{"id":"https://openalex.org/W4302763233","doi":"https://doi.org/10.1371/journal.pone.0274457","title":"Feasibility of a novel non-invasive swab technique for serial whole-exome sequencing of cervical tumors during chemoradiation therapy","display_name":"Feasibility of a novel non-invasive swab technique for serial whole-exome sequencing of cervical tumors during chemoradiation therapy","publication_year":2022,"publication_date":"2022-10-06","ids":{"openalex":"https://openalex.org/W4302763233","doi":"https://doi.org/10.1371/journal.pone.0274457","pmid":"https://pubmed.ncbi.nlm.nih.gov/36201462","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9536567"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0274457","doi":"https://doi.org/10.1371/journal.pone.0274457","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0274457","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0274457&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0274457&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008921907","display_name":"Julianna Bronk","orcid":"https://orcid.org/0000-0003-3459-1833","observed_orcids":["https://orcid.org/0000-0003-3459-1833"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julianna K. Bronk","raw_affiliation_strings":["Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas","Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049407901","display_name":"Chiraag Deepak Kapadia","orcid":"https://orcid.org/0000-0003-1805-8879","observed_orcids":["https://orcid.org/0000-0003-1805-8879"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chiraag Kapadia","raw_affiliation_strings":["Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX","Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas","Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America","Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045121596","display_name":"Xiaogang Wu","orcid":"https://orcid.org/0000-0003-4373-6926","observed_orcids":["https://orcid.org/0000-0003-4373-6926","https://orcid.org/0000-0003-1042-7932","https://orcid.org/0000-0002-7552-5616"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaogang Wu","raw_affiliation_strings":["Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas","Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018123323","display_name":"Bhavana V. Chapman","orcid":"https://orcid.org/0000-0002-2926-3432","observed_orcids":["https://orcid.org/0000-0002-2926-3432"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bhavana V. Chapman","raw_affiliation_strings":["Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas","Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100431113","display_name":"Rui Wang","orcid":"https://orcid.org/0000-0001-5794-7201","observed_orcids":["https://orcid.org/0000-0001-5794-7201"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rui Wang","raw_affiliation_strings":["Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas","Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087636420","display_name":"Tatiana V. Karpinets","orcid":"https://orcid.org/0000-0002-3668-8148","observed_orcids":["https://orcid.org/0000-0002-3668-8148"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tatiana V. Karpinets","raw_affiliation_strings":["Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas","Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025934990","display_name":"Xingzhi Song","orcid":"https://orcid.org/0000-0002-9436-2728","observed_orcids":["https://orcid.org/0000-0002-9436-2728"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xingzhi Song","raw_affiliation_strings":["Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas","Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104227323","display_name":"Andrew M. Futreal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew M. Futreal","raw_affiliation_strings":["Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas","Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100434755","display_name":"Jianhua Zhang","orcid":"https://orcid.org/0000-0001-5412-9860","observed_orcids":["https://orcid.org/0000-0001-5412-9860","https://orcid.org/0000-0001-9277-2507"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianhua Zhang","raw_affiliation_strings":["Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas","Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024043125","display_name":"Ann H. Klopp","orcid":"https://orcid.org/0000-0002-2081-0735","observed_orcids":["https://orcid.org/0000-0002-2081-0735"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ann H. Klopp","raw_affiliation_strings":["Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas","Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065934113","display_name":"Lauren Elizabeth Colbert","orcid":"https://orcid.org/0000-0001-5806-4339","observed_orcids":["https://orcid.org/0000-0001-5806-4339"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lauren