{"id":"https://openalex.org/W4302819342","doi":"https://doi.org/10.1111/j.1751-1097.1998.tb03245.x","title":"Radiolysis-Induced Oxidation of Bovine \u03b1-Crystallin","display_name":"Radiolysis-Induced Oxidation of Bovine \u03b1-Crystallin","publication_year":1998,"publication_date":"1998-01-01","ids":{"openalex":"https://openalex.org/W4302819342","doi":"https://doi.org/10.1111/j.1751-1097.1998.tb03245.x","mag":"2159970510","pmid":"https://pubmed.ncbi.nlm.nih.gov/9679446"},"language":"en","primary_location":{"id":"doi:10.1111/j.1751-1097.1998.tb03245.x","doi":"https://doi.org/10.1111/j.1751-1097.1998.tb03245.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1751-1097.1998.tb03245.x","pdf_url":null,"source":{"id":"https://openalex.org/S61245073","display_name":"Photochemistry and Photobiology","issn_l":"0031-8655","issn":["0031-8655","1751-1097"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Photochemistry and Photobiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Eric L. Finley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eric L. Finley","raw_affiliation_strings":["Departments of Cellular and Molecular Pharmacology and Experimental Therapeutics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Cellular and Molecular Pharmacology and Experimental Therapeutics","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113701398","display_name":"James P. Dillon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Dillon","raw_affiliation_strings":["Department of Ophthalmology, Columbia University, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086889001","display_name":"Rosalie K. Crouch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rosalie K. Crouch","raw_affiliation_strings":["Ophthalmology, Medical University of South Carolina, Charleston, SC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology, Medical University of South Carolina, Charleston, SC, USA","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043823252","display_name":"Kevin L. Schey","orcid":"https://orcid.org/0000-0002-3959-1712","observed_orcids":["https://orcid.org/0000-0002-3959-1712"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kevin L. Schey","raw_affiliation_strings":["Departments of Cellular and Molecular Pharmacology and Experimental Therapeutics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Cellular and Molecular Pharmacology and Experimental Therapeutics","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5043823252"],"corresponding_institution_ids":[],"apc_list":{"value":4330,"currency":"USD","value_usd":4330},"apc_paid":null,"fwci":1.1015,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.76926212,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"68","issue":"1","first_page":"9","last_page":"15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.7505000233650208,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.7505000233650208,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.11699999868869781,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.029899999499320984,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-crystallin","display_name":"alpha-crystallin","score":0.8769999742507935},{"id":"https://openalex.org/keywords/hydroxyl-radicals","display_name":"hydroxyl radicals","score":0.9309999942779541},{"id":"https://openalex.org/keywords/radiolysis","display_name":"radiolysis","score":0.8519999980926514},{"id":"https://openalex.org/keywords/protein-oxidation","display_name":"protein oxidation","score":0.7839999794960022},{"id":"https://openalex.org/keywords/methionine-sulfoxide","display_name":"methionine sulfoxide","score":0.906000018119812},{"id":"https://openalex.org/keywords/n-formylkynurenine","display_name":"N-formylkynurenine","score":0.8320000171661377},{"id":"https://openalex.org/keywords/tryptophan-oxidation","display_name":"tryptophan oxidation","score":0.8029999732971191},{"id":"https://openalex.org/keywords/site-specific-modification","display_name":"site-specific modification","score":0.5260000228881836},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6940000057220459},{"id":"https://openalex.org/keywords/lens-proteins","display_name":"lens proteins","score":0.7850000262260437},{"id":"https://openalex.org/keywords/bovine-lens","display_name":"bovine lens","score":0.597000002861023}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8775067329406738},{"id":"https://openalex.org/C139066938","wikidata":"https://www.wikidata.org/wiki/Q185056","display_name":"Radical","level":2,"score":0.7891876697540283},{"id":"https://openalex.org/C2776706248","wikidata":"https://www.wikidata.org/wiki/Q181003","display_name":"Tryptophan","level":3,"score":0.7135012149810791},{"id":"https://openalex.org/C2777568990","wikidata":"https://www.wikidata.org/wiki/Q6823656","display_name":"Methionine sulfoxide","level":4,"score":0.6919154524803162},{"id":"https://openalex.org/C66887884","wikidata":"https://www.wikidata.org/wiki/Q2126498","display_name":"Radiolysis","level":3,"score":0.6519148945808411},{"id":"https://openalex.org/C2780912031","wikidata":"https://www.wikidata.org/wiki/Q180341","display_name":"Methionine","level":3,"score":0.5362059473991394},{"id":"https://openalex.org/C2776778087","wikidata":"https://www.wikidata.org/wiki/Q427071","display_name":"Hydroxyl radical","level":3,"score":0.5306989550590515},{"id":"https://openalex.org/C7263354","wikidata":"https://www.wikidata.org/wiki/Q2992167","display_name":"Crystallin","level":2,"score":0.5070888996124268},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.4625982344150543},{"id":"https://openalex.org/C35378473","wikidata":"https://www.wikidata.org/wiki/Q647574","display_name":"Maillard reaction","level":2,"score":0.4451071619987488},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.4357995390892029},{"id":"https://openalex.org/C31827203","wikidata":"https://www.wikidata.org/wiki/Q874296","display_name":"Tandem mass spectrometry","level":3,"score":0.410855770111084},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3766034245491028},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2645752429962158},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.226511150598526}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003459","descriptor_name":"Crystallins","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D003459","descriptor_name":"Crystallins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005720","descriptor_name":"Gamma Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010777","descriptor_name":"Photochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017665","descriptor_name":"Hydroxyl Radical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/j.1751-1097.1998.tb03245.x","doi":"https://doi.org/10.1111/j.1751-1097.1998.tb03245.