ror":"https://ror.org/05p45f608","country_code":"CH","type":"government","lineage":["https://openalex.org/I4210105614","https://openalex.org/I4405278312"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Charaf Benarafa","raw_affiliation_strings":["Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland. charaf.benarafa@vetsuisse.unibe.ch","Institute of Virology and Immunology, Bern and Mittelh\u00e4usern, Bern, Switzerland. charaf.benarafa@vetsuisse.unibe.ch","Multidisciplinary Center for Infectious Diseases, University of Bern, Bern, Switzerland. charaf.benarafa@vetsuisse.unibe.ch"],"raw_orcid":"https://orcid.org/0000-0002-2049-7769","affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland. charaf.benarafa@vetsuisse.unibe.ch","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"Institute of Virology and Immunology, Bern and Mittelh\u00e4usern, Bern, Switzerland. charaf.benarafa@vetsuisse.unibe.ch","institution_ids":["https://openalex.org/I4405278312"]},{"raw_affiliation_string":"Multidisciplinary Center for Infectious Diseases, University of Bern, Bern, Switzerland. charaf.benarafa@vetsuisse.unibe.ch","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036973907","display_name":"Martin Beer","orcid":"https://orcid.org/0000-0002-0598-5254","observed_orcids":["https://orcid.org/0000-0002-0598-5254"]},"institutions":[{"id":"https://openalex.org/I1310048521","display_name":"Friedrich-Loeffler-Institut","ror":"https://ror.org/025fw7a54","country_code":"DE","type":"government","lineage":["https://openalex.org/I1310048521","https://openalex.org/I2801963157"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Martin Beer","raw_affiliation_strings":["European Virus Bioinformatics Center, Jena, Germany. martin.beer@fli.de","Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Greifswald, Germany. martin.beer@fli.de"],"raw_orcid":"https://orcid.org/0000-0002-0598-5254","affiliations":[{"raw_affiliation_string":"European Virus Bioinformatics Center, Jena, Germany. martin.beer@fli.de","institution_ids":[]},{"raw_affiliation_string":"Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Greifswald, Germany. martin.beer@fli.de","institution_ids":["https://openalex.org/I1310048521"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086273776","display_name":"Volker Thiel","orcid":"https://orcid.org/0000-0002-5783-0887","observed_orcids":["https://orcid.org/0000-0002-5783-0887"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I4405278312","display_name":"Institut f\u00fcr Virologie und Immunologie","ror":"https://ror.org/05p45f608","country_code":"CH","type":"government","lineage":["https://openalex.org/I4210105614","https://openalex.org/I4405278312"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Volker Thiel","raw_affiliation_strings":["Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland. volker.thiel@vetsuisse.unibe.ch","European Virus Bioinformatics Center, Jena, Germany. volker.thiel@vetsuisse.unibe.ch","Institute of Virology and Immunology, Bern and Mittelh\u00e4usern, Bern, Switzerland. volker.thiel@vetsuisse.unibe.ch","Multidisciplinary Center for Infectious Diseases, University of Bern, Bern, Switzerland. volker.thiel@vetsuisse.unibe.ch"],"raw_orcid":"https://orcid.org/0000-0002-5783-0887","affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland. volker.thiel@vetsuisse.unibe.ch","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"European Virus Bioinformatics Center, Jena, Germany. volker.thiel@vetsuisse.unibe.ch","institution_ids":[]},{"raw_affiliation_string":"Institute of Virology and Immunology, Bern and Mittelh\u00e4usern, Bern, Switzerland. volker.thiel@vetsuisse.unibe.ch","institution_ids":["https://openalex.org/I4405278312"]},{"raw_affiliation_string":"Multidisciplinary Center for Infectious Diseases, University of Bern, Bern, Switzerland. volker.thiel@vetsuisse.unibe.ch","institution_ids":["https://openalex.org/I118564535"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5009899510","https://openalex.org/A5036973907","https://openalex.org/A5039135113","https://openalex.org/A5086273776"],"corresponding_institution_ids":["https://openalex.org/I118564535","https://openalex.org/I1310048521","https://openalex.org/I4405278312"],"apc_list":{"value":5890,"currency":"USD","value_usd":5890},"apc_paid":{"value":5890,"currency":"USD","value_usd":5890},"fwci":6.3303,"has_fulltext":true,"cited_by_count":60,"citation_normalized_percentile":{"value":0.97716747,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"13","issue":"1","first_page":"5929","last_page":"5929"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sars-cov-2-omicron-ba-1","display_name":"SARS-CoV-2 