E. Colbert","raw_affiliation_strings":["Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas","Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5024043125","https://openalex.org/A5065934113"],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":{"value":1805,"currency":"USD","value_usd":1805},"apc_paid":{"value":1805,"currency":"USD","value_usd":1805},"fwci":0.1786,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.37096517,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"17","issue":"10","first_page":"e0274457","last_page":"e0274457"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.8823000192642212,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.8823000192642212,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.08370000123977661,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cervical-cancer","display_name":"cervical cancer","score":0.9900000095367432},{"id":"https://openalex.org/keywords/chemoradiotherapy","display_name":"chemoradiotherapy","score":0.984000027179718},{"id":"https://openalex.org/keywords/tumor-mutational-burden","display_name":"tumor mutational burden","score":0.6320000290870667},{"id":"https://openalex.org/keywords/radioresistance-biology","display_name":"radioresistance (biology)","score":0.6710000038146973},{"id":"https://openalex.org/keywords/tumor-purity","display_name":"tumor purity","score":0.4729999899864197},{"id":"https://openalex.org/keywords/treatment-response-monitoring","display_name":"treatment response monitoring","score":0.5149999856948853},{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.6669999957084656}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5530576705932617},{"id":"https://openalex.org/C16671776","wikidata":"https://www.wikidata.org/wiki/Q5420592","display_name":"Exome sequencing","level":4,"score":0.5386362671852112},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3772679567337036},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.35558021068573},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3088192939758301},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13458341360092163},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.10333329439163208},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000073359","descriptor_name":"Exome Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D005240","descriptor_name":"Feasibility Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059472","descriptor_name":"Exome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pone.0274457","doi":"https://doi.org/10.1371/journal.pone.0274457","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0274457","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0274457&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"doi:10.1101/2022.02.23.22271256","doi":"https://doi.org/10.1101/2022.02.23.22271256","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.02.23.22271256","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2022/03/28/2022.02.23.22271256.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:9536567","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9536567","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:36201462","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36201462","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:digitalcommons.library.tmc.edu:uthgsbs_docs-1501","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.library.tmc.edu/uthgsbs_docs/509","pdf_url":null,"source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty, Staff and Student Publications","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:54e97542f370464888ea7969f65a6d91","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/54e97542f370464888ea7969f65a6d91","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 17, Iss 10 (2022)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:f2991e7204054ebb993d048929222b82","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f2991e7204054ebb993d048929222b82","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 17, Iss 10, p e0274457 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0274457","doi":"https://doi.org/10.1371/journal.pone.0274457","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0274457","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0274457&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G293715275","display_name":null,"funder_award_id":"P30-CA-016672","funder_id":"https://openalex.org/F4320332521","funder_display_name":"University of Texas MD Anderson Cancer Center"},{"id":"https://openalex.org/G3223699165","display_name":null,"funder_award_id":"P30 CA016672","funder_id":"https://openalex.org/F4320306080","funder_display_name":"Foundation for the National Institutes of Health"},{"id":"https://openalex.org/G9000878657","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA016672","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306080","display_name":"Foundation for the National Institutes of Health","ror":"https://ror.org/00k86s890"},{"id":"https://openalex.org/F4320308932","display_name":"Radiological Society of North America","ror":"https://ror.org/00rj4x019"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332521","display_name":"University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320338247","display_name":"Moonshot Research and Development Program","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4302763233.pdf","grobid_xml":"https://content.openalex.org/works/W4302763233.