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1751-1097.1998.tb03245.x","pdf_url":null,"source":{"id":"https://openalex.org/S61245073","display_name":"Photochemistry and Photobiology","issn_l":"0031-8655","issn":["0031-8655","1751-1097"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Photochemistry and Photobiology","raw_type":"journal-article"},{"id":"doi:10.1562/0031-8655(1998)068<0009:rioobc>2.3.co;2","doi":"https://doi.org/10.1562/0031-8655(1998)068<0009:rioobc>2.3.co;2","is_oa":false,"landing_page_url":"https://doi.org/10.1562/0031-8655(1998)068<0009:rioobc>2.3.co;2","pdf_url":null,"source":{"id":"https://openalex.org/S61245073","display_name":"Photochemistry and Photobiology","issn_l":"0031-8655","issn":["0031-8655","1751-1097"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Photochemistry and Photobiology","raw_type":"journal-article"},{"id":"pmid:9679446","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9679446","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Photochemistry and photobiology","raw_type":"Journal Article"},{"id":"mag:2159970510","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9679446","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6290957023","display_name":"POSTTRANSLATIONAL MODIFICATIONS OF LENS PROTEINS","funder_award_id":"R01EY010722","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G848974753","display_name":null,"funder_award_id":"EY 10722","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1506520614","https://openalex.org/W1654460714","https://openalex.org/W1759706356","https://openalex.org/W1827875159","https://openalex.org/W1828605086","https://openalex.org/W1926950498","https://openalex.org/W1936380547","https://openalex.org/W1969887535","https://openalex.org/W1978819260","https://openalex.org/W1987657904","https://openalex.org/W1987741979","https://openalex.org/W1992194517","https://openalex.org/W1993800031","https://openalex.org/W1997928705","https://openalex.org/W2002434766","https://openalex.org/W2012533970","https://openalex.org/W2030223179","https://openalex.org/W2033123702","https://openalex.org/W2040395696","https://openalex.org/W2041293207","https://openalex.org/W2044031095","https://openalex.org/W2048966030","https://openalex.org/W2056405177","https://openalex.org/W2056438749","https://openalex.org/W2070828755","https://openalex.org/W2087292928","https://openalex.org/W2087981895","https://openalex.org/W2094639288","https://openalex.org/W2094665292","https://openalex.org/W2101465706","https://openalex.org/W2111630567","https://openalex.org/W2116420172","https://openalex.org/W2141315526","https://openalex.org/W2158001247","https://openalex.org/W2158161840","https://openalex.org/W2165241568","https://openalex.org/W2177092266","https://openalex.org/W3034996121"],"related_works":["https://openalex.org/W2159970510","https://openalex.org/W2165241568","https://openalex.org/W2065813707","https://openalex.org/W2019662886","https://openalex.org/W2111630567","https://openalex.org/W2512529945","https://openalex.org/W2099542937","https://openalex.org/W1615660430","https://openalex.org/W1973306487","https://openalex.org/W2138318611"],"abstract_inverted_index":{"Radiolysis":[0],"of":[1,10,31,79,88,97,118,135,155,159,169,179,188],"water":[2],"by":[3,19,57,65,71,146],"ionizing":[4],"radiation":[5],"results":[6],"in":[7,112,141,156,166],"the":[8,29,35,44,52,75,80,129,133,138,142,153,165,175,180,186,189],"production":[9],"pure":[11,162],"hydroxyl":[12,32,149,163],"radicals.":[13,150],"This":[14,125],"technique,":[15],"combined":[16],"with":[17,49],"analysis":[18,83],"tandem":[20],"mass":[21],"spectrometry":[22],"(MS/MS),":[23],"has":[24],"been":[25],"used":[26],"to":[27,42,73,102,148,161,174,191],"study":[28,126],"effect":[30],"radicals":[33],"on":[34],"intact":[36,143,195],"bovine":[37],"alpha-crystallin":[38,46,144,160,192],"protein.":[39],"After":[40],"exposure":[41,147,158],"gamma-irradiation,":[43],"oxidized":[45,101],"was":[47,106,121],"digested":[48],"trypsin":[50],"and":[51,70,77,91,94,137],"resulting":[53],"peptides":[54],"were":[55,63,100],"fractionated":[56],"reverse-phase":[58],"HPLC.":[59],"The":[60],"isolated":[61],"fractions":[62],"analyzed":[64],"matrix-assisted":[66],"laser":[67],"desorption":[68],"ionization":[69],"MS/MS":[72],"determine":[74],"locations":[76],"identities":[78],"modifications.":[81],"Structural":[82],"revealed":[84],"that":[85],"methionine":[86,95,103],"1":[87],"alpha":[89,92,98,119],"A-":[90],"B-crystallin":[93,99],"68":[96],"sulfoxide.":[104],"Hydroxytryptophan":[105],"formed":[107],"from":[108,185,194],"each":[109],"tryptophan":[110,116],"residue":[111],"alpha-crystallin,":[113],"although":[114],"only":[115],"9":[117],"A-crystallin":[120],"converted":[122],"into":[123],"N-formylkynurenine.":[124],"has,":[127],"for":[128],"first":[130],"time,":[131],"identified":[132],"sites":[134],"modification":[136],"structures":[139],"produced":[140],"protein":[145],"By":[151],"determining":[152],"consequences":[154],"vitro":[157],"radicals,":[164],"vivo":[167],"contribution":[168],"this":[170],"reactive":[171],"oxygen":[172],"species":[173],"overall":[176],"oxidative":[177],"stress":[178],"lens":[181],"will":[182],"be":[183],"achieved":[184],"identification":[187],"modifications":[190],"purified":[193],"human":[196],"lenses.":[197]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2022-10-07T00:00:00"}