Omicron BA.1","score":0.9729999899864197},{"id":"https://openalex.org/keywords/spike-gene","display_name":"S gene","score":0.8080000281333923},{"id":"https://openalex.org/keywords/spike-protein-mutations","display_name":"spike protein mutations","score":0.5329999923706055},{"id":"https://openalex.org/keywords/delta-variant","display_name":"Delta variant","score":0.7630000114440918},{"id":"https://openalex.org/keywords/viral-fitness","display_name":"viral fitness","score":0.625},{"id":"https://openalex.org/keywords/nasal-epithelial-cells","display_name":"nasal epithelial cells","score":0.8009999990463257},{"id":"https://openalex.org/keywords/bronchial-epithelial-cells","display_name":"bronchial epithelial cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hamster-model","display_name":"hamster model","score":0.6050000190734863},{"id":"https://openalex.org/keywords/ferret-model","display_name":"ferret model","score":0.9940000176429749},{"id":"https://openalex.org/keywords/k18-hace2-mice","display_name":"K18-hACE2 mice","score":0.9430000185966492},{"id":"https://openalex.org/keywords/pathogenicity","display_name":"pathogenicity","score":0.7099999785423279},{"id":"https://openalex.org/keywords/immune-evasion","display_name":"immune evasion","score":0.8140000104904175},{"id":"https://openalex.org/keywords/mrna-vaccines","display_name":"mRNA vaccines","score":0.48899999260902405},{"id":"https://openalex.org/keywords/variants-of-concern","display_name":"variants of concern","score":0.6520000100135803},{"id":"https://openalex.org/keywords/viral-replication","display_name":"viral replication","score":0.43700000643730164}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6823058724403381},{"id":"https://openalex.org/C151913843","wikidata":"https://www.wikidata.org/wiki/Q3454555","display_name":"Dominance (genetics)","level":3,"score":0.5795175433158875},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5148069262504578},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4628758728504181},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4552653133869171},{"id":"https://openalex.org/C2781390188","wikidata":"https://www.wikidata.org/wiki/Q25203449","display_name":"Spike (software development)","level":2,"score":0.45033010840415955},{"id":"https://openalex.org/C81089528","wikidata":"https://www.wikidata.org/wiki/Q5134986","display_name":"clone (Java method)","level":3,"score":0.4344680905342102},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.41494932770729065},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24267122149467468},{"id":"https://openalex.org/C187736073","wikidata":"https://www.wikidata.org/wiki/Q2920921","display_name":"Management","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005289","descriptor_name":"Ferrets","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005289","descriptor_name":"Ferrets","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005289","descriptor_name":"Ferrets","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005289","descriptor_name":"Ferrets","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005719","descriptor_name":"gamma-Globulins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005719","descriptor_name":"gamma-Globulins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005719","descriptor_name":"gamma-Globulins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005719","descriptor_name":"gamma-Globulins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008558","descriptor_name":"Melphalan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008558","descriptor_name":"Melphalan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008558","descriptor_name":"Melphalan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008558","descriptor_name":"Melphalan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064370","descriptor_name":"Spike Glycoprotein, Coronavirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064370","descriptor_name":"Spike Glycoprotein, Coronavirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064370","descriptor_name":"Spike Glycoprotein, Coronavirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064370","descriptor_name":"Spike Glycoprotein, Coronavirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":11,"locations":[{"id":"doi:10.1038/s41467-022-33632-y","doi":"https://doi.org/10.1038/s41467-022-33632-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-022-33632-y","pdf_url":"https://www.nature.com/articles/s41467-022-33632-y.