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1527347967","https://openalex.org/W1534603498","https://openalex.org/W1957853838","https://openalex.org/W1966676297","https://openalex.org/W1992708996","https://openalex.org/W2023410485","https://openalex.org/W2033751993","https://openalex.org/W2073419672","https://openalex.org/W2081319583","https://openalex.org/W2103441770","https://openalex.org/W2121531763","https://openalex.org/W2130430382","https://openalex.org/W2131538171","https://openalex.org/W2154397429","https://openalex.org/W2154787712","https://openalex.org/W2166421896","https://openalex.org/W2170490448","https://openalex.org/W2171892226","https://openalex.org/W2185207072","https://openalex.org/W2225308925","https://openalex.org/W2575837388","https://openalex.org/W2586769521","https://openalex.org/W2782647267","https://openalex.org/W2809409170","https://openalex.org/W2867868648","https://openalex.org/W2896872272","https://openalex.org/W2911188335","https://openalex.org/W2946272661","https://openalex.org/W2946295060","https://openalex.org/W2948370860","https://openalex.org/W2956054465","https://openalex.org/W2960198954","https://openalex.org/W2986020589","https://openalex.org/W2990871782","https://openalex.org/W2993250673","https://openalex.org/W3010938966","https://openalex.org/W3036106560","https://openalex.org/W3100245912","https://openalex.org/W3122075075","https://openalex.org/W3163446898","https://openalex.org/W4200575596","https://openalex.org/W4220690241","https://openalex.org/W6633658626"],"related_works":["https://openalex.org/W3211205136","https://openalex.org/W2990241419","https://openalex.org/W4390751580","https://openalex.org/W2955571891","https://openalex.org/W4389059962","https://openalex.org/W4386788336","https://openalex.org/W4398213386","https://openalex.org/W4387949866","https://openalex.org/W4405134754","https://openalex.org/W4200617810"],"abstract_inverted_index":{"BACKGROUND:":[0],"Clinically":[1],"relevant":[2],"genetic":[3,24],"predictors":[4],"of":[5,17,33,61,87,128,144,147,153,160,222],"radiation":[6,248],"response":[7],"for":[8,113,140,173,189,227],"cervical":[9,37],"cancer":[10,67],"are":[11],"understudied":[12],"due":[13],"to":[14,22,29,40,48,234,242],"the":[15,31,59,85,126,177,218],"morbidity":[16],"repeat":[18],"invasive":[19],"biopsies":[20],"required":[21],"obtain":[23],"material.":[25],"Thus,":[26],"we":[27],"aimed":[28],"demonstrate":[30],"feasibility":[32,219],"a":[34,92,109,157,223],"novel":[35,244],"noninvasive":[36,93,224],"swab":[38],"technique":[39,226],"(1)":[41],"collect":[42],"tumor":[43,68,119,148,237],"DNA":[44],"with":[45,101,105,117],"adequate":[46],"throughput":[47],"(2)":[49],"perform":[50],"whole-exome":[51,102,115],"sequencing":[52,103,116],"(WES)":[53,104],"at":[54,76,78,84,162,206,211],"serial":[55],"time":[56,165],"points":[57],"over":[58,125],"course":[60,127],"chemoradiation":[62,73],"therapy":[63],"(CRT).":[64],"METHODS:":[65],"Cervical":[66],"samples":[69,98,134,149,161],"from":[70],"patients":[71,142,155],"undergoing":[72],"were":[74,99,130,135],"collected":[75,136],"baseline,":[77],"week":[79,81,212],"1,":[80],"3,":[82],"and":[83,137,176,201,208,220],"completion":[86],"CRT":[88,197],"(week":[89],"5)":[90],"using":[91,108],"swab-based":[94,225],"biopsy":[95],"technique.":[96],"Swab":[97],"analyzed":[100],"mutation":[106,123,193],"calling":[107],"custom":[110],"pipeline":[111],"optimized":[112],"shallow":[114],"low":[118],"purity":[120],"(TP).":[121],"Tumor":[122],"changes":[124,239],"treatment":[129,241],"profiled.":[131],"RESULTS:":[132],"216":[133],"successfully":[138],"sequenced":[139],"70":[141],"(94%":[143],"total":[145,152],"number":[146],"collected).":[150],"A":[151],"33":[154],"had":[156],"complete":[158],"set":[159],"all":[163,174,190],"four":[164],"points.":[166],"The":[167],"mean":[168,178,202],"mapping":[169,199],"rate":[170,200],"was":[171,181,185],"98%":[172],"samples,":[175],"target":[179,203],"coverage":[180,204],"180.":[182],"Estimated":[183],"TP":[184],"greater":[186],"than":[187],"5%":[188],"samples.":[191],"Overall":[192],"frequency":[194],"decreased":[195],"during":[196,240],"but":[198],"remained":[205],">98%":[207],">180":[209],"reads":[210],"5.":[213],"CONCLUSION:":[214],"This":[215],"study":[216],"demonstrates":[217],"application":[221],"WES":[228],"analysis":[229],"which":[230,246],"may":[231],"be":[232],"applied":[233],"investigate":[235],"dynamic":[236],"mutational":[238],"identify":[243],"genes":[245],"confer":[247],"resistance.":[249]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2022-10-07T00:00:00"}