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"doi:10.1101/2022.04.28.489537","doi":"https://doi.org/10.1101/2022.04.28.489537","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.04.28.489537","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/04/28/2022.04.28.489537.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:36207334","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36207334","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9543931","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9543931","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmh:doi:10.48350/173334","doi":null,"is_oa":false,"landing_page_url":"https://boris-portal.unibe.ch/handle/20.500.12422/87758","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:doi:10.48350/173612","doi":null,"is_oa":false,"landing_page_url":"https://boris-portal.unibe.ch/handle/20.500.12422/87977","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"pmh:oai:RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33632-y","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-022-33632-y","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:boris.unibe.ch:173334","doi":null,"is_oa":true,"landing_page_url":"https://boris.unibe.ch/173334/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401086","display_name":"Bern Open Repository and Information System (University of Bern)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I118564535","host_organization_name":"University of Bern","host_organization_lineage":["https://openalex.org/I118564535"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/workingPaper"},{"id":"pmh:oai:boris.unibe.ch:173612","doi":null,"is_oa":true,"landing_page_url":"https://boris.unibe.ch/173612/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401747","display_name":"BORIS (University Library Bern)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210103840","host_organization_name":"Nakuru County Council","host_organization_lineage":["https://openalex.org/I4210103840"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:d61f64a2bd024554b35cf6a993be8d5f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d61f64a2bd024554b35cf6a993be8d5f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)","raw_type":"article"},{"id":"pmh:oai:www.openagrar.de:openagrar_mods_00082621","doi":null,"is_oa":true,"landing_page_url":"https://www.openagrar.de/receive/openagrar_mods_00082621","pdf_url":null,"source":{"id":"https://openalex.org/S7407055137","display_name":"OpenAgrar","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41467-022-33632-y","doi":"https://doi.org/10.1038/s41467-022-33632-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-022-33632-y","pdf_url":"https://www.nature.com/articles/s41467-022-33632-y.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.5899999737739563,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1912659486","display_name":"Host switching pathogens, infectious outbreaks and zoonosis; a Marie Sklodowska-Curie Training Network","funder_award_id":"721367","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G2478297159","display_name":"Host innate immune responses to viral RNA","funder_award_id":"173085","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G2583336430","display_name":"Versatile Emerging infectious disease Observatory","funder_award_id":"874735","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G389541734","display_name":"Rekodierung des SARSCoV2Genoms  Ein multidisziplin\u00e4rer Ansatz zur Entwicklung von attenuierten CoronavirusLebendimpfstoffen","funder_award_id":"453012513","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G434337789","display_name":null,"funder_award_id":"HORIZON2020","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G4463840603","display_name":null,"funder_award_id":"874735","funder_id":"https://openalex.org/F4320323499","funder_display_name":"Bundesministerium f\u00fcr Ern\u00e4hrung und Landwirtschaft"},{"id":"https://openalex.org/G5976128996","display_name":"Real-time pandemic functional characterization of SARS-CoV-2","funder_award_id":"196644","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G6979148196","display_name":"Rapid Evaluation and Development of Cellular and Animal Tools to fight SARS-CoV-2","funder_award_id":"196062","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G838529247","display_name":"Swift COronavirus therapeutics REsponse","funder_award_id":"101003627","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G910849018","display_name":"Molecular characterization of Influenza D virus - host interactions","funder_award_id":"179260","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320310992","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05"},{"id":"https://openalex.org/F4320318017","display_name":"Inselspital, Universit\u00e4tsspital Bern","ror":"https://ror.org/01q9sj412"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320321421","display_name":"Albert-Ludwigs-Universit\u00e4t Freiburg","ror":"https://ror.org/0245cg223"},{"id":"https://openalex.org/F4320323499","display_name":"Bundesministerium f\u00fcr Ern\u00e4hrung und Landwirtschaft","ror":"https://ror.org/04jw21793"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4303457390.pdf","grobid_xml":"https://content.openalex.org/works/W4303457390.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W2043343078","https://openalex.org/W2079064267","https://openalex.org/W2888236118","https://openalex.org/W3021391231","https://openalex.org/W3039680806","https://openalex.org/W3083653247","https://openalex.org/W3093768302","https://openalex.org/W3102451335","https://openalex.org/W3129399011","https://openalex.org/W3170097501","https://openalex.org/W3175362420","https://openalex.org/W3181868703","https://openalex.org/W3186915172","https://openalex.org/W3209387764","https://openalex.org/W4200344940","https://openalex.org/W4205867676","https://openalex.org/W4206250357","https://openalex.org/W4210308999","https://openalex.org/W4220673385","https://openalex.org/W4220729450","https://openalex.org/W4221029846","https://openalex.org/W4226059255","https://openalex.org/W4226064398","https://openalex.org/W4226088781","https://openalex.org/W4285023345"],"related_works":["https://openalex.org/W2377327490","https://openalex.org/W2560253012","https://openalex.org/W2174331923","https://openalex.org/W2157355069","https://openalex.org/W1524590520","https://openalex.org/W2050175337","https://openalex.org/W2412288087","https://openalex.org/W2069460318","https://openalex.org/W2333960626","https://openalex.org/W2371792548"],"abstract_inverted_index":{"Variant":[0],"of":[1,17,77,80,156],"concern":[2],"(VOC)":[3],"Omicron-BA.1":[4,18,34,37,81,103,120,123,141,162,197],"has":[5],"achieved":[6],"global":[7],"predominance":[8],"in":[9,19,41,46,55,59,63,82,89,101,128,170],"early":[10,78],"2022.":[11],"Therefore,":[12],"surveillance":[13],"and":[14,25,35,51,66,69,100,111,121,138,140,145,158,172,180],"comprehensive":[15],"characterization":[16,62],"advanced":[20],"primary":[21,48],"cell":[22],"culture":[23],"systems":[24],"animal":[26],"models":[27],"are":[28],"urgently":[29],"needed.":[30],"Here,":[31],"we":[32,132],"characterize":[33],"recombinant":[36],"spike":[38,114,124,150,163,182,186],"gene":[39,151],"mutants":[40],"comparison":[42],"with":[43],"VOC":[44],"Delta":[45,95,110,113,134,181],"well-differentiated":[47],"human":[49],"nasal":[50,83],"bronchial":[52,90],"epithelial":[53,84,91],"cells":[54],"vitro,":[56],"followed":[57],"by":[58,168],"vivo":[60],"fitness":[61],"hamsters,":[64,94],"ferrets":[65,102],"hACE2-expressing":[67],"mice,":[68,109,131],"immunized":[70],"hACE2-mice.":[71],"We":[72],"demonstrate":[73],"a":[74,112,153],"spike-mediated":[75,135,142],"enhancement":[76],"replication":[79,88,137,144,157],"cultures,":[85],"but":[86],"limited":[87],"cultures.":[92],"In":[93,107],"shows":[96],"dominance":[97,118],"over":[98,119],"Omicron-BA.1,":[99],"infection":[104],"is":[105,152,165,190],"abortive.":[106],"hACE2-knock-in":[108],"clone":[115,164],"also":[116],"show":[117],"an":[122],"clone,":[125],"respectively.":[126],"Interestingly,":[127],"na\u00efve":[129],"K18-hACE2":[130],"observe":[133],"increased":[136],"pathogenicity":[139],"reduced":[143],"pathogenicity,":[146],"suggesting":[147,184],"that":[148,185,194],"the":[149,161,178],"major":[154],"determinant":[155],"pathogenicity.":[159],"Finally,":[160],"less":[166],"well-controlled":[167],"mRNA-vaccination":[169],"K18-hACE2-mice":[171],"becomes":[173],"more":[174],"competitive":[175],"compared":[176],"to":[177,196],"progenitor":[179],"clones,":[183],"gene-mediated":[187],"immune":[188],"evasion":[189],"another":[191],"important":[192],"factor":[193],"led":[195],"dominance.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":15},{"year":2023,"cited_by_count":21},{"year":2022,"cited_by_count":7}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2025-10-10T00:00:00"}